{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:56:18Z","timestamp":1793141778374,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304896"],"award-info":[{"award-number":["82304896"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.phymed.2024.156170","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T13:16:53Z","timestamp":1730121413000},"page":"156170","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Kaixinsan regulates neuronal mitochondrial homeostasis to improve the cognitive function of Alzheimer's disease by activating CaMKK\u03b2-AMPK-PGC-1\u03b1 signaling axis"],"prefix":"10.1016","volume":"135","author":[{"given":"Jiale","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beibei","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dehou J\u00e9suton","family":"Ren\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiying","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2024.156170_bib0001","article-title":"Development of white cabbage, coffee, and red onion extracts as natural phosphodiesterase-4B (PDE4B) inhibitors for cognitive dysfunction: in vitro and in silicostudies","volume":"2024","author":"Ahmad","year":"2024","journal-title":"Adv. Pharmacol. Pharmaceut. Sci."},{"issue":"12","key":"10.1016\/j.phymed.2024.156170_bib0002","doi-asserted-by":"crossref","first-page":"8420","DOI":"10.1007\/s12035-019-01680-z","article-title":"Neurotrophic factors mediated activation of astrocytes ameliorate memory loss by amyloid clearance after transplantation of lineage negative stem cells","volume":"56","author":"Bali","year":"2019","journal-title":"Mol. Neurobiol."},{"issue":"3","key":"10.1016\/j.phymed.2024.156170_bib0003","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.nano.2016.10.004","article-title":"Neuronal protection against oxidative insult by polyanhydride nanoparticle-based mitochondria-targeted antioxidant therapy","volume":"13","author":"Brenza","year":"2017","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"issue":"1","key":"10.1016\/j.phymed.2024.156170_bib0004","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1038\/s41467-020-16074-2","article-title":"Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer's disease","volume":"11","author":"Calvo-Rodriguez","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2024.156170_bib0005","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ejphar.2016.11.006","article-title":"Ginsenoside Re reduces A\u03b2 production by activating PPAR\u03b3 to inhibit BACE1 in N2a\/APP695 cells","volume":"793","author":"Cao","year":"2016","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.phymed.2024.156170_bib0006","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.cell.2023.11.029","article-title":"APOE3ch alters microglial response and suppresses A\u03b2-induced tau seeding and spread","volume":"187","author":"Chen","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2024.156170_bib0007","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jchromb.2016.02.007","article-title":"Metabolomics approach to explore the effects of Kai-Xin-San on Alzheimer's disease using UPLC\/ESI-Q-TOF mass spectrometry","volume":"1015-1016","author":"Chu","year":"2016","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"issue":"4","key":"10.1016\/j.phymed.2024.156170_bib0008","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1111\/jfbc.13644","article-title":"Potential neuroprotective activity of Mentha longifolia L. in aluminum chloride-induced rat model of Alzheimer's disease","volume":"45","author":"Elshamy","year":"2021","journal-title":"J. Food Biochem."},{"key":"10.1016\/j.phymed.2024.156170_bib0009","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.biochi.2021.11.008","article-title":"Role of AMPK mediated pathways in autophagy and aging","volume":"195","author":"Ge","year":"2022","journal-title":"Biochimie"},{"issue":"11","key":"10.1016\/j.phymed.2024.156170_bib0010","doi-asserted-by":"crossref","first-page":"6598","DOI":"10.1007\/s12035-023-03505-6","article-title":"Rutaecarpine Mitigates Cognitive Impairment by Balancing Mitochondrial Function Through Activation of the AMPK\/PGC1\u03b1 Pathway","volume":"60","author":"Gong","year":"2023","journal-title":"Mol. Neurobiol."