{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:37:12Z","timestamp":1787679432316,"version":"build-2784847793"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004863","name":"Zhejiang Chinese Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004863","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204918"],"award-info":[{"award-number":["82204918"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.phymed.2024.156168","type":"journal-article","created":{"date-parts":[[2024,10,20]],"date-time":"2024-10-20T02:09:43Z","timestamp":1729390183000},"page":"156168","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["The volatile oil of Acorus tatarinowii Schott ameliorates Alzheimer's disease through improving insulin resistance via activating the PI3K\/AKT pathway"],"prefix":"10.1016","volume":"135","author":[{"given":"Junhao","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenshi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liting","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2024.156168_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111684","article-title":"Phycocyanin alleviates ICV-STZ induced cognitive and molecular deficits via PI3-Kinase dependent pathway","volume":"145","author":"Agrawal","year":"2020","journal-title":"Food Chem. Toxicol.: Int. J. Published Brit. Ind. Biol. Res. Assoc."},{"key":"10.1016\/j.phymed.2024.156168_bib0002","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1080\/00325481.2024.2360887","article-title":"The interaction between insulin resistance and Alzheimer's disease: a review article","volume":"136","author":"Albar","year":"2024","journal-title":"Postgrad. Med."},{"key":"10.1016\/j.phymed.2024.156168_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2023.105326","article-title":"Evidence of disturbed insulin signaling in animal models of Alzheimer's disease","volume":"152","author":"Alves","year":"2023","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.phymed.2024.156168_bib0004","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cca.2022.12.016","article-title":"Insulin resistance in Alzheimer's disease: the genetics and metabolomics links","volume":"539","author":"Amin","year":"2023","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.phymed.2024.156168_bib0005","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1007\/s12035-018-1231-5","article-title":"Biliverdin Reductase-a Mediates the Beneficial Effects of Intranasal Insulin in Alzheimer Disease","volume":"56","author":"Barone","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phymed.2024.156168_bib0006","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10081923","article-title":"Falling short: the contribution of central insulin receptors to gait dysregulation in brain aging","volume":"10","author":"Case","year":"2022","journal-title":"Biomedicines."},{"key":"10.1016\/j.phymed.2024.156168_bib0007","doi-asserted-by":"crossref","first-page":"897","DOI":"10.3233\/JAD-141791","article-title":"Long-acting intranasal insulin detemir improves cognition for adults with mild cognitive impairment or early-stage Alzheimer's disease dementia","volume":"44","author":"Claxton","year":"2015","journal-title":"J. Alzheimer's Dis.: JAD"},{"key":"10.1016\/j.phymed.2024.156168_bib0008","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.3233\/JAD-161256","article-title":"Effects of regular and long-acting insulin on cognition and Alzheimer's disease biomarkers: a pilot clinical trial","volume":"57","author":"Craft","year":"2017","journal-title":"J. Alzheimer's Dis.: JAD"},{"key":"10.1016\/j.phymed.2024.156168_bib0009","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.lfs.2019.05.046","article-title":"Asarone and metformin delays experimentally induced hepatocellular carcinoma in diabetic milieu","volume":"230","author":"Das","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2024.156168_bib0010","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.freeradbiomed.2022.09.032","article-title":"Altered glucose metabolism in Alzheimer's disease: role of mitochondrial dysfunction and oxidative stress","volume":"193","author":"Dewanjee","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2024.156168_bib0011","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.666502","article-title":"Enhancement of insulin\/PI3K\/Akt signaling pathway and modulation of Gut Microbiome by probiotics fermentation technology, a Kefir grain product, in sporadic Alzheimer's disease model in mice","volume":"12","author":"El Sayed","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2024.156168_bib0013","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/WNR.0000000000001406","article-title":"Rats with prenatal dexamethasone exposure and postnatal high-fat diet exhibited insulin resistance, and spatial learning and memory impairment: effects of enriched environment","volume":"31","author":"Hsu","year":"2020","journal-title":"Neuroreport"},{"key":"10.1016\/j.phymed.2024.156168_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103104","article-title":"Inhibition of MST1 ameliorates neuronal apoptosis via GSK3\u03b2\/\u03b2-TrCP\/NRF2 pathway in spinal cord injury accompanied by diabetes","volume":"71","author":"Huang","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.phymed.2024.156168_bib0015","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S1474-4422(19)30290-X","article-title":"Dementia in China: epidemiology, clinical management, and research advances","volume":"19","author":"Jia","year":"2020","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.phymed.2024.156168_bib0016","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s10020-023-00718-2","article-title":"Exendin-4 ameliorates tau hyperphosphorylation and cognitive impairment in type 2 diabetes through acting on Wnt\/\u03b2-catenin\/NeuroD1 pathway","volume":"29","author":"Kang","year":"2023","journal-title":"Mol. Med."