{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:45:14Z","timestamp":1787755514324,"version":"build-2784847793"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.phymed.2024.155960","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T21:08:11Z","timestamp":1724447291000},"page":"155960","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Efficacy and safety of Kegan Liyan oral liquid for patients with acute pharyngitis: A randomized, double-blinded, placebo-controlled, multi-center trial"],"prefix":"10.1016","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0542-9730","authenticated-orcid":false,"given":"Luoqi","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7055-1914","authenticated-orcid":false,"given":"Jingmin","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4049-6779","authenticated-orcid":false,"given":"Feiting","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8840-9813","authenticated-orcid":false,"given":"Gang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengde","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Gou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuwu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baihua","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangbo","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junping","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minling","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9699-055X","authenticated-orcid":false,"given":"Wenhan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaifeng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1169-5904","authenticated-orcid":false,"given":"Yuanbin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongchun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9147-5516","authenticated-orcid":false,"given":"Lin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2024.155960_bib0001","article-title":"Corticosteroids as standalone or add-on treatment for sore throat","volume":"5","author":"de Cassan","year":"2020","journal-title":"Cochr. Datab. Syst. Rev."},{"key":"10.1016\/j.phymed.2024.155960_bib0002","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1142\/S0192415X09007570","article-title":"Regulation of influenza virus-caused oxidative stress by Kegan Liyan oral prescription, as monitored by ascorbyl radical ESR signals","volume":"37","author":"Duan","year":"2009","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.phymed.2024.155960_bib0004","first-page":"563","article-title":"Scutellaria baicalensis: a promising natural source of antiviral compounds for the treatment of viral diseases","volume":"21","author":"Huang","year":"2023","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.phymed.2024.155960_bib0005","article-title":"Chinese medicinal herbs for sore throat","author":"Huang","year":"2012","journal-title":"Cochr. Datab. Syst. Rev. CD004877."},{"key":"10.1016\/j.phymed.2024.155960_bib0006","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/S0140-6736(74)90884-8","article-title":"Measurement of pain","volume":"2","author":"Huskisson","year":"1974","journal-title":"Lancet Lond. Engl."},{"key":"10.1016\/j.phymed.2024.155960_bib0007","first-page":"188","article-title":"Clinical practice guideline: sore throat","volume":"118","author":"Kr\u00fcger","year":"2021","journal-title":"Dtsch. Arzteblatt Int."},{"key":"10.1016\/j.phymed.2024.155960_bib0008","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/9458676","article-title":"Systematic review of herbal tea (a traditional Chinese treatment method) in the therapy of chronic simple pharyngitis and preliminary exploration about its medication rules","volume":"2019","author":"Li","year":"2019","journal-title":"Evid.-Based Complement. Altern. Med. ECAM"},{"key":"10.1016\/j.phymed.2024.155960_bib0009","first-page":"29","author":"Li","year":"2017"},{"key":"10.1016\/j.phymed.2024.155960_bib0010","first-page":"10","article-title":"Clinical analysis of 180 cases of acute upper respiratory tract infection treated by Kegan Liyan oral liquid","volume":"16","author":"Lin","year":"2019","journal-title":"J. North Pharm."},{"key":"10.1016\/j.phymed.2024.155960_bib0011","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1046\/j.1525-1497.2003.21101.x","article-title":"Desire for antibiotics and antibiotic prescribing for adults with upper respiratory tract infections","volume":"18","author":"Linder","year":"2003","journal-title":"J. Gen. Intern. Med."},{"key":"10.1016\/j.phymed.2024.155960_bib0012","article-title":"Inhibitory activity of honeysuckle extracts against influenza A virus in vitro and in vivo","volume":"36","author":"Li","year":"2021","journal-title":"Virol. Sin."},{"key":"10.1016\/j.phymed.2024.155960_bib0013","unstructured":"Overview | Sore throat (acute): antimicrobial prescribing | Guidance | NICE [WWW Document], 2018. URLhttps:\/\/www.nice.org.uk\/guidance\/ng84 (accessed 12.25.23)."