{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:31:27Z","timestamp":1790188287228,"version":"4.1.0"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015939","name":"Hubei Provincial Key Laboratory of Bioinorganic Chemistry and Materia Medica, Huazhong University of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015939","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008844","name":"Liaoning University of Traditional Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008844","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013291","name":"Tongji Medical College, Huazhong University of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013291","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011328","name":"State Key Lab of Biological Fermentation Engineering of Beer, Tsingtao Brewery Co. Ltd.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011328","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015640","name":"Tongji Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015640","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.phymed.2024.155931","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T06:20:23Z","timestamp":1723011623000},"page":"155931","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Jiawei Buzhong Yiqi Decoction attenuates polycystic ovary syndrome through regulating kisspeptin-GPR54-AKT-SHBG system"],"prefix":"10.1016","volume":"133","author":[{"given":"Runan","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuli","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunkun","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1605-3900","authenticated-orcid":false,"given":"Haoxu","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingmin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.phymed.2024.155931_bib0001","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12929-018-0452-2","article-title":"rs4889 polymorphism in KISS1 gene, its effect on polycystic ovary syndrome development and anthropometric and hormonal parameters in Saudi women","volume":"25","author":"Albalawi","year":"2018","journal-title":"J. Biomed. Sci."},{"issue":"5","key":"10.1016\/j.phymed.2024.155931_bib0002","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1007\/s00404-017-4509-3","article-title":"Kisspeptin expression features in the arcuate and anteroventral periventricular nuclei of hypothalamus of letrozole-induced polycystic ovarian syndrome in rats","volume":"296","author":"Aliabadi","year":"2017","journal-title":"Arch. Gynecol. Obstet."},{"issue":"6","key":"10.1016\/j.phymed.2024.155931_bib0003","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/humupd\/dmw025","article-title":"The management of anovulatory infertility in women with polycystic ovary syndrome: an analysis of the evidence to support the development of global WHO guidance","volume":"22","author":"Balen","year":"2016","journal-title":"Hum. Reprod. Update"},{"issue":"5","key":"10.1016\/j.phymed.2024.155931_bib0004","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/j.1365-2265.2008.03459.x","article-title":"The effects of metformin on endogenous androgens and SHBG in women: a systematic review and meta-analysis","volume":"70","author":"Barba","year":"2009","journal-title":"Clin. Endocrinol. (Oxf)"},{"issue":"17","key":"10.1016\/j.phymed.2024.155931_bib0005","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201901253","article-title":"Caffeine upregulates hepatic sex hormone-binding globulin production by increasing adiponectin through AKT\/FOXO1 pathway in white adipose tissue","volume":"64","author":"Brians\u00f3-Llort","year":"2020","journal-title":"Mol. Nutr. Food Res."},{"issue":"1","key":"10.1016\/j.phymed.2024.155931_bib0006","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ejogrb.2009.11.018","article-title":"Increased plasma metastin levels in adolescent women with polycystic ovary syndrome","volume":"149","author":"Chen","year":"2010","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"issue":"4","key":"10.1016\/j.phymed.2024.155931_bib0007","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1365-2826.2009.01835.x","article-title":"Oestrogen, kisspeptin, GPR54 and the pre-ovulatory luteinising hormone surge","volume":"21","author":"Clarkson","year":"2009","journal-title":"J. Neuroendocrinol."},{"issue":"2","key":"10.1016\/j.phymed.2024.155931_bib0008","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/ijgo.12527","article-title":"Evaluation of biochemical, endocrine, and metabolic biomarkers for the early diagnosis of polycystic ovary syndrome among non-obese Saudi women","volume":"142","author":"Daghestani","year":"2018","journal-title":"Int. J. Gynaecol. Obstet."},{"issue":"6","key":"10.1016\/j.phymed.2024.155931_bib0009","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1210\/endrev\/bnac001","article-title":"Deconstructing a Syndrome: genomic Insights Into PCOS Causal Mechanisms and Classification","volume":"43","author":"Dapas","year":"2022","journal-title":"Endocr. Rev."