{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:44:50Z","timestamp":1790948690571,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008856","name":"Zhejiang Provincial Health Commission","doi-asserted-by":"publisher","award":["2023KY863"],"award-info":[{"award-number":["2023KY863"]}],"id":[{"id":"10.13039\/501100008856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004863","name":"Zhejiang Chinese Medical University","doi-asserted-by":"publisher","award":["2022JKZKTS25"],"award-info":[{"award-number":["2022JKZKTS25"]}],"id":[{"id":"10.13039\/501100004863","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010706","name":"Luzhou Medical College","doi-asserted-by":"publisher","award":["00004F1RCYJ2402"],"award-info":[{"award-number":["00004F1RCYJ2402"]}],"id":[{"id":"10.13039\/501100010706","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017529","name":"Major Scientific and Technological Project of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017529","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010012","name":"National Aerospace Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010012","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013149","name":"Science and Technology Innovation as a Whole Plan Projects of Shaanxi Province","doi-asserted-by":"publisher","award":["2023ZL366"],"award-info":[{"award-number":["2023ZL366"]}],"id":[{"id":"10.13039\/501100013149","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"publisher","award":["82004405"],"award-info":[{"award-number":["82004405"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.phymed.2024.155920","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T16:02:22Z","timestamp":1722268942000},"page":"155920","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Bu-Shen-Ning-Xin decoction ameliorates premature ovarian insufficiency by suppressing oxidative stress through rno_circRNA_012284\/rno_miR-760\u20133p\/HBEGF pathway"],"prefix":"10.1016","volume":"133","author":[{"given":"Xianli","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianwen","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8865-5188","authenticated-orcid":false,"given":"Wenjun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2024.155920_bib0002","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s10735-023-10166-1","article-title":"LOC102549726\/miR-760-3p network is involved in the progression of ISO-induced pathological cardiomyocyte hypertrophy via endoplasmic reticulum stress","volume":"54","author":"Chen","year":"2023","journal-title":"J. Mol. Histol."},{"key":"10.1016\/j.phymed.2024.155920_bib0003","first-page":"76","article-title":"Clinical study on Bushen Ningxin Prescription for early-onset ovarian insufficiency of non-interaction between heart and kidney type","volume":"52","author":"Chen","year":"2020","journal-title":"J. N. Chinese Med."},{"key":"10.1016\/j.phymed.2024.155920_bib0004","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s12964-022-00983-4","article-title":"HB-EGF upregulates StAR expression and stimulates progesterone production through ERK1\/2 signaling in human granulosa-lutein cells","volume":"20","author":"Cheng","year":"2022","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.phymed.2024.155920_bib0005","doi-asserted-by":"crossref","first-page":"W357","DOI":"10.1093\/nar\/gkz382","article-title":"SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules","volume":"47","author":"Daina","year":"2019","journal-title":"Nucleic. Acids. Res."},{"key":"10.1016\/j.phymed.2024.155920_bib0006","doi-asserted-by":"crossref","first-page":"P3","DOI":"10.1186\/gb-2003-4-5-p3","article-title":"DAVID: database for annotation, visualization, and integrated discovery","volume":"4","author":"Dennis","year":"2003","journal-title":"Genome Biol."},{"key":"10.1016\/j.phymed.2024.155920_bib0007","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1080\/09513590.2022.2112941","article-title":"Bu-Shen-Ning-Xin decoction alleviates premature ovarian insufficiency (POI) by regulating autophagy of granule cells through activating PI3K\/AKT\/mTOR pathway","volume":"38","author":"Dou","year":"2022","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.phymed.2024.155920_bib0008","doi-asserted-by":"crossref","first-page":"e20022","DOI":"10.1016\/j.heliyon.2023.e20022","article-title":"The impact of Yiwei decoction on the LncRNA and CircRNA regulatory networks in premature ovarian insufficiency","volume":"9","author":"Fan","year":"2023","journal-title":"Heliyon."