{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T04:56:23Z","timestamp":1793508983920,"version":"4.5.0"},"reference-count":181,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.phymed.2024.156027","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T23:41:03Z","timestamp":1725406863000},"page":"156027","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["Polysaccharides in Medicinal and Food Homologous Plants regulate intestinal flora to improve type 2 diabetes: Systematic review"],"prefix":"10.1016","volume":"134","author":[{"given":"Wanting","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1765-3304","authenticated-orcid":false,"given":"Yikai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingze","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1127-4559","authenticated-orcid":false,"given":"Yixiao","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mujia","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2024.156027_bib0001","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jep.2012.11.002","article-title":"Antioxidant and anti-inflammatory effects of Urtica pilulifera extracts in type 2 diabetic rats","volume":"145","author":"Abo-Elmatty","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2024.156027_bib0002","doi-asserted-by":"crossref","first-page":"77","DOI":"10.22317\/jcms.v5i2.568","article-title":"Effects of eryngium caucasicum extract on testosterone, inflammation and oxidative status of nicotinamide-streptozotocin induced type-2 diabetes in male rats","volume":"5","author":"Afshari","year":"2019","journal-title":"J. Contemp. Med. Sci."},{"key":"10.1016\/j.phymed.2024.156027_bib0003","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1016\/S0140-6736(22)01655-5","article-title":"Type 2 diabetes","volume":"400","author":"Ahmad","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2024.156027_bib0004","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3390\/jcm6090086","article-title":"Gut microbiota-dependent trimethylamine-n-oxide and serum biomarkers in patients with T2DM and advanced CKD","volume":"6","author":"Al-Obaide","year":"2017","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.phymed.2024.156027_bib0005","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.ijbiomac.2019.10.270","article-title":"Synergistic effect of novel chitosan combined metformin drug on streptozotocin-induced diabetes mellitus rat","volume":"153","author":"Arun","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2024.156027_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodhyd.2023.108670","article-title":"Polysaccharides from small black soybean alleviating type 2 diabetes via modulation of gut microbiota and serum metabolism","volume":"141","author":"Bai","year":"2023","journal-title":"Food Hydrocoll."},{"key":"10.1016\/j.phymed.2024.156027_bib0007","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.tips.2013.02.002","article-title":"GPR43\/FFA2: physiopathological relevance and therapeutic prospects","volume":"34","author":"Bindels","year":"2013","journal-title":"Trends. Pharmacol. Sci."},{"key":"10.1016\/j.phymed.2024.156027_bib0008","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1007\/s00394-020-02282-5","article-title":"Prebiotic effect of inulin-type fructans on faecal microbiota and short-chain fatty acids in type 2 diabetes: a randomised controlled trial","volume":"59","author":"Birkeland","year":"2020","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.phymed.2024.156027_bib0009","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.1016\/j.bbagen.2012.11.020","article-title":"Glutathione peroxidases","volume":"1830","author":"Brigelius-Flohe","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.phymed.2024.156027_bib0010","doi-asserted-by":"crossref","first-page":"11312","DOI":"10.1074\/jbc.M211609200","article-title":"The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids","volume":"278","author":"Brown","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2024.156027_bib0011","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1210\/jc.2006-2540","article-title":"Hypothalamic-pituitary-adrenal axis dysregulation and memory impairments in type 2 diabetes","volume":"92","author":"Bruehl","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.phymed.2024.156027_bib0012","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s00125-017-4278-3","article-title":"The gut microbiome as a target for prevention and treatment of hyperglycaemia in type 2 diabetes: from current human evidence to future possibilities","volume":"60","author":"Brunkwall","year":"2017","journal-title":"Diabetologia"},{"key":"10.1016\/j.phymed.2024.156027_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.111060","article-title":"Comprehensive chemical analysis of Zhenshu Tiaozhi formula and its effect on ameliorating glucolipid metabolic disorders in diabetic rats","volume":"133","author":"Cai","year":"2021","journal-title":"Biomed. PharmacOther"},{"key":"10.1016\/j.phymed.2024.156027_bib0014","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.molmet.2016.05.011","article-title":"How gut microbes talk to organs: the role of endocrine and nervous routes","volume":"5","author":"Cani","year":"2016","journal-title":"Mol. Metab."},{"key":"10.1016\/j.phymed.2024.156027_bib0015","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.3390\/nu9101105","article-title":"Inhibition of 5alpha-reductase, IL-6 secretion, and oxidation process of equisetum debile Roxb. Ex vaucher extract as functional food and nutraceuticals ingredients","volume":"9","author":"Chaiyana","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2024.156027_bib0016","doi-asserted-by":"crossref","first-page":"H2042","DOI":"10.1152\/ajpheart.00467.2015","article-title":"Lipopolysaccharide modulates neutrophil recruitment and macrophage polarization on lymphatic vessels and impairs lymphatic function in rat mesentery","volume":"309","author":"Chakraborty","year":"2015","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"key":"10.1016\/j.phymed.2024.156027_bib0017","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1038\/s41589-021-00861-z","article-title":"Chains of evidence from correlations to causal molecules in microbiome-linked diseases","volume":"17","author":"Chaudhari","year":"2021","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.phymed.2024.156027_bib0018","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1053\/j.gastro.2017.01.055","article-title":"Bile acid control of metabolism and inflammation in obesity, type 2 diabetes, dyslipidemia, and nonalcoholic fatty liver disease","volume":"152","author":"Chavez-Talavera","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phymed.2024.156027_bib0019","doi-asserted-by":"crossref","first-page":"3732","DOI":"10.1039\/C7FO01346A","article-title":"Modulation of gut microbiota by mulberry fruit polysaccharide treatment of obese diabetic db\/db mice","volume":"9","author":"Chen","year":"2018","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2024.156027_bib0020","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/j.crfs.2022.08.016","article-title":"Structure-immunomodulatory activity relationships of dietary polysaccharides","volume":"5","author":"Chen","year":"2022","journal-title":"Curr. Res. Food Sci."