{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:24:23Z","timestamp":1792531463622,"version":"4.5.0"},"reference-count":220,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.phymed.2024.155949","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T22:25:43Z","timestamp":1723242343000},"page":"155949","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Unlocking daidzein's healing power: Present applications and future possibilities in phytomedicine"],"prefix":"10.1016","volume":"134","author":[{"given":"Pouya","family":"Goleij","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pantea Majma","family":"Sanaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waqas","family":"Alam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junmin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Amin Khazeei","family":"Tabari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanna","family":"Filosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Jeandet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai San","family":"Cheang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2637-1681","authenticated-orcid":false,"given":"Thomas","family":"Efferth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1736-4404","authenticated-orcid":false,"given":"Haroon","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2024.155949_bib0001","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1080\/13697137.2016.1238451","article-title":"Effects of phytoestrogens on bone mineral density during the menopause transition: a systematic review of randomized, controlled trials","volume":"19","author":"Abdi","year":"2016","journal-title":"Climacteric"},{"key":"10.1016\/j.phymed.2024.155949_bib0002","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2174\/1874467215666220324114624","article-title":"Immunomodulatory therapeutic effects of curcumin on M1\/M2 macrophage polarization in inflammatory diseases","volume":"16","author":"Abdollahi","year":"2023","journal-title":"Curr. Mol. Pharmacol."},{"key":"10.1016\/j.phymed.2024.155949_bib0003","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S2095-4964(15)60175-3","article-title":"Antioxidant, antiangiogenic and antiproliferative activities of root methanol extract of Calliandra portoricensis in human prostate cancer cells","volume":"13","author":"Adaramoye","year":"2015","journal-title":"J. Integr. Med."},{"key":"10.1016\/j.phymed.2024.155949_bib0004","first-page":"39","article-title":"Genistein and daidzein: different molecular effects on prostate cancer","volume":"33","author":"Adjakly","year":"2013","journal-title":"Anticancer Res."},{"key":"10.1016\/j.phymed.2024.155949_bib0005","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0960-0760(94)00146-D","article-title":"Lignan and isoflavonoid conjugates in human urine","volume":"52","author":"Adlercreutz","year":"1995","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.phymed.2024.155949_bib0006","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21165622","article-title":"Anticancer potential of furanocoumarins: mechanistic and therapeutic aspects","volume":"21","author":"Ahmed","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2024.155949_bib0007","doi-asserted-by":"crossref","DOI":"10.3390\/polym14061221","article-title":"Broad-spectrum theranostics and biomedical application of functionalized nanomaterials","volume":"14","author":"Alshamrani","year":"2022","journal-title":"Polymers. (Basel)"},{"key":"10.1016\/j.phymed.2024.155949_bib0008","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6331630","article-title":"Therapeutic potential of isoflavones with an emphasis on daidzein","volume":"2021","author":"Alshehri","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.phymed.2024.155949_bib0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2021\/6331630","article-title":"Therapeutic potential of isoflavones with an emphasis on daidzein","volume":"2021","author":"Alshehri","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.phymed.2024.155949_bib0010","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1039\/C7FO00205J","article-title":"The role of soybean extracts and isoflavones in hormone-dependent breast cancer: aromatase activity and biological effects","volume":"8","author":"Amaral","year":"2017","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2024.155949_bib0011","first-page":"1117","article-title":"Update on osteoporosis screening and management","volume":"105","author":"Anam","year":"2021","journal-title":"Med. Clin."},{"key":"10.1016\/j.phymed.2024.155949_bib0012","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1056\/NEJM199508033330502","article-title":"Meta-analysis of the effects of soy protein intake on serum lipids","volume":"333","author":"Anderson","year":"1995","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.phymed.2024.155949_bib0013","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3390\/nu10010040","article-title":"Soy consumption and the risk of prostate cancer: an updated systematic review and meta-analysis","volume":"10","author":"Applegate","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2024.155949_bib0014","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/4558299","article-title":"Ameliorating effects of curcumin on testicular cancer","volume":"2023","author":"Arefnezhad","year":"2023","journal-title":"Andrologia"},{"key":"10.1016\/j.phymed.2024.155949_bib0015","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","article-title":"Natural products in drug discovery: advances and opportunities","volume":"20","author":"Atanasov","year":"2021","journal-title":"Nat. Rev. Drug Discovery"},{"key":"10.1016\/j.phymed.2024.155949_bib0016","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1093\/jn\/134.3.596","article-title":"In vitro incubation of human feces with daidzein and antibiotics suggests interindividual differences in the bacteria responsible for equol production","volume":"134","author":"Atkinson","year":"2004","journal-title":"J. Nutr."},{"key":"10.1016\/j.phymed.2024.155949_bib0017","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1177\/153537020523000302","article-title":"Gut bacterial metabolism of the soy isoflavone daidzein: exploring the relevance to human health","volume":"230","author":"Atkinson","year":"2005","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.phymed.2024.155949_bib0018","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.bcp.2009.10.005","article-title":"Genistein and daidzein prevent low potassium-dependent apoptosis of cerebellar granule cells","volume":"79","author":"Atlante","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phymed.2024.155949_bib0019","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1021\/jf500231t","article-title":"Daidzein suppresses tumor necrosis factor-\u03b1 induced migration and invasion by inhibiting hedgehog\/Gli1 signaling in human breast cancer cells","volume":"62","author":"Bao","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2024.155949_bib0020","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.molmed.2006.07.004","article-title":"Estrogen receptors: new players in diabetes mellitus","volume":"12","author":"Barros","year":"2006","journal-title":"Trends. Mol. Med."},{"key":"10.1016\/j.phymed.2024.155949_bib0021","doi-asserted-by":"crossref","first-page":"774","DOI":"10.3390\/foods10040774","article-title":"Regulation of intestinal inflammation by soybean and soy-derived compounds","volume":"10","author":"Basson","year":"2021","journal-title":"Foods."},{"key":"10.1016\/j.phymed.2024.155949_bib0022","doi-asserted-by":"crossref","first-page":"5656","DOI":"10.3390\/ijms22115656","article-title":"Pleiotropic effects of isoflavones in inflammation and chronic degenerative diseases","volume":"22","author":"Bernatoniene","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2024.155949_bib0023","doi-asserted-by":"crossref","first-page":"e02669","DOI":"10.1016\/j.heliyon.2019.e02669","article-title":"Daidzein cocrystals: an opportunity to improve its biopharmaceutical parameters","volume":"5","author":"Bhalla","year":"2019","journal-title":"Heliyon."},{"key":"10.1016\/j.phymed.2024.155949_bib0024","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.3390\/ijms12053303","article-title":"Nanomedicine: application areas and development prospects","volume":"12","author":"Boulaiz","year":"2011","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2024.155949_bib0025","doi-asserted-by":"crossref","DOI":"10.1071\/AR9670355","article-title":"Oestrogenic activity and metabolism of certain isoflavones in sheep","volume":"18","author":"Braden","year":"1967","journal-title":"Aust. J. Agric. Res."