{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T15:13:29Z","timestamp":1790090009793,"version":"4.0.1"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.phymed.2024.156198","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T12:11:05Z","timestamp":1730981465000},"page":"156198","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Efficacy and safety of yangxinshi versus trimetazidine on exercise tolerance in patients with coronary heart disease after percutaneous coronary intervention: Multicenter, double-blind clinical trial"],"prefix":"10.1016","volume":"135","author":[{"given":"Yang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haichu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaling","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2024.156198_bib0002","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0140-6736(17)32714-9","article-title":"Percutaneous coronary intervention in stable angina (ORBITA): a double-blind, randomised controlled trial","volume":"391","author":"Al-Lamee","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2024.156198_bib0003","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1097\/HJR.0b013e328304feec","article-title":"Trimetazidine potentiates the effects of exercise training in patients with ischemic cardiomyopathy referred for cardiac rehabilitation","volume":"15","author":"Belardinelli","year":"2008","journal-title":"Eur. J. Cardiovasc. Prev. Rehabil."},{"key":"10.1016\/j.phymed.2024.156198_bib0004","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.jep.2017.12.011","article-title":"Network pharmacology-based strategy for predicting active ingredients and potential targets of Yangxinshi tablet for treating heart failure","volume":"219","author":"Chen","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2024.156198_bib0005","first-page":"241","article-title":"Long-term Management of Patients with Myocardial Infarction: an Updated Review","volume":"2","author":"Chen","year":"2022","journal-title":"Cardiol. Discov."},{"key":"10.1016\/j.phymed.2024.156198_bib0006","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1001\/jamacardio.2018.4847","article-title":"Effect of Trimetazidine Dihydrochloride Therapy on Exercise Capacity in Patients With Nonobstructive Hypertrophic Cardiomyopathy: a Randomized Clinical Trial","volume":"4","author":"Coats","year":"2019","journal-title":"JAMa Cardiol."},{"key":"10.1016\/j.phymed.2024.156198_bib0007","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s10654-018-0454-0","article-title":"Incidence of cardiovascular events in patients with stabilized coronary heart disease: the EUROASPIRE IV follow-up study","volume":"34","author":"De Bacquer","year":"2019","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.phymed.2024.156198_bib0008","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1111\/imj.15394","article-title":"Real-world estimate of the value of one metabolic equivalent in a population of patients planning major surgery","volume":"52","author":"Douglas","year":"2022","journal-title":"Intern. Med. J."},{"key":"10.1016\/j.phymed.2024.156198_bib0009","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.4114","article-title":"Metabolic analysis of the antidepressive effects of Yangxinshi Tablet in a vascular depression model in mice","volume":"32","author":"Du","year":"2018","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.phymed.2024.156198_bib0010","first-page":"696","article-title":"Prevention: non-recreational physical activity reduces CVD risk","volume":"14","author":"Fernan\u00e1ndez-Ruiz","year":"2017","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.phymed.2024.156198_bib0011","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.jacc.2006.03.060","article-title":"A randomized clinical trial of trimetazidine, a partial free fatty acid oxidation inhibitor, in patients with heart failure","volume":"48","author":"Fragasso","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.phymed.2024.156198_bib0012","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1016\/j.jacc.2019.01.041","article-title":"Screening and Management of Depression in Patients With Cardiovascular Disease: JACC State-of-the-Art Review","volume":"73","author":"Jha","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.phymed.2024.156198_bib0013","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/eurheartj\/ehz425","article-title":"2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes","volume":"41","author":"Knuuti","year":"2020","journal-title":"Eur. Heart. J."},{"key":"10.1016\/j.phymed.2024.156198_bib0014","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/3968494","article-title":"Mechanism of Yangxinshi Intervention on Cardiac Fibrosis in Diabetic Cardiomyopathy Based on Network Pharmacology","volume":"2022","author":"Kuang","year":"2022","journal-title":"Evid. Based. Complement. Alternat. Med."