},{"key":"10.1016\/j.phymed.2024.155960_bib0014","doi-asserted-by":"crossref","first-page":"e13272","DOI":"10.1111\/ijcp.13272","article-title":"Efficacy and safety of a triple active sore throat lozenge in the treatment of patients with acute pharyngitis: Results of a multi-centre, randomised, placebo-controlled, double-blind, parallel-group trial (DoriPha)","volume":"72","author":"Palm","year":"2018","journal-title":"Int. J. Clin. Pract."},{"issue":"18 Suppl","key":"10.1016\/j.phymed.2024.155960_bib0003","first-page":"1","article-title":"Guideline for the management of acute sore throat","volume":"1","author":"Pelucchi","year":"2012","journal-title":"Clin. Microbiol. Infect. Off. Publ. Eur. Soc. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.phymed.2024.155960_bib0015","doi-asserted-by":"crossref","first-page":"e86","DOI":"10.1093\/cid\/cis629","article-title":"Clinical practice guideline for the diagnosis and management of group A streptococcal pharyngitis: 2012 update by the Infectious Diseases Society of America","volume":"55","author":"Shulman","year":"2012","journal-title":"Clin. Infect. Dis. Off. Publ. Infect. Dis. Soc. Am."},{"key":"10.1016\/j.phymed.2024.155960_bib0016","doi-asserted-by":"crossref","first-page":"ii36","DOI":"10.1093\/jac\/dkx500","article-title":"Potential for reducing inappropriate antibiotic prescribing in English primary care","volume":"73","author":"Smieszek","year":"2018","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.phymed.2024.155960_bib0017","article-title":"Antibiotics for treatment of sore throat in children and adults","volume":"12","author":"Spinks","year":"2021","journal-title":"Cochr. Datab. Syst. Rev."},{"key":"10.1016\/j.phymed.2024.155960_bib0018","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/joim.13505","article-title":"Lessons from 20 years with COX-2 inhibitors: Importance of dose-response considerations and fair play in comparative trials","volume":"292","author":"Stiller","year":"2022","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.phymed.2024.155960_bib0019","first-page":"38","article-title":"A multicenter randomized controlled trial on the treatment of acute pharyngitis caused by wind heat invading the lung with Ganjubingmei tablets","volume":"58","author":"Sun","year":"2017","journal-title":"J. Tradit. Chin. Med."},{"key":"10.1016\/j.phymed.2024.155960_bib0020","first-page":"251","article-title":"Pharyngitis: Approach to diagnosis and treatment","volume":"66","author":"Sykes","year":"2020","journal-title":"Can. Fam. Physician Med. Fam. Can."},{"key":"10.1016\/j.phymed.2024.155960_bib0021","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3399\/bjgp22X718793","article-title":"Use of antibiotics for acute sore throat and tonsillitis in primary care","volume":"72","author":"Wilcox","year":"2022","journal-title":"Br. J. Gen. Pract. J. R. Coll. Gen. Pract."},{"key":"10.1016\/j.phymed.2024.155960_bib0022","first-page":"54","article-title":"Observation on the therapeutic effect of KeGan LiYan oral liquid in the treatment of 120 cases of acute upper respiratory tract infection","volume":"47","author":"Wu","year":"2015","journal-title":"New Chin. Med."},{"key":"10.1016\/j.phymed.2024.155960_bib0023","first-page":"62","article-title":"A randomized, double-blind, placebo-controlled multicenter clinical study of compound Yuxingcao mixture in treatment of throat swelling and pain caused by exogenous wind heat syndrome","volume":"49","author":"Zhang","year":"2022","journal-title":"LiaoNing J. Tradit. Chin. Med."},{"key":"10.1016\/j.phymed.2024.155960_bib0024","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jep.2016.03.057","article-title":"Kegan Liyan oral liquid ameliorates lipopolysaccharide-induced acute lung injury through inhibition of TLR4-mediated NF-\u03baB signaling pathway and MMP-9 expression","volume":"186","author":"Zhang","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2024.155960_bib0025","first-page":"178","article-title":"Outline analysis of TCM master ZHOU Zhong-ying's differentiation and treatment of five major syndromes of exogenous febrile disease","volume":"36","author":"Zheng","year":"2021","journal-title":"China J. Tradit. Chin. Med. Pharm."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324006184?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324006184?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T21:14:52Z","timestamp":1730927692000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711324006184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":25,"alternative-id":["S0944711324006184"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155960","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and safety of Kegan Liyan oral liquid for patients with acute pharyngitis: A randomized, double-blinded, placebo-controlled, multi-center trial","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155960","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"155960"}}