},{"key":"10.1016\/j.phymed.2024.156027_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.127307","article-title":"White hyacinth bean polysaccharide ameliorates diabetes via microbiota-gut-brain axis in type 2 diabetes mellitus rats","volume":"253","author":"Chen","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2024.156027_bib0022","doi-asserted-by":"crossref","first-page":"10121","DOI":"10.1039\/D2FO02300H","article-title":"Hypoglycemic effect of the polysaccharides from Astragalus membranaceus on type 2 diabetic mice based on the \u201cgut microbiota\u2013mucosal barrier","volume":"13","author":"Chen","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2024.156027_bib0023","doi-asserted-by":"crossref","first-page":"11929","DOI":"10.1021\/acs.jafc.3c02429","article-title":"Dendrobium officinale polysaccharide alleviates type 2 diabetes mellitus by restoring gut microbiota and repairing intestinal barrier via the LPS\/TLR4\/TRIF\/NF-kB axis","volume":"71","author":"Chen","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2024.156027_bib0024","doi-asserted-by":"crossref","first-page":"e15484","DOI":"10.1016\/j.heliyon.2023.e15484","article-title":"Hypoglycemic mechanisms of Polygonatum sibiricum polysaccharide in db\/db mice via regulation of glycolysis\/gluconeogenesis pathway and alteration of gut microbiota","volume":"9","author":"Chen","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.phymed.2024.156027_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.126038","article-title":"Fructus mori polysaccharide alleviates diabetic symptoms by regulating intestinal microbiota and intestinal barrier against TLR4\/NF-kappaB pathway","volume":"249","author":"Chen","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2024.156027_bib0026","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.18811","article-title":"Association of insulin resistance and type 2 diabetes with gut microbial diversity: a microbiome-wide analysis from population studies","volume":"4","author":"Chen","year":"2021","journal-title":"JAMa Netw. Open"},{"key":"10.1016\/j.phymed.2024.156027_bib0027","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1039\/C7FO00983F","article-title":"Hypoglycemic and hypolipidemic effects of anthocyanins extract from black soybean seed coat in high fat diet and streptozotocin-induced diabetic mice","volume":"9","author":"Chen","year":"2018","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2024.156027_bib0028","doi-asserted-by":"crossref","first-page":"7929","DOI":"10.1080\/10408398.2021.1920884","article-title":"Short-chain fatty acids-producing probiotics: a novel source of psychobiotics","volume":"62","author":"Cheng","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.phymed.2024.156027_bib0029","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.1186161","article-title":"Research progress on the prevention and treatment of hyperuricemia by medicinal and edible plants and its bioactive components","volume":"10","author":"Cheng-Yuan","year":"2023","journal-title":"Front. Nutr."},{"key":"10.1016\/j.phymed.2024.156027_bib0030","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/s00018-020-03656-y","article-title":"TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling","volume":"78","author":"Ciesielska","year":"2021","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.phymed.2024.156027_bib0031","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/35096075","article-title":"The renaissance of GSK3","volume":"2","author":"Cohen","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2024.156027_bib0032","series-title":"Chinese Pharmacopoeia, Part I","author":"Commission","year":"2020"},{"key":"10.1016\/j.phymed.2024.156027_bib0033","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.diabet.2016.09.004","article-title":"Increased intestinal permeability as a risk factor for type 2 diabetes","volume":"43","author":"Cox","year":"2017","journal-title":"Diabetes Metab."},{"key":"10.1016\/j.phymed.2024.156027_bib0034","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cell.2013.12.016","article-title":"Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits","volume":"156","author":"De Vadder","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2024.156027_bib0035","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1194\/jlr.R036012","article-title":"The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism","volume":"54","author":"den Besten","year":"2013","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.phymed.2024.156027_bib0036","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.nmni.2017.09.003","article-title":"Accurate differentiation of Escherichia coli and Shigella serogroups: challenges and strategies","volume":"21","author":"Devanga","year":"2018","journal-title":"New. Microbes. New. Infect."},{"key":"10.1016\/j.phymed.2024.156027_bib0037","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jss.2009.09.019","article-title":"Nitric oxide and redox regulation in the liver: part I. General considerations and redox biology in hepatitis","volume":"162","author":"Diesen","year":"2010","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.phymed.2024.156027_bib0038","doi-asserted-by":"crossref","first-page":"242","DOI":"10.5507\/bp.2014.036","article-title":"The effect of Helicobacter pylori eradication on insulin resistance and HbA1c level in people with normal glucose levels: a prospective study","volume":"159","author":"Dogan","year":"2015","journal-title":"Biomed. Pap. Med. Fac. Univ. Palacky. Olomouc. Czech. Repub."},{"key":"10.1016\/j.phymed.2024.156027_bib0039","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/nrmicro3552","article-title":"Gut biogeography of the bacterial microbiota","volume":"14","author":"Donaldson","year":"2016","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.phymed.2024.156027_bib0040","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.2337\/dc20-1104","article-title":"Risk of anemia with metformin use in type 2 diabetes: a MASTERMIND study","volume":"43","author":"Donnelly","year":"2020","journal-title":"Diabetes Care"},{"key":"10.1016\/j.phymed.2024.156027_bib0041","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1016\/S0140-6736(06)69705-5","article-title":"The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes","volume":"368","author":"Drucker","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2024.156027_bib0042","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nrmicro3050","article-title":"The abundance and variety of carbohydrate-active enzymes in the human gut microbiota","volume":"11","author":"El","year":"2013","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.phymed.2024.156027_bib0043","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41579-020-0433-9","article-title":"Gut microbiota in human metabolic health and disease","volume":"19","author":"Fan","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.phymed.2024.156027_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.fochx.2022.100207","article-title":"Dendrobium officinale leaf polysaccharides ameliorated hyperglycemia and promoted gut bacterial associated SCFAs to alleviate type 2 diabetes in adult mice","volume":"13","author":"Fang","year":"2022","journal-title":"Food Chem. X."