},{"key":"10.1016\/j.phymed.2024.155949_bib0026","doi-asserted-by":"crossref","first-page":"5492","DOI":"10.1128\/MCB.22.15.5492-5505.2002","article-title":"Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound","volume":"22","author":"Braun","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.phymed.2024.155949_bib0027","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1111\/jam.15253","article-title":"Synergistic antimicrobial activities of epigallocatechin gallate, myricetin, daidzein, gallic acid, epicatechin, 3-hydroxy-6-methoxyflavone and genistein combined with antibiotics against ESKAPE pathogens","volume":"132","author":"Buchmann","year":"2022","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.phymed.2024.155949_bib0028","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1024\/0300-9831.73.2.120","article-title":"Potential risks and benefits of phytoestrogen-rich diets","volume":"73","author":"Cassidy","year":"2003","journal-title":"Int. J. Vitamin Nutr. Res."},{"key":"10.1016\/j.phymed.2024.155949_bib0029","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.3945\/ajcn.114.088708","article-title":"Intake of dietary flavonoids and risk of epithelial ovarian cancer","volume":"100","author":"Cassidy","year":"2014","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.phymed.2024.155949_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12935-018-0559-2","article-title":"Estrogen receptor modulators genistein, daidzein and ERB-041 inhibit cell migration, invasion, proliferation and sphere formation via modulation of FAK and PI3K\/AKT signaling in ovarian cancer","volume":"18","author":"Chan","year":"2018","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.phymed.2024.155949_bib0031","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1021\/np50126a014","article-title":"Metabolism of daidzein and genistein by intestinal bacteria","volume":"58","author":"Chang","year":"1995","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phymed.2024.155949_bib0032","doi-asserted-by":"crossref","first-page":"393","DOI":"10.4162\/nrp.2013.7.5.393","article-title":"Plasma pharmacokinetics and urinary excretion of isoflavones after ingestion of soy products with different aglycone\/glucoside ratios in South Korean women","volume":"7","author":"Chang","year":"2013","journal-title":"Nutr. Res. Pract."},{"key":"10.1016\/j.phymed.2024.155949_bib0033","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2407-13-238","article-title":"Equol enhances tamoxifen's anti-tumor activity by induction of caspase-mediated apoptosis in MCF-7 breast cancer cells","volume":"13","author":"Charalambous","year":"2013","journal-title":"BMC Cancer"},{"key":"10.1016\/j.phymed.2024.155949_bib0034","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jnutbio.2013.09.012","article-title":"Daidzein promotes glucose uptake through glucose transporter 4 translocation to plasma membrane in L6 myocytes and improves glucose homeostasis in Type 2 diabetic model mice","volume":"25","author":"Cheong","year":"2014","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.phymed.2024.155949_bib0035","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.phymed.2008.04.006","article-title":"Daidzein causes cell cycle arrest at the G1 and G2\/M phases in human breast cancer MCF-7 and MDA-MB-453 cells","volume":"15","author":"Choi","year":"2008","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2024.155949_bib0036","doi-asserted-by":"crossref","first-page":"328","DOI":"10.3892\/mmr.2013.1752","article-title":"The antioxidant activity of daidzein metabolites, O\u2011desmethylangolensin and equol, in HepG2 cells","volume":"9","author":"Choi","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.phymed.2024.155949_bib0037","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1600-0765.2011.01422.x","article-title":"Anti-inflammatory effects and the underlying mechanisms of action of daidzein in murine macrophages stimulated with Prevotella intermedia lipopolysaccharide","volume":"47","author":"Choi","year":"2012","journal-title":"J. Periodont. Res."},{"key":"10.1016\/j.phymed.2024.155949_bib0038","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/dmrr.780","article-title":"Genistein and daidzein prevent diabetes onset by elevating insulin level and altering hepatic gluconeogenic and lipogenic enzyme activities in non-obese diabetic (NOD) mice","volume":"24","author":"Choi","year":"2008","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.phymed.2024.155949_bib0039","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jdermsci.2007.02.001","article-title":"Increase of collagen synthesis by obovatol through stimulation of the TGF-\u03b2 signaling and inhibition of matrix metalloproteinase in UVB-irradiated human fibroblast","volume":"46","author":"Choi","year":"2007","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.phymed.2024.155949_bib0040","doi-asserted-by":"crossref","DOI":"10.3390\/nu12092572","article-title":"Modification of in vitro and in vivo antioxidant activity by consumption of cooked chickpea in a colon cancer model","volume":"12","author":"Cid-Gallegos","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2024.155949_bib0041","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1080\/00498250110085809","article-title":"Comparative metabolism of genistin by human and rat gut microflora: detection and identification of the end-products of metabolism","volume":"32","author":"Coldham","year":"2002","journal-title":"Xenobiotica"},{"key":"10.1016\/j.phymed.2024.155949_bib0042","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1002\/cssc.201801404","article-title":"Biobased benzoxazine derived from daidzein and furfurylamine: microwave-assisted synthesis and thermal properties investigation","volume":"11","author":"Dai","year":"2018","journal-title":"ChemSusChem."},{"key":"10.1016\/j.phymed.2024.155949_bib0043","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/biof.1439","article-title":"Daidzein, its effects on impaired glucose and lipid metabolism and vascular inflammation associated with type 2 diabetes","volume":"44","author":"Das","year":"2018","journal-title":"Biofactors"},{"key":"10.1016\/j.phymed.2024.155949_bib0044","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/jcp.20008","article-title":"A low dose of daidzein acts as an ER\u03b2-selective agonist in trabecular osteoblasts of young female piglets","volume":"200","author":"De Wilde","year":"2004","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.phymed.2024.155949_bib0045","doi-asserted-by":"crossref","DOI":"10.1177\/20503121211034366","article-title":"New approaches and procedures for cancer treatment: current perspectives","volume":"9","author":"Debela","year":"2021","journal-title":"SAGe Open. Med."},{"key":"10.1016\/j.phymed.2024.155949_bib0046","first-page":"1","article-title":"Assessment of pharmacokinetic parameters of daidzein-containing nanosuspension and nanoemulsion formulations after oral administration to rats","author":"Demirt\u00fcrk","year":"2022","journal-title":"Eur. J. Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.phymed.2024.155949_bib0047","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-9255-4-17","article-title":"Soy isoflavones avert chronic inflammation-induced bone loss and vascular disease","volume":"4","author":"Droke","year":"2007","journal-title":"J. Inflamm."},{"key":"10.1016\/j.phymed.2024.155949_bib0048","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jphotobiol.2009.06.012","article-title":"Antioxidant activity of daidzein, a natural antioxidant, and its spectroscopic properties in organic solvents and phosphatidylcholine liposomes","volume":"96","author":"Dwiecki","year":"2009","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"10.1016\/j.phymed.2024.155949_bib0049","article-title":"Protective effects of curcumin against medulloblastoma: a review","volume":"19","author":"Elahi","year":"2024","journal-title":"Nat. Prod. Commun."},{"key":"10.1016\/j.phymed.2024.155949_bib0050","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.intimp.2015.04.002","article-title":"Daidzein attenuates lipopolysaccharide-induced acute lung injury via toll-like receptor 4\/NF-kappaB pathway","volume":"26","author":"Feng","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2024.155949_bib0051","doi-asserted-by":"crossref","first-page":"193","DOI":"10.4103\/pm.pm_325_21","article-title":"Elucidating the immunomodulatory effect of daidzein in Benzo (a) pyrene-Induced lung cancer mice model through modulation of proliferating cell nuclear antigen, NF-\u03baB, CYP1A1, and NRF","volume":"18","author":"Feng","year":"2022","journal-title":"Pharmacogn. Mag."},{"key":"10.1016\/j.phymed.2024.155949_bib0052","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1007\/s00198-009-1092-x","article-title":"Daidzein administration positively affects thyroid C cells and bone structure in orchidectomized middle-aged rats","volume":"21","author":"Filipovi\u0107","year":"2010","journal-title":"Osteoporosis Int."