},{"issue":"12","key":"10.1016\/j.phymed.2024.155931_bib0010","doi-asserted-by":"crossref","first-page":"6609","DOI":"10.1210\/jc.2005-1468","article-title":"Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males","volume":"90","author":"Dhillo","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.phymed.2024.155931_bib0011","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.npep.2016.01.005","article-title":"Effects of high-fat diet-induced obesity and diabetes on Kiss1 and GPR54 expression in the hypothalamic-pituitary-gonadal (HPG) axis and peripheral organs (fat, pancreas and liver) in male rats","volume":"56","author":"Dudek","year":"2016","journal-title":"Neuropeptides."},{"issue":"10","key":"10.1016\/j.phymed.2024.155931_bib0012","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/nmeth.2604","article-title":"UPARSE: highly accurate OTU sequences from microbial amplicon reads","volume":"10","author":"Edgar","year":"2013","journal-title":"Nat. Methods"},{"issue":"9","key":"10.1016\/j.phymed.2024.155931_bib0013","doi-asserted-by":"crossref","first-page":"718","DOI":"10.3109\/09513590.2016.1161019","article-title":"Role of kisspeptin in polycystic ovary syndrome (PCOS)","volume":"32","author":"Emekci Ozay","year":"2016","journal-title":"Gynecol. Endocrinol."},{"issue":"5","key":"10.1016\/j.phymed.2024.155931_bib0014","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nrendo.2018.24","article-title":"Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment","volume":"14","author":"Escobar-Morreale","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"issue":"7","key":"10.1016\/j.phymed.2024.155931_bib0015","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1080\/09513590.2017.1411474","article-title":"SHBG expression is correlated with PI3K\/AKT pathway activity in a cellular model of human insulin resistance","volume":"34","author":"Feng","year":"2018","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.phymed.2024.155931_bib0016","article-title":"Water extract of cacumen platycladi promotes hair growth through the Akt\/GSK3\u03b2\/\u03b2-catenin signaling pathway","volume":"14","author":"Fu","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2024.155931_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155280","article-title":"Troxerutin dampened hypothalamic neuroinflammation via microglial IL-22\/IL-22R1\/IRF3 activation in dihydrotestosterone-induced polycystic ovary syndrome rats","volume":"124","author":"Gao","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2024.155931_bib0018","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.metabol.2018.11.002","article-title":"Characteristics of obesity in polycystic ovary syndrome: etiology, treatment, and genetics","volume":"92","author":"Glueck","year":"2019","journal-title":"Metabolism."},{"issue":"2","key":"10.1016\/j.phymed.2024.155931_bib0019","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1080\/09513590.2017.1379499","article-title":"Is there a role for kisspeptin in pathogenesis of polycystic ovary syndrome?","volume":"34","author":"Gorkem","year":"2018","journal-title":"Gynecol. Endocrinol."},{"issue":"1","key":"10.1016\/j.phymed.2024.155931_bib0020","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12958-023-01055-z","article-title":"Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials","volume":"21","author":"Greff","year":"2023","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"10","key":"10.1016\/j.phymed.2024.155931_bib0021","doi-asserted-by":"crossref","DOI":"10.1172\/JCI145889","article-title":"Targeting hepatic kisspeptin receptor ameliorates nonalcoholic fatty liver disease in a mouse model","volume":"132","author":"Guzman","year":"2022","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.phymed.2024.155931_bib0022","doi-asserted-by":"crossref","first-page":"R173","DOI":"10.1530\/JOE-18-0108","article-title":"The role of kisspeptin neurons in reproduction and metabolism","volume":"238","author":"Harter","year":"2018","journal-title":"J. Endocrinol."},{"issue":"3","key":"10.1016\/j.phymed.2024.155931_bib0023","doi-asserted-by":"crossref","first-page":"e1071","DOI":"10.1210\/clinem\/dgaa839","article-title":"Update on PCOS: consequences, challenges, and guiding treatment","volume":"106","author":"Hoeger","year":"2021","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.phymed.2024.155931_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117654","article-title":"Jiawei Buzhong Yiqi Decoction ameliorates polycystic ovary syndrome via oocyte-granulosa cell communication","volume":"323","author":"Hu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2024.155931_bib0025","first-page":"99","article-title":"Kisspeptin-54 attenuates oxidative stress and neuronal apoptosis in early brain injury after subarachnoid hemorrhage in rats via GPR54\/ARRB2\/AKT\/GSK3\u03b2 signaling pathway Free Radic","volume":"171","author":"Huang","year":"2021","journal-title":"Biol. Med."},{"key":"10.1016\/j.phymed.2024.155931_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107974","article-title":"Metabolic actions of kisspeptin signaling: effects on body weight, energy expenditure, and feeding","volume":"231","author":"Hudson","year":"2022","journal-title":"Pharmacol. Ther."