},{"key":"10.1016\/j.phymed.2024.156168_bib0017","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1002\/oby.23761","article-title":"Insulin resistance, cognition, and Alzheimer disease","volume":"31","author":"Kim","year":"2023","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.phymed.2024.156168_bib0018","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/s41398-020-01166-w","article-title":"Lower functional hippocampal redundancy in mild cognitive impairment","volume":"11","author":"Langella","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.phymed.2024.156168_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2021.173273","article-title":"Object recognition and Morris water maze to detect cognitive impairment from mild hippocampal damage in rats: a reflection based on the literature and experience","volume":"210","author":"Lissner","year":"2021","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.phymed.2024.156168_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154594","article-title":"Inhibition of GluN2B pathway is involved in the neuroprotective effect of silibinin on streptozotocin-induced Alzheimer's disease models","volume":"109","author":"Liu","year":"2023","journal-title":"Phytomedicine: Int. J. Phytother. Phytopharmacol."},{"key":"10.1016\/j.phymed.2024.156168_bib0021","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.cell.2019.09.001","article-title":"Alzheimer disease: an update on pathobiology and treatment strategies","volume":"179","author":"Long","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2024.156168_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.104755","article-title":"ApoE and cerebral insulin: trafficking, receptors, and resistance","volume":"137","author":"Rhea","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.phymed.2024.156168_bib0023","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3233\/JAD-2005-7107","article-title":"Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease\u2013is this type 3 diabetes?","volume":"7","author":"Steen","year":"2005","journal-title":"J. Alzheimer's Dis.: JAD"},{"key":"10.1016\/j.phymed.2024.156168_bib0024","first-page":"1063","article-title":"Mechanisms of dexamethasone-induced insulin resistance in healthy humans","volume":"79","author":"Tappy","year":"1994","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.phymed.2024.156168_bib0025","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.phrs.2015.12.003","article-title":"\u03b2-Asarone modulate adipokines and attenuates high fat diet-induced metabolic abnormalities in Wistar rats","volume":"103","author":"Thakare","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2024.156168_bib0026","article-title":"Acorus tatarinowii Schott: a review of its botany, traditional uses, phytochemistry, and pharmacology","volume":"28","author":"Wang","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2024.156168_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115057","article-title":"Network pharmacology integrated with experimental validation reveals the regulatory mechanism of action of Hehuan Yin decoction in polycystic ovary syndrome with insulin resistance","volume":"289","author":"Wu","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2024.156168_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112548","article-title":"Polyphenols isolated from lychee seed inhibit Alzheimer's disease-associated Tau through improving insulin resistance via the IRS-1\/PI3K\/Akt\/GSK-3\u03b2 pathway","volume":"251","author":"Xiong","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2024.156168_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154695","article-title":"Essential oil of Acorus tatarinowii Schott inhibits neuroinflammation by suppressing NLRP3 inflammasome activation in 3 \u00d7 Tg-AD transgenic mice","volume":"112","author":"Xu","year":"2023","journal-title":"Phytomedicine: Int. J. Phytother. Phytopharmacol."},{"key":"10.1016\/j.phymed.2024.156168_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2022.173402","article-title":"\u03b17nAChR activation protects against oxidative stress, neuroinflammation and central insulin resistance in ICV-STZ induced sporadic Alzheimer's disease","volume":"217","author":"Yamini","year":"2022","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.phymed.2024.156168_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173612","article-title":"Neuroprotective effects of vildagliptin on drug induced Alzheimer's disease in rats with metabolic syndrome: role of hippocampal klotho and AKT signaling pathways","volume":"889","author":"Yossef","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2024.156168_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.111967","article-title":"Bioactivities of serotonin transporter mediate antidepressant effects of Acorus tatarinowii Schott","volume":"241","author":"Zhang","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2024.156168_bib0033","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41392-024-01911-3","article-title":"Recent advances in Alzheimer's disease: mechanisms, clinical trials and new drug development strategies","volume":"9","author":"Zhang","year":"2024","journal-title":"Signal. Transduct. Target. Ther."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324008250?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324008250?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T02:42:06Z","timestamp":1747968126000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711324008250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":32,"alternative-id":["S0944711324008250"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2024.156168","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The volatile oil of Acorus tatarinowii Schott ameliorates Alzheimer's disease through improving insulin resistance via activating the PI3K\/AKT pathway","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2024.156168","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156168"}}