{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:37:49Z","timestamp":1786995469782,"version":"build-2736575974"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8217120876"],"award-info":[{"award-number":["8217120876"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8187120301"],"award-info":[{"award-number":["8187120301"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.phymed.2024.156273","type":"journal-article","created":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T01:27:56Z","timestamp":1733016476000},"page":"156273","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Unveiling the impact of traditional Chinese herbal medicines on cutaneous adverse drug reactions: A landmark 15-year nationwide study"],"prefix":"10.1016","volume":"136","author":[{"given":"Shan","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanping","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiqing","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenggong","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaozhi","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqun","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2024.156273_bib0001","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s40263-021-00794-0","article-title":"Sex differences in the risk of cutaneous adverse drug reactions induced by antiseizure medications: a systematic review and meta-analysis","volume":"35","author":"Alfares","year":"2021","journal-title":"CNS Drugs"},{"key":"10.1016\/j.phymed.2024.156273_bib0002","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1111\/bcp.13923","article-title":"Sex differences in adverse drug reactions reported to the National Pharmacovigilance Centre in the Netherlands: an explorative observational study","volume":"85","author":"de Vries","year":"2019","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.phymed.2024.156273_bib0003","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1111\/bcp.15490","article-title":"Drugs and the skin: a concise review of cutaneous adverse drug reactions","volume":"90","author":"Del Pozzo-Magana","year":"2024","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.phymed.2024.156273_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109530","article-title":"Clinical features and prognostic factors of severe cutaneous adverse drug reactions: a single-center retrospective study of 209 cases in China","volume":"114","author":"Deng","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2024.156273_bib0005","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1016\/S0140-6736(16)30378-6","article-title":"Severe cutaneous adverse reactions to drugs","volume":"390","author":"Duong","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2024.156273_bib0006","doi-asserted-by":"crossref","first-page":"D1197","DOI":"10.1093\/nar\/gkaa1063","article-title":"HERB: a high-throughput experiment-and reference-guided database of traditional Chinese medicine","volume":"49","author":"Fang","year":"2021","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.phymed.2024.156273_bib0007","doi-asserted-by":"crossref","first-page":"895","DOI":"10.3390\/medicina57090895","article-title":"Stevens\u2013Johnson syndrome and toxic epidermal necrolysis: a review of diagnosis and management","volume":"57","author":"Frantz","year":"2021","journal-title":"Medicina (B Aires)"},{"key":"10.1016\/j.phymed.2024.156273_bib0008","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.jaip.2022.02.004","article-title":"Drug-Induced Hypersensitivity Syndrome (DIHS)\/Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS): clinical features and pathogenesis","volume":"10","author":"Hama","year":"2022","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"10.1016\/j.phymed.2024.156273_bib0009","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00281-015-0540-2","article-title":"Adverse cutaneous drug eruptions: current understanding","volume":"38","author":"Hoetzenecker","year":"2016","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.phymed.2024.156273_bib0010","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/jdv.18640","article-title":"Temporal shifts of the microbiome associated with antibiotic treatment of purpuric drug eruptions related to epidermal growth factor receptor inhibitors","volume":"37","author":"Hsieh","year":"2023","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.phymed.2024.156273_bib0011","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s13659-020-00293-7","article-title":"Natural products in cancer therapy: past, present and future","volume":"11","author":"Huang","year":"2021","journal-title":"Nat. Prod. Bioprospect."},{"key":"10.1016\/j.phymed.2024.156273_bib0012","doi-asserted-by":"crossref","first-page":"8875","DOI":"10.1038\/s41598-021-88339-9","article-title":"Safety of traditional Chinese medicine injection based on spontaneous reporting system from 2014 to 2019 in Hubei Province, China","volume":"11","author":"Huang","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2024.156273_bib0013","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0199456","article-title":"Causality and preventability assessment of adverse drug reactions and adverse drug events of antibiotics among hospitalized patients: a multicenter, cross-sectional study in Lahore, Pakistan","volume":"13","author":"Iftikhar","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2024.156273_bib0014","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0252161","article-title":"Prevalence of adverse drug reactions in the primary care setting: a systematic review and meta-analysis","volume":"16","author":"Insani","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2024.156273_bib0015","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12913-019-4651-7","article-title":"Adverse drug reactions in primary care: a scoping review","volume":"20","author":"Khalil","year":"2020","journal-title":"BMC Health Serv. Res."