},{"issue":"7","key":"10.1016\/j.phymed.2024.156170_bib0011","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1007\/s11011-021-00750-3","article-title":"Flavonoids modulate AMPK\/PGC-1\u03b1 and interconnected pathways toward potential neuroprotective activities","volume":"36","author":"Gravandi","year":"2021","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.phymed.2024.156170_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102848","article-title":"Protective effects of luteolin against amyloid beta-induced oxidative stress and mitochondrial impairments through peroxisome proliferator-activated receptor \u03b3-dependent mechanism in Alzheimer's disease","volume":"66","author":"He","year":"2023","journal-title":"Redox. Biol."},{"issue":"1","key":"10.1016\/j.phymed.2024.156170_bib0013","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.1038\/s41467-019-11813-6","article-title":"Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer's disease","volume":"10","author":"Jadiya","year":"2019","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.phymed.2024.156170_bib0014","doi-asserted-by":"crossref","first-page":"e12696","DOI":"10.1111\/cpr.12696","article-title":"Mechanisms of Panax ginseng action as an antidepressant","volume":"52","author":"Jin","year":"2019","journal-title":"Cell Prolif."},{"key":"10.1016\/j.phymed.2024.156170_bib0015","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.bbrc.2023.02.076","article-title":"The mitochondria-targeted small molecule SS31 delays progression of behavioral deficits by attenuating \u03b2-amyloid plaque formation and mitochondrial\/synaptic deterioration in APP\/PS1 mice","volume":"658","author":"Jia","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phymed.2024.156170_bib0016","doi-asserted-by":"crossref","DOI":"10.1177\/17590914231159226","article-title":"Thioredoxin-1 promotes mitochondrial biogenesis through regulating AMPK\/Sirt1\/PGC1\u03b1 pathway in Alzheimer's Disease","volume":"15","author":"Jia","year":"2023","journal-title":"ASN neuro"},{"key":"10.1016\/j.phymed.2024.156170_bib0017","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.lfs.2018.11.035","article-title":"Tilianin mediates neuroprotection against ischemic injury by attenuating CaMKII-dependent mitochondrion-mediated apoptosis and MAPK\/NF-\u03baB signaling","volume":"216","author":"Jiang","year":"2019","journal-title":"Life Sci."},{"issue":"14","key":"10.1016\/j.phymed.2024.156170_bib0018","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1089\/ars.2016.6905","article-title":"Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice","volume":"27","author":"Langley","year":"2017","journal-title":"Antioxid. Redox Signaling"},{"issue":"1","key":"10.1016\/j.phymed.2024.156170_bib0019","doi-asserted-by":"crossref","first-page":"4444","DOI":"10.1038\/s41467-022-32130-5","article-title":"A\u03b242 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy","volume":"13","author":"Lee","year":"2022","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.phymed.2024.156170_bib0020","doi-asserted-by":"crossref","first-page":"e14878","DOI":"10.1111\/cns.14878","article-title":"Honokiol relieves hippocampal neuronal damage in Alzheimer's disease by activating the SIRT3-mediated mitochondrial autophagy","volume":"30","author":"Li","year":"2024","journal-title":"CNS Neurosci. Ther."},{"issue":"10","key":"10.1016\/j.phymed.2024.156170_bib0021","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1055\/a-2014-6061","article-title":"Network pharmacology and mechanism studies of the protective effect of ginseng against Alzheimer's disease based on A\u03b2 pathogenesis","volume":"89","author":"Liu","year":"2023","journal-title":"Planta Med."},{"key":"10.1016\/j.phymed.2024.156170_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102697","article-title":"Acetylated tau exacerbates learning and memory impairment by disturbing with mitochondrial homeostasis","volume":"62","author":"Liu","year":"2023","journal-title":"Redox. Biol."},{"key":"10.1016\/j.phymed.2024.156170_bib0023","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jep.2016.10.002","article-title":"Kai Xin San aqueous extract improves A\u03b21-40-induced cognitive deficits on adaptive behavior learning by enhancing memory-related molecules expression in the hippocampus","volume":"201","author":"Lu","year":"2017","journal-title":"J. Ethnopharmacol."