},{"key":"10.1016\/j.phymed.2024.155949_bib0053","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1046\/j.0022-202x.2001.01432.x","article-title":"Ultraviolet irradiation increases matrix metalloproteinase-8 protein in human skin in vivo","volume":"117","author":"Fisher","year":"2001","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.phymed.2024.155949_bib0054","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.bone.2004.03.031","article-title":"Daidzein together with high calcium preserve bone mass and biomechanical strength at multiple sites in ovariectomized mice","volume":"35","author":"Fonseca","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.phymed.2024.155949_bib0055","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1089\/jmf.2011.0322","article-title":"Daidzein\u2013estrogen interaction in the rat uterus and its effect on human breast cancer cell growth","volume":"15","author":"Gaete","year":"2012","journal-title":"J. Med. Food"},{"key":"10.1016\/j.phymed.2024.155949_bib0056","doi-asserted-by":"crossref","first-page":"4129","DOI":"10.1016\/j.biomaterials.2008.07.008","article-title":"The role of daidzein-loaded sterically stabilized solid lipid nanoparticles in therapy for cardio-cerebrovascular diseases","volume":"29","author":"Gao","year":"2008","journal-title":"Biomaterials"},{"issue":"10","key":"10.1016\/j.phymed.2024.155949_bib0057","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.3390\/antiox10091455","article-title":"Role of phytochemicals in cancer chemoprevention: insights","volume":"2021","author":"George","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.phymed.2024.155949_bib0058","first-page":"1","article-title":"Revolutionizing non-melanoma skin cancer treatment: receptor tyrosine kinase inhibitors take the stage","volume":"00","author":"Gholizadeh","year":"2024","journal-title":"J. Cosmet."},{"key":"10.1016\/j.phymed.2024.155949_bib0059","doi-asserted-by":"crossref","first-page":"624","DOI":"10.2174\/138920112799857585","article-title":"Soy isoflavones and cardiovascular disease epidemiological, clinical and -omics perspectives","volume":"13","author":"Gil-Izquierdo","year":"2012","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.phymed.2024.155949_bib0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.leukres.2024.107464","article-title":"Phytostilbenes in lymphoma: focuses on the mechanistic and clinical prospects of resveratrol, pterostilbene, piceatannol, and pinosylvin","volume":"138","author":"Goleij","year":"2024","journal-title":"Leuk. Res."},{"key":"10.1016\/j.phymed.2024.155949_bib0061","first-page":"130","article-title":"Prevention effects of hydroalcoholic extracts bottle gourd (Lagenaria siceraria standl.) on life cells faced with anti-cancer drug doxorubicin","volume":"1","author":"Goleij","year":"2018","journal-title":"Int. Pharmacy Acta"},{"key":"10.1016\/j.phymed.2024.155949_bib0062","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1158\/1055-9965.698.13.5","article-title":"Phytoestrogen concentrations in serum and spot urine as biomarkers for dietary phytoestrogen intake and their relation to breast cancer risk in European prospective investigation of cancer and nutrition-norfolk","volume":"13","author":"Grace","year":"2004","journal-title":"Cancer Epidemiol. Biomarkers Prevent."},{"key":"10.1016\/j.phymed.2024.155949_bib0063","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.4161\/cbt.8.18.9285","article-title":"7-(O)-Carboxymethyl daidzein conjugated to Nt-Boc-hexylenediamine: a novel compound capable of inducing cell death in epithelial ovarian cancer stem cells","volume":"8","author":"Green","year":"2009","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.phymed.2024.155949_bib0064","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1042\/bj1301161","article-title":"Metabolism of flavonoid compounds in germ-free rats","volume":"130","author":"Griffiths","year":"1972","journal-title":"Biochem. J."},{"key":"10.1016\/j.phymed.2024.155949_bib0065","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s10549-009-0321-5","article-title":"Soy isoflavones and risk of cancer recurrence in a cohort of breast cancer survivors: the life after cancer epidemiology study","volume":"118","author":"Guha","year":"2009","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.phymed.2024.155949_bib0066","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/j.fct.2004.06.001","article-title":"Biphasic effect of daidzein on cell growth of human colon cancer cells","volume":"42","author":"Guo","year":"2004","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.phymed.2024.155949_bib0067","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.imlet.2020.03.004","article-title":"Daidzein-rich isoflavones aglycone inhibits lung cancer growth through inhibition of NF-\u03baB signaling pathway","volume":"222","author":"Guo","year":"2020","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.phymed.2024.155949_bib0068","doi-asserted-by":"crossref","DOI":"10.1155\/2007\/45673","volume":"2007","author":"H\u00e4m\u00e4l\u00e4inen","year":"2007","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.phymed.2024.155949_bib0069","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.3390\/polym11081341","article-title":"Synthesis of highly thermally stable daidzein-based main-chain-type benzoxazine resins","volume":"11","author":"Han","year":"2019","journal-title":"Polymers. (Basel)"},{"key":"10.1016\/j.phymed.2024.155949_bib0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-143-1-200507050-00004","article-title":"Effect of soybean protein on blood pressure: a randomized, controlled trial","volume":"143","author":"He","year":"2005","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.phymed.2024.155949_bib0071","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jsbmb.2003.09.003","article-title":"Metabolism of the soy isoflavones daidzein, genistein and glycitein in human subjects.: identification of new metabolites having an intact isoflavonoid skeleton","volume":"87","author":"Heinonen","year":"2003","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.phymed.2024.155949_bib0072","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2020.104164","article-title":"Bioavailability and health benefits of major isoflavone aglycones and their metabolites","volume":"74","author":"Hsiao","year":"2020","journal-title":"J. Funct. Foods."},{"key":"10.1016\/j.phymed.2024.155949_bib0074","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0151134","article-title":"Association among dietary flavonoids, flavonoid subclasses and ovarian cancer risk: a meta-analysis","volume":"11","author":"Hua","year":"2016","journal-title":"PLoS. One"},{"key":"10.1016\/j.phymed.2024.155949_bib0075","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ijpharm.2008.08.002","article-title":"In vitro and in vivo evaluation of topical delivery and potential dermal use of soy isoflavones genistein and daidzein","volume":"364","author":"Huang","year":"2008","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.phymed.2024.155949_bib0076","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/s002030000222","article-title":"Isolation of human intestinal bacteria metabolizing the natural isoflavone glycosides daidzin and genistin","volume":"174","author":"Hur","year":"2000","journal-title":"Arch. Microbiol."},{"key":"10.1016\/j.phymed.2024.155949_bib0077","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.neuint.2012.04.007","article-title":"Daidzein has neuroprotective effects through ligand-binding-independent PPAR\u03b3 activation","volume":"61","author":"Hurtado","year":"2012","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.phymed.2024.155949_bib0078","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/S0891-5849(03)00104-7","article-title":"The phytoestrogen equol increases nitric oxide availability by inhibiting superoxide production: an antioxidant mechanism for cell-mediated LDL modification","volume":"34","author":"Hwang","year":"2003","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.phymed.2024.155949_bib0079","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1208\/s12249-021-02151-2","article-title":"Inclusion complexes of daidzein with cyclodextrin-based metal\u2013organic framework-1 enhance its solubility and antioxidant capacity","volume":"23","author":"Inoue","year":"2022","journal-title":"AAPS. PharmSciTech."},{"key":"10.1016\/j.phymed.2024.155949_bib0080","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0006-2952(02)01585-X","article-title":"Daidzein enhances osteoblast growth that may be mediated by increased bone morphogenetic protein (BMP) production","volume":"65","author":"Jia","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phymed.2024.155949_bib0081","doi-asserted-by":"crossref","DOI":"10.1098\/rsos.201475","article-title":"Study on pharmacological properties and cell absorption metabolism of novel daidzein napsylates","volume":"8","author":"Jiao","year":"2021","journal-title":"R. Soc. Open. Sci."},{"key":"10.1016\/j.phymed.2024.155949_bib0082","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/annonc\/mdp499","article-title":"Daidzein induces MCF-7 breast cancer cell apoptosis via the mitochondrial pathway","volume":"21","author":"Jin","year":"2010","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.phymed.2024.155949_bib0083","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.nutres.2017.04.009","article-title":"Daidzein stimulates osteogenesis facilitating proliferation, differentiation, and antiapoptosis in human osteoblast-like MG-63 cells via estrogen receptor\u2013dependent MEK\/ERK and PI3K\/Akt activation","volume":"42","author":"Jin","year":"2017","journal-title":"Nutr. Res."