},{"key":"10.1016\/j.phymed.2024.156027_bib0045","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/0278-6915(91)90046-A","article-title":"Developmental toxicology of potato alkaloids in the frog embryo teratogenesis assay\u2013Xenopus (FETAX)","volume":"29","author":"Friedman","year":"1991","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.phymed.2024.156027_bib0046","doi-asserted-by":"crossref","first-page":"S130","DOI":"10.1080\/10408398.2018.1542587","article-title":"Nondigestible carbohydrates, butyrate, and butyrate-producing bacteria","volume":"59","author":"Fu","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.phymed.2024.156027_bib0047","doi-asserted-by":"crossref","first-page":"14991","DOI":"10.3390\/ijms241914991","article-title":"A metabolite perspective on the involvement of the gut microbiota in type 2 diabetes","volume":"24","author":"Fu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2024.156027_bib0048","first-page":"776","article-title":"The gut microbiota at the intersection of diet and human health","volume":"362","author":"Gentile","year":"2018","journal-title":"Science (1979)"},{"key":"10.1016\/j.phymed.2024.156027_bib0049","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1111\/1462-2920.13658","article-title":"Oscillospira and related bacteria - from metagenomic species to metabolic features","volume":"19","author":"Gophna","year":"2017","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.phymed.2024.156027_bib0050","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.anaerobe.2004.06.004","article-title":"Allobaculum stercoricanis gen. Nov., Sp. Nov., isolated from canine feces","volume":"10","author":"Greetham","year":"2004","journal-title":"Anaerobe"},{"key":"10.1016\/j.phymed.2024.156027_bib0051","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1146\/annurev.nu.04.070184.002205","article-title":"Branched-chain amino acid metabolism","volume":"4","author":"Harper","year":"1984","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.phymed.2024.156027_bib0052","doi-asserted-by":"crossref","DOI":"10.1099\/jmm.0.001435","article-title":"The role of Akkermansia muciniphila in obesity, diabetes and atherosclerosis","volume":"70","author":"Hasani","year":"2021","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.phymed.2024.156027_bib0053","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1080\/19490976.2017.1290756","article-title":"Dietary fiber and prebiotics and the gastrointestinal microbiota","volume":"8","author":"Holscher","year":"2017","journal-title":"Gut. Microbes"},{"key":"10.1016\/j.phymed.2024.156027_bib0054","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1471-2288-14-43","article-title":"SYRCLE's risk of bias tool for animal studies","volume":"14","author":"Hooijmans","year":"2014","journal-title":"BMC Med. Res. Methodol."},{"key":"10.1016\/j.phymed.2024.156027_bib0055","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1039\/c3fo60295h","article-title":"Origin and concept of medicine food homology and its application in modern functional foods","volume":"4","author":"Hou","year":"2013","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2024.156027_bib0056","doi-asserted-by":"crossref","first-page":"128","DOI":"10.15277\/bjd.2016.091","article-title":"Glucagon like peptide-1 receptor agonist (GLP-1RA) therapy in management of type 2 diabetes: choosing the right agent for individualised care","volume":"16","author":"Htike","year":"2016","journal-title":"Brit. J. Diab."},{"key":"10.1016\/j.phymed.2024.156027_bib0057","doi-asserted-by":"crossref","DOI":"10.1016\/j.phyplu.2021.100114","article-title":"Physcion ameliorates pancreatic \u03b2-cell dysfunction and diabetes-related oxidative stress markers in type 2 diabetes rat model","volume":"1","author":"Inalegwu","year":"2021","journal-title":"Phytomed. Plus"},{"key":"10.1016\/j.phymed.2024.156027_bib0058","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1038\/ejcn.2014.114","article-title":"Vitamin D and l-cysteine levels correlate positively with GSH and negatively with insulin resistance levels in the blood of type 2 diabetic patients","volume":"68","author":"Jain","year":"2014","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.phymed.2024.156027_bib0059","doi-asserted-by":"crossref","first-page":"7918","DOI":"10.1039\/D2FO01083F","article-title":"The potential mechanisms of Macrocystis pyrifera polysaccharides mitigating type 2 diabetes in rats","volume":"13","author":"Jia","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2024.156027_bib0060","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.3390\/foods11101416","article-title":"The beneficial effects of two polysaccharide fractions from Sargassum fusiform against diabetes mellitus accompanied by dyslipidemia in rats and their underlying mechanisms","volume":"11","author":"Jia","year":"2022","journal-title":"Foods"},{"key":"10.1016\/j.phymed.2024.156027_bib0061","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.ijbiomac.2011.01.023","article-title":"Sulfated modification and antioxidant activity of exopolysaccahrides produced by Enterobacter cloacae Z0206","volume":"48","author":"Jin","year":"2011","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2024.156027_bib0062","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0076-6879(02)48630-2","article-title":"Redox potential of GSH\/GSSG couple: assay and biological significance","volume":"348","author":"Jones","year":"2002","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.phymed.2024.156027_bib0063","doi-asserted-by":"crossref","first-page":"16535","DOI":"10.3390\/ijms242216535","article-title":"Liver oxidative status, serum lipids levels after bariatric surgery and high-fat, high-sugar diet in animal model of induced obesity","volume":"24","author":"Kazura","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2024.156027_bib0064","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1111\/1758-2229.12319","article-title":"Interactions between the intestinal microbiota and bile acids in gallstones patients","volume":"7","author":"Keren","year":"2015","journal-title":"Environ. Microbiol. Rep."