{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:21:23Z","timestamp":1791652883726,"version":"4.3.4"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.phymed.2024.156123","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T11:51:59Z","timestamp":1727956319000},"page":"156123","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Arctigenin ameliorates high-fat diet-induced metabolic disorders by reshaping gut microbiota and modulating GPR\/HDAC3 and TLR4\/NF-\u03baB pathways"],"prefix":"10.1016","volume":"135","author":[{"given":"Nana","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2024.156123_bib0001","doi-asserted-by":"crossref","first-page":"750","DOI":"10.3390\/cells11040750","article-title":"Free Fatty Acid Receptors (FFARs) in Adipose: physiological Role and Therapeutic Outlook","volume":"11","author":"Al Mahri","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.phymed.2024.156123_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103153","article-title":"An orally active carbon monoxide-releasing molecule enhances beneficial gut microbial species to combat obesity in mice","volume":"72","author":"Benrahla","year":"2024","journal-title":"Redox. Biol."},{"key":"10.1016\/j.phymed.2024.156123_bib0003","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1038\/cti.2016.17","article-title":"Regulation of immune cell function by short-chain fatty acids","volume":"5","author":"Corr\u00eaa-Oliveira","year":"2016","journal-title":"Clin. Transl. Immunol."},{"key":"10.1016\/j.phymed.2024.156123_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.112948","article-title":"Tectorigenin ameliorated high-fat diet-induced nonalcoholic fatty liver disease through anti-inflammation and modulating gut microbiota in mice","volume":"164","author":"Duan","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.phymed.2024.156123_bib0005","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2021.1874815","article-title":"Spatial analysis of gut microbiome reveals a distinct ecological niche associated with the mucus layer","volume":"13","author":"Duncan","year":"2021","journal-title":"Gut. Microbes."},{"key":"10.1016\/j.phymed.2024.156123_bib0006","doi-asserted-by":"crossref","first-page":"9066","DOI":"10.1073\/pnas.1219451110","article-title":"Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity","volume":"110","author":"Everard","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phymed.2024.156123_bib0007","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1277102","article-title":"The role of intestinal microbes on intestinal barrier function and host immunity from a metabolite perspective","volume":"14","author":"Fu","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2024.156123_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155470","article-title":"Alleviation of allergic asthma by rosmarinic acid via gut-lung axis","volume":"126","author":"Guo","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2024.156123_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111552","article-title":"Arctigenin promotes mucosal healing in ulcerative colitis through facilitating focal adhesion assembly and colonic epithelial cell migration via targeting focal adhesion kinase","volume":"128","author":"Guo","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2024.156123_bib0010","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.3390\/nu14112208","article-title":"Prevention of Ulcerative Colitis in Mice by Sweet Tea (Lithocarpus litseifolius) via the Regulation of Gut Microbiota and Butyric-Acid-Mediated Anti-Inflammatory Signaling","volume":"14","author":"He","year":"2022","journal-title":"Nutrients."},{"key":"10.1016\/j.phymed.2024.156123_bib0011","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/3910116","article-title":"Ameliorating Effect on Glycolipid Metabolism of Spirulina Functional Formulation Combination from Traditional Chinese Medicine","volume":"2022","author":"Huang","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.phymed.2024.156123_bib0012","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1038\/ijo.2008.102","article-title":"Global burden of obesity in 2005 and projections to 2030","volume":"32","author":"Kelly","year":"2008","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.phymed.2024.156123_bib0013","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1038\/ncomms2852","article-title":"The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43","volume":"4","author":"Kimura","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2024.156123_bib0014","article-title":"Chemical transformation of xenobiotics by the human gut microbiota","volume":"356","author":"Koppel","year":"2017","journal-title":"Science (1979)"},{"key":"10.1016\/j.phymed.2024.156123_bib0015","doi-asserted-by":"crossref","first-page":"11070","DOI":"10.1073\/pnas.0504978102","article-title":"Obesity alters gut microbial ecology","volume":"102","author":"Ley","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phymed.2024.156123_bib0016","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.ijbiomac.2019.10.069","article-title":"Artemisia sphaerocephala Krasch polysaccharide mediates lipid metabolism and metabolic endotoxaemia in associated with the modulation of gut microbiota in diet-induced obese mice","volume":"147","author":"Li","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2024.156123_bib0017","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1017\/S0029665120006916","article-title":"SCFA: mechanisms and functional importance in the gut","volume":"80","author":"Martin-Gallausiaux","year":"2021","journal-title":"Proc. Nutr. Soc."},{"key":"10.1016\/j.phymed.2024.156123_bib0018","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/s41531-022-00328-5","article-title":"Short chain fatty acids-producing and mucin-degrading intestinal bacteria predict the progression of early Parkinson's disease","volume":"8","author":"Nishiwaki","year":"2022","journal-title":"NPJ. Parkinsons. Dis."},{"key":"10.1016\/j.phymed.2024.156123_bib0019","doi-asserted-by":"crossref","unstructured":"Pasparakis, M.J.N.R.I., 2009. Regulation of tissue homeostasis by NF-\u03baB signalling: implications for inflammatory diseases. 