{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:27:12Z","timestamp":1793395632250,"version":"4.5.0"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["ZYJC21001"],"award-info":[{"award-number":["ZYJC21001"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204376"],"award-info":[{"award-number":["82204376"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U21A20393"],"award-info":[{"award-number":["U21A20393"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.phymed.2024.155892","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T20:15:40Z","timestamp":1721160940000},"page":"155892","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Withaferin A protects against epilepsy by promoting LCN2-mediated astrocyte polarization to stopping neuronal ferroptosis"],"prefix":"10.1016","volume":"132","author":[{"given":"Zixian","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengcheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongshan","family":"Ya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4857-5201","authenticated-orcid":false,"given":"Yinchun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rujia","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2024.155892_bib0001","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1002\/ptr.7598","article-title":"Does Ashwagandha supplementation have a beneficial effect on the management of anxiety and stress? A systematic review and meta-analysis of randomized controlled trials","volume":"36","author":"Akhgarjand","year":"2022","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2024.155892_bib0002","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/S0140-6736(23)01048-6","article-title":"Adult epilepsy","volume":"402","author":"Asadi-Pooya","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2024.155892_bib0003","doi-asserted-by":"crossref","first-page":"7657","DOI":"10.1074\/jbc.M109.093765","article-title":"Withaferin A targets intermediate filaments glial fibrillary acidic protein and vimentin in a model of retinal gliosis","volume":"285","author":"Bargagna-Mohan","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2024.155892_bib0004","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1159\/000503831","article-title":"The Epidemiology of Epilepsy","volume":"54","author":"Beghi","year":"2020","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.phymed.2024.155892_bib0005","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s11065-021-09514-3","article-title":"The Impact of Right Temporal Lobe Epilepsy On Nonverbal Memory: Meta-regression of Stimulus- and Task-related Moderators","volume":"32","author":"Bentvelzen","year":"2022","journal-title":"Neuropsychol. Rev."},{"key":"10.1016\/j.phymed.2024.155892_bib0006","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242216280","article-title":"Genetic background of epilepsy and antiepileptic treatments","volume":"24","author":"Borowicz-Reutt","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2024.155892_bib0007","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1007\/s13311-021-01123-5","article-title":"Clinical Trial Design for Disease-Modifying Therapies for Genetic Epilepsies","volume":"18","author":"Brock","year":"2021","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.phymed.2024.155892_bib0008","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.696889","article-title":"Ferroptosis and its role in epilepsy","volume":"15","author":"Cai","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.phymed.2024.155892_bib0009","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/s41586-023-06935-3","article-title":"A molecular switch for neuroprotective astrocyte reactivity","volume":"626","author":"Cameron","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2024.155892_bib0010","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.78877","article-title":"Disease-modifying effects of sodium selenate in a model of drug-resistant, temporal lobe epilepsy","volume":"12","author":"Casillas-Espinosa","year":"2023","journal-title":"Elife"},{"key":"10.1016\/j.phymed.2024.155892_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2019.101677","article-title":"Disease-modifying effects of a novel T-type calcium channel antagonist, Z944, in a model of temporal lobe epilepsy","volume":"182","author":"Casillas-Espinosa","year":"2019","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.phymed.2024.155892_bib0012","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S1474-4422(21)00096-X","article-title":"Epilepsy care in China and its relevance for other countries","volume":"20","author":"Cendes","year":"2021","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.phymed.2024.155892_bib0013","article-title":"KYNA ameliorates glutamate toxicity of HAND by enhancing glutamate uptake in A2 astrocytes","volume":"25","author":"Chen","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2024.155892_bib0014","doi-asserted-by":"crossref","first-page":"40528","DOI":"10.1038\/srep40528","article-title":"Disease-modifying effect of intravenous immunoglobulin in an experimental model of epilepsy","volume":"7","author":"Chen","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2024.155892_bib0015","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/s41593-023-01288-6","article-title":"Lipid-accumulated reactive astrocytes promote disease progression in epilepsy","volume":"26","author":"Chen","year":"2023","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.phymed.2024.155892_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2023.102480","article-title":"Multi-omics integration and epilepsy: Towards a better understanding of biological mechanisms","volume":"227","author":"Chong","year":"2023","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.phymed.2024.155892_bib0017","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1007\/s12035-021-02605-5","article-title":"Hemorrhage-induced sphingosine kinase 1 contributes to ferroptosis-mediated secondary brain injury in intracerebral hemorrhage","volume":"59","author":"Diao","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phymed.2024.155892_bib0018","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/S1474-4422(21)00023-5","article-title":"Epilepsy in China: major progress in the past two decades","volume":"20","author":"Ding","year":"2021","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.phymed.2024.155892_bib0019","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/s12974-022-02587-8","article-title":"Captopril alleviates epilepsy and cognitive impairment by attenuation of C3-mediated inflammation and synaptic phagocytosis","volume":"19","author":"Dong","year":"2022","journal-title":"J. Neuroinflammat."