},{"issue":"6","key":"10.1016\/j.phymed.2024.155931_bib0027","doi-asserted-by":"crossref","first-page":"E953","DOI":"10.1210\/jc.2013-1569","article-title":"Increasing LH pulsatility in women with hypothalamic amenorrhoea using intravenous infusion of Kisspeptin-54","volume":"99","author":"Jayasena","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.phymed.2024.155931_bib0028","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1159\/000350217","article-title":"Kisspeptin, leptin, and retinol-binding protein 4 in women with polycystic ovary syndrome","volume":"75","author":"Jeon","year":"2013","journal-title":"Gynecol. Obstet. Invest."},{"key":"10.1016\/j.phymed.2024.155931_bib0029","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.metabol.2017.11.018","article-title":"The hypothalamus-pituitary-gonad axis: tales of mice and men","volume":"86","author":"Kaprara","year":"2018","journal-title":"Metabolism."},{"issue":"1","key":"10.1016\/j.phymed.2024.155931_bib0030","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s12020-018-1609-1","article-title":"Kisspeptin and LH pulsatile temporal coupling in PCOS patients","volume":"61","author":"Katulski","year":"2018","journal-title":"Endocrine"},{"issue":"3","key":"10.1016\/j.phymed.2024.155931_bib0031","first-page":"69","article-title":"Novel letrozole model recapitulates both the reproductive and metabolic phenotypes of polycystic ovary syndrome in female","volume":"93","author":"Kauffman","year":"2015","journal-title":"Mice Biol. Reprod."},{"issue":"3","key":"10.1016\/j.phymed.2024.155931_bib0032","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1080\/09513590.2018.1519792","article-title":"Serum Kisspeptin levels in unexplained infertility, polycystic ovary syndrome, and male factor infertility","volume":"35","author":"Kaya","year":"2019","journal-title":"Gynecol. Endocrinol."},{"issue":"19","key":"10.1016\/j.phymed.2024.155931_bib0033","article-title":"Novel Insight into the Role of the Kiss1\/GPR54 system in energy metabolism in major","volume":"11","author":"Li","year":"2022","journal-title":"Metab. Organs Cells"},{"issue":"06","key":"10.1016\/j.phymed.2024.155931_bib0034","first-page":"947","article-title":"Clinical study of modified Buzhong Yiqi Decoction for infertile patient with obese polycystic ovary syndrome","volume":"43","author":"Li","year":"2021","journal-title":"Hebei J. Tradit. Chin. Med."},{"issue":"5","key":"10.1016\/j.phymed.2024.155931_bib0035","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.ajpath.2018.01.013","article-title":"A novel AKT activator, SC79, prevents acute hepatic failure induced by FAS-mediated apoptosis of hepatocytes","volume":"188","author":"Liu","year":"2018","journal-title":"Am. J. Pathol."},{"issue":"3","key":"10.1016\/j.phymed.2024.155931_bib0036","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1093\/humupd\/dmv059","article-title":"GnRH and GnRH receptors in the pathophysiology of the human female reproductive system","volume":"22","author":"Maggi","year":"2016","journal-title":"Hum. Reprod. Update"},{"issue":"5","key":"10.1016\/j.phymed.2024.155931_bib0037","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1073\/pnas.0409330102","article-title":"Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54","volume":"102","author":"Messager","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.phymed.2024.155931_bib0038","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/s41574-020-00438-1","article-title":"Functions of galanin, spexin and kisspeptin in metabolism, mood and behaviour","volume":"17","author":"Mills","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"issue":"10","key":"10.1016\/j.phymed.2024.155931_bib0039","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.tem.2012.07.001","article-title":"Status of clomiphene citrate and metformin for infertility in PCOS","volume":"23","author":"Misso","year":"2012","journal-title":"Trends. Endocrinol. Metab."},{"issue":"11","key":"10.1016\/j.phymed.2024.155931_bib0040","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqab158","article-title":"Prenatal androgen exposure alters KNDy neurons and their afferent network in a model of polycystic ovarian syndrome","volume":"162","author":"Moore","year":"2021","journal-title":"Endocrinology"},{"issue":"31","key":"10.1016\/j.phymed.2024.155931_bib0041","doi-asserted-by":"crossref","first-page":"28969","DOI":"10.1074\/jbc.M102743200","article-title":"AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1","volume":"276","author":"Muir","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.phymed.2024.155931_bib0042","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/s41574-020-0363-7","article-title":"Metabolic regulation of kisspeptin - the link between energy balance and reproduction","volume":"16","author":"Navarro","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"issue":"38","key":"10.1016\/j.phymed.2024.155931_bib0043","doi-asserted-by":"crossref","first-page":"11859","DOI":"10.1523\/JNEUROSCI.1569-09.2009","article-title":"Regulation of gonadotropin-releasing hormone secretion by kisspeptin\/dynorphin\/neurokinin B neurons in the arcuate nucleus of the mouse","volume":"29","author":"Navarro","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phymed.2024.155931_bib0044","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6671367","article-title":"Impact of Buzhong Yiqi prescription on the gut microbiota of patients with obesity manifesting polycystic ovarian syndrome","volume":"2021","author":"Ni","year":"2021","journal-title":"Evid. Based Complement. Alternat. Med."