},{"key":"10.1016\/j.phymed.2024.156027_bib0065","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1055\/s-0034-1366278","article-title":"Definition, classification and diagnosis of diabetes mellitus","volume":"122","author":"Kerner","year":"2014","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.phymed.2024.156027_bib0066","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.ijbiomac.2020.07.145","article-title":"Therapeutic potential of mushrooms in diabetes mellitus: role of polysaccharides","volume":"164","author":"Khursheed","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2024.156027_bib0067","doi-asserted-by":"crossref","first-page":"306","DOI":"10.2337\/db07-0381","article-title":"Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP","volume":"57","author":"Kim","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.phymed.2024.156027_bib0068","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3389\/fendo.2014.00085","article-title":"The SCFA receptor GPR43 and energy metabolism","volume":"5","author":"Kimura","year":"2014","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.phymed.2024.156027_bib0069","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","article-title":"From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites","volume":"165","author":"Koh","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2024.156027_bib0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.116326","article-title":"Structural characterization and hypoglycemic effect via stimulating glucagon-like peptide-1 secretion of two polysaccharides from Dendrobium officinale","volume":"241","author":"Kuang","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.phymed.2024.156027_bib0071","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1017\/S0007114512000219","article-title":"Effect of dietary fibre of barley variety 'Rihane' on azoxymethane-induced aberrant crypt foci development and on colonic microbiota diversity in rats","volume":"108","author":"Lahouar","year":"2012","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.phymed.2024.156027_bib0072","doi-asserted-by":"crossref","first-page":"e9085","DOI":"10.1371\/journal.pone.0009085","article-title":"Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults","volume":"5","author":"Larsen","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2024.156027_bib0073","doi-asserted-by":"crossref","first-page":"10015","DOI":"10.1021\/acs.jafc.0c01968","article-title":"Hypoglycemic and hypolipidemic mechanism of tea polysaccharides on type 2 diabetic rats via gut microbiota and metabolism alteration","volume":"68","author":"Li","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2024.156027_bib0074","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.119055","article-title":"Effects of in vitro digestion and fermentation of Nostoc commune Vauch. Polysaccharides on properties and gut microbiota","volume":"281","author":"Li","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.phymed.2024.156027_bib0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.128873","article-title":"Recent advances in medicinal and edible homologous plant polysaccharides: preparation, structure and prevention and treatment of diabetes","volume":"258","author":"Li","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2024.156027_bib0076","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.fct.2004.12.001","article-title":"Toxicological evaluation of fucoidan extracted from Laminaria japonica in Wistar rats","volume":"43","author":"Li","year":"2005","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.phymed.2024.156027_bib0077","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s11427-019-1647-6","article-title":"Hypoglycemic mechanism of polysaccharide from Cyclocarya paliurus leaves in type 2 diabetic rats by gut microbiota and host metabolism alteration","volume":"64","author":"Li","year":"2021","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.phymed.2024.156027_bib0078","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.3389\/fimmu.2017.01882","article-title":"Gut microbiota dysbiosis drives and implies novel therapeutic strategies for diabetes mellitus and related metabolic diseases","volume":"8","author":"Li","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2024.156027_bib0079","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1111\/dom.12533","article-title":"GSK2374697, a long duration glucagon-like peptide-1 (GLP-1) receptor agonist, reduces postprandial circulating endogenous total GLP-1 and peptide YY in healthy subjects","volume":"17","author":"Lin","year":"2015","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.phymed.2024.156027_bib0080","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/j.crfs.2022.09.001","article-title":"Antidiabetic potential of polysaccharides from Brasenia schreberi regulating insulin signaling pathway and gut microbiota in type 2 diabetic mice","volume":"5","author":"Liu","year":"2022","journal-title":"Curr. Res. Food Sci."},{"key":"10.1016\/j.phymed.2024.156027_bib0081","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.ijbiomac.2018.04.127","article-title":"Pumpkin polysaccharide modifies the gut microbiota during alleviation of type 2 diabetes in rats","volume":"115","author":"Liu","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2024.156027_bib0082","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.119001","article-title":"The structures of two polysaccharides from Angelica sinensis and their effects on hepatic insulin resistance through blocking RAGE","volume":"280","author":"Liu","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.phymed.2024.156027_bib0083","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nrmicro3344","article-title":"The gut microbiota, bacterial metabolites and colorectal cancer","volume":"12","author":"Louis","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.phymed.2024.156027_bib0084","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/ismej.2010.133","article-title":"UniFrac: an effective distance metric for microbial community comparison","volume":"5","author":"Lozupone","year":"2011","journal-title":"ISMe J."},{"key":"10.1016\/j.phymed.2024.156027_bib0085","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1080\/13880209.2021.1898648","article-title":"Pueraria lobata root polysaccharide alleviates glucose and lipid metabolic dysfunction in diabetic db\/db mice","volume":"59","author":"Luo","year":"2021","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.phymed.2024.156027_bib0086","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.3390\/molecules24071343","article-title":"Antioxidant and anti-diabetic activities of polysaccharides from guava leaves","volume":"24","author":"Luo","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2024.156027_bib0087","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.tox.2015.07.008","article-title":"Triptolide disrupts fatty acids and peroxisome proliferator-activated receptor (PPAR) levels in male mice testes followed by testicular injury: a GC\u2013MS based metabolomics study","volume":"336","author":"Ma","year":"2015","journal-title":"Toxicology"},{"key":"10.1016\/j.phymed.2024.156027_bib0088","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/1541-4337.12401","article-title":"Dietary amino acids and the gut-microbiome-immune axis: physiological metabolism and therapeutic prospects","volume":"18","author":"Ma","year":"2019","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"10.1016\/j.phymed.2024.156027_bib0089","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.109873","article-title":"Investigation of gut microbiome changes in type 1 diabetic mellitus rats based on high-throughput sequencing","volume":"124","author":"Ma","year":"2020","journal-title":"Biomed. PharmacOther"},{"key":"10.1016\/j.phymed.2024.156027_bib0090","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1038\/s41591-018-0125-4","article-title":"Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo","volume":"24","author":"Madiraju","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.phymed.2024.156027_bib0091","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.2047-6310.2012.00087.x","article-title":"Circulating branched-chain amino acid concentrations are associated with obesity and future insulin resistance in children and adolescents","volume":"8","author":"Mccormack","year":"2013","journal-title":"Pediatr. Obes."