{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T12:14:35Z","timestamp":1793621675312,"version":"4.5.0"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360871"],"award-info":[{"award-number":["82360871"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260863"],"award-info":[{"award-number":["82260863"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011833","name":"Guangxi University of Chinese Medicine","doi-asserted-by":"publisher","award":["2023WBZR005"],"award-info":[{"award-number":["2023WBZR005"]}],"id":[{"id":"10.13039\/501100011833","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009102","name":"Education Department of Jiangxi Province","doi-asserted-by":"publisher","award":["GJJ190664"],"award-info":[{"award-number":["GJJ190664"]}],"id":[{"id":"10.13039\/501100009102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20232BAB206172"],"award-info":[{"award-number":["20232BAB206172"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20224ACB206043"],"award-info":[{"award-number":["20224ACB206043"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.phymed.2024.156153","type":"journal-article","created":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T11:05:13Z","timestamp":1728731113000},"page":"156153","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Formononetin alleviates ulcerative colitis via reshaping the balance of M1\/M2 macrophage polarization in a gut microbiota-dependent manner"],"prefix":"10.1016","volume":"135","author":[{"given":"Qiuping","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5015-5727","authenticated-orcid":false,"given":"Xiyan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhao","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7243-2038","authenticated-orcid":false,"given":"Shanshan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2855-2811","authenticated-orcid":false,"given":"Duanyong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronghua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2761-8639","authenticated-orcid":false,"given":"Youbao","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2024.156153_bib0001","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/ni.2967","article-title":"Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice","volume":"15","author":"Bain","year":"2014","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.phymed.2024.156153_bib0002","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2022.2028366","article-title":"A specific microbiota signature is associated to various degrees of ulcerative colitis as assessed by a machine learning approach","volume":"14","author":"Barberio","year":"2022","journal-title":"Gut Microbes"},{"key":"10.1016\/j.phymed.2024.156153_bib0003","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202300946","article-title":"Oral delivery of transformable bilirubin self-assembled system for targeted therapy of colitis","volume":"12","author":"Chen","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.phymed.2024.156153_bib0004","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/02648725.2021.1989847","article-title":"Gut-microbiota derived bioactive metabolites and their functions in host physiology","volume":"37","author":"Debnath","year":"2021","journal-title":"Biotechnol. Genet. Eng. Rev."},{"key":"10.1016\/j.phymed.2024.156153_bib0005","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1093\/ibd\/izab029","article-title":"Human intestinal macrophages are involved in the pathology of both ulcerative colitis and crohn disease","volume":"27","author":"Dharmasiri","year":"2021","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.phymed.2024.156153_bib0006","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.gtc.2020.07.005","article-title":"Epidemiology and pathogenesis of ulcerative colitis","volume":"49","author":"Du","year":"2020","journal-title":"Gastroenterol. Clin. North Am."},{"key":"10.1016\/j.phymed.2024.156153_bib0007","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/s41598-021-04098-7","article-title":"CCR2 promotes monocyte recruitment and intestinal inflammation in mice lacking the interleukin-10 receptor","volume":"12","author":"El","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2024.156153_bib0008","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/8075344","article-title":"Traditional Chinese medicine alleviates ulcerative colitis via modulating gut microbiota","volume":"2022","author":"Feng","year":"2022","journal-title":"Evid.-Based Complement Altern. Med."},{"key":"10.1016\/j.phymed.2024.156153_bib0009","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41564-018-0306-4","article-title":"Gut microbiome structure and metabolic activity in inflammatory bowel disease","volume":"4","author":"Franzosa","year":"2019","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.phymed.2024.156153_bib0010","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jaci.2019.11.003","article-title":"The microbiome and inflammatory bowel disease","volume":"145","author":"Glassner","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.phymed.2024.156153_bib0011","doi-asserted-by":"crossref","first-page":"5647","DOI":"10.1074\/jbc.M114.618249","article-title":"Transmission of atherosclerosis susceptibility with gut microbial transplantation","volume":"290","author":"Gregory","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2024.156153_bib0012","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1001\/jama.2023.15389","article-title":"Ulcerative Colitis in adults: a review","volume":"330","author":"Gros","year":"2023","journal-title":"Jama"},{"key":"10.1016\/j.phymed.2024.156153_bib0013","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1019594","article-title":"Protective