},{"key":"10.1016\/j.phymed.2024.155892_bib0020","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1007\/s11064-007-9375-0","article-title":"The pivotal role of astrocytes in the metabolism of iron in the brain","volume":"32","author":"Dringen","year":"2007","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.phymed.2024.155892_bib0021","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/s41593-020-00783-4","article-title":"Reactive astrocyte nomenclature, definitions, and future directions","volume":"24","author":"Escartin","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.phymed.2024.155892_bib0022","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1111\/epi.17625","article-title":"Intracerebroventricular administration for delivery of antiseizure therapeutics: challenges and opportunities","volume":"64","author":"Fahoum","year":"2023","journal-title":"Epilepsia"},{"key":"10.1016\/j.phymed.2024.155892_bib0023","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2023.1125412","article-title":"Tetramethylpyrazine promotes stroke recovery by inducing the restoration of neurovascular unit and transformation of A1\/A2 reactive astrocytes","volume":"17","author":"Feng","year":"2023","journal-title":"Front. Cell Neurosci."},{"key":"10.1016\/j.phymed.2024.155892_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2022.105823","article-title":"Miconazole exerts disease-modifying effects during epilepsy by suppressing neuroinflammation via NF-kappaB pathway and iNOS production","volume":"172","author":"Gong","year":"2022","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.phymed.2024.155892_bib0025","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.bbi.2023.11.030","article-title":"Intestinal dysbiosis exacerbates susceptibility to the anti-NMDA receptor encephalitis-like phenotype by changing blood brain barrier permeability and immune homeostasis","volume":"116","author":"Gong","year":"2023","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.phymed.2024.155892_bib0026","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41586-021-03960-y","article-title":"Neurotoxic reactive astrocytes induce cell death via saturated lipids","volume":"599","author":"Guttenplan","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2024.155892_bib0027","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.freeradbiomed.2018.09.002","article-title":"Circadian control of BDNF-mediated Nrf2 activation in astrocytes protects dopaminergic neurons from ferroptosis","volume":"133","author":"Ishii","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2024.155892_bib0028","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1001\/jama.2022.3880","article-title":"Antiseizure medications for adults with epilepsy: a review","volume":"327","author":"Kanner","year":"2022","journal-title":"JAMA"},{"key":"10.1016\/j.phymed.2024.155892_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.113784","article-title":"Pharmacodynamic and pharmacokinetic interactions of hydroalcoholic leaf extract of Centella asiatica with valproate and phenytoin in experimental models of epilepsy in rats","volume":"270","author":"Kumar","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2024.155892_bib0030","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s40478-023-01526-9","article-title":"Roles of neuropathology-associated reactive astrocytes: a systematic review","volume":"11","author":"Lawrence","year":"2023","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.phymed.2024.155892_bib0031","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/s12974-020-01891-5","article-title":"Microglia induce the transformation of A1\/A2 reactive astrocytes via the CXCR7\/PI3K\/Akt pathway in chronic post-surgical pain","volume":"17","author":"Li","year":"2020","journal-title":"J. Neuroinflammat."},{"key":"10.1016\/j.phymed.2024.155892_bib0032","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.freeradbiomed.2023.01.002","article-title":"Neurotoxic A1 astrocytes promote neuronal ferroptosis via CXCL10\/CXCR3 axis in epilepsy","volume":"195","author":"Liang","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2024.155892_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.108098","article-title":"The role of HIF-1alpha\/HO-1 pathway in hippocampal neuronal ferroptosis in epilepsy","volume":"26","author":"Liang","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.phymed.2024.155892_bib0034","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20180992","article-title":"Endothelial Cdk5 deficit leads to the development of spontaneous epilepsy through CXCL1\/CXCR2-mediated reactive astrogliosis","volume":"217","author":"Liu","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.phymed.2024.155892_bib0035","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1007\/s40263-021-00827-8","article-title":"The pharmacology and clinical efficacy of antiseizure medications: from bromide salts to cenobamate and beyond","volume":"35","author":"Loscher","year":"2021","journal-title":"CNS Drug."