{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:30:41Z","timestamp":1790476241398,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010722","name":"Harbin Medical University","doi-asserted-by":"publisher","award":["2017YFC1702003"],"award-info":[{"award-number":["2017YFC1702003"]}],"id":[{"id":"10.13039\/100010722","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.phymed.2024.155891","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T01:08:12Z","timestamp":1721869692000},"page":"155891","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Diosgenin alleviates arsenic trioxide induced cardiac fibrosis by inhibiting endothelial mesenchymal transition"],"prefix":"10.1016","volume":"132","author":[{"given":"Hao","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanqing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henghui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minzhen","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menghan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8754-8938","authenticated-orcid":false,"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.phymed.2024.155891_bib0001","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.1745-7254.2008.00771.x","article-title":"Arsenic trioxide: safety issues and their management","volume":"29","author":"Au","year":"2008","journal-title":"Acta Pharmacol. Sin."},{"issue":"2","key":"10.1016\/j.phymed.2024.155891_bib0002","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1161\/CIRCRESAHA.119.315259","article-title":"Activated endothelial TGFbeta1 signaling promotes venous thrombus nonresolution in mice via endothelin-1: potential role for chronic thromboembolic pulmonary hypertension","volume":"126","author":"Bochenek","year":"2020","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.phymed.2024.155891_bib0003","doi-asserted-by":"crossref","first-page":"4938","DOI":"10.3390\/nu7064938","article-title":"In Vivo protective effects of diosgenin against doxorubicin-induced cardiotoxicity","volume":"7","author":"Chen","year":"2015","journal-title":"Nutrients"},{"issue":"14","key":"10.1016\/j.phymed.2024.155891_bib0004","doi-asserted-by":"crossref","first-page":"3980","DOI":"10.7150\/thno.32352","article-title":"Blocking interleukin-6 trans-signaling protects against renal fibrosis by suppressing STAT3 activation","volume":"9","author":"Chen","year":"2019","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.phymed.2024.155891_bib0005","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/cvr\/cvs230","article-title":"Arsenic-induced interstitial myocardial fibrosis reveals a new insight into drug-induced long QT syndrome","volume":"96","author":"Chu","year":"2012","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.phymed.2024.155891_bib0006","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12931-020-1319-0","article-title":"TGF-beta pathway activation by idiopathic pulmonary fibrosis (IPF) fibroblast derived soluble factors is mediated by IL-6 trans-signaling","volume":"21","author":"Epstein Shochet","year":"2020","journal-title":"Respir. Res."},{"key":"10.1016\/j.phymed.2024.155891_bib0007","doi-asserted-by":"crossref","first-page":"11853","DOI":"10.1038\/ncomms11853","article-title":"Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability","volume":"7","author":"Evrard","year":"2016","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.phymed.2024.155891_bib0008","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s00277-014-2174-1","article-title":"Torsade de Pointes during oral arsenic trioxide therapy for acute promyelocytic leukemia in a patient with heart failure","volume":"94","author":"Hai","year":"2015","journal-title":"Ann. Hematol."},{"issue":"2","key":"10.1016\/j.phymed.2024.155891_bib0009","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jacc.2018.09.089","article-title":"Endothelial to mesenchymal transition in cardiovascular disease: JACC state-of-the-art review","volume":"73","author":"Kovacic","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.phymed.2024.155891_bib0010","article-title":"Pharmacokinetic characteristics, tissue bioaccumulation and toxicity profiles of oral arsenic trioxide in rats: implications for the treatment and risk assessment of acute promyelocytic leukemia","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"11","key":"10.1016\/j.phymed.2024.155891_bib0011","article-title":"Jak-stat signaling induced by interleukin-6 family cytokines in hepatocellular carcinoma","volume":"11","author":"Lokau","year":"2019","journal-title":"Cancer. (Basel)"},{"issue":"27","key":"10.1016\/j.phymed.2024.155891_bib0012","doi-asserted-by":"crossref","first-page":"16039","DOI":"10.1016\/S0021-9258(17)46184-9","article-title":"Structurally based, selective interaction of arsenite with steroid receptors","volume":"265","author":"Lopez","year":"1990","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.phymed.2024.155891_bib0013","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.jaci.2013.09.007","article-title":"The biology of the glucocorticoid receptor: new signaling mechanisms in health and disease","volume":"132","author":"Oakley","year":"2013","journal-title":"J. Allerg. Clin. Immunol."