{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:55:11Z","timestamp":1791244511115,"version":"4.1.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100017700","name":"Henan Provincial Science and Technology Research Project","doi-asserted-by":"publisher","award":["242102310507"],"award-info":[{"award-number":["242102310507"]}],"id":[{"id":"10.13039\/501100017700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M721060"],"award-info":[{"award-number":["2022M721060"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M750816"],"award-info":[{"award-number":["2024M750816"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104551"],"award-info":[{"award-number":["82104551"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.phymed.2024.156219","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T13:40:29Z","timestamp":1730814029000},"page":"156219","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Taohe Chengqi decoction improves diabetic cognitive dysfunction by alleviating neural stem cell senescence through HIF1\u03b1-driven metabolic signaling"],"prefix":"10.1016","volume":"135","author":[{"given":"Tingting","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangxu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9463-6007","authenticated-orcid":false,"given":"Hozeifa Mohamed","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhou","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4579-3748","authenticated-orcid":false,"given":"Ziqiao","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2024.156219_bib0001","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1212\/WNL.0b013e3181f4d7f8","article-title":"Diabetes, alzheimer disease, and vascular dementia: a population-based neuropathologic study","volume":"75","author":"Ahtiluoto","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.phymed.2024.156219_bib0002","doi-asserted-by":"crossref","first-page":"e73138","DOI":"10.7554\/eLife.73138","article-title":"Type 2 diabetes mellitus accelerates brain aging and cognitive decline: complementary findings from UK Biobank and meta-analyses","volume":"11","author":"Antal","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.phymed.2024.156219_bib0003","doi-asserted-by":"crossref","first-page":"S168","DOI":"10.2337\/dc21-S012","article-title":"Older adults: Standards of medical care in diabetes-2021","volume":"44","author":"Association","year":"2021","journal-title":"Diabetes Care"},{"key":"10.1016\/j.phymed.2024.156219_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2020.111323","article-title":"Mechanisms of enhanced quiescence in neural stem cell aging","volume":"191","author":"Audesse","year":"2020","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.phymed.2024.156219_bib0005","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.stemcr.2021.01.019","article-title":"Adult hippocampal neurogenesis in aging and alzheimer's disease","volume":"16","author":"Babcock","year":"2021","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.phymed.2024.156219_bib0006","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.neuron.2016.12.017","article-title":"Role of mitochondrial metabolism in the control of early lineage progression and aging phenotypes in adult hippocampal neurogenesis","volume":"93","author":"Beckervordersandforth","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.phymed.2024.156219_bib0007","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.neurobiolaging.2008.03.002","article-title":"Early age-related changes in adult hippocampal neurogenesis in c57 mice","volume":"31","author":"Ben Abdallah","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.phymed.2024.156219_bib0008","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/s41574-018-0048-7","article-title":"Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications","volume":"14","author":"Biessels","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.phymed.2024.156219_bib0009","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00125-019-04977-9","article-title":"Cognitive dysfunction in diabetes: how to implement emerging guidelines","volume":"63","author":"Biessels","year":"2020","journal-title":"Diabetologia"},{"key":"10.1016\/j.phymed.2024.156219_bib0010","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.stem.2018.03.015","article-title":"Human hippocampal neurogenesis persists throughout aging","volume":"22","author":"Boldrini","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.phymed.2024.156219_bib0011","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0197-4580(03)00083-6","article-title":"Impact of age and caloric restriction on neurogenesis in the dentate gyrus of c57bl\/6 mice","volume":"25","author":"Bondolfi","year":"2004","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.phymed.2024.156219_bib0012","doi-asserted-by":"crossref","first-page":"19426","DOI":"10.1073\/pnas.0805230105","article-title":"Stabilization of hif-1alpha is critical to improve wound healing in diabetic mice","volume":"105","author":"Botusan","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phymed.2024.156219_bib0013","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1111\/acel.12343","article-title":"Increased gene dosage of INK4\/ARF and p53 delays age-associated central nervous system functional decline","volume":"14","author":"Carrasco-Garcia","year":"2015","journal-title":"Aging Cell"},{"key":"10.1016\/j.phymed.2024.156219_bib0014","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s00125-021-05380-z","article-title":"Hypoxia and hypoxia-inducible factors in diabetes and its complications","volume":"64","author":"Catrina","year":"2021","journal-title":"Diabetologia"},{"key":"10.1016\/j.phymed.2024.156219_bib0015","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.3390\/nu12061777","article-title":"Chronic supplementation with a mix of salvia officinalis and salvia lavandulaefolia improves morris water maze learning in normal adult C57BL\/6J mice","volume":"12","author":"Dinel","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2024.156219_bib0016","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.jacbts.2018.04.005","article-title":"Fatty acids prevent hypoxia-inducible factor-1\u03b1 signaling through decreased succinate in diabetes","volume":"3","author":"Dodd","year":"2018","journal-title":"JACC Basic Transl Sci"},{"key":"10.1016\/j.phymed.2024.156219_bib0017","doi-asserted-by":"crossref","first-page":"415","DOI":"10.2337\/dc12-1125","article-title":"Impact of the hypoxia-inducible factor-1 \u03b1 (HIF1A) pro582ser polymorphism on diabetes