effect of astragalus membranaceus and its bioactive compounds against the intestinal inflammation in Drosophila","volume":"13","author":"He","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2024.156153_bib0014","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1093\/ecco-jcc\/jjw096","article-title":"Germ-free and Antibiotic-treated mice are highly susceptible to epithelial injury in DSS colitis","volume":"10","author":"Hernandez-Chirlaque","year":"2016","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.phymed.2024.156153_bib0015","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1142\/S0192415X23500684","article-title":"Astragalus membranaceus as a drug candidate for inflammatory bowel disease: the preclinical evidence","volume":"51","author":"Hou","year":"2023","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.phymed.2024.156153_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113394","article-title":"Qingchang Huashi formula attenuates DSS-induced colitis in mice by restoring gut microbiota-metabolism homeostasis and goblet cell function","volume":"266","author":"Hu","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2024.156153_bib0017","doi-asserted-by":"crossref","DOI":"10.3390\/nu14235140","article-title":"Disturbances of the gut microbiota and microbiota-derived metabolites in inflammatory bowel disease","volume":"14","author":"Hu","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2024.156153_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.132580","article-title":"Functional fractions of Astragalus polysaccharides as a potential prebiotic to alleviate ulcerative colitis","volume":"271","author":"Huo","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2024.156153_bib0019","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/3334994","article-title":"Curcumin alleviated dextran sulfate sodium-induced colitis by regulating M1\/M2 macrophage polarization and TLRs signaling pathway","volume":"2021","author":"Kang","year":"2021","journal-title":"Evid.-Based Complement Altern. Med."},{"key":"10.1016\/j.phymed.2024.156153_bib0020","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23169344","article-title":"Inflammatory bowel disease: a review of pre-clinical murine models of human disease","volume":"23","author":"Katsandegwaza","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2024.156153_bib0021","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.161096","article-title":"CLUH functions as a negative regulator of inflammation in human macrophages and determines ulcerative colitis pathogenesis","volume":"8","author":"Khan","year":"2023","journal-title":"JCI Insight"},{"key":"10.1016\/j.phymed.2024.156153_bib0022","doi-asserted-by":"crossref","first-page":"5787","DOI":"10.3748\/wjg.v11.i37.5787","article-title":"Amelioration of experimental colitis by Astragalus membranaceus through anti-oxidation and inhibition of adhesion molecule synthesis","volume":"11","author":"Ko","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.phymed.2024.156153_bib0023","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1136\/gutjnl-2019-318264","article-title":"Anti-TNF therapy in IBD exerts its therapeutic effect through macrophage IL-10 signalling","volume":"69","author":"Koelink","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.phymed.2024.156153_bib0024","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1053\/j.gastro.2022.01.023","article-title":"What does disease progression look like in ulcerative colitis, and how might it be prevented?","volume":"162","author":"Krugliak","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phymed.2024.156153_bib0025","first-page":"564","article-title":"Ulcerative colitis-diagnostic and therapeutic algorithms","volume":"117","author":"Kucharzik","year":"2020","journal-title":"Dtsch. Arztebl. Int."},{"key":"10.1016\/j.phymed.2024.156153_bib0026","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1080\/15548627.2019.1635384","article-title":"New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD","volume":"16","author":"Larabi","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2024.156153_bib0027","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00726-019-02719-0","article-title":"The role of polyamines in the regulation of macrophage polarization and function","volume":"52","author":"Latour","year":"2020","journal-title":"Amino Acids"},{"key":"10.1016\/j.phymed.2024.156153_bib0028","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0140-6736(23)00966-2","article-title":"Ulcerative colitis","volume":"402","author":"Le Berre","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2024.156153_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113517","article-title":"Chemical profile of Xian-He-Cao-Chang-Yan formula and its effects on ulcerative colitis","volume":"267","author":"Li","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2024.156153_bib0030","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.clim.2018.07.018","article-title":"Formononetin attenuated allergic diseases through inhibition of epithelial-derived cytokines by regulating E-cadherin","volume":"195","author":"Li","year":"2018","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.phymed.2024.156153_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154052","article-title":"Huangqin decoction ameliorates DSS-induced ulcerative colitis: role of gut microbiota and amino acid metabolism, mTOR pathway and intestinal epithelial barrier","volume":"100","author":"Li","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2024.156153_bib0032","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.3389\/fphar.2020.01036","article-title":"Kuijieyuan