},{"key":"10.1016\/j.phymed.2024.156198_bib0015","first-page":"257","article-title":"Retrospective analysis of exercise capacity in patients with coronary artery disease after percutaneous coronary intervention or coronary artery bypass graft","volume":"8","author":"Li","year":"2021","journal-title":"Int. J. Nurs. Sci."},{"key":"10.1016\/j.phymed.2024.156198_bib0016","first-page":"122","article-title":"Yangxinshi Tablets Versus Trimetazidine on Exercise Tolerance After Percutaneous Coronary Intervention: rationale and Design of the Double-blind, Randomized HEARTRIP Trial","volume":"3","author":"Li","year":"2023","journal-title":"Cardiol. Discov."},{"key":"10.1016\/j.phymed.2024.156198_bib0017","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1056\/NEJMoa1915922","article-title":"Initial Invasive or Conservative Strategy for Stable Coronary Disease","volume":"382","author":"Maron","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phymed.2024.156198_bib0018","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1056\/NEJMoa011858","article-title":"Exercise capacity and mortality among men referred for exercise testing","volume":"346","author":"Myers","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phymed.2024.156198_bib0019","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1177\/2047487318778088","article-title":"Cardiac rehabilitation and symptoms of anxiety and depression after percutaneous coronary intervention","volume":"25","author":"Olsen","year":"2018","journal-title":"Eur. J. Prev. Cardiol."},{"key":"10.1016\/j.phymed.2024.156198_bib0020","first-page":"133","article-title":"Exercise, exerkines, and cardiometabolic health: from individual players to a team sport","author":"Robbins","year":"2023","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2024.156198_bib0021","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1007\/s00380-020-01576-2","article-title":"Reduced exercise capacity and clinical outcomes following acute myocardial infarction","volume":"35","author":"Tashiro","year":"2020","journal-title":"Heart Vessels"},{"key":"10.1016\/j.phymed.2024.156198_bib0001","first-page":"7","volume":"44","year":"2016","journal-title":"Zhonghua Xin Xue Guan Bing Za Zhi"},{"key":"10.1016\/j.phymed.2024.156198_bib0022","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.ijcard.2012.11.001","article-title":"Efficacy of trimetazidine on functional capacity in symptomatic patients with stable exertional angina\u2013the VASCO-angina study","volume":"168","author":"Vitale","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.phymed.2024.156198_bib0023","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1016\/j.ehj.2004.06.034","article-title":"Trimetazidine improves left ventricular function and quality of life in elderly patients with coronary artery disease","volume":"25","author":"Vitale","year":"2004","journal-title":"Eur. Heart. J."},{"key":"10.1016\/j.phymed.2024.156198_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112227","article-title":"A network pharmacology approach to discover action mechanisms of Yangxinshi Tablet for improving energy metabolism in chronic ischemic heart failure","volume":"246","author":"Wu","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2024.156198_bib0025","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jep.2017.09.003","article-title":"Metabolic profiles revealed anti-ischemia-reperfusion injury of Yangxinshi tablet in Rats","volume":"214","author":"Zhang","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2024.156198_bib0026","first-page":"23","article-title":"Yangxinshi Tablet Improves Exercise Capacity for Patients with Coronary Heart Disease: results from a Randomized","author":"Zhang","year":"2022","journal-title":"Double-Blind"},{"key":"10.1016\/j.phymed.2024.156198_bib0027","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1007\/s00059-015-4392-2","article-title":"Trimetazidine improves exercise tolerance in patients with ischemic heart disease: a meta-analysis","volume":"41","author":"Zhao","year":"2016","journal-title":"Herz"},{"key":"10.1016\/j.phymed.2024.156198_bib0028","doi-asserted-by":"crossref","first-page":"e13770","DOI":"10.1111\/eci.13770","article-title":"Association between cardiorespiratory fitness and risk of all-cause and cause-specific mortality","volume":"52","author":"Zhao","year":"2022","journal-title":"Eur. J. Clin. Invest."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324008559?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324008559?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T08:59:51Z","timestamp":1762333191000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711324008559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":28,"alternative-id":["S0944711324008559"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2024.156198","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and safety of yangxinshi versus trimetazidine on exercise tolerance in patients with coronary heart disease after percutaneous coronary intervention: Multicenter, double-blind clinical trial","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2024.156198","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"156198"}}