9, 778\u2013788.","DOI":"10.1038\/nri2655"},{"key":"10.1016\/j.phymed.2024.156123_bib0020","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.beem.2013.02.004","article-title":"Metabolic complications of obesity","volume":"27","author":"Pedersen","year":"2013","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.phymed.2024.156123_bib0021","article-title":"Tight Junction ZO Proteins Maintain Tissue Fluidity, Ensuring Efficient Collective Cell Migration","volume":"8","author":"Skamrahl","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.phymed.2024.156123_bib0022","first-page":"569","article-title":"The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis","volume":"341","author":"Smith","year":"2013","journal-title":"Science (1979)"},{"key":"10.1016\/j.phymed.2024.156123_bib0023","doi-asserted-by":"crossref","first-page":"13275","DOI":"10.1002\/jcb.28602","article-title":"Arctigenin improves lipid metabolism by regulating AMP-activated protein kinase and downstream signaling pathways","volume":"120","author":"Song","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.phymed.2024.156123_bib0024","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.phymed.2013.08.003","article-title":"Mechanism of arctigenin-mediated specific cytotoxicity against human lung adenocarcinoma cell lines","volume":"21","author":"Susanti","year":"2013","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2024.156123_bib0025","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1093\/jac\/dkm503","article-title":"Novel strategy for treatment of Japanese encephalitis using arctigenin, a plant lignan","volume":"61","author":"Swarup","year":"2008","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.phymed.2024.156123_bib0026","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1002\/ptr.7495","article-title":"Phytoestrogen arctigenin preserves the mucus barrier in inflammatory bowel diseases by inhibiting goblet cell apoptosis via the ER\u03b2\/TRIM21\/PHB1 pathway","volume":"36","author":"Tao","year":"2022","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2024.156123_bib0027","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1080\/10408398.2020.1744512","article-title":"Dietary polyphenol impact on gut health and microbiota","volume":"61","author":"Wan","year":"2021","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.phymed.2024.156123_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.134232","article-title":"Phenolics from noni (Morinda citrifolia L.) fruit alleviate obesity in high fat diet-fed mice via modulating the gut microbiota and mitigating intestinal damage","volume":"402","author":"Wang","year":"2023","journal-title":"Food Chem."},{"key":"10.1016\/j.phymed.2024.156123_bib0029","unstructured":"WHO, World Health Organization, 2023."},{"key":"10.1016\/j.phymed.2024.156123_bib0030","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.01596-21","article-title":"Akkermansia muciniphila Ameliorates Acetaminophen-Induced Liver Injury by Regulating Gut Microbial Composition and Metabolism","volume":"10","author":"Xia","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.phymed.2024.156123_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2023.101737","article-title":"A major mechanism for immunomodulation: dietary fibres and acid metabolites","volume":"66","author":"Xie","year":"2023","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.phymed.2024.156123_bib0032","doi-asserted-by":"crossref","first-page":"21660","DOI":"10.18632\/aging.103962","article-title":"Human mesenchymal stem cells treatment improved hepatic lesions and reversed gut microbiome disorder in non-alcoholic steatohepatitis","volume":"12","author":"Yang","year":"2020","journal-title":"Aging"},{"key":"10.1016\/j.phymed.2024.156123_bib0033","article-title":"The Therapeutic Effect of SCFA-Mediated Regulation of the Intestinal Environment on","volume":"9","author":"You","year":"2022","journal-title":"Obesity. Front. Nutr."},{"key":"10.1016\/j.phymed.2024.156123_bib0034","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1039\/D1FO04037E","article-title":"Secoisolariciresinol diglucoside ameliorates high fat diet-induced colon inflammation and regulates gut microbiota in mice","volume":"13","author":"Zhang","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2024.156123_bib0035","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1007\/s10753-015-0115-3","article-title":"Arctigenin Protects against lipopolysaccharide-induced pulmonary oxidative stress and inflammation in a mouse model via suppression of MAPK, HO-1, and iNOS Signaling","volume":"38","author":"Zhang","year":"2015","journal-title":"Inflammation"},{"key":"10.1016\/j.phymed.2024.156123_bib0036","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.690138","article-title":"Allobaculum involves in the modulation of intestinal ANGPTLT4 Expression in Mice Treated by High-Fat Diet","volume":"8","author":"Zheng","year":"2021","journal-title":"Front. Nutr."},{"key":"10.1016\/j.phymed.2024.156123_bib0037","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/s12944-023-01949-2","article-title":"ACT001 alleviates chronic kidney injury induced by a high-fat diet in mice through the GPR43\/AMPK pathway","volume":"22","author":"Zhou","year":"2023","journal-title":"Lipids Health Dis."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324007803?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324007803?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T09:05:00Z","timestamp":1762333500000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711324007803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":37,"alternative-id":["S0944711324007803"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2024.156123","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Arctigenin ameliorates high-fat diet-induced metabolic disorders by reshaping gut microbiota and modulating GPR\/HDAC3 and TLR4\/NF-\u03baB pathways","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2024.156123","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156123"}}