{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:25:28Z","timestamp":1789611928862,"version":"build-2803163510"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.phymed.2024.155925","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T10:51:54Z","timestamp":1722595914000},"page":"155925","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["The phthalide compound tokinolide B from Angelica sinensis exerts anti-inflammatory effects through Nur77 binding"],"prefix":"10.1016","volume":"133","author":[{"given":"Yongzhen","family":"Xia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingbo","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huachun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongying","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoqun","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixue","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5070-2578","authenticated-orcid":false,"given":"Quancheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2024.155925_bib0001","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.intimp.2011.01.034","article-title":"LPS-induced CD11b+Gr1(int)F4\/80+ regulatory myeloid cells suppress allergen-induced airway inflammation","volume":"11","author":"Arora","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2024.155925_bib0002","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.ajpath.2018.10.002","article-title":"Key functions and therapeutic prospects of Nur77 in inflammation related lung diseases","volume":"189","author":"Banno","year":"2019","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.phymed.2024.155925_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112722","article-title":"Novel phthalide derivatives: synthesis and anti-inflammatory activity in vitro and in vivo","volume":"206","author":"Chen","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.phymed.2024.155925_bib0004","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1158\/1535-7163.MCT-18-0918","article-title":"BI1071, a novel Nur77 modulator, induces apoptosis of cancer cells by activating the Nur77-Bcl-2 apoptotic pathway","volume":"18","author":"Chen","year":"2019","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.phymed.2024.155925_bib0005","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.apsb.2023.11.017","article-title":"Phase separation of Nur77 mediates XS561-induced apoptosis by promoting the formation of Nur77\/Bcl-2 condensates","volume":"14","author":"Chen","year":"2024","journal-title":"Acta. Pharmaceutica. Sinica. B"},{"key":"10.1016\/j.phymed.2024.155925_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.106156","article-title":"SAR study of oxidative DIMs analogs targeting the Nur77-mediated apoptotic pathway of cancer cells","volume":"129","author":"Chen","year":"2022","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.phymed.2024.155925_bib0007","doi-asserted-by":"crossref","first-page":"577","DOI":"10.3724\/SP.J.1009.2013.00577","article-title":"Phytochemical and pharmacological studies on Radix Angelica sinensis","volume":"11","author":"Chen","year":"2013","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.phymed.2024.155925_bib0008","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ejmech.2019.05.009","article-title":"SAR study of celastrol analogs targeting Nur77-mediated inflammatory pathway","volume":"177","author":"Chen","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.phymed.2024.155925_bib0009","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/5985255","article-title":"Anti-inflammatory activity of glabralactone, a coumarin compound from Angelica sinensis, via suppression of TRIF-dependent IRF-3 signaling and NF-\u03baB pathways","volume":"2022","author":"Choi","year":"2022","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.phymed.2024.155925_bib0010","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ejphar.2015.01.026","article-title":"Anti-inflammatory effect of natural and semi-synthetic phthalides","volume":"752","author":"Del-Angel","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2024.155925_bib44","doi-asserted-by":"crossref","first-page":"605","DOI":"10.2174\/1389200219666180302152752","article-title":"Pharmacokinetic and toxicological characteristics of tripterigium glycosides and their derivatives","volume":"19","author":"Du","year":"2018","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.phymed.2024.155925_bib0011","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/s41586-019-1770-6","article-title":"Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis","volume":"575","author":"Fritsch","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2024.155925_bib0012","doi-asserted-by":"crossref","unstructured":"Green, D.R., Galluzzi, L., Kroemer, G., 2011. Mitochondria and the autophagy\u2013inflammation\u2013cell death axis in organismal aging. 