},{"key":"10.1016\/j.phymed.2024.155949_bib0084","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0960-0760(95)00131-I","article-title":"A urinary profile study of dietary phytoestrogens. The identification and mode of metabolism of new isoflavonoids","volume":"54","author":"Joannou","year":"1995","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.phymed.2024.155949_bib0085","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1093\/carcin\/bgi320","article-title":"Effects of dietary daidzein and its metabolite, equol, at physiological concentrations on the growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in ovariectomized athymic mice","volume":"27","author":"Ju","year":"2006","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.phymed.2024.155949_bib0086","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.neuroscience.2013.02.005","article-title":"The key involvement of estrogen receptor \u03b2 and G-protein-coupled receptor 30 in the neuroprotective action of daidzein","volume":"238","author":"Kajta","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.phymed.2024.155949_bib0087","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.nutres.2008.06.002","article-title":"Isoflavone daidzein possesses no antioxidant activities in cell-free assays but induces the antioxidant enzyme catalase","volume":"28","author":"Kampk\u00f6tter","year":"2008","journal-title":"Nutr. Res."},{"key":"10.1016\/j.phymed.2024.155949_bib0088","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1742-7843.2007.00173.x","article-title":"Increased expression of catalase in human hepatoma cells by the soy isoflavone, daidzein","volume":"102","author":"Kampk\u00f6tter","year":"2008","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.phymed.2024.155949_bib0089","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1289\/ehp.9810685","article-title":"Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: a site-directed mutagenesis study","volume":"106","author":"Kao","year":"1998","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.phymed.2024.155949_bib0090","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0009-8981(93)90058-C","article-title":"Metabolites of dietary (soya) isoflavones in human urine","volume":"223","author":"Kelly","year":"1993","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.phymed.2024.155949_bib0091","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2019.04.007","article-title":"Anti-cancer effects of polyphenols via targeting p53 signaling pathway: updates and future directions","volume":"38","author":"Khan","year":"2020","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.phymed.2024.155949_bib0092","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1007\/s12272-010-1019-2","article-title":"The effects of daidzin and its aglycon, daidzein, on the scopolamineinduced memory impairment in male mice","volume":"33","author":"Kim","year":"2010","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.phymed.2024.155949_bib0093","article-title":"Current perspectives on the beneficial effects of soybean isoflavones and their metabolites for humans","volume":"10","author":"Kim","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.phymed.2024.155949_bib0094","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.lfs.2008.12.005","article-title":"Daidzein administration in vivo reduces myocardial injury in a rat ischemia\/reperfusion model by inhibiting NF-kB activation","volume":"84","author":"Kim","year":"2009","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2024.155949_bib0095","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.advenzreg.2006.01.007","article-title":"Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species","volume":"46","author":"Kobayashi","year":"2006","journal-title":"Adv. Enzyme Regul."},{"key":"10.1016\/j.phymed.2024.155949_bib0096","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1001\/jamaoncol.2021.6987","article-title":"Cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life years for 29 cancer groups from 2010 to 2019: a systematic analysis for the global burden of disease study 2019","volume":"8","author":"Kocarnik","year":"2022","journal-title":"JAMa Oncol."},{"key":"10.1016\/j.phymed.2024.155949_bib0097","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1097\/01.hjh.0000125435.28861.d2","article-title":"Dietary phytoestrogens and vascular function in postmenopausal women: a cross-sectional study","volume":"22","author":"Kreijkamp-Kaspers","year":"2004","journal-title":"J. Hypertens."},{"key":"10.1016\/j.phymed.2024.155949_bib0098","doi-asserted-by":"crossref","first-page":"4252","DOI":"10.1210\/endo.139.10.6216","article-title":"Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor \u03b2","volume":"139","author":"Kuiper","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.phymed.2024.155949_bib0099","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1021\/jf0012695","article-title":"Oxidative metabolism of the soy isoflavones daidzein and genistein in humans in vitro and in vivo","volume":"49","author":"Kulling","year":"2001","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2024.155949_bib0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119664","article-title":"Daidzein mitigates myocardial injury in streptozotocin-induced diabetes in rats","volume":"284","author":"Laddha","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2024.155949_bib0101","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1002\/ptr.7852","article-title":"Pharmacokinetics, pharmacodynamics, toxicity, and formulations of daidzein: an important isoflavone","volume":"37","author":"Laddha","year":"2023","journal-title":"Phytotherapy Res."},{"key":"10.1016\/j.phymed.2024.155949_bib0102","doi-asserted-by":"crossref","first-page":"14246","DOI":"10.1074\/jbc.M110.147348","article-title":"7, 3\u2032, 4\u2032-Trihydroxyisoflavone, a metabolite of the soy isoflavone daidzein, suppresses ultraviolet B-induced skin cancer by targeting Cot and MKK4","volume":"286","author":"Lee","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2024.155949_bib0103","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.pupt.2010.08.003","article-title":"Daidzein regulates secretion, production and gene expression of mucin from airway epithelial cells stimulated by proinflammatory factor and growth factor","volume":"24","author":"Lee","year":"2011","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2024.155949_bib0104","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1161\/CIRCULATIONAHA.107.718585","article-title":"Antioxidant gene therapy for cardiovascular disease: current status and future perspectives","volume":"117","author":"Levonen","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.phymed.2024.155949_bib0105","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/aps.2013.191","article-title":"Daidzein suppresses pro-inflammatory chemokine Cxcl2 transcription in TNF-\u03b1-stimulated murine lung epithelial cells via depressing PARP-1 activity","volume":"35","author":"Li","year":"2014","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2024.155949_bib0106","article-title":"Daidzein ameliorated concanavalin A-induced liver injury through the Akt\/GSK-3\u03b2\/Nrf2 pathway in mice","volume":"9","author":"Li","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.phymed.2024.155949_bib0107","doi-asserted-by":"crossref","first-page":"8618","DOI":"10.1021\/acs.jafc.4c01251","article-title":"Natural amino acid-bearing carbamate prodrugs of daidzein increase water solubility and improve phase ii metabolic stability for enhanced oral bioavailability","volume":"72","author":"Li","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2024.155949_bib0108","doi-asserted-by":"crossref","first-page":"10376","DOI":"10.1021\/jf801907m","article-title":"Daidzein as an antioxidant of lipid: effects of the microenvironment in relation to chemical structure","volume":"56","author":"Liang","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2024.155949_bib0109","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1017\/S0007114500002075","article-title":"Daidzein and genistein contents of vegetables","volume":"84","author":"Liggins","year":"2000","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.phymed.2024.155949_bib0110","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1600-0781.2008.00329.x","article-title":"Topical isoflavones provide effective photoprotection to skin","volume":"24","author":"Lin","year":"2008","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"10.1016\/j.phymed.2024.155949_bib0111","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.domaniend.2005.11.002","article-title":"Estrogenic and antioxidant effects of a phytoestrogen daidzein on ovarian germ cells in embryonic chickens","volume":"31","author":"Liu","year":"2006","journal-title":"Domest. Anim. Endocrinol."