},{"issue":"4","key":"10.1016\/j.phymed.2024.156170_bib0024","doi-asserted-by":"crossref","first-page":"698","DOI":"10.3892\/mmr.2021.12337","article-title":"Ginsenoside Re exhibits neuroprotective effects by inhibiting neuroinflammation via CAMK\/MAPK\/NF\u03baB signaling in microglia","volume":"24","author":"Madhi","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.phymed.2024.156170_bib0025","article-title":"Ginsenoside-Re inhibits experimental autoimmune encephalomyelitis as a mouse model of multiple sclerosis by downregulating TLR4\/MyD88\/NF-\u03baB signaling pathways","volume":"122","author":"Oh","year":"2024","journal-title":"Phytomed. Int. J Phytother. Phytopharmacol."},{"key":"10.1016\/j.phymed.2024.156170_bib0026","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.bbi.2017.12.009","article-title":"Metformin treatment prevents amyloid plaque deposition and memory impairment in APP\/PS1 mice","volume":"69","author":"Ou","year":"2018","journal-title":"Brain Behav. Immun."},{"issue":"2","key":"10.1016\/j.phymed.2024.156170_bib0027","doi-asserted-by":"crossref","first-page":"eaau6328","DOI":"10.1126\/sciadv.aau6328","article-title":"Sodium rutin ameliorates Alzheimer's disease-like pathology by enhancing microglial amyloid-\u03b2 clearance","volume":"5","author":"Pan","year":"2019","journal-title":"Sci. Adv."},{"issue":"6","key":"10.1016\/j.phymed.2024.156170_bib0028","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1007\/s13311-023-01441-w","article-title":"Paradigm shift: multiple potential pathways to neurodegenerative dementia","volume":"20","author":"Perna","year":"2023","journal-title":"Neurother. J. Am. Soc. Exp. NeuroTherap."},{"issue":"8","key":"10.1016\/j.phymed.2024.156170_bib0029","doi-asserted-by":"crossref","first-page":"735","DOI":"10.2174\/1567205017666201111120919","article-title":"Curcumin prevents neuroinflammation by inducing microglia to transform into the M2-phenotype via CaMKK\u03b2-dependent activation of the AMP-activated protein kinase signal pathway","volume":"17","author":"Qiao","year":"2020","journal-title":"Curr. Alzheimer Res."},{"issue":"D1","key":"10.1016\/j.phymed.2024.156170_bib0030","doi-asserted-by":"crossref","first-page":"D1541","DOI":"10.1093\/nar\/gkaa1011","article-title":"MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations","volume":"49","author":"Rath","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"11","key":"10.1016\/j.phymed.2024.156170_bib0031","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0962-8924(98)01363-4","article-title":"The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease","volume":"8","author":"Selkoe","year":"1998","journal-title":"Trends Cell Biol."},{"issue":"7684","key":"10.1016\/j.phymed.2024.156170_bib0032","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nature25143","article-title":"Enhancing mitochondrial proteostasis reduces amyloid-\u03b2 proteotoxicity","volume":"552","author":"Sorrentino","year":"2017","journal-title":"Nature"},{"issue":"19","key":"10.1016\/j.phymed.2024.156170_bib0033","doi-asserted-by":"crossref","first-page":"11025","DOI":"10.3390\/ijms231911025","article-title":"Molecular mechanisms underlying Ca2+\/calmodulin-dependent protein kinase kinase signal transduction","volume":"23","author":"Tokumitsu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.phymed.2024.156170_bib0034","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00401-020-02234-7","article-title":"Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer's disease models and human brains","volume":"141","author":"Vaillant-Beuchot","year":"2021","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.phymed.2024.156170_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.129381","article-title":"Mitigation of honokiol on fluoride-induced mitochondrial oxidative stress, mitochondrial dysfunction, and cognitive deficits through activating AMPK\/PGC-1\u03b1\/Sirt3","volume":"437","author":"Wang","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.phymed.2024.156170_bib0036","first-page":"371","article-title":"Rapid discovery of quality-markers from Kaixin San using chinmedomics analysis approach","volume":"54","author":"Wang","year":"2019","journal-title":"Phytomed. Int. J. Phytother. Phytopharmacol."},{"issue":"3","key":"10.1016\/j.phymed.2024.156170_bib0037","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1089\/rej.2022.0063","article-title":"Kai-xin-san improves cognitive impairment via wnt\/\u03b2-catenin and IRE1\/XBP1s signalings in APP\/PS1 Mice","volume":"26","author":"Xu","year":"2023","journal-title":"Rejuvenation Res."