{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:04:29Z","timestamp":1787061869469,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["LZ23H010001"],"award-info":[{"award-number":["LZ23H010001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170061"],"award-info":[{"award-number":["82170061"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170062"],"award-info":[{"award-number":["82170062"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.phymed.2024.155976","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T22:47:18Z","timestamp":1724366838000},"page":"155976","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Parthenolide attenuates hypoxia-induced pulmonary hypertension through inhibiting STAT3 signaling"],"prefix":"10.1016","volume":"134","author":[{"given":"Yizhu","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanlan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7172-3342","authenticated-orcid":false,"given":"Zhili","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijian","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7929-8078","authenticated-orcid":false,"given":"Yanting","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8434-4264","authenticated-orcid":false,"given":"Zhanghang","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiale","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rujie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boxiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4592-8841","authenticated-orcid":false,"given":"Lehe","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangxing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.phymed.2024.155976_bib0001","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1164\/rccm.202009-3698OC","article-title":"Association between Initial Treatment Strategy and Long-Term Survival in Pulmonary Arterial Hypertension","volume":"204","author":"Boucly","year":"2021","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"6","key":"10.1016\/j.phymed.2024.155976_bib0002","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1002\/jcp.22494","article-title":"Parthenolide sensitizes hepatocellular carcinoma cells to TRAIL by inducing the expression of death receptors through inhibition of STAT3 activation","volume":"226","author":"Carlisi","year":"2011","journal-title":"J. Cell Physiol."},{"issue":"3","key":"10.1016\/j.phymed.2024.155976_bib0003","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1183\/09031936.00084211","article-title":"Plumbagin reverses proliferation and resistance to apoptosis in experimental PAH","volume":"40","author":"Courboulin","year":"2012","journal-title":"Eur. Respir. J."},{"issue":"10","key":"10.1016\/j.phymed.2024.155976_bib0004","doi-asserted-by":"crossref","first-page":"5680","DOI":"10.1002\/ptr.7214","article-title":"Parthenolide, bioactive compound of Chrysanthemum parthenium L., ameliorates fibrogenesis and inflammation in hepatic fibrosis via regulating the crosstalk of TLR4 and STAT3 signaling pathway","volume":"35","author":"Cui","year":"2021","journal-title":"PhytOther Res."},{"issue":"1","key":"10.1016\/j.phymed.2024.155976_bib0005","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.chest.2016.09.001","article-title":"Hypoxic Pulmonary Vasoconstriction: From Molecular Mechanisms to Medicine","volume":"151","author":"Dunham-Snary","year":"2017","journal-title":"Chest"},{"issue":"3","key":"10.1016\/j.phymed.2024.155976_bib0006","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/cvr\/cvv103","article-title":"Emerging translational approaches to target STAT3 signalling and its impact on vascular disease","volume":"106","author":"Dutzmann","year":"2015","journal-title":"Cardiovasc. Res."},{"issue":"4","key":"10.1016\/j.phymed.2024.155976_bib0007","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1039\/C9NP00049F","article-title":"Advances in chemistry and bioactivity of parthenolide","volume":"37","author":"Freund","year":"2020","journal-title":"Nat. Prod. Rep."},{"issue":"3","key":"10.1016\/j.phymed.2024.155976_bib0008","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.healun.2022.10.007","article-title":"Smoking history and pulmonary arterial hypertension: Demographics, onset, and outcomes","volume":"42","author":"Frost","year":"2023","journal-title":"J. Heart Lung TransPlant"},{"issue":"1","key":"10.1016\/j.phymed.2024.155976_bib0009","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/s41420-020-00333-8","article-title":"Parthenolide promotes the repair of spinal cord injury by modulating M1\/M2 polarization via the NF-kappaB and STAT 1\/3 signaling pathway","volume":"6","author":"Gaojian","year":"2020","journal-title":"Cell Death. Discov."},{"issue":"39","key":"10.1016\/j.phymed.2024.155976_bib0010","doi-asserted-by":"crossref","first-page":"13311","DOI":"10.1021\/acs.analchem.1c03011","article-title":"Pyroglutamate Aminopeptidase I Promotes Hepatocellular Carcinoma via IL-6\/STAT3 Activation as Revealed by a Specific Biosensor","volume":"93","author":"Guo","year":"2021","journal-title":"Anal. Chem."},{"issue":"25","key":"10.1016\/j.phymed.2024.155976_bib0011","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1056\/NEJMra2000348","article-title":"Pulmonary Arterial Hypertension","volume":"385","author":"Hassoun","year":"2021","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.phymed.2024.155976_bib0012","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1165\/rcmb.2022-0349OC","article-title":"RNA Binding Protein Quaking Promotes Hypoxia-induced Smooth Muscle Reprogramming in Pulmonary Hypertension","volume":"69","author":"Huang","year":"2023","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"2","key":"10.1016\/j.phymed.2024.155976_bib0013","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jphs.2022.12.007","article-title":"Corosolic acid ameliorates vascular remodeling in pulmonary arterial hypertension via the downregulation of STAT3 signaling","volume":"151","author":"Kawade","year":"2023","journal-title":"J. Pharmacol. Sci."},{"issue":"6","key":"10.1016\/j.phymed.2024.155976_bib0014","first-page":"23","article-title":"Parthenolide Inhibits STAT3 Signaling by Covalently Targeting Janus Kinases","author":"Liu","year":"2018","journal-title":"Molecules."