},{"key":"10.1016\/j.phymed.2024.155892_bib0036","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1124\/pr.120.019539","article-title":"Drug resistance in epilepsy: clinical impact, potential mechanisms, and new innovative treatment options","volume":"72","author":"Loscher","year":"2020","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.phymed.2024.155892_bib0037","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.047449","article-title":"Modelling epilepsy in the mouse: challenges and solutions","volume":"14","author":"Marshall","year":"2021","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.phymed.2024.155892_bib0038","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/381964","article-title":"Withaferin A inhibits nuclear factor-kappaB-dependent pro-inflammatory and stress response pathways in the astrocytes","volume":"2015","author":"Martorana","year":"2015","journal-title":"Neural. Plast."},{"key":"10.1016\/j.phymed.2024.155892_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101947","article-title":"NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer's diseases","volume":"41","author":"Park","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.phymed.2024.155892_bib0040","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/s41583-019-0126-4","article-title":"Neuron-glia interactions in the pathophysiology of epilepsy","volume":"20","author":"Patel","year":"2019","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.phymed.2024.155892_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112175","article-title":"Withania somnifera (L.) Dunal (Ashwagandha): a comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects","volume":"143","author":"Paul","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2024.155892_bib0042","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S1474-4422(24)00079-6","article-title":"Improving epilepsy diagnosis across the lifespan: approaches and innovations","volume":"23","author":"Pellinen","year":"2024","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.phymed.2024.155892_bib0043","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/WCO.0000000000001144","article-title":"Recent advances in pharmacotherapy for epilepsy","volume":"36","author":"Pong","year":"2023","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.phymed.2024.155892_bib0044","doi-asserted-by":"crossref","first-page":"304","DOI":"10.4103\/1673-5374.290894","article-title":"Implications of Withaferin A in neurological disorders","volume":"16","author":"Ram","year":"2021","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.phymed.2024.155892_bib0045","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/s41583-024-00805-1","article-title":"mTOR and neuroinflammation in epilepsy: implications for disease progression and treatment","volume":"25","author":"Ravizza","year":"2024","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.phymed.2024.155892_bib0046","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2022.114240","article-title":"Efficacy of the FDA-approved cannabidiol on the development and persistence of temporal lobe epilepsy and complex focal onset seizures","volume":"359","author":"Reddy","year":"2023","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.phymed.2024.155892_bib0047","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/WCO.0000000000001251","article-title":"Editorial: Epilepsy advances in 2023","volume":"37","author":"Ryvlin","year":"2024","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.phymed.2024.155892_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2022.105835","article-title":"Cholesterol 24-hydroxylase is a novel pharmacological target for anti-ictogenic and disease modification effects in epilepsy","volume":"173","author":"Salamone","year":"2022","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.phymed.2024.155892_bib0049","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1186\/s12967-023-04695-2","article-title":"Repurposing dimethyl fumarate as an antiepileptogenic and disease-modifying treatment for drug-resistant epilepsy","volume":"21","author":"Sandouka","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.phymed.2024.155892_bib0050","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/S1474-4422(23)00370-8","article-title":"Classic ketogenic diet versus further antiseizure medicine in infants with drug-resistant epilepsy (KIWE): a UK, multicentre, open-label, randomised clinical trial","volume":"22","author":"Schoeler","year":"2023","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.phymed.2024.155892_bib0051","doi-asserted-by":"crossref","first-page":"e21330","DOI":"10.1096\/fj.202001737RR","article-title":"Silencing of circIgf1r plays a protective role in neuronal injury via regulating astrocyte polarization during epilepsy","volume":"35","author":"Shao","year":"2021","journal-title":"FASEB J."},{"key":"10.1016\/j.phymed.2024.155892_bib0052","doi-asserted-by":"crossref","first-page":"e14596","DOI":"10.1111\/cns.14596","article-title":"Inhibiting acid-sensing ion channel exerts neuroprotective effects in experimental epilepsy via suppressing ferroptosis","volume":"30","author":"Shi","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.phymed.2024.155892_bib0053","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.107966","article-title":"Mechanisms of action of currently used antiseizure drugs","volume":"168","author":"Sills","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.phymed.2024.155892_bib0054","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.2174\/1570159X19666210712151556","article-title":"Effects of Withania somnifera (Ashwagandha) on stress and the stress- related neuropsychiatric disorders anxiety, depression, and insomnia","volume":"19","author":"Speers","year":"2021","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.phymed.2024.155892_bib0055","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S1474-4422(18)30495-2","article-title":"Management of epilepsy in women","volume":"18","author":"Stephen","year":"2019","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.phymed.2024.155892_bib0056","first-page":"1289","article-title":"Mitochondrial dysfunction of astrocytes mediates lipid accumulation in temporal lobe epilepsy","volume":"15","author":"Su","year":"2024","journal-title":"Aging Dis."