},{"key":"10.1016\/j.phymed.2024.156027_bib0092","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000439364","article-title":"Treatment goals in diabetes","volume":"31","author":"Melmer","year":"2016","journal-title":"Endocr. Dev."},{"key":"10.1016\/j.phymed.2024.156027_bib0093","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1080\/19490976.2020.1778261","article-title":"Serum metabolites reflecting gut microbiome alpha diversity predict type 2 diabetes","volume":"11","author":"Menni","year":"2020","journal-title":"Gut. Microbes"},{"key":"10.1016\/j.phymed.2024.156027_bib0094","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.3390\/nu12082251","article-title":"Barrier protection and recovery effects of gut commensal bacteria on differentiated intestinal epithelial cells in vitro","volume":"12","author":"Mohebali","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2024.156027_bib0095","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/19490976.2015.1134082","article-title":"Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism","volume":"7","author":"Morrison","year":"2016","journal-title":"Gut. Microbes"},{"key":"10.1016\/j.phymed.2024.156027_bib0096","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.cmet.2009.02.002","article-title":"A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance","volume":"9","author":"Newgard","year":"2009","journal-title":"Cell Metab."},{"key":"10.1016\/j.phymed.2024.156027_bib0097","doi-asserted-by":"crossref","first-page":"954","DOI":"10.3390\/ijms19040954","article-title":"Branched chain amino acids: beyond nutrition metabolism","volume":"19","author":"Nie","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2024.156027_bib0098","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.foodhyd.2017.12.026","article-title":"Polysaccharide from Plantago asiatica L. Attenuates hyperglycemia, hyperlipidemia and affects colon microbiota in type 2 diabetic rats","volume":"86","author":"Nie","year":"2019","journal-title":"Food Hydrocoll."},{"key":"10.1016\/j.phymed.2024.156027_bib0099","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1530\/JME-19-0132","article-title":"Butyrate modulates diabetes-linked gut dysbiosis: epigenetic and mechanistic modifications","volume":"64","author":"Noureldein","year":"2020","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.phymed.2024.156027_bib0100","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jclinepi.2021.03.001","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"134","author":"Page","year":"2021","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.phymed.2024.156027_bib0101","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s40618-020-01260-2","article-title":"Insufficient glucocorticoid receptor signaling and flattened salivary cortisol profile are associated with metabolic and inflammatory indices in type 2 diabetes","volume":"44","author":"Panagiotou","year":"2021","journal-title":"J. Endocrinol. Invest."},{"key":"10.1016\/j.phymed.2024.156027_bib0102","doi-asserted-by":"crossref","first-page":"eabh3831","DOI":"10.1126\/scitranslmed.abh3831","article-title":"Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of Ppp2r1b","volume":"14","author":"Patel","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.phymed.2024.156027_bib0103","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1136\/postgradmedj-2015-133285","article-title":"Gut microbiota, obesity and diabetes","volume":"92","author":"Patterson","year":"2016","journal-title":"Postgrad. Med. J."},{"key":"10.1016\/j.phymed.2024.156027_bib0104","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature18646","article-title":"Human gut microbes impact host serum metabolome and insulin sensitivity","volume":"535","author":"Pedersen","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2024.156027_bib0105","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.3390\/polym14153217","article-title":"Natural polysaccharide-based nanodrug delivery systems for treatment of diabetes","volume":"14","author":"Qiu","year":"2022","journal-title":"Polymers. (Basel)"},{"key":"10.1016\/j.phymed.2024.156027_bib0106","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.679897","article-title":"Kaempferol alleviates murine experimental colitis by restoring gut microbiota and inhibiting the LPS-TLR4-NF-kappaB axis","volume":"12","author":"Qu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2024.156027_bib0107","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.freeradbiomed.2010.12.006","article-title":"Oxidative stress, insulin signaling, and diabetes","volume":"50","author":"Rains","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2024.156027_bib0108","doi-asserted-by":"crossref","first-page":"3577","DOI":"10.1002\/jcb.26097","article-title":"Mechanism of generation of oxidative stress and pathophysiology of type 2 diabetes mellitus: how are they interlinked?","volume":"118","author":"Rehman","year":"2017","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.phymed.2024.156027_bib0109","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.ijbiomac.2014.09.060","article-title":"A polysaccharide extract of mulberry leaf ameliorates hepatic glucose metabolism and insulin signaling in rats with type 2 diabetes induced by high fat-diet and streptozotocin","volume":"72","author":"Ren","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2024.156027_bib0110","article-title":"Low nanogel stiffness favors nanogel transcytosis across an in vitro blood-brain barrier","volume":"34","author":"Ribovski","year":"2021","journal-title":"Nanomedicine (Lond)"},{"key":"10.1016\/j.phymed.2024.156027_bib0111","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41467-020-20313-x","article-title":"Transkingdom interactions between Lactobacilli and hepatic mitochondria attenuate western diet-induced diabetes","volume":"12","author":"Rodrigues","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2024.156027_bib0112","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1128\/aem.33.2.319-322.1977","article-title":"Fermentation of mucin and plant polysaccharides by strains of Bacteroides from the human colon","volume":"33","author":"Salyers","year":"1977","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.phymed.2024.156027_bib0113","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.trsl.2016.10.002","article-title":"Feeding the microbiota-gut-brain axis: diet, microbiome, and neuropsychiatry","volume":"179","author":"Sandhu","year":"2017","journal-title":"Transl. Res."