},{"key":"10.1016\/j.phymed.2024.155949_bib0112","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1179\/147683009X423274","article-title":"Anti-inflammatory effects of daidzein on primary astroglial cell culture","volume":"12","author":"Liu","year":"2009","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.phymed.2024.155949_bib0113","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.clinbiochem.2014.05.054","article-title":"Effect of whole soy and purified isoflavone daidzein on renal function\u2014A 6-month randomized controlled trial in equol-producing postmenopausal women with prehypertension","volume":"47","author":"Liu","year":"2014","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.phymed.2024.155949_bib0114","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.biopha.2007.08.021","article-title":"Studies on the anti-tumor activities of the soy isoflavone daidzein on murine neuroblastoma cells","volume":"61","author":"Lo","year":"2007","journal-title":"Biomed. Pharmacotherapy"},{"key":"10.1016\/j.phymed.2024.155949_bib0115","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0092-8674(01)00237-9","article-title":"The TNF and TNF receptor superfamilies: integrating mammalian biology","volume":"104","author":"Locksley","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2024.155949_bib0116","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.3382\/ps\/pew483","article-title":"Safety evaluation of daidzein in laying hens: effects on laying performance, hatchability, egg quality, clinical blood parameters, and organ development","volume":"96","author":"Lu","year":"2017","journal-title":"Poult. Sci."},{"key":"10.1016\/j.phymed.2024.155949_bib0117","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1021\/jf00094a021","article-title":"Conjugation of the plant estrogens formononetin and daidzein and their metabolite equol by gastrointestinal epithelium from cattle and sheep","volume":"38","author":"Lundh","year":"1990","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2024.155949_bib0118","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.2174\/187152012803833062","article-title":"Developing phytoestrogens for breast cancer prevention","volume":"12","author":"M Liu","year":"2012","journal-title":"Anti-Cancer Agents Med. Chem."},{"key":"10.1016\/j.phymed.2024.155949_bib0119","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1523\/JNEUROSCI.5266-09.2010","article-title":"A large-scale chemical screen for regulators of the arginase 1 promoter identifies the soy isoflavone daidzeinas a clinically approved small molecule that can promote neuronal protection or regeneration via a cAMP-independent pathway","volume":"30","author":"Ma","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phymed.2024.155949_bib0120","first-page":"559","article-title":"The comparison of different daidzein-PLGA nanoparticles in increasing its oral bioavailability","volume":"7","author":"Ma","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.phymed.2024.155949_bib0121","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.coph.2008.12.012","article-title":"Targeting the redox sensitive Nrf2\u2013Keap1 defense pathway in cardiovascular disease: protection afforded by dietary isoflavones","volume":"9","author":"Mann","year":"2009","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.phymed.2024.155949_bib0122","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s12026-012-8331-5","article-title":"Regulation of the immune response by soybean isoflavones","volume":"54","author":"Masilamani","year":"2012","journal-title":"Immunol. Res."},{"key":"10.1016\/j.phymed.2024.155949_bib0123","article-title":"Management of prostate cancer by targeting 3\u03b2HSD1 after enzalutamide and abiraterone treatment","volume":"3","author":"Mei","year":"2022","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.phymed.2024.155949_bib0124","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/3140680","article-title":"Ameliorative effect of daidzein on cisplatin-induced nephrotoxicity in mice via modulation of inflammation, oxidative stress, and cell death","volume":"2017","author":"Meng","year":"2017","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.phymed.2024.155949_bib0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2023.105705","article-title":"Curcumin and its novel formulations for the treatment of hepatocellular carcinoma: new trends and future perspectives in cancer therapy","volume":"108","author":"Meybodi","year":"2023","journal-title":"J. Funct. Foods."},{"key":"10.1016\/j.phymed.2024.155949_bib0126","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1093\/jn\/133.5.1238","article-title":"Soy isoflavones exert antidiabetic and hypolipidemic effects through the PPAR pathways in obese Zucker rats and murine RAW 264.7 cells","volume":"133","author":"Mezei","year":"2003","journal-title":"J. Nutr."},{"key":"10.1016\/j.phymed.2024.155949_bib0127","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1263\/jbb.102.247","article-title":"Production of equol from daidzein by gram-positive rod-shaped bacterium isolated from rat intestine","volume":"102","author":"Minamida","year":"2006","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.phymed.2024.155949_bib0128","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13045-022-01235-1","article-title":"The long and short non-coding RNAs modulating EZH2 signaling in cancer","volume":"15","author":"Mirzaei","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.phymed.2024.155949_bib0129","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/CEJ.0000000000000645","article-title":"Role of microRNAs in the anticancer effects of the flavonoid luteolin: a systematic review","volume":"30","author":"Mishan","year":"2021","journal-title":"Eur. J. Cancer Prevent."},{"key":"10.1016\/j.phymed.2024.155949_bib0130","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.jaci.2005.02.016","article-title":"Soy, isoflavones, and prevalence of allergic rhinitis in Japanese women: the Osaka Maternal and Child Health Study","volume":"115","author":"Miyake","year":"2005","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.phymed.2024.155949_bib0131","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3390\/cancers12010167","article-title":"Divergent effects of daidzein and its metabolites on estrogen-induced survival of breast cancer cells","volume":"12","author":"Montalesi","year":"2020","journal-title":"Cancers. (Basel)"},{"key":"10.1016\/j.phymed.2024.155949_bib0132","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/biof.1701","article-title":"Anti-neuroinflammatory effect of daidzein in human hypothalamic GnRH neurons in an in vitro membrane-based model","volume":"47","author":"Morelli","year":"2021","journal-title":"Biofactors"},{"key":"10.1016\/j.phymed.2024.155949_bib0133","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.nutres.2019.06.007","article-title":"Daidzein and genistein have differential effects in decreasing whole body bone mineral density but had no effect on hip and spine density in premenopausal women: a 2-year randomized, double-blind, placebo-controlled study","volume":"68","author":"Nayeem","year":"2019","journal-title":"Nutr. Res."},{"key":"10.1016\/j.phymed.2024.155949_bib0134","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.mce.2013.06.015","article-title":"Identification of daidzein as a ligand of retinoic acid receptor that suppresses expression of matrix metalloproteinase-9 in HaCaT cells","volume":"376","author":"Oh","year":"2013","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.phymed.2024.155949_bib0135","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00128-007-9098-6","article-title":"Effect of daidzein in rats on cadmium excretion","volume":"78","author":"Om","year":"2007","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.phymed.2024.155949_bib0136","doi-asserted-by":"crossref","first-page":"1","DOI":"10.55549\/ephels.16","article-title":"Preparation and in vitro evaluation of daidzein-loaded nanoparticulate systems","volume":"1","author":"Ozakar","year":"2022","journal-title":"The Eurasia Proceedings of Health, Environ. Life Sci."},{"key":"10.1016\/j.phymed.2024.155949_bib0137","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ejphar.2013.04.047","article-title":"Daidzein inhibits carbohydrate digestive enzymes in vitro and alleviates postprandial hyperglycemia in diabetic mice","volume":"712","author":"Park","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2024.155949_bib0138","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13045-022-01305-4","article-title":"Emerging role of exosomes in cancer progression and tumor microenvironment remodeling","volume":"15","author":"Paskeh","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.phymed.2024.155949_bib0139","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.jff.2017.06.027","article-title":"Anti-inflammatory and anti-oxidative activities of daidzein and its sulfonic acid ester derivatives","volume":"35","author":"Peng","year":"2017","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.phymed.2024.155949_bib0140","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1093\/jn\/130.7.1675","article-title":"Daidzein is more efficient than genistein in preventing ovariectomy-induced bone loss in rats","volume":"130","author":"Picherit","year":"2000","journal-title":"J. Nutr."