},{"issue":"6","key":"10.1016\/j.phymed.2024.155931_bib0045","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1016\/j.fertnstert.2005.11.044","article-title":"Plasma metastin levels are negatively correlated with insulin resistance and free androgens in women with polycystic ovary syndrome","volume":"85","author":"Panidis","year":"2006","journal-title":"Fertil. Steril."},{"issue":"6","key":"10.1016\/j.phymed.2024.155931_bib0046","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.rbmo.2020.07.020","article-title":"The proportion of cleaved anti-M\u00fcllerian hormone is higher in serum but not follicular fluid of obese women independently of polycystic ovary syndrome","volume":"41","author":"Peign\u00e9","year":"2020","journal-title":"Reprod. Biomed. Online"},{"issue":"1","key":"10.1016\/j.phymed.2024.155931_bib0047","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.mce.2009.09.020","article-title":"Sex hormone-binding globulin gene expression in the liver: drugs and the metabolic syndrome","volume":"316","author":"Pugeat","year":"2010","journal-title":"Mol. Cell Endocrinol."},{"issue":"21","key":"10.1016\/j.phymed.2024.155931_bib0048","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21218191","article-title":"Sex hormone-binding globulin (SHBG) as an early biomarker and therapeutic target in polycystic ovary syndrome","volume":"21","author":"Qu","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.phymed.2024.155931_bib0049","first-page":"288","article-title":"Correlation of serum kisspeptin levels, ovarian kisspeptin expression, and ovarian BMP15 expression in rat model of polycystic ovary syndrome Open","volume":"13","author":"Rheza","year":"2023","journal-title":"Vet. J."},{"issue":"4","key":"10.1016\/j.phymed.2024.155931_bib0050","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1002\/mnfr.201300304","article-title":"Oleic acid increases hepatic sex hormone binding globulin production in men","volume":"58","author":"S\u00e1ez-L\u00f3pez","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"issue":"5","key":"10.1016\/j.phymed.2024.155931_bib0051","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1210\/en.2008-1289","article-title":"Peroxisome-proliferator receptor gamma represses hepatic sex hormone-binding globulin expression","volume":"150","author":"Selva","year":"2009","journal-title":"Endocrinology"},{"issue":"7","key":"10.1016\/j.phymed.2024.155931_bib0052","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.tem.2015.05.001","article-title":"Novel insights in SHBG regulation and clinical implications","volume":"26","author":"Sim\u00f3","year":"2015","journal-title":"Trends. Endocrinol. Metab."},{"key":"10.1016\/j.phymed.2024.155931_bib0053","doi-asserted-by":"crossref","DOI":"10.1016\/j.yfrne.2021.100977","article-title":"Kisspeptins and the neuroendocrine control of reproduction: recent progress and new frontiers in kisspeptin research","volume":"65","author":"Sobrino","year":"2022","journal-title":"Front. Neuroendocrinol."},{"issue":"4","key":"10.1016\/j.phymed.2024.155931_bib0054","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.cmet.2014.03.005","article-title":"Glucagon regulates hepatic kisspeptin to impair insulin secretion","volume":"19","author":"Song","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.phymed.2024.155931_bib0055","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.951938","article-title":"Kisspeptin-neuron control of LH pulsatility and ovulation","volume":"13","author":"Stevenson","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"1","key":"10.1016\/j.phymed.2024.155931_bib0056","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12905-022-02154-6","article-title":"Kisspeptin regulates the proliferation and apoptosis of ovary granulosa cells in polycystic ovary syndrome by modulating the PI3K\/AKT\/ERK signalling pathway","volume":"23","author":"Sun","year":"2023","journal-title":"BMC. Womens Health"},{"key":"10.1016\/j.phymed.2024.155931_bib0057","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3389\/fendo.2019.00298","article-title":"Kisspeptin and polycystic ovary syndrome","volume":"10","author":"Tang","year":"2019","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"5","key":"10.1016\/j.phymed.2024.155931_bib0058","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/humupd\/dml023","article-title":"GPR54 and kisspeptin in reproduction","volume":"12","author":"Tena-Sempere","year":"2006","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.phymed.2024.155931_bib0059","doi-asserted-by":"crossref","DOI":"10.1093\/humrep\/deae066","article-title":"Epigenetic\/circadian clocks and PCOS","author":"Vatier","year":"2024","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.phymed.2024.155931_bib0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116940","article-title":"Hyperandrogenemia and insulin resistance: the chief culprit of polycystic ovary syndrome","volume":"236","author":"Wang","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2024.155931_bib0061","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1051797","article-title":"Gut microbiota and its derived SCFAs regulate the HPGA to reverse obesity-induced precocious puberty in female rats","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"16","key":"10.1016\/j.phymed.2024.155931_bib0062","doi-asserted-by":"crossref","first-page":"5261","DOI":"10.1128\/AEM.00062-07","article-title":"Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy","volume":"73","author":"Wang","year":"2007","journal-title":"Appl. Environ. Microbiol."