},{"key":"10.1016\/j.phymed.2024.156027_bib0114","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.989230","article-title":"Effect of Angelica polysaccharide on mouse myeloid-derived suppressor cells","volume":"13","author":"Shen","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2024.156027_bib0115","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1136\/gutjnl-2012-303839","article-title":"An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice","volume":"63","author":"Shin","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.phymed.2024.156027_bib0116","doi-asserted-by":"crossref","DOI":"10.1016\/j.cpr.2020.101943","article-title":"The gut microbiota in anxiety and depression - a systematic review","volume":"83","author":"Simpson","year":"2021","journal-title":"Clin. Psychol. Rev."},{"key":"10.1016\/j.phymed.2024.156027_bib0117","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s11892-018-1057-6","article-title":"Altered gut microbiota in type 2 diabetes: just a coincidence?","volume":"18","author":"Sircana","year":"2018","journal-title":"Curr. Diab. Rep."},{"key":"10.1016\/j.phymed.2024.156027_bib181","first-page":"625","article-title":"Phytomedicine: a Potential Alternative Medicine in Controlling Neurological Disorders","author":"Srivastava","year":"2019"},{"key":"10.1016\/j.phymed.2024.156027_bib0118","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1043527","article-title":"Gut microbiota mediated hypoglycemic effect of Astragalus membranaceus polysaccharides in db\/db mice","volume":"13","author":"Song","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2024.156027_bib0119","doi-asserted-by":"crossref","first-page":"4558","DOI":"10.1002\/ptr.7575","article-title":"Quercetin improves high-fat diet-induced obesity by modulating gut microbiota and metabolites in C57BL\/6J mice","volume":"36","author":"Su","year":"2022","journal-title":"PhytOther Res."},{"key":"10.1016\/j.phymed.2024.156027_bib0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2021.109119","article-title":"IDF diabetes atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045","volume":"183","author":"Sun","year":"2022","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.phymed.2024.156027_bib0121","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00535-016-1242-9","article-title":"Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases","volume":"52","author":"Sun","year":"2017","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.phymed.2024.156027_bib0122","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.ijbiomac.2020.07.208","article-title":"The modulatory effect of plant polysaccharides on gut flora and the implication for neurodegenerative diseases from the perspective of the microbiota-gut-brain axis","volume":"164","author":"Sun","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2024.156027_bib0123","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1080\/09540105.2020.1789071","article-title":"Protective effect and mechanism of fucoidan on intestinal mucosal barrier function in NOD mice","volume":"31","author":"Sun","year":"2020","journal-title":"Food Agric. Immunol."},{"key":"10.1016\/j.phymed.2024.156027_bib0124","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/s41586-023-06466-x","article-title":"Gut microbial carbohydrate metabolism contributes to insulin resistance","volume":"621","author":"Takeuchi","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2024.156027_bib0125","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/B978-0-12-800100-4.00003-9","article-title":"The role of short-chain fatty acids in health and disease","volume":"121","author":"Tan","year":"2014","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.phymed.2024.156027_bib0126","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1373\/clinchem.2016.263640","article-title":"Increased trimethylamine n-oxide portends high mortality risk independent of glycemic control in patients with type 2 diabetes mellitus","volume":"63","author":"Tang","year":"2017","journal-title":"Clin. Chem."},{"key":"10.1016\/j.phymed.2024.156027_bib0127","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1186\/s12866-023-03029-y","article-title":"Angelica polysaccharides relieve blood glucose levels in diabetic KKAy mice possibly by modulating gut microbiota: an integrated gut microbiota and metabolism analysis","volume":"23","author":"Tang","year":"2023","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.phymed.2024.156027_bib0128","doi-asserted-by":"crossref","first-page":"364","DOI":"10.2337\/db11-1019","article-title":"Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2","volume":"61","author":"Tolhurst","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.phymed.2024.156027_bib0129","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41387-021-00164-1","article-title":"Amino acid metabolism and signalling pathways: potential targets in the control of infection and immunity","volume":"11","author":"Tome","year":"2021","journal-title":"Nutr. Diabetes"},{"key":"10.1016\/j.phymed.2024.156027_bib0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.128853","article-title":"Laminaria japonica polysaccharide alleviates type 2 diabetes by regulating the microbiota-gut-liver axis: a multi-omics mechanistic analysis","volume":"258","author":"Tong","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2024.156027_bib0131","doi-asserted-by":"crossref","first-page":"3809","DOI":"10.3390\/foods12203809","article-title":"The potential hypoglycemic competence of low molecular weight polysaccharides obtained from Laminaria japonica","volume":"12","author":"Tong","year":"2023","journal-title":"Foods"},{"key":"10.1016\/j.phymed.2024.156027_bib0132","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1152\/physrev.2001.81.3.1031","article-title":"Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides","volume":"81","author":"Topping","year":"2001","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.phymed.2024.156027_bib0133","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/nature05414","article-title":"An obesity-associated gut microbiome with increased capacity for energy harvest","volume":"444","author":"Turnbaugh","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2024.156027_bib0134","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.abb.2014.12.012","article-title":"The Keap1-Nrf2 system and diabetes mellitus","volume":"566","author":"Uruno","year":"2015","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.phymed.2024.156027_bib0135","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.1080\/13880209.2016.1211153","article-title":"Effects of Maydis stigma polysaccharide on the intestinal microflora in type-2 diabetes","volume":"54","author":"Wang","year":"2016","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.phymed.2024.156027_bib0136","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.ijbiomac.2017.04.056","article-title":"Hypoglycemic and hypolipidemic effects of a polysaccharide from flower buds of Lonicera japonica in streptozotocin-induced diabetic rats","volume":"102","author":"Wang","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2024.156027_bib0137","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2147\/DMSO.S346007","article-title":"Moderate treadmill exercise modulates gut microbiota and improves intestinal barrier in high-fat-diet-induced obese mice via the AMPK\/CDX2 signaling