{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:29:30Z","timestamp":1791430170103,"version":"4.3.3"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"publisher","award":["32000509"],"award-info":[{"award-number":["32000509"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.phymed.2024.156131","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T22:48:46Z","timestamp":1728082126000},"page":"156131","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Targeted apoptosis of senescent cells by valproic acid alleviates therapy-induced cellular senescence and lung aging"],"prefix":"10.1016","volume":"135","author":[{"given":"Wentao","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaofan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JiaXiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjiao","family":"Luan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weili","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijuan","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3528-5854","authenticated-orcid":false,"given":"Xingjie","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2024.156131_bib0001","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/s41422-020-0314-9","article-title":"Elimination of senescent cells by \u03b2-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice","volume":"30","author":"Cai","year":"2020","journal-title":"Cell. Res."},{"key":"10.1016\/j.phymed.2024.156131_bib0002","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.3390\/ijms25031792","article-title":"Senotherapeutics to counteract senescent cells are prominent topics in the context of anti-ageing strategies","volume":"25","author":"Calabr\u00f2","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2024.156131_bib0003","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1038\/s41591-022-01923-y","article-title":"Cellular senescence and senolytics: the path to the clinic","volume":"28","author":"Chaib","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.phymed.2024.156131_bib0004","article-title":"ELAVL4 encoded RNA binding protein HuD controls skin cellular senescence through CDKN1A","volume":"33","author":"Chen","year":"2023","journal-title":"Gene. Rep."},{"key":"10.1016\/j.phymed.2024.156131_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155459","article-title":"Investigating the synergy of Shikonin and Valproic acid in inducing apoptosis of osteosarcoma cells via ROS-mediated EGR1 expression","volume":"126","author":"Chen","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2024.156131_bib0006","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s41580-023-00585-z","article-title":"Autophagy and autophagy-related pathways in cancer","volume":"24","author":"Debnath","year":"2023","journal-title":"Nat. Rev. Molecul. Cell. Biol."},{"key":"10.1016\/j.phymed.2024.156131_bib0007","doi-asserted-by":"crossref","first-page":"9363","DOI":"10.1073\/pnas.92.20.9363","article-title":"A biomarker that identifies senescent human cells in culture and in aging skin in vivo","volume":"92","author":"Dimri","year":"1995","journal-title":"Proceed. Natl. Acad. Sci."},{"key":"10.1016\/j.phymed.2024.156131_bib0008","doi-asserted-by":"crossref","first-page":"10352","DOI":"10.3390\/ijms231810352","article-title":"Extraction and concentration of waste pueraria lobata stems with antioxidants and anti-melanogenesis activity as a novel skin whitening agent for natural cosmetic prototypes","volume":"23","author":"Gao","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2024.156131_bib0009","doi-asserted-by":"crossref","first-page":"8105","DOI":"10.3390\/ijms22158105","article-title":"Evaluation of anti-melanogenesis activity of enriched pueraria lobata stem extracts and characterization of its phytochemical components using HPLC\u2013PDA\u2013ESI\u2013MS\/MS","volume":"22","author":"Gao","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2024.156131_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2024.111902","article-title":"Calcium transferring from ER to mitochondria via miR-129\/ITPR2 axis controls cellular senescence in vitro and in vivo","volume":"218","author":"Gao","year":"2024","journal-title":"Mech. Ageing. Dev."},{"key":"10.1016\/j.phymed.2024.156131_bib0011","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.cell.2017.05.015","article-title":"Senescence in health and disease","volume":"169","author":"He","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2024.156131_bib0012","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1080\/15548627.2015.1082024","article-title":"Induction of autophagy by valproic acid enhanced lymphoma cell chemosensitivity through HDAC-independent and IP3-mediated PRKAA activation","volume":"11","author":"Ji","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2024.156131_bib0013","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/s41574-020-0335-y","article-title":"The role of cellular senescence in ageing and endocrine disease","volume":"16","author":"Khosla","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.phymed.2024.156131_bib0014","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1006\/bbrc.2002.6753","article-title":"Differential effects of histone deacetylase inhibitors on interleukin-18 gene expression in myeloid cells","volume":"292","author":"Koyama","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phymed.2024.156131_bib0015","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1101\/gad.1971610","article-title":"The essence of senescence","volume":"24","author":"Kuilman","year":"2010","journal-title":"Genes. Dev."