nephropathy","volume":"36","author":"Gu","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.phymed.2024.156219_bib0018","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.tins.2021.06.007","article-title":"Cellular senescence at the crossroads of inflammation and Alzheimer's disease","volume":"44","author":"Guerrero","year":"2021","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.phymed.2024.156219_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116158","article-title":"Hif-1\u03b1 serves as a co-linker between ad and t2dm","volume":"171","author":"Hai","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2024.156219_bib0020","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/ki.2010.99","article-title":"High glucose activates hif-1-mediated signal transduction in glomerular mesangial cells through a carbohydrate response element binding protein","volume":"78","author":"Isoe","year":"2010","journal-title":"Kidney Int"},{"key":"10.1016\/j.phymed.2024.156219_bib0021","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41419-019-1438-z","article-title":"Maternal hyperglycemia disturbs neocortical neurogenesis via epigenetic regulation in c57bl\/6j mice","volume":"10","author":"Ji","year":"2019","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.phymed.2024.156219_bib0022","doi-asserted-by":"crossref","DOI":"10.3390\/cells12162086","article-title":"From youthful vigor to aging decline: Unravelling the intrinsic and extrinsic determinants of hippocampal neural stem cell aging","volume":"12","author":"Jim\u00e9nez Peinado","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.phymed.2024.156219_bib0023","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a018812","article-title":"Neurogenesis in the adult hippocampus","volume":"7","author":"Kempermann","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.phymed.2024.156219_bib0024","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cmet.2006.02.002","article-title":"Hif-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia","volume":"3","author":"Kim","year":"2006","journal-title":"Cell Metab"},{"key":"10.1016\/j.phymed.2024.156219_bib0025","doi-asserted-by":"crossref","first-page":"609","DOI":"10.4103\/1673-5374.350205","article-title":"Small extracellular vesicles secreted by induced pluripotent stem cell-derived mesenchymal stem cells improve postoperative cognitive dysfunction in mice with diabetes","volume":"18","author":"Lang","year":"2023","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.phymed.2024.156219_bib0026","doi-asserted-by":"crossref","first-page":"924","DOI":"10.15252\/embj.201592372","article-title":"Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis","volume":"35","author":"Lange","year":"2016","journal-title":"EMBO J"},{"key":"10.1016\/j.phymed.2024.156219_bib0027","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.cell.2014.05.012","article-title":"Increased adipocyte o2 consumption triggers HIF-1\u03b1, causing inflammation and insulin resistance in obesity","volume":"157","author":"Lee","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2024.156219_bib0028","first-page":"323","article-title":"Network pharmacology approaches for research of traditional Chinese medicines","volume":"21","author":"Li","year":"2023","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.phymed.2024.156219_bib0029","doi-asserted-by":"crossref","first-page":"3396","DOI":"10.1038\/s41380-022-01600-z","article-title":"High-fat diet-induced diabetes couples to Alzheimer's disease through inflammation-activated C\/EBP\u0392\/AEP pathway","volume":"27","author":"Liu","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.phymed.2024.156219_bib0030","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0140-6736(20)30367-6","article-title":"Dementia prevention, intervention, and care: 2020 report of the lancet commission","volume":"396","author":"Livingston","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2024.156219_bib0031","first-page":"195","article-title":"Progress in approved drugs from natural product resources","volume":"22","author":"Luo","year":"2024","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.phymed.2024.156219_bib0032","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1172\/JCI79742","article-title":"Hyperglycemia modulates extracellular amyloid-\u03b2 concentrations and neuronal activity in vivo","volume":"125","author":"Macauley","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2024.156219_bib0033","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1038\/s41593-022-01176-5","article-title":"Adult-born dentate granule cells promote hippocampal population sparsity","volume":"25","author":"McHugh","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.phymed.2024.156219_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114464","article-title":"The role of traditional chinese medicine in the treatment of cognitive dysfunction in type 2 diabetes","volume":"280","author":"Meng","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2024.156219_bib0035","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20220391","article-title":"Augmenting neurogenesis rescues memory impairments in Alzheimer's disease by restoring the memory-storing neurons","volume":"219","author":"Mishra","year":"2022","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.phymed.2024.156219_bib0036","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nature05091","article-title":"Increasing P16INK4A expression decreases forebrain progenitors and neurogenesis during ageing","volume":"443","author":"Molofsky","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2024.156219_bib0037","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1212\/WNL.0000000000001982","article-title":"Type 2 diabetes mellitus and biomarkers of neurodegeneration","volume":"85","author":"Moran","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.phymed.2024.156219_bib0038","doi-asserted-by":"crossref","first-page":"14291","DOI":"10.3390\/ijms241814291","article-title":"Altered mitochondrial function and accelerated aging phenotype in neural stem cells derived from dnm1l knockout embryonic stem cells","volume":"24","author":"Na","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2024.156219_bib0039","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1212\/WNL.53.9.1937","article-title":"Diabetes mellitus and the risk of dementia: The rotterdam study","volume":"53","author":"Ott","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.phymed.2024.156219_bib0040","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.2337\/db14-1820","article-title":"Cellular