pathway","volume":"15","author":"Wang","year":"2022","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"10.1016\/j.phymed.2024.156027_bib0138","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1021\/acs.jafc.9b06247","article-title":"Polysaccharide from Rosa roxburghii tratt fruit attenuates hyperglycemia and hyperlipidemia and regulates colon microbiota in diabetic db\/db mice","volume":"68","author":"Wang","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2024.156027_bib0139","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.2337\/dc17-1642","article-title":"Genetic support for a causal role of insulin resistance on circulating branched-chain amino acids and inflammation","volume":"40","author":"Wang","year":"2017","journal-title":"Diabetes Care"},{"key":"10.1016\/j.phymed.2024.156027_bib0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.116261","article-title":"Odd-numbered agaro-oligosaccharides alleviate type 2 diabetes mellitus and related colonic microbiota dysbiosis in mice","volume":"240","author":"Wang","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.phymed.2024.156027_bib0141","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.ijbiomac.2020.11.208","article-title":"Advances in the extraction, purification, structural-property relationships and bioactive molecular mechanism of Flammulina velutipes polysaccharides: a review","volume":"167","author":"Wang","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2024.156027_bib0142","doi-asserted-by":"crossref","first-page":"3926","DOI":"10.3390\/nu14193926","article-title":"Efficacy and mechanism of Pueraria lobata and Pueraria thomsonii polysaccharides in the treatment of type 2 diabetes","volume":"14","author":"Wang","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2024.156027_bib0143","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature09922","article-title":"Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease","volume":"472","author":"Wang","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2024.156027_bib0144","doi-asserted-by":"crossref","first-page":"444","DOI":"10.3390\/md18090444","article-title":"Sargassum fusiforme polysaccharides prevent high-fat diet-induced early fasting hypoglycemia and regulate the gut microbiota composition","volume":"18","author":"Wei","year":"2020","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.phymed.2024.156027_bib0145","first-page":"e13441","article-title":"Zanthoxylum alkylamides improve amino acid metabolism in type 2 diabetes mellitus rats","author":"Wei","year":"2020","journal-title":"J. Food Biochem."},{"key":"10.1016\/j.phymed.2024.156027_bib0146","doi-asserted-by":"crossref","first-page":"5107","DOI":"10.1021\/acs.jafc.0c00605","article-title":"Hypoglycemic effect of ginsenoside Rg5 mediated partly by modulating gut microbiota dysbiosis in diabetic db\/db mice","volume":"68","author":"Wei","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2024.156027_bib0147","doi-asserted-by":"crossref","first-page":"3572","DOI":"10.1039\/D0FO03329D","article-title":"Sargassum fusiforme fucoidan modifies gut microbiota and intestinal metabolites during alleviation of hyperglycemia in type 2 diabetic mice","volume":"12","author":"Wu","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2024.156027_bib0148","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2021.110717","article-title":"Coix seed polysaccharides alleviate type 2 diabetes mellitus via gut microbiota-derived short-chain fatty acids activation of IGF1\/PI3K\/AKT signaling","volume":"150","author":"Xia","year":"2021","journal-title":"Food Res. Int."},{"key":"10.1016\/j.phymed.2024.156027_bib0149","doi-asserted-by":"crossref","first-page":"9155","DOI":"10.1038\/s41598-017-09641-z","article-title":"Cyclocarya paliurus tea leaves enhances pancreatic beta cell preservation through inhibition of apoptosis","volume":"7","author":"Xiao","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2024.156027_bib0150","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1073\/pnas.2637002100","article-title":"Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41","volume":"101","author":"Xiong","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phymed.2024.156027_bib0151","article-title":"Astragalus mongholicus powder, a traditional Chinese medicine formula ameliorate type 2 diabetes by regulating adipoinsular axis in diabetic mice","volume":"13","author":"Xu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2024.156027_bib0152","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.foodchem.2019.03.050","article-title":"Microbial catabolism of Porphyra haitanensis polysaccharides by human gut microbiota","volume":"289","author":"Xu","year":"2019","journal-title":"Food Chem."},{"key":"10.1016\/j.phymed.2024.156027_bib0153","doi-asserted-by":"crossref","first-page":"5804","DOI":"10.1039\/C9FO01062A","article-title":"Lactobacillus acidophilus alleviates type 2 diabetes by regulating hepatic glucose, lipid metabolism and gut microbiota in mice","volume":"10","author":"Yan","year":"2019","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2024.156027_bib0154","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.phymed.2017.01.007","article-title":"Intake of total saponins and polysaccharides from Polygonatum kingianum affects the gut microbiota in diabetic rats","volume":"26","author":"Yan","year":"2017","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2024.156027_bib0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2021.154712","article-title":"Role of the gut microbiota in type 2 diabetes and related diseases","volume":"117","author":"Yang","year":"2021","journal-title":"Metabolism"},{"key":"10.1016\/j.phymed.2024.156027_bib0156","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2021.1987783","article-title":"Oscillospira - a candidate for the next-generation probiotics","volume":"13","author":"Yang","year":"2021","journal-title":"Gut. Microbes"},{"key":"10.1016\/j.phymed.2024.156027_bib0157","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s11033-023-09081-1","article-title":"Advances in polysaccharides of natural source of anti-diabetes effect and mechanism","volume":"51","author":"Yang","year":"2024","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.phymed.2024.156027_bib0158","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153268","article-title":"Cyclocarya paliurus polysaccharides alleviate type 2 diabetic symptoms by modulating gut microbiota and short-chain fatty acids","volume":"77","author":"Yao","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2024.156027_bib0159","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00615-20","article-title":"Lactobacillus plantarum reduces low-grade inflammation and glucose levels in a mouse model of chronic stress and diabetes","volume":"89","author":"Youn","year":"2021","journal-title":"Infect. Immun."