},{"key":"10.1016\/j.phymed.2024.155891_bib0014","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.phytochem.2015.10.008","article-title":"Steroidal saponins from stems and leaves of Paris polyphylla var. yunnanensis","volume":"121","author":"Qin","year":"2016","journal-title":"Phytochemistry"},{"issue":"3","key":"10.1016\/j.phymed.2024.155891_bib0015","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1530\/JOE-16-0458","article-title":"Glucocorticoid receptor alters isovolumetric contraction and restrains cardiac fibrosis","volume":"232","author":"Richardson","year":"2017","journal-title":"J. Endocrinol."},{"issue":"33","key":"10.1016\/j.phymed.2024.155891_bib0016","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1200\/JCO.2013.51.2913","article-title":"Prevalence, management, and clinical consequences of QT interval prolongation during treatment with arsenic trioxide","volume":"32","author":"Roboz","year":"2014","journal-title":"J. Clin. Oncol."},{"issue":"12","key":"10.1016\/j.phymed.2024.155891_bib0017","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1093\/jmcb\/mjz001","article-title":"Glucocorticoid receptor-IRS-1 axis controls EMT and the metastasis of breast cancers","volume":"11","author":"Shi","year":"2019","journal-title":"J. Mol. Cell Biol"},{"issue":"4","key":"10.1016\/j.phymed.2024.155891_bib0018","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/S0021-9258(19)39922-3","article-title":"Arsenite and cadmium(II) as probes of glucocorticoid receptor structure and function","volume":"265","author":"Simons","year":"1990","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.phymed.2024.155891_bib0019","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1038\/s41467-021-22617-y","article-title":"Loss of endothelial glucocorticoid receptor accelerates diabetic nephropathy","volume":"12","author":"Srivastava","year":"2021","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.phymed.2024.155891_bib0020","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/s10456-020-09741-x","article-title":"Exacerbated inflammatory signaling underlies aberrant response to BMP9 in pulmonary arterial hypertension lung endothelial cells","volume":"23","author":"Szulcek","year":"2020","journal-title":"Angiogenesis"},{"key":"10.1016\/j.phymed.2024.155891_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.119963","article-title":"A self-driven bioinspired nanovehicle by leukocyte membrane-hitchhiking for early detection and treatment of atherosclerosis","volume":"250","author":"Wu","year":"2020","journal-title":"Biomaterials"},{"issue":"9","key":"10.1016\/j.phymed.2024.155891_bib0022","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/s41419-018-0902-5","article-title":"Polyphyllin I suppresses the formation of vasculogenic mimicry via Twist1\/VE-cadherin pathway","volume":"9","author":"Xiao","year":"2018","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.phymed.2024.155891_bib0023","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1161\/CIRCRESAHA.113.301792","article-title":"A role for the endothelium in vascular calcification","volume":"113","author":"Yao","year":"2013","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.phymed.2024.155891_bib0024","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1093\/cvr\/cvx234","article-title":"Vascular peroxidase 1 mediates hypoxia-induced pulmonary artery smooth muscle cell proliferation, apoptosis resistance and migration","volume":"114","author":"You","year":"2018","journal-title":"Cardiovasc. Res."},{"issue":"3","key":"10.1016\/j.phymed.2024.155891_bib0025","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1124\/jpet.114.212795","article-title":"Berberine hydrochloride prevents postsurgery intestinal adhesion and inflammation in rats","volume":"349","author":"Zhang","year":"2014","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"2","key":"10.1016\/j.phymed.2024.155891_bib0026","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12449","article-title":"Melatonin prevents endothelial cell pyroptosis via regulation of long noncoding RNA MEG3\/miR-223\/NLRP3 axis","volume":"64","author":"Zhang","year":"2018","journal-title":"J. Pineal. Res."},{"key":"10.1016\/j.phymed.2024.155891_bib0027","doi-asserted-by":"crossref","first-page":"33787","DOI":"10.1038\/srep33787","article-title":"Endothelial to mesenchymal transition contributes to arsenic-trioxide-induced cardiac fibrosis","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.phymed.2024.155891_bib0028","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1182\/blood.2019000760","article-title":"The simpler, the better: oral arsenic for acute promyelocytic leukemia","volume":"134","author":"Zhu","year":"2019","journal-title":"Blood"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132400549X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132400549X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T15:20:20Z","timestamp":1723648820000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S094471132400549X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":28,"alternative-id":["S094471132400549X"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155891","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diosgenin alleviates arsenic trioxide induced cardiac fibrosis by inhibiting endothelial mesenchymal transition","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155891","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"155891"}}