decoction improved intestinal barrier injury of ulcerative colitis by affecting TLR4-dependent PI3K\/AKT\/NF-kappaB oxidative and inflammatory signaling and gut microbiota","volume":"11","author":"Liu","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2024.156153_bib0033","doi-asserted-by":"crossref","first-page":"7506","DOI":"10.1039\/D3FO01929B","article-title":"Salidroside alleviates dextran sulfate sodium-induced colitis in mice by modulating the gut microbiota","volume":"14","author":"Liu","year":"2023","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2024.156153_bib0034","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.3389\/fimmu.2019.01324","article-title":"Fusobacterium nucleatum aggravates the progression of colitis by regulating M1 macrophage polarization via AKT2 pathway","volume":"10","author":"Liu","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2024.156153_bib0035","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1038\/s41418-023-01148-7","article-title":"Deubiquitinase OTUD6A in macrophages promotes intestinal inflammation and colitis via deubiquitination of NLRP3","volume":"30","author":"Liu","year":"2023","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.phymed.2024.156153_bib0036","doi-asserted-by":"crossref","first-page":"5225","DOI":"10.7150\/thno.43716","article-title":"Parthenolide ameliorates colon inflammation through regulating Treg\/Th17 balance in a gut microbiota-dependent manner","volume":"10","author":"Liu","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.phymed.2024.156153_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.174742","article-title":"Ginsenoside Rg1 ameliorated experimental colitis by regulating the balance of M1\/M2 macrophage polarization and the homeostasis of intestinal flora","volume":"917","author":"Long","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2024.156153_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105613","article-title":"Didymin switches M1-like toward M2-like macrophage to ameliorate ulcerative colitis via fatty acid oxidation","volume":"169","author":"Lv","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2024.156153_bib0039","doi-asserted-by":"crossref","DOI":"10.3389\/fnint.2022.908378","article-title":"Formononetin: a pathway to protect neurons","volume":"16","author":"Ma","year":"2022","journal-title":"Front. Integr. Neurosci."},{"key":"10.1016\/j.phymed.2024.156153_bib0040","article-title":"Formononetin: biological effects and uses - a review","volume":"359","author":"Machado","year":"2021","journal-title":"Food Chem."},{"key":"10.1016\/j.phymed.2024.156153_bib0041","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1136\/gutjnl-2015-309990","article-title":"The gut microbiota and host health: a new clinical frontier","volume":"65","author":"Marchesi","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.phymed.2024.156153_bib0042","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrgastro.2017.88","article-title":"Gut microbiota and IBD: causation or correlation?","volume":"14","author":"Ni","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phymed.2024.156153_bib0043","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1365-2036.1988.tb00689.x","article-title":"Inhibition of intestinal macrophage chemotaxis to leukotriene B4 by sulphasalazine, olsalazine, and 5-aminosalicylic acid","volume":"2","author":"Nielsen","year":"1988","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2024.156153_bib0044","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1002\/ibd.20916","article-title":"Increased number and activation of colonic macrophages in pediatric patients with untreated Crohn's disease","volume":"15","author":"Perminow","year":"2009","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.phymed.2024.156153_bib0045","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s40168-022-01458-x","article-title":"Gut microbiota-derived ursodeoxycholic acid alleviates low birth weight-induced colonic inflammation by enhancing M2 macrophage polarization","volume":"11","author":"Pi","year":"2023","journal-title":"Microbiome"},{"key":"10.1016\/j.phymed.2024.156153_bib0046","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1053\/j.gastro.2019.11.294","article-title":"Differences in gut microbiota in patients with vs without inflammatory bowel diseases: a systematic review","volume":"158","author":"Pittayanon","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phymed.2024.156153_bib0047","doi-asserted-by":"crossref","first-page":"6843","DOI":"10.4049\/jimmunol.0903987","article-title":"An independent subset of TLR expressing CCR2-dependent macrophages promotes colonic inflammation","volume":"184","author":"Platt","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.phymed.2024.156153_bib0048","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1080\/08923973.2016.1274997","article-title":"5-Aminosalicylic acid inhibits inflammatory responses by suppressing JNK and p38 activity in murine macrophages","volume":"39","author":"Qu","year":"2017","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.phymed.2024.156153_bib0049","doi-asserted-by":"crossref","first-page":"4053","DOI":"10.3748\/wjg.v28.i30.4053","article-title":"Gut microbiota, inflammatory bowel disease and colorectal cancer","volume":"28","author":"Quaglio","year":"2022","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.phymed.2024.156153_bib0050","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1136\/gut.2009.203554","article-title":"Targeting the proteasome: partial inhibition of the proteasome by bortezomib or deletion of the immunosubunit LMP7 attenuates experimental colitis","volume":"59","author":"Schmidt","year":"2010","journal-title":"Gut"},{"key":"10.1016\/j.phymed.2024.156153_bib0051","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s00005-020-00576-4","article-title":"Current status of M1 and M2 macrophages pathway as drug targets for inflammatory bowel disease","volume":"68","author":"Seyedizade","year":"2020","journal-title":"Arch. Immunol. Ther. Exp. (Warsz)."