},{"key":"10.1016\/j.phymed.2024.156027_bib0160","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1210\/clinem\/dgae009","article-title":"Association between trimethylamine n-oxide and adverse kidney outcomes and overall mortality in type 2 diabetes mellitus","volume":"109","author":"Yu","year":"2024","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.phymed.2024.156027_bib0161","doi-asserted-by":"crossref","first-page":"E73","DOI":"10.1152\/ajpendo.00256.2018","article-title":"Berberine alleviates insulin resistance by reducing peripheral branched-chain amino acids","volume":"316","author":"Yue","year":"2019","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.phymed.2024.156027_bib0162","doi-asserted-by":"crossref","first-page":"e1071","DOI":"10.1002\/iid3.1071","article-title":"Astragalus polysaccharide ameliorates insulin resistance in HepG2 cells through activating the STAT5\/IGF-1 pathway","volume":"11","author":"Yue","year":"2023","journal-title":"Immun. Inflamm. Dis."},{"key":"10.1016\/j.phymed.2024.156027_bib0163","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1038\/ismej.2012.4","article-title":"Ruminococcus bromii is a keystone species for the degradation of resistant starch in the human colon","volume":"6","author":"Ze","year":"2012","journal-title":"ISMe J."},{"key":"10.1016\/j.phymed.2024.156027_bib0164","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3390\/foods12010033","article-title":"Fucoidan from Laminaria japonica ameliorates type 2 diabetes mellitus in association with modulation of gut microbiota and metabolites in streptozocin-treated mice","volume":"12","author":"Zhang","year":"2022","journal-title":"Foods"},{"key":"10.1016\/j.phymed.2024.156027_bib0165","doi-asserted-by":"crossref","first-page":"270","DOI":"10.2174\/1389200224666230406114012","article-title":"Integrated 16S rRNA sequencing and untargeted metabolomics analysis to reveal the protective mechanisms of Polygonatum sibiricum polysaccharide on type 2 diabetes mellitus model rats","volume":"24","author":"Zhang","year":"2023","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.phymed.2024.156027_bib0166","article-title":"Decreased abundance of Akkermansia muciniphila leads to the impairment of insulin secretion and glucose homeostasis in lean type 2 diabetes","volume":"8","author":"Zhang","year":"2021","journal-title":"Adv. Sci. (Weinh)"},{"key":"10.1016\/j.phymed.2024.156027_bib0167","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/s40618-022-01914-3","article-title":"Calorie restriction ameliorates hyperglycemia, modulates the disordered gut microbiota, and mitigates metabolic endotoxemia and inflammation in type 2 diabetic rats","volume":"46","author":"Zhang","year":"2023","journal-title":"J. Endocrinol. Invest."},{"key":"10.1016\/j.phymed.2024.156027_bib0168","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.201800219","article-title":"Evaluation of the anti-diabetic activity of polysaccharide from Cordyceps cicadae in experimental diabetic rats","volume":"15","author":"Zhang","year":"2018","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.phymed.2024.156027_bib0169","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.3390\/nu10081055","article-title":"Beneficial effect of intestinal fermentation of natural polysaccharides","volume":"10","author":"Zhang","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2024.156027_bib0170","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.ijbiomac.2020.03.111","article-title":"Anti-inflammatory activity of alkali-soluble polysaccharides from Arctium lappa L. And its effect on gut microbiota of mice with inflammation","volume":"154","author":"Zhang","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2024.156027_bib0171","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.intimp.2014.01.010","article-title":"Lycium barbarum polysaccharide LBPF4-OL may be a new Toll-like receptor 4\/MD2-MAPK signaling pathway activator and inducer","volume":"19","author":"Zhang","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2024.156027_bib0172","first-page":"680","article-title":"[Plasm trimethylamine-N-oxide level and association with lesion severity in coronary heart disease patients with type 2 diabetes mellitus]","volume":"49","author":"Zhang","year":"2021","journal-title":"Chin. J. Cardiovasc. Diseases"},{"key":"10.1016\/j.phymed.2024.156027_bib0173","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.111854","article-title":"Edgeworthia gardneri (Wall.) Meisn. Water extract improves diabetes and modulates gut microbiota","volume":"239","author":"Zhang","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2024.156027_bib0174","first-page":"1151","article-title":"Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes","volume":"359","author":"Zhao","year":"2018","journal-title":"Science (1979)"},{"key":"10.1016\/j.phymed.2024.156027_bib0175","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1080\/13880209.2017.1345953","article-title":"Effects of polysaccharide from Physalis alkekengi var. Francheti on liver injury and intestinal microflora in type-2 diabetic mice","volume":"55","author":"Zhao","year":"2017","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.phymed.2024.156027_bib0176","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.126504","article-title":"Fucus vesiculosus polysaccharide alleviates type 2 diabetes in rats via remodeling gut microbiota and regulating glycolipid metabolism-related gene expression","volume":"248","author":"Zheng","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2024.156027_bib0177","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.jff.2017.03.045","article-title":"Strategies to promote abundance of Akkermansia muciniphila, an emerging probiotics in the gut, evidence from dietary intervention studies","volume":"33","author":"Zhou","year":"2017","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.phymed.2024.156027_bib0178","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2022.105381","article-title":"Polysaccharides in Berberis dasystachya improve intestinal flora depending on the molecular weight and ameliorate type 2 diabetes in rats","volume":"100","author":"Zhou","year":"2023","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.phymed.2024.156027_bib0179","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.119626","article-title":"The polysaccharides from the fruits of Lycium barbarum L. Confer anti-diabetic effect by regulating gut microbiota and intestinal barrier","volume":"291","author":"Zhou","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.phymed.2024.156027_bib0180","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1056\/NEJMoa1003795","article-title":"Severe hypoglycemia and risks of vascular events and death","volume":"363","author":"Zoungas","year":"2010","journal-title":"N. Engl. J. Med."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324006846?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324006846?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T21:17:10Z","timestamp":1730927830000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711324006846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":181,"alternative-id":["S0944711324006846"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2024.156027","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polysaccharides in Medicinal and Food Homologous Plants regulate intestinal flora to improve type 2 diabetes: Systematic review","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2024.156027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156027"}}