333, 1109\u20131112.","DOI":"10.1126\/science.1201940"},{"key":"10.1016\/j.phymed.2024.155925_bib0013","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0133598","article-title":"Deficiency of nuclear receptor Nur77 aggravates mouse experimental colitis by increased nfkappab activity in macrophages","volume":"10","author":"Hamers","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.phymed.2024.155925_bib0014","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1161\/CIRCRESAHA.111.253377","article-title":"NR4A1 (Nur77) deletion polarizes macrophages toward an inflammatory phenotype and increases atherosclerosis","volume":"110","author":"Hanna","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.phymed.2024.155925_bib0015","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1007623","article-title":"Supercritical fluid extract of Angelica sinensis promotes the anti-colorectal cancer effect of oxaliplatin","volume":"13","author":"Hao","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2024.155925_bib0016","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.molcel.2017.03.008","article-title":"Celastrol-induced Nur77 interaction with TRAF2 alleviates inflammation by promoting mitochondrial ubiquitination and autophagy","volume":"66","author":"Hu","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.phymed.2024.155925_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.105970","article-title":"Six pairs of enantiomeric phthalide dimers from the rhizomes of ligusticum chuanxiong and their absolute configurations and anti-inflammatory activities","volume":"127","author":"Huang","year":"2022","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.phymed.2024.155925_bib0018","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23081880","article-title":"Decursinol angelate inhibits lps-induced macrophage polarization through modulation of the NF\u03baB and MAPK signaling pathways","volume":"23","author":"Islam","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2024.155925_bib0019","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1038\/nprot.2014.138","article-title":"The cellular thermal shift assay for evaluating drug target interactions in cells","volume":"9","author":"Jafari","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.phymed.2024.155925_bib0020","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jep.2008.07.027","article-title":"Study of the anti-proliferative effects and synergy of phthalides from Angelica sinensis on colon cancer cells","volume":"120","author":"Kan","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2024.155925_bib0021","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.4049\/jimmunol.1401714","article-title":"Nuclear receptor Nur77 attenuates airway inflammation in mice by suppressing NF-\u03baB activity in lung epithelial cells","volume":"195","author":"Kurakula","year":"2015","journal-title":"J. immunol. (Baltimore, Md.: 1950)"},{"key":"10.1016\/j.phymed.2024.155925_bib0022","first-page":"127","article-title":"Phthalides: distribution in nature, chemical reactivity, synthesis, and biological activity","volume":"104","author":"Leon","year":"2017","journal-title":"Prog. Chem. Org. Nat. Prod."},{"key":"10.1016\/j.phymed.2024.155925_bib0023","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jep.2015.03.010","article-title":"Metabolomics study of hematopoietic function of Angelica sinensis on blood deficiency mice model","volume":"166","author":"Li","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2024.155925_bib0024","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1159\/000492641","article-title":"Anti-cancer effects of radix angelica sinensis (Danggui) and N-Butylidenephthalide on gastric cancer: implications for REDD1 activation and mTOR inhibition","volume":"48","author":"Liao","year":"2018","journal-title":"Cell Physiol. Biochem."},{"key":"10.1016\/j.phymed.2024.155925_bib0025","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0092-8674(04)00162-X","article-title":"Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77\/TR3","volume":"116","author":"Lin","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2024.155925_bib0026","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1111\/j.1471-4159.2008.05432.x","article-title":"Orphan nuclear receptor, Nurr-77 was a possible target gene of butylidenephthalide chemotherapy on glioblastoma multiform brain tumor","volume":"106","author":"Lin","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.phymed.2024.155925_bib45","doi-asserted-by":"crossref","first-page":"608703","DOI":"10.3389\/fphar.2020.608703","article-title":"Clinical practice guideline for tripterygium glycosides\/tripterygium wilfordii tablets in the treatment of rheumatoid arthritis","volume":"11","author":"Lin","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2024.155925_bib0027","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s10637-010-9518-z","article-title":"Expression of Nur77 induced by an n-butylidenephthalide derivative promotes apoptosis and inhibits cell growth in oral squamous cell carcinoma","volume":"30","author":"Liu","year":"2012","journal-title":"Invest New Drugs"},{"key":"10.1016\/j.phymed.2024.155925_bib0028","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nature07201","article-title":"Origin and physiological roles of inflammation","volume":"454","author":"Medzhitov","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2024.155925_bib0029","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1016\/j.ijbiomac.2021.05.213","article-title":"Extraction, structure, pharmacological activities and drug carrier applications of Angelica sinensis polysaccharide","volume":"183","author":"Nai","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2024.155925_bib0030","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.cell.2010.02.029","article-title":"Nonresolving