},{"issue":"12","key":"10.1016\/j.phymed.2024.155976_bib0015","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1164\/rccm.202012-4317SO","article-title":"Pulmonary Arterial Hypertension: Diagnosis, Treatment, and Novel Advances","volume":"203","author":"Maron","year":"2021","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"2","key":"10.1016\/j.phymed.2024.155976_bib0016","first-page":"233","article-title":"Antiproliferative activity of parthenolide against three human cancer cell lines and human umbilical vein endothelial cells","volume":"59","author":"Parada-Turska","year":"2007","journal-title":"Pharmacol. Rep."},{"issue":"11","key":"10.1016\/j.phymed.2024.155976_bib0017","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1161\/CIRCULATIONAHA.110.963314","article-title":"Signal transducers and activators of transcription-3\/pim1 axis plays a critical role in the pathogenesis of human pulmonary arterial hypertension","volume":"123","author":"Paulin","year":"2011","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.phymed.2024.155976_bib0018","first-page":"223","article-title":"STAT3 signaling in pulmonary arterial hypertension","volume":"1","author":"Paulin","year":"2012","journal-title":"JAKSTAT."},{"issue":"14","key":"10.1016\/j.phymed.2024.155976_bib0019","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1001\/jama.2022.4402","article-title":"Diagnosis and Treatment of Pulmonary Arterial Hypertension: A Review","volume":"327","author":"Ruopp","year":"2022","journal-title":"JAMa"},{"issue":"4","key":"10.1016\/j.phymed.2024.155976_bib0020","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.yjmcc.2011.01.001","article-title":"Parthenolide inhibits STAT3 signaling and attenuates angiotensin II-induced left ventricular hypertrophy via modulation of fibroblast activity","volume":"50","author":"Skoumal","year":"2011","journal-title":"J. Mol. Cell Cardiol."},{"issue":"5","key":"10.1016\/j.phymed.2024.155976_bib0021","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01429-2018","article-title":"Traffic exposures, air pollution and outcomes in pulmonary arterial hypertension: a UK cohort study analysis","volume":"53","author":"Sofianopoulou","year":"2019","journal-title":"Eur. Respir. J."},{"issue":"3","key":"10.1016\/j.phymed.2024.155976_bib0022","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.3892\/or.2020.7649","article-title":"Parthenolide inhibits human lung cancer cell growth by modulating the IGF\u20111R\/PI3K\/Akt signaling pathway","volume":"44","author":"Sun","year":"2020","journal-title":"Oncol. Rep."},{"issue":"4","key":"10.1016\/j.phymed.2024.155976_bib0023","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.cmet.2014.01.004","article-title":"The metabolic basis of pulmonary arterial hypertension","volume":"19","author":"Sutendra","year":"2014","journal-title":"Cell Metab."},{"issue":"9","key":"10.1016\/j.phymed.2024.155976_bib0024","first-page":"1157","article-title":"Different contributions of STAT3, ERK1\/2, and PI3-K signaling to cardiomyocyte hypertrophy by cardiotrophin-1","volume":"25","author":"Tian","year":"2004","journal-title":"Acta Pharmacol. Sin."},{"issue":"41","key":"10.1016\/j.phymed.2024.155976_bib0025","doi-asserted-by":"crossref","first-page":"38954","DOI":"10.1074\/jbc.M203842200","article-title":"Oxidative stress-mediated apoptosis. The anticancer effect of the sesquiterpene lactone parthenolide","volume":"277","author":"Wen","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.phymed.2024.155976_bib0026","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1631\/jzus.B0820351","article-title":"Parthenolide inhibits proliferation of vascular smooth muscle cells through induction of G0\/G1 phase cell cycle arrest","volume":"10","author":"Weng","year":"2009","journal-title":"J. Zhejiang. Univ. Sci. B"},{"issue":"1","key":"10.1016\/j.phymed.2024.155976_bib0027","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1165\/rcmb.2019-0431OC","article-title":"Targeting Jak-Stat Signaling in Experimental Pulmonary Hypertension","volume":"64","author":"Yerabolu","year":"2021","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"1","key":"10.1016\/j.phymed.2024.155976_bib0028","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41420-023-01390-5","article-title":"JMJD1C promotes smooth muscle cell proliferation by activating glycolysis in pulmonary arterial hypertension","volume":"9","author":"Zhang","year":"2023","journal-title":"Cell Death. Discov."},{"issue":"2","key":"10.1016\/j.phymed.2024.155976_bib0029","doi-asserted-by":"crossref","first-page":"e12742","DOI":"10.1111\/cpr.12742","article-title":"Blockade of JAK2 protects mice against hypoxia-induced pulmonary arterial hypertension by repressing pulmonary arterial smooth muscle cell proliferation","volume":"53","author":"Zhang","year":"2020","journal-title":"Cell Prolif."},{"issue":"1","key":"10.1016\/j.phymed.2024.155976_bib0030","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1186\/s12931-023-02600-5","article-title":"Inhibition of Hsp110-STAT3 interaction in endothelial cells alleviates vascular remodeling in hypoxic pulmonary arterial Hypertension model","volume":"24","author":"Zhao","year":"2023","journal-title":"Respir. Res."},{"issue":"1","key":"10.1016\/j.phymed.2024.155976_bib0031","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1756-9966-33-3","article-title":"Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung cancer cells","volume":"33","author":"Zhao","year":"2014","journal-title":"J. Exp. Clin. Cancer Res."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324006342?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324006342?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T21:15:24Z","timestamp":1730927724000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711324006342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":31,"alternative-id":["S0944711324006342"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155976","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Parthenolide attenuates hypoxia-induced pulmonary hypertension through inhibiting STAT3 signaling","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155976","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"155976"}}