},{"key":"10.1016\/j.phymed.2024.156131_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101737","article-title":"Knockout of PRDX6 induces mitochondrial dysfunction and cell cycle arrest at G2\/M in HepG2 hepatocarcinoma cells","volume":"37","author":"L\u00f3pez-Grueso","year":"2020","journal-title":"Redox. Biol."},{"key":"10.1016\/j.phymed.2024.156131_bib0017","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"L\u00f3pez-Ot\u00edn","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2024.156131_bib0018","doi-asserted-by":"crossref","first-page":"7502","DOI":"10.1523\/JNEUROSCI.0096-06.2006","article-title":"Endogenous alpha-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity","volume":"26","author":"Leng","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phymed.2024.156131_bib0019","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1016\/j.cell.2023.05.003","article-title":"Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones","volume":"186","author":"Liang","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2024.156131_bib0020","doi-asserted-by":"crossref","first-page":"291","DOI":"10.2478\/acph-2020-0021","article-title":"Anticonvulsant valproic acid and other short-chain fatty acids as novel anticancer therapeutics: possibilities and challenges","volume":"70","author":"Lipska","year":"2020","journal-title":"Acta Pharm."},{"key":"10.1016\/j.phymed.2024.156131_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2020.111264","article-title":"Regulation of cellular senescence by microRNAs","volume":"189","author":"Ma","year":"2020","journal-title":"Mech. Ageing. Dev."},{"key":"10.1016\/j.phymed.2024.156131_bib0022","article-title":"Combination of arsenic trioxide and valproic acid efficiently inhibits growth of lung cancer cells via G2\/M-phase arrest and apoptotic cell death","volume":"21","author":"Park","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2024.156131_bib0023","doi-asserted-by":"crossref","first-page":"36734","DOI":"10.1074\/jbc.M101287200","article-title":"Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen","volume":"276","author":"Phiel","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2024.156131_bib0024","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1126\/science.abf3326","article-title":"Sentinel p16 INK4a+ cells in the basement membrane form a reparative niche in the lung","volume":"378","author":"Reyes","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.phymed.2024.156131_bib0025","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.chembiol.2023.10.011","article-title":"Sensitization of cancer cells to ferroptosis coincident with cell cycle arrest","volume":"31","author":"Rodencal","year":"2024","journal-title":"Cell. Chem. Biol."},{"key":"10.1016\/j.phymed.2024.156131_bib0026","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jsps.2022.12.001","article-title":"A comprehensive review on pharmacological applications and drug-induced toxicity of valproic acid","volume":"31","author":"Safdar","year":"2023","journal-title":"Saud. Pharm. J."},{"key":"10.1016\/j.phymed.2024.156131_bib0027","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1101\/gad.235184.113","article-title":"Cellular senescence and its effector programs","volume":"28","author":"Salama","year":"2014","journal-title":"Gene. Dev."},{"key":"10.1016\/j.phymed.2024.156131_bib0028","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.it.2009.05.001","article-title":"An evolutionary perspective on the mechanisms of immunosenescence","volume":"30","author":"Shanley","year":"2009","journal-title":"Trend. Immunol."},{"key":"10.1016\/j.phymed.2024.156131_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2021.111591","article-title":"Strategies for late phase preclinical and early clinical trials of senolytics","volume":"200","author":"Wissler Gerdes","year":"2021","journal-title":"Mech. Ageing. Dev."},{"key":"10.1016\/j.phymed.2024.156131_bib0030","article-title":"Valproic acid neuroprotection in the 6-OHDA model of parkinson's disease is possibly related to its anti-inflammatory and HDAC inhibitory properties","volume":"2015","author":"Ximenes","year":"2015","journal-title":"J. Neurodegener. Dis."},{"key":"10.1016\/j.phymed.2024.156131_bib0031","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1038\/s41591-018-0092-9","article-title":"Senolytics improve physical function and increase lifespan in old age","volume":"24","author":"Xu","year":"2018","journal-title":"Nat. Med."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324007888?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324007888?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T09:04:26Z","timestamp":1762333466000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711324007888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":31,"alternative-id":["S0944711324007888"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2024.156131","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeted apoptosis of senescent cells by valproic acid alleviates therapy-induced cellular senescence and lung aging","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2024.156131","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156131"}}