inflammation","volume":"140","author":"Nathan","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2024.155925_bib0031","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1002\/ptr.6098","article-title":"Antimicrobial activity of extracts and phthalides occurring in Apiaceae plants","volume":"32","author":"Pannek","year":"2018","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2024.155925_bib0032","doi-asserted-by":"crossref","first-page":"5989","DOI":"10.1038\/s41467-021-26295-8","article-title":"Phase separation of Nur77 mediates celastrol-induced mitophagy by promoting the liquidity of p62\/SQSTM1 condensates","volume":"12","author":"Peng","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2024.155925_bib0033","doi-asserted-by":"crossref","first-page":"15847","DOI":"10.1021\/acs.jmedchem.3c01336","article-title":"Discovery of 5-(Pyrimidin-2-ylamino)-1H-indole-2-carboxamide derivatives as Nur77 modulators with selective and potent activity against triple-negative breast cancer","volume":"66","author":"Qin","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.phymed.2024.155925_bib46","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1631\/jzus.B1900607","article-title":"Use of Tripterygium wilfordii Hook F for immune-mediated inflammatory diseases: progress and future prospects","volume":"21","author":"Song","year":"2020","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"10.1016\/j.phymed.2024.155925_bib43","article-title":"Comprehensive evaluation of the quality of tripterygium glycosides tablets based on multi-component quantification combined with an in vitro biological assay","author":"Wang","year":"2022","journal-title":"Molecules (Basel, Switzerland)"},{"key":"10.1016\/j.phymed.2024.155925_bib0034","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.intimp.2015.12.021","article-title":"Angelica sinensis polysaccharide attenuates concanavalin a-induced liver injury in mice","volume":"31","author":"Wang","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2024.155925_bib0035","doi-asserted-by":"crossref","first-page":"4889","DOI":"10.1039\/C6FO01196A","article-title":"Protective effects of Angelica sinensis polysaccharide against hyperglycemia and liver injury in multiple low-dose streptozotocin-induced type 2 diabetic BALB\/c mice","volume":"7","author":"Wang","year":"2016","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2024.155925_bib0036","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jep.2016.05.023","article-title":"Angelica sinensis in china-a review of botanical profile, ethnopharmacology, phytochemistry and chemical analysis","volume":"190","author":"Wei","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2024.155925_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2022.105223","article-title":"Recent advances in natural phthalides: distribution, chemistry, and biological activities","volume":"160","author":"Wei","year":"2022","journal-title":"Fitoterapia"},{"key":"10.1016\/j.phymed.2024.155925_bib0038","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/path.4670","article-title":"Nur77 exerts a protective effect against inflammatory bowel disease by negatively regulating the TRAF6\/TLR-IL-1R signalling axis","volume":"238","author":"Wu","year":"2016","journal-title":"J. Pathol."},{"key":"10.1016\/j.phymed.2024.155925_bib0039","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/9206951","article-title":"The combination of astragalus membranaceus and Angelica sinensis inhibits lung cancer and cachexia through its immunomodulatory function","volume":"2019","author":"Wu","year":"2019","journal-title":"J. Oncol."},{"key":"10.1016\/j.phymed.2024.155925_bib0040","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1159\/000493415","article-title":"Chinese Angelica Polysaccharide (CAP) alleviates lps-induced inflammation and apoptosis by down-regulating COX-1 in PC12 Cells","volume":"49","author":"Xie","year":"2018","journal-title":"cell Physiol. Biochem."},{"key":"10.1016\/j.phymed.2024.155925_bib0041","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ijbiomac.2006.02.013","article-title":"Immunomodulatory activity of polysaccharide isolated from Angelica sinensis","volume":"39","author":"Yang","year":"2006","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2024.155925_bib0042","first-page":"e14196","article-title":"The synergistic effect of Angelica sinensis (Oliv.) Diels and rehmannia glutinosa (Gaertn.) DC. on antioxidant activity and protective ability against cell injury","volume":"46","author":"Zhang","year":"2022","journal-title":"J. Food Biochem."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132400583X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132400583X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T16:38:33Z","timestamp":1725727113000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S094471132400583X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":46,"alternative-id":["S094471132400583X"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155925","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The phthalide compound tokinolide B from Angelica sinensis exerts anti-inflammatory effects through Nur77 binding","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155925","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"155925"}}