},{"key":"10.1016\/j.phymed.2024.155949_bib0141","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.ejphar.2005.12.068","article-title":"Nanomedicine for respiratory diseases","volume":"533","author":"Pison","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2024.155949_bib0142","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/383574","article-title":"Enhancement of antioxidant and isoflavones concentration in gamma irradiated soybean","volume":"2013","author":"Popovi\u0107","year":"2013","journal-title":"Sci. World J."},{"key":"10.1016\/j.phymed.2024.155949_bib0143","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.jnutbio.2007.10.002","article-title":"Glucuronidation of the soyabean isoflavones genistein and daidzein by human liver is related to levels of UGT1A1 and UGT1A9 activity and alters isoflavone response in the MCF-7 human breast cancer cell line","volume":"19","author":"Pritchett","year":"2008","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.phymed.2024.155949_bib0144","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3945\/jn.113.182725","article-title":"Daidzein supplementation decreases serum triglyceride and uric acid concentrations in hypercholesterolemic adults with the effect on triglycerides being greater in those with the GA compared with the GG genotype of ESR-\u03b2 Rsa I","volume":"144","author":"Qin","year":"2014","journal-title":"J. Nutr."},{"key":"10.1016\/j.phymed.2024.155949_bib0145","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.canep.2009.12.018","article-title":"Genistein and daidzein act on a panel of genes implicated in cell cycle and angiogenesis by polymerase chain reaction arrays in human prostate cancer cell lines","volume":"34","author":"Rabiau","year":"2010","journal-title":"Cancer Epidemiol."},{"key":"10.1016\/j.phymed.2024.155949_bib0146","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3390\/metabo5010056","article-title":"The role of colonic bacteria in the metabolism of the natural isoflavone daidzin to equol","volume":"5","author":"Rafii","year":"2015","journal-title":"Metabolites"},{"key":"10.1016\/j.phymed.2024.155949_bib0147","doi-asserted-by":"crossref","first-page":"4981","DOI":"10.3390\/ijms20204981","article-title":"Role of phytochemicals in cancer prevention","volume":"20","author":"Ranjan","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2024.155949_bib0148","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1080\/1120009X.2021.1924935","article-title":"Novel daidzein molecules exhibited anti-prostate cancer activity through nuclear receptor ER\u03b2 modulation, in vitro and in vivo studies","volume":"33","author":"Ranjithkumar","year":"2021","journal-title":"J. Chemotherapy"},{"key":"10.1016\/j.phymed.2024.155949_bib0149","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1359\/jbmr.2002.17.4.630","article-title":"Down-regulation of osteoclast differentiation by daidzein via caspase 3","volume":"17","author":"Rassi","year":"2002","journal-title":"J. Bone Mineral Res."},{"key":"10.1016\/j.phymed.2024.155949_bib0150","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0891-5849(02)00877-8","article-title":"The metabolic fate of dietary polyphenols in humans","volume":"33","author":"Rechner","year":"2002","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.phymed.2024.155949_bib0151","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S1360-1385(97)01018-2","article-title":"Antioxidant properties of phenolic compounds","volume":"2","author":"Rice-Evans","year":"1997","journal-title":"Trends Plant Sci."},{"key":"10.1016\/j.phymed.2024.155949_bib0152","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11120-006-9065-9","article-title":"Consistent sets of spectrophotometric chlorophyll equations for acetone, methanol and ethanol solvents","volume":"89","author":"Ritchie","year":"2006","journal-title":"Photosyn. Res."},{"key":"10.1016\/j.phymed.2024.155949_bib0153","doi-asserted-by":"crossref","first-page":"e64750","DOI":"10.1371\/journal.pone.0064750","article-title":"Pharmacological administration of the isoflavone daidzein enhances cell proliferation and reduces high fat diet-induced apoptosis and gliosis in the rat hippocampus","volume":"8","author":"Rivera","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2024.155949_bib0154","doi-asserted-by":"crossref","first-page":"4521","DOI":"10.7150\/jca.34374","article-title":"The power of phytochemicals combination in cancer chemoprevention","volume":"11","author":"Rizeq","year":"2020","journal-title":"J. Cancer"},{"key":"10.1016\/j.phymed.2024.155949_bib0155","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/ptr.4699","article-title":"Chronic administration of daidzein, a soybean isoflavone, improves endothelial dysfunction and attenuates oxidative stress in streptozotocin-induced diabetic rats","volume":"27","author":"Roghani","year":"2013","journal-title":"Phytotherapy Res."},{"key":"10.1016\/j.phymed.2024.155949_bib0156","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1093\/jn\/132.3.370","article-title":"The phytoestrogen daidzein affects the antioxidant enzyme system of rat hepatoma H4IIE cells","volume":"132","author":"R\u00f6hrdanz","year":"2002","journal-title":"J. Nutr."},{"key":"10.1016\/j.phymed.2024.155949_bib0157","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1042\/bst0270304","article-title":"Metabolism of oestrogens and phytoestrogens: role of the gut microflora","volume":"27","author":"Rowland","year":"1999","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.phymed.2024.155949_bib0158","doi-asserted-by":"crossref","first-page":"e1145","DOI":"10.1002\/hsr2.1145","article-title":"Curcumin effects on chronic obstructive pulmonary disease: a systematic review","volume":"6","author":"Safari","year":"2023","journal-title":"Health Sci. Rep."},{"key":"10.1016\/j.phymed.2024.155949_bib0159","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1002\/mnfr.201300482","article-title":"Daidzein regulates proinflammatory adipokines thereby improving obesity-related inflammation through PPAR\u03b3","volume":"58","author":"Sakamoto","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.phymed.2024.155949_bib0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173763","article-title":"Promising targets of chrysin and daidzein in colorectal cancer: amphiregulin, CXCL1, and MMP-9","volume":"892","author":"Salama","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2024.155949_bib0161","doi-asserted-by":"crossref","first-page":"7391","DOI":"10.1007\/s00289-021-03853-0","article-title":"Evaluation of daidzein-loaded chitosan microcapsules for the colon cancer drug delivery: synthesis, characterization and release behaviour","volume":"79","author":"Sanatkar","year":"2022","journal-title":"Polymer Bull"},{"key":"10.1016\/j.phymed.2024.155949_bib0162","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.cbpc.2018.05.012","article-title":"Toxicity and non-harmful effects of the soya isoflavones, genistein and daidzein, in embryos of the zebrafish, Danio rerio","volume":"211","author":"Sarasquete","year":"2018","journal-title":"Comparat. Biochem. Physiol. Part C Toxicol. Pharmacol."},{"key":"10.1016\/j.phymed.2024.155949_bib0163","doi-asserted-by":"crossref","unstructured":"Sardar, H., 2023. Drug like potential of Daidzein using SwissADME prediction: In silico Approaches. PHYTONutrients, 01\u201307.","DOI":"10.62368\/pn.vi.18"},{"key":"10.1016\/j.phymed.2024.155949_bib0164","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1016\/S0959-8049(97)00303-1","article-title":"Differential effects of dietary phyto-oestrogens daidzein and equol on human breast cancer MCF-7 cells","volume":"33","author":"Sathyamoorthy","year":"1997","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.phymed.2024.155949_bib0165","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.numecd.2018.03.007","article-title":"Soy isoflavones improve cardiovascular disease risk markers in women during the early menopause","volume":"28","author":"Sathyapalan","year":"2018","journal-title":"Nutr. Metab. Cardiovasc. Diseases"},{"key":"10.1016\/j.phymed.2024.155949_bib0166","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1600-0625.2004.00259.x","article-title":"Skin aging and sex hormones in women\u2013clinical perspectives for intervention by hormone replacement therapy","volume":"13","author":"Sator","year":"2004","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.phymed.2024.155949_bib0167","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/dju189","article-title":"The effects of soy supplementation on gene expression in breast cancer: a randomized placebo-controlled study","volume":"106","author":"Shike","year":"2014","journal-title":"JNCI: J. Natl. Cancer Inst."