{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T04:18:16Z","timestamp":1793765896457,"version":"4.6.1"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.phymed.2024.155868","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T20:23:01Z","timestamp":1721074981000},"page":"155868","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"special_numbering":"C","title":["Linderae Radix extract attenuates ulcerative colitis by inhibiting the JAK\/STAT signaling pathway"],"prefix":"10.1016","volume":"132","author":[{"given":"Yingying","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2156-0800","authenticated-orcid":false,"given":"Weizhi","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunjie","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianli","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7367-3500","authenticated-orcid":false,"given":"Zhaohuan","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2024.155868_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104430","article-title":"The gut microbiota and metabolome are associated with diminished COVID-19 vaccine-induced antibody responses in immunosuppressed inflammatory bowel disease patients","volume":"88","author":"Alexander","year":"2023","journal-title":"EBioMedicine"},{"issue":"3","key":"10.1016\/j.phymed.2024.155868_bib0002","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s12664-018-0850-0","article-title":"Risk factors for inflammatory bowel disease: a prospective multi-center study","volume":"37","author":"Amarapurkar","year":"2018","journal-title":"Indian J. Gastroenterol."},{"issue":"6","key":"10.1016\/j.phymed.2024.155868_bib0003","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.fct.2009.03.003","article-title":"Prophylactic role of curcumin in dextran sulfate sodium (DSS)-induced ulcerative colitis murine model","volume":"47","author":"Arafa","year":"2009","journal-title":"Food Chem. Toxicol."},{"issue":"5","key":"10.1016\/j.phymed.2024.155868_bib0004","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/75068","article-title":"Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo","volume":"6","author":"Atreya","year":"2000","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.phymed.2024.155868_bib0005","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/apt.15771","article-title":"Review article: withdrawal of 5-aminosalicylates in inflammatory bowel disease","volume":"52","author":"Chapman","year":"2020","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2024.155868_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104934","article-title":"Multi-omic insight into the molecular networks of mitochondrial dysfunction in the pathogenesis of inflammatory bowel disease","volume":"99","author":"Chen","year":"2024","journal-title":"EBioMedicine"},{"key":"10.1016\/j.phymed.2024.155868_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104494","article-title":"Therapeutic targets for inflammatory bowel disease: proteome-wide Mendelian randomization and colocalization analyses","volume":"89","author":"Chen","year":"2023","journal-title":"EBioMedicine"},{"issue":"8","key":"10.1016\/j.phymed.2024.155868_bib0008","first-page":"12009","article-title":"IL-6\/STAT3\/SOCS3 signaling pathway playing a regulatory role in ulcerative colitis carcinogenesis","volume":"8","author":"Chen","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"issue":"1","key":"10.1016\/j.phymed.2024.155868_bib0009","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.prp.2017.10.003","article-title":"Overexpression of microRNA-495 improves the intestinal mucosal barrier function by targeting STAT3 via inhibition of the JAK\/STAT3 signaling pathway in a mouse model of ulcerative colitis","volume":"214","author":"Chu","year":"2018","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.phymed.2024.155868_bib0010","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1245535","article-title":"Recent advances in JAK inhibitors for the treatment of metabolic syndrome","volume":"14","author":"Collotta","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.phymed.2024.155868_bib0011","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1093\/ibd\/izy364","article-title":"A JAK1 selective kinase inhibitor and tofacitinib affect macrophage activation and function","volume":"25","author":"De Vries","year":"2019","journal-title":"Inflamm. Bowel. Dis."},{"key":"10.1016\/j.phymed.2024.155868_bib0012","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.intimp.2018.06.024","article-title":"Over-expressed miRNA-200b ameliorates ulcerative colitis-related colorectal cancer in mice through orchestrating epithelial-mesenchymal transition and inflammatory responses by channel of AKT2","volume":"61","author":"Deng","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2024.155868_bib0013","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1184183","article-title":"Rhubarb polysaccharide and berberine co-assembled nanoparticles ameliorate ulcerative colitis by regulating the intestinal flora","volume":"14","author":"Feng","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2024.155868_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154006","article-title":"Protective effects of Ligularia fischeri root extracts against ulcerative colitis in mice through activation of Bcl-2\/Bax signalings","volume":"99","author":"Fu","year":"2022","journal-title":"Phytomedicine"},{"issue":"8","key":"10.1016\/j.phymed.2024.155868_bib0015","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1021\/np900354q","article-title":"Sesquiterpene lactones from the root tubers of Lindera aggregata","volume":"72","author":"Gan","year":"2009","journal-title":"J. Nat. Prod."