},{"issue":"5","key":"10.1016\/j.phymed.2024.156170_bib0038","doi-asserted-by":"crossref","first-page":"794","DOI":"10.4103\/1673-5374.249227","article-title":"Kai Xin San ameliorates scopolamine-induced cognitive dysfunction","volume":"14","author":"Xu","year":"2019","journal-title":"Neural Regenerat. Res."},{"key":"10.1016\/j.phymed.2024.156170_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117915","article-title":"Exploring the anti-ferroptosis mechanism of Kai-Xin-San against Alzheimer's disease through integrating network pharmacology, bioinformatics, and experimental validation strategy in vivo and in vitro","volume":"326","author":"Yan","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2024.156170_bib0040","first-page":"91","article-title":"Mitochondrial homeostasis is involved in inhibiting hippocampus neuronal apoptosis during ZSWF ameliorate the cognitive dysfunction of SAMP8 mice","author":"Yang","year":"2022","journal-title":"J. Funct. Foods"},{"issue":"1","key":"10.1016\/j.phymed.2024.156170_bib0041","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1080\/13880209.2020.1817103","article-title":"Integrated meta-analysis, network pharmacology, and molecular docking to investigate the efficacy and potential pharmacological mechanism of Kai-Xin-San on Alzheimer's disease","volume":"58","author":"Yi","year":"2020","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.phymed.2024.156170_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcn.2019.103409","article-title":"The mitochondria-targeted antioxidant MitoQ inhibits memory loss, neuropathology, and extends lifespan in aged 3xTg-AD mice","volume":"101","author":"Young","year":"2019","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.phymed.2024.156170_bib0043","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.neuroscience.2020.12.026","article-title":"Alpha-asarone improves cognitive function of APP\/PS1 mice and reducing A\u03b242, P-tau and neuroinflammation, and promoting neuron survival in the hippocampus","volume":"458","author":"Zeng","year":"2021","journal-title":"Neuroscience"},{"key":"10.1016\/j.phymed.2024.156170_bib0044","article-title":"Kaixin-San improves A\u03b2-induced synaptic plasticity inhibition by affecting the expression of regulation proteins associated with postsynaptic AMPAR expression","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"22","key":"10.1016\/j.phymed.2024.156170_bib0045","doi-asserted-by":"crossref","first-page":"10097","DOI":"10.1039\/D3FO03987K","article-title":"Fermented soybean foods (natto) ameliorate age-related cognitive decline by hippocampal TAAR1-mediated activation of the CaMKII\/CREB\/BDNF signaling pathway in senescence-accelerated mouse prone 8 (SAMP8)","volume":"14","author":"Zheng","year":"2023","journal-title":"Food Function"},{"issue":"6","key":"10.1016\/j.phymed.2024.156170_bib0046","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.gendis.2020.12.006","article-title":"PGC-1\u03b1 promotes mitochondrial respiration and biogenesis during the differentiation of hiPSCs into cardiomyocytes","volume":"8","author":"Zhou","year":"2020","journal-title":"Genes Dis."},{"key":"10.1016\/j.phymed.2024.156170_bib0047","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.jep.2016.08.013","article-title":"Kai-Xin-San, a traditional Chinese medicine formula, induces neuronal differentiation of cultured PC12 cells: Modulating neurotransmitter regulation enzymes and potentiating NGF inducing neurite outgrowth","volume":"193","author":"Zhu","year":"2016","journal-title":"J. Ethnopharmacol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324008274?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324008274?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T09:00:56Z","timestamp":1762333256000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711324008274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":47,"alternative-id":["S0944711324008274"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2024.156170","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Kaixinsan regulates neuronal mitochondrial homeostasis to improve the cognitive function of Alzheimer's disease by activating CaMKK\u03b2-AMPK-PGC-1\u03b1 signaling axis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2024.156170","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156170"}}