},{"key":"10.1016\/j.phymed.2024.155949_bib0168","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1007\/s11095-010-0107-9","article-title":"Daidzein effect on hormone refractory prostate cancer in vitro and in vivo compared to genistein and soy extract: potentiation of radiotherapy","volume":"27","author":"Singh-Gupta","year":"2010","journal-title":"Pharm. Res."},{"key":"10.1016\/j.phymed.2024.155949_bib0169","doi-asserted-by":"crossref","first-page":"100460","DOI":"10.1016\/j.prmcm.2024.100460","article-title":"Daidzein in traditional chinese medicine: a deep dive into its ethnomedicinal and therapeutic applications","volume":"12","author":"Singla","year":"2024","journal-title":"Pharmacol. Res.-Mod. Chin. Med."},{"key":"10.1016\/j.phymed.2024.155949_bib0170","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.freeradbiomed.2007.01.004","article-title":"Cardiovascular targets for estrogens and phytoestrogens: transcriptional regulation of nitric oxide synthase and antioxidant defense genes","volume":"42","author":"Siow","year":"2007","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.phymed.2024.155949_bib0171","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.freeradbiomed.2007.01.004","article-title":"Cardiovascular targets for estrogens and phytoestrogens: transcriptional regulation of nitric oxide synthase and antioxidant defense genes","volume":"42","author":"Siow","year":"2007","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.phymed.2024.155949_bib0172","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3390\/ph14040373","article-title":"The influence of plant isoflavones daidzein and equol on female reproductive processes","volume":"14","author":"Sirotkin","year":"2021","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.phymed.2024.155949_bib0173","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1089\/thy.2011.0458","article-title":"Growth inhibition of human thyroid carcinoma and goiter cells in vitro by the isoflavone derivative 7-(O)-carboxymethyl daidzein conjugated to Nt-boc-hexylenediamine","volume":"22","author":"Somjen","year":"2012","journal-title":"Thyroid"},{"key":"10.1016\/j.phymed.2024.155949_bib0174","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.1016\/j.fct.2012.05.037","article-title":"The presence of monoiodinated derivates of daidzein and genistein in human urine and its effect on thyroid gland function","volume":"50","author":"Sosvorov\u00e1","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.phymed.2024.155949_bib0175","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1007\/s00204-016-1663-5","article-title":"Phase II metabolism of the soy isoflavones genistein and daidzein in humans, rats and mice: a cross-species and sex comparison","volume":"90","author":"Soukup","year":"2016","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.phymed.2024.155949_bib0176","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.biochi.2014.04.005","article-title":"Daidzein exhibits anti-fibrotic effect by reducing the expressions of Proteinase activated receptor 2 and TGF\u03b21\/smad mediated inflammation and apoptosis in Bleomycin-induced experimental pulmonary fibrosis","volume":"103","author":"Soumyakrishnan","year":"2014","journal-title":"Biochimie"},{"key":"10.1016\/j.phymed.2024.155949_bib0177","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.phymed.2012.12.021","article-title":"Isoformononetin, a methoxydaidzein present in medicinal plants, reverses bone loss in osteopenic rats and exerts bone anabolic action by preventing osteoblast apoptosis","volume":"20","author":"Srivastava","year":"2013","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2024.155949_bib0178","doi-asserted-by":"crossref","first-page":"356","DOI":"10.3945\/ajcn.110.008359","article-title":"Clinical outcomes of a 2-y soy isoflavone supplementation in menopausal women","volume":"93","author":"Steinberg","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.phymed.2024.155949_bib0179","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.bbr.2013.08.027","article-title":"Subcutaneous daidzein administration enhances recovery of skilled ladder rung walking performance following stroke in rats","volume":"256","author":"Stout","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.phymed.2024.155949_bib0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/scrt493","article-title":"Novel daidzein analogs enhance osteogenic activity of bone marrow-derived mesenchymal stem cells and adipose-derived stromal\/stem cells through estrogen receptor dependent and independent mechanisms","volume":"5","author":"Strong","year":"2014","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.phymed.2024.155949_bib0181","doi-asserted-by":"crossref","first-page":"758","DOI":"10.3390\/biom9120758","article-title":"Bioactive compounds: natural defense against cancer?","volume":"9","author":"Subramaniam","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.phymed.2024.155949_bib0182","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0006-2952(99)00351-2","article-title":"Stimulatory effect of daidzein in osteoblastic MC3T3-E1 cells","volume":"59","author":"Sugimoto","year":"2000","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phymed.2024.155949_bib0183","doi-asserted-by":"crossref","first-page":"117","DOI":"10.21010\/ajtcam.v13i3.15","article-title":"Daidzein: a review of pharmacological effects","volume":"13","author":"Sun","year":"2016","journal-title":"Afr. J. Tradit. Complement. Altern. Med."},{"key":"10.1016\/j.phymed.2024.155949_bib0184","first-page":"533","article-title":"Soy isoflavones augment the effect of TRAIL-mediated apoptotic death in prostate cancer cells","volume":"26","author":"Szliszka","year":"2011","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.phymed.2024.155949_bib0185","doi-asserted-by":"crossref","unstructured":"Tabari, M.A.K., Mirjalili, R., Khoshhal, H., Shokouh, E., Khandan, M., Hasheminasabgorji, E., Hafezi-Moghadam, A., Bagheri, A., 2022. Nature against diabetic retinopathy: a review on antiangiogenic, antioxidant, and anti-Inflammatory phytochemicals. Evidence-based Complementary and Alternative Medicine: eCAM 2022.","DOI":"10.1155\/2022\/4708527"},{"key":"10.1016\/j.phymed.2024.155949_bib0186","doi-asserted-by":"crossref","first-page":"921","DOI":"10.3945\/jn.114.190454","article-title":"Dietary soy intake is not associated with risk of cardiovascular disease mortality in singapore chinese adults","volume":"144","author":"Talaei","year":"2014","journal-title":"J. Nutr."},{"key":"10.1016\/j.phymed.2024.155949_bib0187","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/ptr.5751","article-title":"A systematic review on ethnomedicines of anti-cancer plants","volume":"31","author":"Tariq","year":"2017","journal-title":"Phytotherapy Res."},{"key":"10.1016\/j.phymed.2024.155949_bib0188","doi-asserted-by":"crossref","first-page":"4783","DOI":"10.1021\/jf025549r","article-title":"Metabolism of biochanin A and formononetin by human liver microsomes in vitro","volume":"50","author":"Tolleson","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2024.155949_bib0189","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1080\/01635580701328545","article-title":"The effect of the phytoestrogens genistein, daidzein, and equol on the growth of tamoxifen-resistant T47D\/PKC\u03b1","volume":"58","author":"Tonetti","year":"2007","journal-title":"HNUC"},{"key":"10.1016\/j.phymed.2024.155949_bib0190","doi-asserted-by":"crossref","first-page":"360","DOI":"10.3109\/09637486.2013.858238","article-title":"Effects of daidzein and kiwifruit on bone mineral density and equol production in ovariectomised rats","volume":"65","author":"Tousen","year":"2014","journal-title":"Int. J. Food Sci. Nutr."},{"key":"10.1016\/j.phymed.2024.155949_bib0191","first-page":"145","article-title":"The effect of isoflavones on bone mass and bone remodelling markers in postmenopausal women","volume":"38","author":"Turhan","year":"2008","journal-title":"Turk. J. Med. Sci."},{"key":"10.1016\/j.phymed.2024.155949_bib0192","doi-asserted-by":"crossref","first-page":"32271","DOI":"10.1021\/acsomega.3c03741","article-title":"Daidzein from dietary supplement to a drug candidate: an evaluation of potential","volume":"8","author":"Ubaid","year":"2023","journal-title":"ACS Omega"},{"key":"10.1016\/j.phymed.2024.155949_bib0193","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.phymed.2014.03.001","article-title":"Anti-nociceptive, anti-inflammatory and sedative activities of the extracts and chemical constituents of Diospyros lotus L","volume":"21","author":"Uddin","year":"2014","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2024.155949_bib0194","doi-asserted-by":"crossref","first-page":"84","DOI":"10.4274\/tjps.galenos.2021.81905","article-title":"The nanosuspension formulations of daidzein: preparation and in vitro characterization","volume":"19","author":"U\u011fur Kaplan","year":"2022","journal-title":"Turk. J. Pharm. Sci."