},{"issue":"13","key":"10.1016\/j.phymed.2024.155868_bib0016","doi-asserted-by":"crossref","first-page":"E2960","DOI":"10.1073\/pnas.1720696115","article-title":"Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response","volume":"115","author":"Gao","year":"2018","journal-title":"Proc. Natl. Acad. Sci. u S. a"},{"issue":"2","key":"10.1016\/j.phymed.2024.155868_bib0017","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ccr.2009.01.001","article-title":"IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer","volume":"15","author":"Grivennikov","year":"2009","journal-title":"Cancer Cell"},{"issue":"5","key":"10.1016\/j.phymed.2024.155868_bib0018","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s12529-018-9745-9","article-title":"Sleep quality in ulcerative colitis: associations with inflammation, psychological distress, and quality of life","volume":"25","author":"Hood","year":"2018","journal-title":"Int. J. Behav. Med."},{"key":"10.1016\/j.phymed.2024.155868_bib0019","article-title":"Effectiveness and safety of vedolizumab for ulcerative colitis: a single-center retrospective real-world study in China","volume":"14","author":"Huang","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"9","key":"10.1016\/j.phymed.2024.155868_bib0020","doi-asserted-by":"crossref","first-page":"4619","DOI":"10.1002\/cam4.1692","article-title":"Serum type XVI collagen is associated with colorectal cancer and ulcerative colitis indicating a pathological role in gastrointestinal disorders","volume":"7","author":"Jensen","year":"2018","journal-title":"Cancer Med."},{"key":"10.1016\/j.phymed.2024.155868_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104840","article-title":"Allosteric TYK2 inhibition: redefining autoimmune disease therapy beyond JAK1-3 inhibitors","volume":"97","author":"Jensen","year":"2023","journal-title":"EBioMedicine"},{"key":"10.1016\/j.phymed.2024.155868_bib0022","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13020-016-0090-0","article-title":"Herb-partitioned moxibustion upregulated the expression of colonic epithelial tight junction-related proteins in Crohn's disease model rats","volume":"11","author":"Ji","year":"2016","journal-title":"Chin. Med."},{"issue":"1","key":"10.1016\/j.phymed.2024.155868_bib0023","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4103\/1319-3767.91726","article-title":"Herbal medicine in the treatment of ulcerative colitis","volume":"18","author":"Ke","year":"2012","journal-title":"Saudi. J. Gastroenterol."},{"issue":"15","key":"10.1016\/j.phymed.2024.155868_bib0024","first-page":"3115","article-title":"Overexpression of Bcl-X(L) inhibits Ara-C-induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis","volume":"57","author":"Kim","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/j.phymed.2024.155868_bib0025","doi-asserted-by":"crossref","unstructured":"Kim, H.C., Kim, E., Bae, J.I., Lee, K.H., Jeon, Y.T., Hwang, J.W., Lim, Y.J., Min, S.W., Park, H.P., 2017. Sevoflurane postconditioning reduces apoptosis by activating the JAK-STAT pathway after transient global cerebral ischemia in rats. 29(1), 37\u201345. https:\/\/doi.org\/10.1097\/ana.0000000000000331.","DOI":"10.1097\/ANA.0000000000000331"},{"issue":"3","key":"10.1016\/j.phymed.2024.155868_bib0026","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.cellsig.2006.09.003","article-title":"STAT1 as a key modulator of cell death","volume":"19","author":"Kim","year":"2007","journal-title":"Cell Signal."},{"issue":"13","key":"10.1016\/j.phymed.2024.155868_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2020.127224","article-title":"Anti-inflammatory principles from Lindera aggregata","volume":"30","author":"Kuo","year":"2020","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.phymed.2024.155868_bib0028","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.615506","article-title":"Root extract of lindera aggregata (Sims) kosterm. modulates the Th17\/Treg balance to attenuate DSS-Induced colitis in mice by IL-6\/STAT3 signaling pathway","volume":"12","author":"Lai","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"9","key":"10.1016\/j.phymed.2024.155868_bib0029","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1089\/jmf.2016.3859","article-title":"Coenzyme Q10 inhibits Th17 and STAT3 signaling pathways to ameliorate colitis in mice","volume":"20","author":"Lee","year":"2017","journal-title":"J. Med. Food"},{"key":"10.1016\/j.phymed.2024.155868_bib0030","article-title":"Potential of natural flavonols and flavanones in the treatment of ulcerative colitis","volume":"14","author":"Li","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2024.155868_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2023.105416","article-title":"Sialic acid exerts anti-inflammatory effect through inhibiting MAPK-NF-\u03baB\/AP-1 pathway and apoptosis in ulcerative colitis","volume":"101","author":"Li","year":"2023","journal-title":"J. Funct. Foods."