{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T01:42:50Z","timestamp":1785375770114,"version":"3.55.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012476","name":"Fundamental Research Funds for Central Universities of the Central South University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012476","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018628","name":"Scientific Research Foundation of Education Department of Anhui Province of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018628","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.phymed.2024.156154","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T02:43:23Z","timestamp":1729651403000},"page":"156154","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Benzoylmesaconine mitigates NLRP3 inflammasome-related diseases by reducing intracellular K+ efflux and disrupting NLRP3 inflammasome assembly"],"prefix":"10.1016","volume":"135","author":[{"given":"Zhongyun","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilu","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoxiang","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhui","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiqun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xukun","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijin","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohua","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6241-5573","authenticated-orcid":false,"given":"Zhou","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4318-3033","authenticated-orcid":false,"given":"Lvyi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2024.156154_bib0001","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1136\/gut.2009.197822","article-title":"Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome","volume":"59","author":"Bauer","year":"2010","journal-title":"Gut"},{"key":"10.1016\/j.phymed.2024.156154_bib0002","doi-asserted-by":"crossref","first-page":"787","DOI":"10.4049\/jimmunol.0901363","article-title":"Cutting edge: nF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression","volume":"183","author":"Bauernfeind","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.phymed.2024.156154_bib0003","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1038\/s41401-020-00603-2","article-title":"NOD-like receptors in autoimmune diseases","volume":"42","author":"Chen","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2024.156154_bib0004","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1093\/jmcb\/mjy056","article-title":"GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity","volume":"11","author":"Chen","year":"2019","journal-title":"J. Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2024.156154_bib0005","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/s41422-020-0295-8","article-title":"Toward targeting inflammasomes: insights into their regulation and activation","volume":"30","author":"Christgen","year":"2020","journal-title":"Cell Res"},{"key":"10.1016\/j.phymed.2024.156154_bib0006","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1021\/acsptsci.0c00133","article-title":"Simultaneous determination of six alkaloids in rat plasma by SPE-HPLC-MS\/MS and their pharmacokinetics after oral administration of radix aconiti preparata extract","volume":"4","author":"Fan","year":"2021","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"10.1016\/j.phymed.2024.156154_bib0008","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-immunol-081022-021207","article-title":"Structural Mechanisms of NLRP3 Inflammasome Assembly and Activation","volume":"41","author":"Fu","year":"2023","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.phymed.2024.156154_bib0009","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.immuni.2016.08.010","article-title":"K(+) efflux-independent NLRP3 inflammasome activation by small molecules targeting mitochondria","volume":"45","author":"Gro\u00df","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.phymed.2024.156154_bib0010","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1038\/s41467-017-02351-0","article-title":"Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis","volume":"8","author":"Guo","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2024.156154_bib0011","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.intimp.2014.12.009","article-title":"Asiatic acid ameliorates dextran sulfate sodium-induced murine experimental colitis via suppressing mitochondria-mediated NLRP3 inflammasome activation","volume":"24","author":"Guo","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2024.156154_bib0012","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1021\/np300225t","article-title":"Diterpenoid alkaloids from the lateral root of Aconitum carmichaelii","volume":"75","author":"Jiang","year":"2012","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phymed.2024.156154_bib0013","doi-asserted-by":"crossref","first-page":"14867","DOI":"10.1073\/pnas.1111101108","article-title":"NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy","volume":"108","author":"Jin","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.phymed.2024.156154_bib0014","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/cmi.2015.95","article-title":"Molecular mechanisms regulating NLRP3 inflammasome activation","volume":"13","author":"Jo","year":"2016","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.phymed.2024.156154_bib0015","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1046\/j.1440-1711.1998.00736.x","article-title":"The regulation of burn-associated infections with herpes simplex virus type 1 or Candida albicans by a non-toxic aconitine-hydrolysate, benzoylmesaconine. Part 2: mechanism of the antiviral