senescence in type 2 diabetes: a therapeutic opportunity","volume":"64","author":"Palmer","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.phymed.2024.156219_bib0041","article-title":"The arrive guidelines 2.0: updated guidelines for reporting animal research","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol"},{"key":"10.1016\/j.phymed.2024.156219_bib0042","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/stem.1606","article-title":"Moz-mediated repression of p16(ink) (4) (a) is critical for the self-renewal of neural and hematopoietic stem cells","volume":"32","author":"Perez-Campo","year":"2014","journal-title":"Stem Cells"},{"key":"10.1016\/j.phymed.2024.156219_bib0043","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.biopsych.2009.02.013","article-title":"Meta-analysis of Alzheimer's disease risk with obesity, diabetes, and related disorders","volume":"67","author":"Profenno","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phymed.2024.156219_bib0044","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.pneurobio.2010.10.007","article-title":"Energy metabolism in adult neural stem cell fate","volume":"93","author":"Rafalski","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.phymed.2024.156219_bib0045","doi-asserted-by":"crossref","first-page":"6011","DOI":"10.1074\/jbc.M115.699215","article-title":"Pyruvate dehydrogenase kinase-mediated glycolytic metabolic shift in the dorsal root ganglion drives painful diabetic neuropathy","volume":"291","author":"Rahman","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2024.156219_bib0046","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.stem.2015.07.013","article-title":"Single-cell rna-seq with waterfall reveals molecular cascades underlying adult neurogenesis","volume":"17","author":"Shin","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.phymed.2024.156219_bib0047","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1002\/stem.2042","article-title":"Neural stem cells in the adult subventricular zone oxidize fatty acids to produce energy and support neurogenic activity","volume":"33","author":"Stoll","year":"2015","journal-title":"Stem Cells"},{"key":"10.1016\/j.phymed.2024.156219_bib0048","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nn2055","article-title":"Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons","volume":"11","author":"Stranahan","year":"2008","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.phymed.2024.156219_bib0049","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/ncomms1532","article-title":"Mir-137 forms a regulatory loop with nuclear receptor tlx and lsd1 in neural stem cells","volume":"2","author":"Sun","year":"2011","journal-title":"Nat. Commun"},{"key":"10.1016\/j.phymed.2024.156219_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2021.109119","article-title":"Idf diabetes atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045","volume":"183","author":"Sun","year":"2022","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.phymed.2024.156219_bib0051","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.stem.2019.05.003","article-title":"Human hippocampal neurogenesis persists in aged adults and Alzheimer's disease patients","volume":"24","author":"Tobin","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.phymed.2024.156219_bib0052","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41380-018-0036-2","article-title":"The role of adult hippocampal neurogenesis in brain health and disease","volume":"24","author":"Toda","year":"2019","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.phymed.2024.156219_bib0053","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nature10357","article-title":"The ageing systemic milieu negatively regulates neurogenesis and cognitive function","volume":"477","author":"Villeda","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2024.156219_bib0054","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrneurol.2011.137","article-title":"Diabetic neuropathy: cellular mechanisms as therapeutic targets","volume":"7","author":"Vincent","year":"2011","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.phymed.2024.156219_bib0055","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.stem.2012.03.016","article-title":"Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation","volume":"11","author":"Wang","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.phymed.2024.156219_bib0056","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1084\/jem.20131685","article-title":"Neuronal activity regulates extracellular tau in vivo","volume":"211","author":"Yamada","year":"2014","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.phymed.2024.156219_bib0057","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00018-011-0731-5","article-title":"Hif-1 is involved in high glucose-induced paracellular permeability of brain endothelial cells","volume":"69","author":"Yan","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.phymed.2024.156219_bib0058","article-title":"Metabolic insight into the neuroprotective effect of tao-he-cheng-qi (thcq) decoction on ich rats using untargeted metabolomics","volume":"12","author":"Yang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2024.156219_bib0059","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155315","article-title":"Taohe chengqi decoction alleviated metabolic-associated fatty liver disease by boosting branched chain amino acids catabolism in the skeletal muscles of type 2 diabetes mellitus","volume":"126","author":"Yuan","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2024.156219_bib0060","first-page":"71","article-title":"Research progress of clinical application of taohe chengqi decoction","volume":"27","author":"Zhou","year":"2020","journal-title":"Modern Chinese Clin. Med."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324008778?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324008778?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T08:55:01Z","timestamp":1762332901000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711324008778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":60,"alternative-id":["S0944711324008778"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2024.156219","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Taohe Chengqi decoction improves diabetic cognitive dysfunction by alleviating neural stem cell senescence through HIF1\u03b1-driven metabolic signaling","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2024.156219","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156219"}}