},{"key":"10.1016\/j.phymed.2024.156153_bib0052","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3748\/wjg.v24.i1.5","article-title":"Relationship between intestinal microbiota and ulcerative colitis: mechanisms and clinical application of probiotics and fecal microbiota transplantation","volume":"24","author":"Shen","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.phymed.2024.156153_bib0053","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.777665","article-title":"Lactic acid-producing probiotic saccharomyces cerevisiae attenuates ulcerative colitis via suppressing macrophage pyroptosis and modulating gut microbiota","volume":"12","author":"Sun","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2024.156153_bib0054","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113280","article-title":"Combination of polysaccharides from Astragalus membranaceus and Codonopsis pilosula ameliorated mice colitis and underlying mechanisms","volume":"264","author":"Tang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2024.156153_bib0055","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1189\/jlb.0113021","article-title":"CD14(hi)HLA-DR(dim) macrophages, with a resemblance to classical blood monocytes, dominate inflamed mucosa in Crohn's disease","volume":"95","author":"Thiesen","year":"2014","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.phymed.2024.156153_bib0056","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.740565","article-title":"Astragaloside IV alleviates the experimental DSS-induced colitis by remodeling macrophage polarization through STAT signaling","volume":"12","author":"Tian","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2024.156153_bib0057","article-title":"Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome","volume":"10","author":"Vich","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.phymed.2024.156153_bib0058","article-title":"A potential therapeutic approach for ulcerative colitis: targeted regulation of macrophage polarization through phytochemicals","volume":"14","author":"Wang","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2024.156153_bib0059","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116879","article-title":"Traditional Chinese medicine: a promising strategy to regulate the imbalance of bacterial flora, impaired intestinal barrier and immune function attributed to ulcerative colitis through intestinal microecology","volume":"318","author":"Wang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2024.156153_bib0060","article-title":"Modified Gegen Qinlian decoction regulates Treg\/Th17 balance to ameliorate DSS-induced acute experimental colitis in mice by altering the gut microbiota","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2024.156153_bib0061","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.106062","article-title":"Inulin alleviates inflammation of alcoholic liver disease via SCFAs-inducing suppression of M1 and facilitation of M2 macrophages in mice","volume":"78","author":"Wang","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2024.156153_bib0062","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1080\/17474124.2021.1840976","article-title":"Epidemiology, burden of disease, and unmet needs in the treatment of ulcerative colitis in Asia","volume":"15","author":"Wei","year":"2021","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phymed.2024.156153_bib0063","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153743","article-title":"Shaoyao decoction attenuates DSS-induced ulcerative colitis, macrophage and NLRP3 inflammasome activation through the MKP1\/NF-kappaB pathway","volume":"92","author":"Wei","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2024.156153_bib0064","article-title":"Formononetin administration ameliorates dextran sulfate sodium-induced acute colitis by inhibiting NLRP3 inflammasome signaling pathway","volume":"2018","author":"Wu","year":"2018","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.phymed.2024.156153_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2023.103062","article-title":"Gut microbiome, metabolome, host immunity associated with inflammatory bowel disease and intervention of fecal microbiota transplantation","volume":"141","author":"Wu","year":"2023","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.phymed.2024.156153_bib0066","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.121312","article-title":"Deferasirox alleviates DSS-induced ulcerative colitis in mice by inhibiting ferroptosis and improving intestinal microbiota","volume":"314","author":"Wu","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2024.156153_bib0067","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1142\/S0192415X23500325","article-title":"Ginseng-containing Sijunzi decoction ameliorates ulcerative colitis by orchestrating gut homeostasis in microbial modulation and intestinal barrier integrity","volume":"51","author":"Wu","year":"2023","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.phymed.2024.156153_bib0068","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.12998\/wjcc.v8.i11.2081","article-title":"Isoflavones and inflammatory bowel disease","volume":"8","author":"Wu","year":"2020","journal-title":"World