},{"issue":"2","key":"10.1016\/j.phymed.2024.155868_bib0032","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1136\/gut.2009.184176","article-title":"Disease-related expression of the IL6\/STAT3\/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis","volume":"59","author":"Li","year":"2010","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.phymed.2024.155868_bib0033","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.intimp.2015.08.040","article-title":"Norisoboldine ameliorates DSS-induced ulcerative colitis in mice through induction of regulatory T cells in colons","volume":"29","author":"Lv","year":"2015","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.phymed.2024.155868_bib0034","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jcmgh.2020.01.014","article-title":"NCoR1 protects mice from dextran sodium sulfate-induced colitis by guarding colonic crypt cells from luminal insult","volume":"10","author":"Mennillo","year":"2020","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"issue":"5","key":"10.1016\/j.phymed.2024.155868_bib0035","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.4049\/jimmunol.178.5.2623","article-title":"The JAK-STAT signaling pathway: input and output integration","volume":"178","author":"Murray","year":"2007","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.phymed.2024.155868_bib0036","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1053\/j.gastro.2017.11.024","article-title":"Efficacy of indigo naturalis in a multicenter randomized controlled trial of patients with ulcerative colitis","volume":"154","author":"Naganuma","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phymed.2024.155868_bib0037","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/250762","article-title":"Apoptosis, necrosis, and necroptosis in the gut and intestinal homeostasis","volume":"2015","author":"Negroni","year":"2015","journal-title":"Mediators. Inflamm."},{"issue":"5","key":"10.1016\/j.phymed.2024.155868_bib0038","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nrgastro.2016.208","article-title":"Current and emerging therapeutic targets for IBD","volume":"14","author":"Neurath","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"4","key":"10.1016\/j.phymed.2024.155868_bib0039","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/0092-8674(93)90509-O","article-title":"Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death","volume":"74","author":"Oltvai","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2024.155868_bib0040","doi-asserted-by":"crossref","first-page":"280","DOI":"10.3389\/fimmu.2013.00280","article-title":"Central role of the gut epithelial barrier in the pathogenesis of chronic intestinal inflammation: lessons learned from animal models and human genetics","volume":"4","author":"Pastorelli","year":"2013","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2024.155868_bib0041","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1265177","article-title":"ACT001 improved cardiovascular function in septic mice by inhibiting the production of proinflammatory cytokines and the expression of JAK-STAT signaling pathway","volume":"14","author":"Peng","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2024.155868_bib0042","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.molimm.2019.04.005","article-title":"Regulation of CD11b by HIF-1\u03b1 and the STAT3 signaling pathway contributes to the immunosuppressive function of B cells in inflammatory bowel disease","volume":"111","author":"Qian","year":"2019","journal-title":"Mol. Immunol."},{"issue":"5","key":"10.1016\/j.phymed.2024.155868_bib0043","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1172\/JCI42917","article-title":"PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice","volume":"121","author":"Qiu","year":"2011","journal-title":"J. Clin. Invest."},{"issue":"Pt 8","key":"10.1016\/j.phymed.2024.155868_bib0044","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1242\/jcs.00963","article-title":"The JAK\/STAT signaling pathway","volume":"117","author":"Rawlings","year":"2004","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.phymed.2024.155868_bib0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104088","article-title":"Systematic review of donor and recipient predictive biomarkers of response to faecal microbiota transplantation in patients with ulcerative colitis","volume":"81","author":"Rees","year":"2022","journal-title":"EBioMedicine"},{"issue":"4","key":"10.1016\/j.phymed.2024.155868_bib0046","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/jgh3.12216","article-title":"Uncovering the cause of ulcerative colitis","volume":"3","author":"Roberts-Thomson","year":"2019","journal-title":"JGH. Open."},{"issue":"6","key":"10.1016\/j.phymed.2024.155868_bib0047","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/s41575-020-0273-0","article-title":"JAK-STAT pathway targeting for the treatment of inflammatory bowel disease","volume":"17","author":"Salas","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phymed.2024.155868_bib0048","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.pharmthera.2018.07.003","article-title":"Targeting JAK-STAT signal transduction in IBD","volume":"192","author":"Soendergaard","year":"2018","journal-title":"Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.phymed.2024.155868_bib0049","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00384-004-0639-8","article-title":"Apoptosis in the intestinal mucosa of patients with inflammatory bowel disease: evidence of altered expression of FasL and perforin cytotoxic pathways","volume":"20","author":"Souza","year":"2005","journal-title":"Int. J. Colorectal. Dis."},{"issue":"17","key":"10.1016\/j.phymed.2024.155868_bib0050","first-page":"5635","article-title":"Correlations of 25-hydroxyvitamin D3 level in patients with ulcerative colitis with inflammation level, immunity and disease activity","volume":"22","author":"Sun","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"8","key":"10.1016\/j.phymed.2024.155868_bib0051","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1053\/j.gastro.2019.02.023","article-title":"MicroRNA-31 reduces inflammatory signaling and promotes regeneration in colon epithelium, and delivery of mimics in microspheres reduces colitis in mice","volume":"156","author":"Tian","year":"2019","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.phymed.2024.155868_bib0052","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/ecco-jcc\/jjx158","article-title":"Expression patterns of TNF\u03b1, MAdCAM1, and STAT3 in intestinal and skin manifestations of inflammatory bowel disease","volume":"12","author":"Vavricka","year":"2018","journal-title":"J. Crohns. Colitis."