},{"issue":"9","key":"10.1016\/j.phymed.2024.155931_bib0063","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1080\/09513590.2019.1597343","article-title":"Effects of kisspeptin on pathogenesis and energy metabolism in polycystic ovarian syndrome (PCOS)","volume":"35","author":"Wang","year":"2019","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.phymed.2024.155931_bib0064","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153654","article-title":"Berberine improves ovulation and endometrial receptivity in polycystic ovary syndrome","volume":"91","author":"Wang","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2024.155931_bib0065","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.925206","article-title":"The role of Kisspeptin in the control of the hypothalamic-pituitary-gonadal axis and reproduction","volume":"13","author":"Xie","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.phymed.2024.155931_bib0066","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.945609","article-title":"Effect of metformin versus metformin plus liraglutide on gonadal and metabolic profiles in overweight patients with polycystic ovary syndrome","volume":"13","author":"Xing","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"1","key":"10.1016\/j.phymed.2024.155931_bib0067","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13048-022-01078-x","article-title":"Effects of electroacupuncture on the kisspeptin-gonadotropin-releasing hormone (GnRH) \/luteinizing hormone (LH) neural circuit abnormalities and androgen receptor expression of kisspeptin\/neurokinin B\/dynorphin neurons in PCOS rats","volume":"16","author":"Xu","year":"2023","journal-title":"J. Ovarian. Res."},{"key":"10.1016\/j.phymed.2024.155931_bib0068","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ejogrb.2014.06.004","article-title":"Metastin levels in relation with hormonal and metabolic profile in patients with polycystic ovary syndrome","volume":"180","author":"Yilmaz","year":"2014","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"issue":"12","key":"10.1016\/j.phymed.2024.155931_bib0069","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2021.166242","article-title":"Involvement of kisspeptin in androgen-induced hypothalamic endoplasmic reticulum stress and its rescuing effect in PCOS rats","volume":"1867","author":"Yuan","year":"2021","journal-title":"Biochim. Biophys. Acta Mol. Basis. Dis."},{"issue":"1","key":"10.1016\/j.phymed.2024.155931_bib0070","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/s12978-021-01207-7","article-title":"Comparative efficacy of oral insulin sensitizers metformin, thiazolidinediones, inositol, and berberine in improving endocrine and metabolic profiles in women with PCOS: a network meta-analysis","volume":"18","author":"Zhao","year":"2021","journal-title":"Reprod. Health"},{"issue":"1","key":"10.1016\/j.phymed.2024.155931_bib0071","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1186\/s40168-022-01381-1","article-title":"Gut microbiota is associated with the effect of photoperiod on seasonal breeding in male Brandt's voles (Lasiopodomys brandtii)","volume":"10","author":"Zhu","year":"2022","journal-title":"Microbiome"},{"key":"10.1016\/j.phymed.2024.155931_bib0072","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.cca.2019.09.010","article-title":"Sex hormone-binding globulin and polycystic ovary syndrome","volume":"499","author":"Zhu","year":"2019","journal-title":"Clin. Chim. Acta"}],"updated-by":[{"DOI":"10.1016\/j.phymed.2025.156415","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000}}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324005890?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324005890?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T15:30:45Z","timestamp":1725291045000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711324005890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":72,"alternative-id":["S0944711324005890"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155931","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.phymed.2025.156415","asserted-by":"object"}]},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Jiawei Buzhong Yiqi Decoction attenuates polycystic ovary syndrome through regulating kisspeptin-GPR54-AKT-SHBG system","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155931","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"155931"}}