J. Clin. Cases"},{"key":"10.1016\/j.phymed.2024.156153_bib0069","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms11051203","article-title":"Gut microbiota crosstalk with resident macrophages and their role in invasive amebic colitis and giardiasis-review","volume":"11","author":"Xaplanteri","year":"2023","journal-title":"Microorganisms"},{"key":"10.1016\/j.phymed.2024.156153_bib0070","doi-asserted-by":"crossref","first-page":"e14176","DOI":"10.1016\/j.heliyon.2023.e14176","article-title":"Berberine promotes M2 macrophage polarisation through the IL-4-STAT6 signalling pathway in ulcerative colitis treatment","volume":"9","author":"Xiong","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.phymed.2024.156153_bib0071","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113357","article-title":"Baitouweng decoction alleviates dextran sulfate sodium-induced ulcerative colitis by regulating intestinal microbiota and the IL-6\/STAT3 signaling pathway","volume":"265","author":"Xuan-Qing","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2024.156153_bib0072","article-title":"Wu-Mei-Wan ameliorates murine ulcerative colitis by regulating macrophage polarization","volume":"13","author":"Yan","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2024.156153_bib0073","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1136\/gutjnl-2020-320777","article-title":"Cross-talk between the gut microbiota and monocyte-like macrophages mediates an inflammatory response to promote colitis-associated tumourigenesis","volume":"70","author":"Yang","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.phymed.2024.156153_bib0074","article-title":"A potential therapeutic target in traditional Chinese medicine for ulcerative colitis: macrophage polarization","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2024.156153_bib0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.clinre.2023.102276","article-title":"Bacteroides thetaiotaomicron and its inactivated bacteria ameliorate colitis by inhibiting macrophage activation","volume":"48","author":"Yinhe","year":"2024","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"10.1016\/j.phymed.2024.156153_bib0076","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.153961","article-title":"Pharmacological mechanism of Shenlingbaizhu formula against experimental colitis","volume":"98","author":"Yu","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2024.156153_bib0077","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1038\/s41598-021-81628-3","article-title":"Dysbiosis of gut microbiota in Polish patients with ulcerative colitis: a pilot study","volume":"11","author":"Zakerska-Banaszak","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2024.156153_bib0078","article-title":"Roles of macrophages on ulcerative colitis and colitis-associated colorectal cancer","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2024.156153_bib0079","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1002\/ptr.8087","article-title":"International clinical practice guideline on the use of traditional Chinese medicine for ulcerative colitis by Board of specialty committee of digestive system disease of world federation of Chinese medicine societies (2023)","volume":"38","author":"Zhang","year":"2024","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2024.156153_bib0080","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1186\/s12967-024-05168-w","article-title":"Blockade of PI3K\/AKT signaling pathway by Astragaloside IV attenuates ulcerative colitis via improving the intestinal epithelial barrier","volume":"22","author":"Zhang","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.phymed.2024.156153_bib0081","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1186\/s12967-024-05122-w","article-title":"Short-chain fatty acid-producing bacterial strains attenuate experimental ulcerative colitis by promoting M2 macrophage polarization via JAK\/STAT3\/FOXO3 axis inactivation","volume":"22","author":"Zhao","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.phymed.2024.156153_bib0082","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/s41423-023-01081-2","article-title":"FBXO38 regulates macrophage polarization to control the development of cancer and colitis","volume":"20","author":"Zheng","year":"2023","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.phymed.2024.156153_bib0083","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154287","article-title":"Astragaloside \u2163 alleviates ulcerative colitis by regulating the balance of Th17\/Treg cells","volume":"104","author":"Zhong","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2024.156153_bib0084","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109108","article-title":"Astragalus polysaccharide alleviates ulcerative colitis by regulating the balance of Tfh\/Treg cells","volume":"111","author":"Zhong","year":"2022","journal-title":"Int. Immunopharmacol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324008109?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324008109?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T04:18:43Z","timestamp":1778559523000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711324008109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":84,"alternative-id":["S0944711324008109"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2024.156153","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Formononetin alleviates ulcerative colitis via reshaping the balance of M1\/M2 macrophage polarization in a gut microbiota-dependent manner","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2024.156153","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156153"}}