action","volume":"76","author":"Kobayashi","year":"1998","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.phymed.2024.156154_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175091","article-title":"Therapeutic potential of MCC950, a specific inhibitor of NLRP3 inflammasome","volume":"928","author":"Li","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2024.156154_bib0017","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.jep.2016.10.052","article-title":"Identification of NF-\u03baB inhibitors following Shenfu injection and bioactivity-integrated UPLC\/Q-TOF-MS and screening for related anti-inflammatory targets in vitro and in silico","volume":"194","author":"Li","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2024.156154_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115879","article-title":"Neoline, fuziline, songorine and 10-OH mesaconitine are potential quality markers of Fuzi: in vitro and in vivo explorations as well as pharmacokinetics, efficacy and toxicity evaluations","volume":"303","author":"Li","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2024.156154_bib0019","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.580593","article-title":"Gallic acid alleviates gouty arthritis by inhibiting NLRP3 inflammasome activation and pyroptosis through enhancing Nrf2 signaling","volume":"11","author":"Lin","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2024.156154_bib0020","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.752482","article-title":"The ASC speck and NLRP3 inflammasome function are spatially and temporally distinct","volume":"12","author":"Nagar","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2024.156154_bib0021","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/s41423-021-00670-3","article-title":"An update on the regulatory mechanisms of NLRP3 inflammasome activation","volume":"18","author":"Paik","year":"2021","journal-title":"Cell Mol. Immunol."},{"key":"10.1016\/j.phymed.2024.156154_bib0022","article-title":"Regulation of the NLRP3 inflammasome by post-translational modifications and small molecules","volume":"11","author":"Seok","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2024.156154_bib0023","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41586-019-1295-z","article-title":"Structural Mechanism for Nek7-Licensed Activation of Nlrp3 Inflammasome","volume":"570","author":"Sharif","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2024.156154_bib0024","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1254\/fpj.102.399","article-title":"Analgesic effect of benzoylmesaconine","volume":"102","author":"Suzuki","year":"1993","journal-title":"Nihon Yakurigaku Zasshi"},{"key":"10.1016\/j.phymed.2024.156154_bib0025","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 inflammasome: molecular activation and regulation to therapeutics","volume":"19","author":"Swanson","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.phymed.2024.156154_bib0026","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/s41467-017-00227-x","article-title":"CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation","volume":"8","author":"Tang","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.phymed.2024.156154_bib0027","doi-asserted-by":"crossref","first-page":"eabj3859","DOI":"10.1126\/sciimmunol.abj3859","article-title":"NLRP3 inflammasome activation triggers gasdermin D-independent inflammation","volume":"6","author":"Wang","year":"2021","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.phymed.2024.156154_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2020.100889","article-title":"The NLRP3 inflammasome: mechanism of action, role in disease and therapies","volume":"76","author":"Wang","year":"2020","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.phymed.2024.156154_bib0029","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jchromb.2008.08.008","article-title":"Simultaneous quantitation of aconitine, mesaconitine, hypaconitine, benzoylaconine, benzoylmesaconine and benzoylhypaconine in human plasma by liquid chromatography-tandem mass spectrometry and pharmacokinetics evaluation of \"SHEN-FU\" injectable powder","volume":"873","author":"Zhang","year":"2008","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.phymed.2024.156154_bib0030","article-title":"A novel modulator of the renin-angiotensin system, benzoylaconitine, attenuates hypertension by targeting ace\/ace2 in enhancing vasodilation and alleviating vascular inflammation","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2024.156154_bib0031","article-title":"Anti-inflammatory mechanism of action of benzoylmesaconine in lipopolysaccharide-stimulated RAW264.7 Cells Evid Based","volume":"2022","author":"Zhou","year":"2022","journal-title":"Complement Alternat Med"},{"key":"10.1016\/j.phymed.2024.156154_bib0032","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jep.2014.11.043","article-title":"A review on phytochemistry and pharmacological activities of the processed lateral root of Aconitum carmichaelii Debeaux","volume":"160","author":"Zhou","year":"2015","journal-title":"J Ethnopharmacol"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324008110?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324008110?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T02:41:10Z","timestamp":1747968070000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711324008110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":31,"alternative-id":["S0944711324008110"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2024.156154","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Benzoylmesaconine mitigates NLRP3 inflammasome-related diseases by reducing intracellular K+ efflux and disrupting NLRP3 inflammasome assembly","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2024.156154","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156154"}}