{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T08:21:27Z","timestamp":1792570887703,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074328"],"award-info":[{"award-number":["82074328"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473592"],"award-info":[{"award-number":["81473592"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["ZZ16-XRZ-069"],"award-info":[{"award-number":["ZZ16-XRZ-069"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.phymed.2024.156264","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T21:30:18Z","timestamp":1732138218000},"page":"156264","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Sishen Pill & Tongxieyaofang ameliorated ulcerative colitis through the activation of HIF-1\u03b1 acetylation by gut microbiota-derived propionate and butyrate"],"prefix":"10.1016","volume":"136","author":[{"given":"Haifan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dunfang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingbo","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junying","family":"Xian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caijuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weipeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2024.156264_bib0001","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nrgastro.2015.34","article-title":"Epidemiology and risk factors for IBD","volume":"12","author":"Ananthakrishnan","year":"2015","journal-title":"Nat. Rev. Gastro. Hepat."},{"key":"10.1016\/j.phymed.2024.156264_bib0002","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.678360","article-title":"Prebiotic inulin and sodium butyrate attenuate obesity-induced intestinal barrier dysfunction by induction of antimicrobial peptides","volume":"12","author":"Beisner","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2024.156264_bib0003","doi-asserted-by":"crossref","first-page":"3732","DOI":"10.1096\/fj.201902103R","article-title":"Mucosal inflammation downregulates PHD1 expression promoting a barrier-protective HIF-1alpha response in ulcerative colitis patients","volume":"34","author":"Brown","year":"2020","journal-title":"Faseb J."},{"key":"10.1016\/j.phymed.2024.156264_bib0004","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41467-017-00213-3","article-title":"Hypoxia ameliorates intestinal inflammation through NLRP3\/mTOR downregulation and autophagy activation","volume":"8","author":"Cosin-Roger","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2024.156264_bib0005","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/apt.16753","article-title":"Randomised clinical trial: a phase 1b study of GB004, an oral HIF-1alpha stabiliser, for treatment of ulcerative colitis","volume":"55","author":"Danese","year":"2022","journal-title":"Aliment. Pharm. Ther."},{"key":"10.1016\/j.phymed.2024.156264_bib0006","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaf6397","article-title":"Transplantation of fecal microbiota from patients with irritable bowel syndrome alters gut function and behavior in recipient mice","author":"De Palma","year":"2017","journal-title":"Sci. Transl. Med. 9"},{"key":"10.1016\/j.phymed.2024.156264_bib0007","doi-asserted-by":"crossref","first-page":"15893","DOI":"10.1021\/acsnano.3c03959","article-title":"Capsulated cellular nanosponges for the treatment of experimental inflammatory bowel disease","volume":"17","author":"Duan","year":"2023","journal-title":"ACS. Nano"},{"key":"10.1016\/j.phymed.2024.156264_bib0008","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jaci.2019.11.003","article-title":"The microbiome and inflammatory bowel disease","volume":"145","author":"Glassner","year":"2020","journal-title":"J. Allergy Clin. Immun."},{"key":"10.1016\/j.phymed.2024.156264_bib0009","doi-asserted-by":"crossref","first-page":"9637","DOI":"10.1038\/s41598-023-36678-0","article-title":"An antioxidant ameliorates allergic airway inflammation by inhibiting HDAC 1 via HIF-1alpha\/VEGF axis suppression in mice","volume":"13","author":"Islam","year":"2023","journal-title":"Sci. Rep-Uk"},{"key":"10.1016\/j.phymed.2024.156264_bib0010","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2022.2149019","article-title":"Predicting butyrate- and propionate-forming bacteria of gut microbiota from sequencing data","volume":"14","author":"Kircher","year":"2022","journal-title":"Gut. Microbes."},{"key":"10.1016\/j.phymed.2024.156264_bib0011","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s40168-021-01028-7","article-title":"Gut microbiota-derived inosine from dietary barley leaf supplementation attenuates colitis through PPARgamma signaling activation","volume":"9","author":"Li","year":"2021","journal-title":"Microbiome"},{"key":"10.1016\/j.phymed.2024.156264_bib0012","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.3389\/fphar.2018.01110","article-title":"Tong-Xie-Yao-Fang Regulates 5-HT Level in Diarrhea Predominant Irritable Bowel Syndrome Through Gut Microbiota Modulation","volume":"9","author":"Li","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2024.156264_bib0014","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/1462-2920.13589","article-title":"Formation of propionate and butyrate by the human colonic microbiota","volume":"19","author":"Louis","year":"2016","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.phymed.2024.156264_bib0015","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.molimm.2023.09.009","article-title":"3, 3\u2032-diindolylmethane, a natural aryl hydrocarbon receptor agonist, alleviates ulcerative colitis by enhancing \"glycolysis-lactate-STAT3\u2032' and TIP60 signals-mediated Treg differentiation","volume":"163","author":"Liu","year":"2023","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.phymed.2024.156264_bib0016","first-page":"40","article-title":"Research on efficacy and mechanism of sishenwan combined with tongxie yaofang in treating ulcerative colitis with spleen-kidney yang deficiency and liver stagnation","volume":"30","author":"Liu","year":"2024","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"10.1016\/j.phymed.2024.156264_bib0017","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1017\/S0029665120006916","article-title":"SCFA: mechanisms and functional importance in the gut","volume":"80","author":"Martin-Gallausiaux","year":"2021","journal-title":"P. Nutr. Soc."