},{"key":"10.1016\/j.phymed.2024.155920_bib0009","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.biopha.2018.03.006","article-title":"An in vitro comparative study of the antioxidant activity and SIRT1 modulation of natural compounds","volume":"101","author":"Fusi","year":"2018","journal-title":"Biomed. PharmacOther"},{"key":"10.1016\/j.phymed.2024.155920_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155630","article-title":"Bushen Huoxue recipe ameliorates ovarian function via promoting BMSCs proliferation and homing to ovaries in POI mice","volume":"129","author":"Huang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2024.155920_bib0011","doi-asserted-by":"crossref","first-page":"e448","DOI":"10.1002\/ctm2.448","article-title":"T(reg) deficiency-mediated T(H) 1 response causes human premature ovarian insufficiency through apoptosis and steroidogenesis dysfunction of granulosa cells","volume":"11","author":"Jiao","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.phymed.2024.155920_bib0012","doi-asserted-by":"crossref","first-page":"314","DOI":"10.31083\/j.fbl2811314","article-title":"Unveiling circular RNA-mediated regulatory mechanisms in necroptosis in premature ovarian failure","volume":"28","author":"Jin","year":"2023","journal-title":"Front. Biosci. (Landmark. Print)"},{"key":"10.1016\/j.phymed.2024.155920_bib0013","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/s41591-022-02194-3","article-title":"Landscape of pathogenic mutations in premature ovarian insufficiency","volume":"29","author":"Ke","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.phymed.2024.155920_bib0014","doi-asserted-by":"crossref","first-page":"D1373","DOI":"10.1093\/nar\/gkac956","article-title":"PubChem 2023 update","volume":"51","author":"Kim","year":"2023","journal-title":"Nucleic. Acids. Res."},{"key":"10.1016\/j.phymed.2024.155920_bib0015","article-title":"Efficacy of traditional chinese medicine tonifying kidney (Bushen) and activating blood (Huoxue) prescription for premature ovarian insufficiency: a systematic review and meta-analysis","volume":"2020","author":"Li","year":"2020","journal-title":"Evid. Based. Complement. Alternat. Med."},{"key":"10.1016\/j.phymed.2024.155920_bib0016","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s12958-021-00743-y","article-title":"Quercetin prevents primordial follicle loss via suppression of PI3K\/Akt\/Foxo3a pathway activation in cyclophosphamide-treated mice","volume":"19","author":"Li","year":"2021","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.phymed.2024.155920_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155423","article-title":"Baicalein improves the symptoms of polycystic ovary syndrome by mitigating oxidative stress and ferroptosis in the ovary and gravid placenta","volume":"128","author":"Li","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2024.155920_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117756","article-title":"Study on the effects and mechanisms of Wenzhong Bushen formula in improving ovarian reserve decline in mice based on network pharmacology","volume":"324","author":"Liang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2024.155920_bib0019","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/cbin.12090","article-title":"Pachymic acid (PA) inhibits ferroptosis of cardiomyocytes via activation of the AMPK in mice with ischemia\/reperfusion-induced myocardial injury","volume":"48","author":"Liu","year":"2024","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.phymed.2024.155920_bib0020","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/4367359","article-title":"Effectiveness of cotreatment with Kuntai Capsule and Climen for premature ovarian failure: a meta-analysis","volume":"2020","author":"Ma","year":"2020","journal-title":"Evid. Based. Complement. Alternat. Med."},{"key":"10.1016\/j.phymed.2024.155920_bib0021","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1038\/s41592-022-01487-2","article-title":"Best practice standards for circular RNA research","volume":"19","author":"Nielsen","year":"2022","journal-title":"Nat. Methods"},{"key":"10.1016\/j.phymed.2024.155920_bib0022","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/10408347.2014.881250","article-title":"Surface plasmon resonance (SPR) biosensors in pharmaceutical analysis","volume":"45","author":"Olaru","year":"2015","journal-title":"Crit. Rev. Anal. Chem."},{"key":"10.1016\/j.phymed.2024.155920_bib0023","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2003.12.003","article-title":"Differential expression of heparin-binding epidermal growth factor-like growth factor in the rat ovary","volume":"214","author":"Pan","year":"2004","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.phymed.2024.155920_bib0024","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1758-2946-6-13","article-title":"TCMSP: a database of systems pharmacology for drug discovery from herbal medicines","volume":"6","author":"Ru","year":"2014","journal-title":"J. Cheminform."},{"key":"10.1016\/j.phymed.2024.155920_bib0025","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.phymed.2024.155920_bib0026","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1172481","article-title":"Premature ovarian insufficiency: a review on the role of oxidative stress and the application of antioxidants","volume":"14","author":"Shi","year":"2023","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.phymed.2024.155920_bib0027","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic. Acids. Res."