},{"key":"10.1016\/j.phymed.2024.155949_bib0195","doi-asserted-by":"crossref","first-page":"4394","DOI":"10.1021\/jf034021z","article-title":"Thermal stability of genistein and daidzein and its effect on their antioxidant activity","volume":"51","author":"Ungar","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2024.155949_bib0196","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.3390\/molecules27123863","article-title":"Exploring the phytochemicals and anti-cancer potential of the members of Fabaceae family: a comprehensive review","volume":"27","author":"Usman","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2024.155949_bib0197","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1365-2265.2012.04400.x","article-title":"Effects of naturalS-equol supplements on overweight or obesity and metabolic syndrome in the Japanese, based on sex and equol status","volume":"78","author":"Usui","year":"2013","journal-title":"Clin. Endocrinol. (Oxf)"},{"key":"10.1016\/j.phymed.2024.155949_bib0198","first-page":"1389","article-title":"Soy isoflavones suppress invasiveness of breast cancer cells by the inhibition of NF-\u03baB\/AP-1-dependent and-independent pathways","volume":"25","author":"Valachovicova","year":"2004","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.phymed.2024.155949_bib0199","doi-asserted-by":"crossref","first-page":"E119","DOI":"10.1111\/bju.12435","article-title":"Soy and soy isoflavones in prostate cancer: a systematic review and meta-analysis of randomized controlled trials","volume":"113","author":"van Die","year":"2014","journal-title":"BJu Int."},{"key":"10.1016\/j.phymed.2024.155949_bib0200","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.yexmp.2004.08.003","article-title":"Retinoid-induced epidermal hyperplasia in human skin organ culture: inhibition with soy extract and soy isoflavones","volume":"77","author":"Varani","year":"2004","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.phymed.2024.155949_bib0201","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s13318-012-0112-y","article-title":"Isoflavones: estrogenic activity, biological effect and bioavailability","volume":"38","author":"Vitale","year":"2013","journal-title":"Eur. J. Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.phymed.2024.155949_bib0202","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.bbrc.2007.11.147","article-title":"Signaling mechanisms of daidzein-induced axonal outgrowth in hippocampal neurons","volume":"366","author":"Wang","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phymed.2024.155949_bib0203","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.3390\/molecules29081710","article-title":"A novel cocrystal of daidzein with piperazine to optimize the solubility, permeability and bioavailability of daidzein","volume":"29","author":"Wang","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2024.155949_bib0204","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1001\/archinte.167.10.1060","article-title":"Effect of soy nuts on blood pressure and lipid levels in hypertensive, prehypertensive, and normotensive postmenopausal women","volume":"167","author":"Welty","year":"2007","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.phymed.2024.155949_bib0205","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1517\/13543784.9.8.1829","article-title":"The therapeutic potential of phytoestrogens","volume":"9","author":"Wiseman","year":"2000","journal-title":"Expert. Opin. Investig. Drugs"},{"key":"10.1016\/j.phymed.2024.155949_bib0206","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1093\/ajcn\/72.2.395","article-title":"Isoflavone phytoestrogens consumed in soy decrease F2-isoprostane concentrations and increase resistance of low-density lipoprotein to oxidation in humans","volume":"72","author":"Wiseman","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.phymed.2024.155949_bib0207","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1248\/bpb.17.1369","article-title":"Urinary and biliary metabolites of daidzin and daidzein in rats","volume":"17","author":"Yasuda","year":"1994","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.phymed.2024.155949_bib0208","doi-asserted-by":"crossref","first-page":"7997","DOI":"10.1039\/D1FO00712B","article-title":"Effects of daidzein and genistein on markers of cardiovascular disease risk among women with impaired glucose regulation: a double-blind, randomized, placebo-controlled trial","volume":"12","author":"Ye","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2024.155949_bib0209","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/FBP.0b013e32833aec1a","article-title":"Maternal exposure to daidzein alters behaviour and oestrogen receptor \u03b1 expression in adult female offspring","volume":"21","author":"Yu","year":"2010","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.phymed.2024.155949_bib0210","first-page":"1","article-title":"The protective role of daidzein in intestinal health of turbot (Scophthalmus maximus L.) fed soybean meal-based diets","volume":"11","author":"Yu","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2024.155949_bib0211","doi-asserted-by":"crossref","DOI":"10.1016\/j.ultsonch.2021.105772","article-title":"Preparation of daidzein microparticles through liquid antisolvent precipitation under ultrasonication","volume":"79","author":"Yu","year":"2021","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.phymed.2024.155949_bib0212","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1093\/jn\/133.2.389","article-title":"Genistein and daidzein downregulate prostate androgen-regulated transcript-1 (PART-1) gene expression induced by dihydrotestosterone in human prostate LNCaP cancer cells","volume":"133","author":"Yu","year":"2003","journal-title":"J. Nutr."},{"key":"10.1016\/j.phymed.2024.155949_bib0213","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173399","article-title":"Daidzein ameliorates LPS-induced hepatocyte injury by inhibiting inflammation and oxidative stress","volume":"885","author":"Yu","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2024.155949_bib0214","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.pbb.2010.03.015","article-title":"Effect of daidzein on anxiety, social behavior and spatial learning in male Balb\/cJ mice","volume":"96","author":"Zeng","year":"2010","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.phymed.2024.155949_bib0215","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1080\/09637486.2016.1216525","article-title":"Phytoestrogens and risk of prostate cancer: an updated meta-analysis of epidemiologic studies","volume":"68","author":"Zhang","year":"2017","journal-title":"Int. J. Food Sci. Nutr."},{"key":"10.1016\/j.phymed.2024.155949_bib0216","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1177\/0963689717725755","article-title":"Fighting against skin aging: the way from bench to bedside","volume":"27","author":"Zhang","year":"2018","journal-title":"Cell TransPlant"},{"key":"10.1016\/j.phymed.2024.155949_bib0217","doi-asserted-by":"crossref","unstructured":"Zhang WenZhong, Z.W., Cui WenMing, C.W., Zhang Xin, Z.X., Wang Wei, W.W., Jia XuDong, J.X., Zhang XiaoPeng, Z.X., Li Ning, L.N., 2009. Subchronic toxicity study on soy isoflavones in rats.","DOI":"10.1016\/S0895-3988(09)60054-4"},{"key":"10.1016\/j.phymed.2024.155949_bib0218","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1093\/ije\/dys130","article-title":"Urinary isoflavonoids and risk of coronary heart disease","volume":"41","author":"Zhang","year":"2012","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.phymed.2024.155949_bib0219","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1039\/c0nr00879f","article-title":"Daidzein-phospholipid complex loaded lipid nanocarriers improved oral absorption: in vitro characteristics and in vivo behavior in rats","volume":"3","author":"Zhang","year":"2011","journal-title":"Nanoscale"},{"key":"10.1016\/j.phymed.2024.155949_bib0220","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1111\/ajd.12126","article-title":"Daidzein stimulates collagen synthesis by activating the TGF-\u03b2\/smad signal pathway","volume":"56","author":"Zhao","year":"2015","journal-title":"Australas. J. Dermatol."},{"key":"10.1016\/j.phymed.2024.155949_bib0221","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1021\/mp400086n","article-title":"TPGS emulsified zein nanoparticles enhanced oral bioavailability of daidzin: in vitro characteristics and in vivo performance","volume":"10","author":"Zou","year":"2013","journal-title":"Mol. Pharm."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132400607X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132400607X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T16:15:21Z","timestamp":1730909721000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S094471132400607X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":220,"alternative-id":["S094471132400607X"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155949","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unlocking daidzein's healing power: Present applications and future possibilities in phytomedicine","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155949","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"155949"}}