},{"key":"10.1016\/j.phymed.2024.156264_bib0018","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jpsychores.2016.06.001","article-title":"Depression and anxiety in patients with Inflammatory Bowel Disease: A systematic review","volume":"87","author":"Neuendorf","year":"2016","journal-title":"J. Psychosom. Res."},{"key":"10.1016\/j.phymed.2024.156264_bib0019","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/imr.12182","article-title":"The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system","volume":"260","author":"Pelaseyed","year":"2014","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.phymed.2024.156264_bib0020","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.jhep.2018.05.021","article-title":"Intestinal HIF-1alpha deletion exacerbates alcoholic liver disease by inducing intestinal dysbiosis and barrier dysfunction","volume":"69","author":"Shao","year":"2018","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2024.156264_bib0021","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.tibtech.2015.06.011","article-title":"Proteobacteria: microbial signature of dysbiosis in gut microbiota","volume":"33","author":"Shin","year":"2015","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.phymed.2024.156264_bib0022","series-title":"Study on the changes of intestinal mucosal barrier in spleen-yin deficiency rats and the effect of ZiBu PiYin Recipe","first-page":"74","author":"Sun","year":"2019"},{"key":"10.1016\/j.phymed.2024.156264_bib0023","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1089\/jir.2013.0040","article-title":"DMOG ameliorates IFN-gamma-induced intestinal barrier dysfunction by suppressing PHD2-dependent HIF-1alpha degradation","volume":"34","author":"Wang","year":"2014","journal-title":"J. Interf. Cytok. Res."},{"key":"10.1016\/j.phymed.2024.156264_bib0024","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/1432816","article-title":"Sishen wan treats ulcerative colitis in rats by regulating gut microbiota and restoring the Treg\/Th17 balance","author":"Wang","year":"2022","journal-title":"Evid-Based Compl. Alt."},{"key":"10.1016\/j.phymed.2024.156264_bib0025","doi-asserted-by":"crossref","first-page":"e85321","DOI":"10.1128\/JVI.00853-21","article-title":"Porcine epidemic diarrhea virus inhibits HDAC1 expression to facilitate its replication via binding of its nucleocapsid protein to host transcription factor Sp1","volume":"95","author":"Xu","year":"2021","journal-title":"J. Virol."},{"key":"10.1016\/j.phymed.2024.156264_bib0026","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s12941-023-00646-3","article-title":"The oral bacterial microbiota facilitates the stratification for ulcerative colitis patients with oral ulcers","volume":"22","author":"Xu","year":"2023","journal-title":"Ann. Clin. Microb. Anti."},{"key":"10.1016\/j.phymed.2024.156264_bib0027","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0179586","article-title":"Butyrate modifies intestinal barrier function in IPEC-J2 cells through a selective upregulation of tight junction proteins and activation of the Akt signaling pathway","volume":"12","author":"Yan","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2024.156264_bib0028","doi-asserted-by":"crossref","first-page":"4457","DOI":"10.1038\/s41467-020-18262-6","article-title":"Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity","volume":"11","author":"Yang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2024.156264_bib0029","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.615536","article-title":"Short-chain fatty acids promote intracellular bactericidal activity in head kidney macrophages from turbot (Scophthalmus maximus L.) via hypoxia inducible factor-1alpha","volume":"11","author":"Zhang","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2024.156264_bib0030","doi-asserted-by":"crossref","first-page":"9750","DOI":"10.1039\/D1FO01975A","article-title":"Sodium caprylate improves intestinal mucosal barrier function and antioxidant capacity by altering gut microbial metabolism","volume":"12","author":"Zhao","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2024.156264_bib0031","first-page":"811","article-title":"LLGL1 regulates gemcitabine resistance by modulating the erk-sp1-osmr pathway in pancreatic ductal adenocarcinoma","volume":"10","author":"Zhu","year":"2020","journal-title":"Cell. Mol. Gastroenter."},{"key":"10.1016\/j.phymed.2024.156264_bib0032","doi-asserted-by":"crossref","DOI":"10.3390\/nu13041244","article-title":"Short-chain fatty acids, maternal microbiota and metabolism in pregnancy","volume":"13","author":"Zietek","year":"2021","journal-title":"Nutrients"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324008870?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324008870?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T16:31:49Z","timestamp":1778776309000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711324008870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":31,"alternative-id":["S0944711324008870"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2024.156264","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sishen Pill & Tongxieyaofang ameliorated ulcerative colitis through the activation of HIF-1\u03b1 acetylation by gut microbiota-derived propionate and butyrate","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2024.156264","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156264"}}