},{"issue":"1","key":"10.1016\/j.phymed.2024.155868_bib0053","doi-asserted-by":"crossref","first-page":"107","DOI":"10.5114\/aoms.2017.68696","article-title":"Prognostic value of assessment of stool and serum IL-1\u03b2, IL-1ra and IL-6 concentrations in children with active and inactive ulcerative colitis","volume":"14","author":"W\u0119drychowicz","year":"2018","journal-title":"Arch. Med. Sci."},{"key":"10.1016\/j.phymed.2024.155868_bib0054","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1228969","article-title":"The mechanism of traditional medicine in alleviating ulcerative colitis: regulating intestinal barrier function","volume":"14","author":"Xu","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2024.155868_bib0055","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8291413","article-title":"Ganoderic acid d protects human amniotic mesenchymal stem cells against oxidative stress-induced senescence through the PERK\/NRF2 signaling pathway","volume":"2020","author":"Xu","year":"2020","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.phymed.2024.155868_bib0056","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113357","article-title":"Baitouweng decoction alleviates dextran sulfate sodium-induced ulcerative colitis by regulating intestinal microbiota and the IL-6\/STAT3 signaling pathway","volume":"265","author":"Xuan-Qing","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2024.155868_bib0057","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154362","article-title":"Treatment of ulcerative colitis with Wu-Mei-Wan by inhibiting intestinal inflammatory response and repairing damaged intestinal mucosa","volume":"105","author":"Yan","year":"2022","journal-title":"Phytomedicine"},{"issue":"2","key":"10.1016\/j.phymed.2024.155868_bib0058","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s11418-019-01385-6","article-title":"Chemical constituents from the roots of Lindera aggregata and their biological activities","volume":"74","author":"Yang","year":"2020","journal-title":"J. Nat. Med."},{"key":"10.1016\/j.phymed.2024.155868_bib0059","unstructured":"Ying, X., Xiaowen, W., Na, L., Jianying, B., Hui, L., Limei, W.J.C.J.o.E.T.M.F., 2023. Historical Evolution and Modern Clinical Application of Classic Formula Wuyaotang. 31\u201338."},{"issue":"3","key":"10.1016\/j.phymed.2024.155868_bib0060","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1136\/gut.2005.076000","article-title":"Role of interleukin 15 in colitis induced by dextran sulphate sodium in mice","volume":"55","author":"Yoshihara","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.phymed.2024.155868_bib0061","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113442","article-title":"Anti-inflammation effect of Qingchang suppository in ulcerative colitis through JAK2\/STAT3 signaling pathway in vitro and in vivo","volume":"266","author":"Yu","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2024.155868_bib0062","article-title":"Advances in natural compound-based nanomedicine and the interaction with gut microbiota in ulcerative colitis therapy","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2024.155868_bib0063","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.intimp.2017.05.033","article-title":"Administration of geniposide ameliorates dextran sulfate sodium-induced colitis in mice via inhibition of inflammation and mucosal damage","volume":"49","author":"Zhang","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2024.155868_bib0064","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/1562010","article-title":"Chemopreventive effects of silibinin on colitis-associated tumorigenesis by inhibiting IL-6\/STAT3 signaling pathway","volume":"2018","author":"Zheng","year":"2018","journal-title":"Mediators. Inflamm."},{"key":"10.1016\/j.phymed.2024.155868_bib0065","article-title":"Curcumin regulated the homeostasis of memory T cell and ameliorated dextran sulfate sodium-induced experimental colitis","volume":"11","author":"Zhong","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"10","key":"10.1016\/j.phymed.2024.155868_bib0066","doi-asserted-by":"crossref","first-page":"G841","DOI":"10.1152\/ajpgi.00149.2014","article-title":"Bilirubin prevents acute DSS-induced colitis by inhibiting leukocyte infiltration and suppressing upregulation of inducible nitric oxide synthase","volume":"309","author":"Zucker","year":"2015","journal-title":"Am. J. Physiol. Gastrointest. Liver. Physiol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324005269?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324005269?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T13:06:16Z","timestamp":1728392776000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711324005269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":66,"alternative-id":["S0944711324005269"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155868","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Linderae Radix extract attenuates ulcerative colitis by inhibiting the JAK\/STAT signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155868","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"155868"}}