},{"key":"10.1016\/j.phymed.2024.155892_bib0057","doi-asserted-by":"crossref","DOI":"10.1007\/s12035-024-04023-9","article-title":"NRF2 deficiency promotes ferroptosis of astrocytes mediated by oxidative stress in Alzheimer\u2019s disease","author":"Tang","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phymed.2024.155892_bib0058","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1111\/epi.17884","article-title":"Current state of the epilepsy drug and device pipeline","volume":"65","author":"Terman","year":"2024","journal-title":"Epilepsia"},{"key":"10.1016\/j.phymed.2024.155892_bib0059","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1111\/epi.17875","article-title":"Challenges and directions in epilepsy diagnostics and therapeutics: proceedings of the 17th Epilepsy Therapies and Diagnostics Development conference","volume":"65","author":"Terman","year":"2024","journal-title":"Epilepsia"},{"key":"10.1016\/j.phymed.2024.155892_bib0060","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0140-6736(18)32596-0","article-title":"Epilepsy in adults","volume":"393","author":"Thijs","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2024.155892_bib0061","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/s41582-022-00727-5","article-title":"Astrocytes in the initiation and progression of epilepsy","volume":"18","author":"Vezzani","year":"2022","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.phymed.2024.155892_bib0062","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.pharmthera.2019.05.010","article-title":"An update for epilepsy research and antiepileptic drug development: toward precise circuit therapy","volume":"201","author":"Wang","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2024.155892_bib0063","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1002\/glia.23955","article-title":"The complement C3-C3aR pathway mediates microglia-astrocyte interaction following status epilepticus","volume":"69","author":"Wei","year":"2021","journal-title":"Glia"},{"key":"10.1016\/j.phymed.2024.155892_bib0064","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242216513","article-title":"Can Ashwagandha benefit the endocrine system?-A review","volume":"24","author":"Wicinski","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2024.155892_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155022","article-title":"Research progress on the treatment of epilepsy with traditional Chinese medicine","volume":"120","author":"Wu","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2024.155892_bib0066","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.freeradbiomed.2022.09.001","article-title":"Quercetin alleviates kainic acid-induced seizure by inhibiting the Nrf2-mediated ferroptosis pathway","volume":"191","author":"Xie","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2024.155892_bib0067","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1007\/s13311-022-01198-8","article-title":"Inhibition of transient receptor potential vanilloid 4 (TRPV4) mitigates seizures","volume":"19","author":"Zeng","year":"2022","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.phymed.2024.155892_bib0068","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.freeradbiomed.2022.11.018","article-title":"Ferritin confers protection against iron-mediated neurotoxicity and ferroptosis through iron chelating mechanisms in MPP(+)-induced MES23.5 dopaminergic cells","volume":"193","author":"Zhang","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2024.155892_bib0069","doi-asserted-by":"crossref","first-page":"7136","DOI":"10.1038\/s41467-022-34662-2","article-title":"Activated astrocytes attenuate neocortical seizures in rodent models through driving Na(+)-K(+)-ATPase","volume":"13","author":"Zhao","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2024.155892_bib0070","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1038\/s41418-021-00767-2","article-title":"The DJ1-Nrf2-STING axis mediates the neuroprotective effects of Withaferin A in Parkinson's disease","volume":"28","author":"Zhao","year":"2021","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.phymed.2024.155892_bib0071","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.172988","article-title":"Withaferin A alleviates traumatic brain injury induced secondary brain injury via suppressing apoptosis in endothelia cells and modulating activation in the microglia","volume":"874","author":"Zhou","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2024.155892_bib0072","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.4103\/1673-5374.355822","article-title":"Withaferin A inhibits ferroptosis and protects against intracerebral hemorrhage","volume":"18","author":"Zhou","year":"2023","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.phymed.2024.155892_bib0073","doi-asserted-by":"crossref","first-page":"29876","DOI":"10.1021\/acsami.3c03455","article-title":"Reactive A1 astrocyte-targeted nucleic acid nanoantiepileptic drug downregulating adenosine kinase to rescue endogenous antiepileptic pathway","volume":"15","author":"Zhu","year":"2023","journal-title":"ACS Appl. Mater Interface."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324005506?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324005506?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T04:16:50Z","timestamp":1778559410000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711324005506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":73,"alternative-id":["S0944711324005506"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155892","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Withaferin A protects against epilepsy by promoting LCN2-mediated astrocyte polarization to stopping neuronal ferroptosis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155892","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"155892"}}