},{"key":"10.1016\/j.phymed.2024.155920_bib0028","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12943-022-01706-6","article-title":"Crosstalk between 5-methylcytosine and N(6)-methyladenosine machinery defines disease progression, therapeutic response and pharmacogenomic landscape in hepatocellular carcinoma","volume":"22","author":"Tian","year":"2023","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.phymed.2024.155920_bib0029","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.ygcen.2009.09.012","article-title":"Spatial localization of EGF family ligands and receptors in the zebrafish ovarian follicle and their expression profiles during folliculogenesis","volume":"167","author":"Tse","year":"2010","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.phymed.2024.155920_bib0030","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s12951-023-01862-x","article-title":"Anti-CHAC1 exosomes for nose-to-brain delivery of miR-760-3p in cerebral ischemia\/reperfusion injury mice inhibiting neuron ferroptosis","volume":"21","author":"Wang","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.phymed.2024.155920_bib0031","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/2756611","article-title":"Definition of a novel Cuproptosis-Relevant lncRNA signature for uncovering distinct survival, genomic alterations, and treatment implications in lung adenocarcinoma","volume":"2022","author":"Wang","year":"2022","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.phymed.2024.155920_bib0032","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1007\/s00404-023-07219-x","article-title":"Circular RNA as new serum metabolic biomarkers in patients with premature ovarian insufficiency","volume":"308","author":"Wang","year":"2023","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.phymed.2024.155920_bib0033","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1093\/humrep\/dew027","article-title":"ESHRE Guideline: management of women with premature ovarian insufficiency","volume":"31","author":"Webber","year":"2016","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.phymed.2024.155920_bib0034","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s12958-021-00850-w","article-title":"microRNA-194 is increased in polycystic ovary syndrome granulosa cell and induce KGN cells apoptosis by direct targeting heparin-binding EGF-like growth factor","volume":"19","author":"Wu","year":"2021","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.phymed.2024.155920_bib0035","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1186\/s12882-023-03366-0","article-title":"Paeoniflorin alleviates hypoxia\/reoxygenation injury in HK-2 cells by inhibiting apoptosis and repressing oxidative damage via Keap1\/Nrf2\/HO-1 pathway","volume":"24","author":"Xing","year":"2023","journal-title":"BMC. Nephrol."},{"key":"10.1016\/j.phymed.2024.155920_bib0036","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1007\/s12015-023-10564-8","article-title":"EIF4A3-Induced Exosomal circLRRC8A Alleviates Granulosa Cells Senescence Via the miR-125a-3p\/NFE2L1 axis","volume":"19","author":"Xing","year":"2023","journal-title":"Stem Cell Rev. Rep."},{"key":"10.1016\/j.phymed.2024.155920_bib0037","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/6170936","article-title":"HB-EGF ameliorates oxidative stress-mediated uterine decidualization damage","volume":"2019","author":"Yu","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.phymed.2024.155920_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcp.2022.101830","article-title":"circNup188\/miR-760-3p\/Map3k8 axis regulates inflammation in cerebral ischemia","volume":"64","author":"Zhang","year":"2022","journal-title":"Mol. Cell Probes."},{"key":"10.1016\/j.phymed.2024.155920_bib0039","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1210\/clinem\/dgad070","article-title":"Recent insights into noncoding RNAs in primary ovarian insufficiency: focus on mechanisms and treatments","volume":"108","author":"Zhang","year":"2023","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.phymed.2024.155920_bib0040","doi-asserted-by":"crossref","first-page":"319","DOI":"10.2217\/epi-2019-0147","article-title":"Expression profiles of circular RNA in granulosa cells from women with biochemical premature ovarian insufficiency","volume":"12","author":"Zhou","year":"2020","journal-title":"Epigenomics-UK"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324005786?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324005786?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T13:44:22Z","timestamp":1725284662000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711324005786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":39,"alternative-id":["S0944711324005786"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155920","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bu-Shen-Ning-Xin decoction ameliorates premature ovarian insufficiency by suppressing oxidative stress through rno_circRNA_012284\/rno_miR-760\u20133p\/HBEGF pathway","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155920","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"155920"}}