},{"key":"10.1016\/j.phymed.2024.156273_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.waojou.2022.100738","article-title":"Clinical aspects of severe cutaneous adverse reactions caused by beta-lactam antibiotics: a study from the Korea SCAR registry","volume":"16","author":"Kim","year":"2023","journal-title":"World Allergy Organ. J."},{"key":"10.1016\/j.phymed.2024.156273_bib0017","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1001\/jamadermatol.2021.3154","article-title":"Assessment of treatment approaches and outcomes in Stevens-Johnson syndrome and toxic epidermal necrolysis: insights from a pan-European multicenter study","volume":"157","author":"Kridin","year":"2021","journal-title":"JAMa Dermatol."},{"key":"10.1016\/j.phymed.2024.156273_bib0018","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.1016\/j.jaip.2023.09.031","article-title":"Drug allergy in women","volume":"11","author":"Lee","year":"2023","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"10.1016\/j.phymed.2024.156273_bib0019","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s12016-017-8654-z","article-title":"Current perspectives on stevens-johnson syndrome and toxic epidermal necrolysis","volume":"54","author":"Lerch","year":"2018","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.phymed.2024.156273_bib0020","article-title":"Effects of traditional Chinese medicine and its active ingredients on drug-resistant bacteria","volume":"13","author":"Li","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2024.156273_bib0021","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s11882-019-0872-4","article-title":"Drug Safety Evaluation in China","volume":"19","author":"Li","year":"2019","journal-title":"Curr. Allergy Asthma Rep."},{"key":"10.1016\/j.phymed.2024.156273_bib0022","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/j.1365-2230.2006.02185.x","article-title":"Epidemiological study of severe cutaneous adverse drug reactions in a city district of China","volume":"31","author":"Li","year":"2006","journal-title":"Clin. Exp. Dermatol."},{"key":"10.1016\/j.phymed.2024.156273_bib0023","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s40264-014-0250-z","article-title":"Safety surveillance of traditional Chinese medicine: current and future","volume":"38","author":"Liu","year":"2015","journal-title":"Drug Saf."},{"key":"10.1016\/j.phymed.2024.156273_bib0024","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.944540","article-title":"Changing characteristics of pharmaceutical prices in China under centralized procurement policy: a multi-intervention interrupted time series","volume":"13","author":"Long","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2024.156273_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.05.014","article-title":"Let's talk about sex: differences in drug therapy in males and females","volume":"175","author":"Madla","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.phymed.2024.156273_bib0026","series-title":"Traditional Chinese Medicine and Clinical Pharmacology","author":"Marshall","year":"2020"},{"key":"10.1016\/j.phymed.2024.156273_bib0027","article-title":"Sex- and gender-based pharmacological response to drugs","volume":"73","author":"Mauvais-Jarvis","year":"2021"},{"key":"10.1016\/j.phymed.2024.156273_bib0028","first-page":"58","article-title":"Prevalence and genetic polymorphism of HLA-B* 15 in the North Indian population: insights into SJS\/TEN prevention, vaccines and clinical trials","volume":"9","author":"Mishra","year":"2022","journal-title":"Vaccine Res."},{"key":"10.1016\/j.phymed.2024.156273_bib0029","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s40257-023-00779-3","article-title":"Acute generalized exanthematous pustulosis: clinical features, differential diagnosis, and management","volume":"24","author":"Parisi","year":"2023","journal-title":"Am. J. Clin. Dermatol."},{"key":"10.1016\/j.phymed.2024.156273_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106528","article-title":"Opportunities and hurdles to European market access for multi-herbal traditional Chinese medicine products: an analysis of EU regulations for combination herbal medicinal products","volume":"186","author":"Qu","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2024.156273_bib0031","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1177\/2374373517706612","article-title":"Prevalence and predictors of herbal medicine use among adults in the United States","volume":"4","author":"Rashrash","year":"2017","journal-title":"J. Patient. Exp."},{"key":"10.1016\/j.phymed.2024.156273_bib0032","doi-asserted-by":"crossref","first-page":"422","DOI":"10.3389\/fphar.2020.00422","article-title":"Herbal medicine for cardiovascular diseases: efficacy, mechanisms, and safety","volume":"11","author":"Shaito","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2024.156273_bib0033","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1053\/j.gastro.2019.02.002","article-title":"Incidence and etiology of drug-induced liver injury in Mainland China","volume":"156","author":"Shen","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phymed.2024.156273_bib0034","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/bcp.15277","article-title":"Pharmacovigilance in China: evolution and future challenges","volume":"89","author":"Song","year":"2023","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.phymed.2024.156273_bib0035","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.832048","article-title":"Drug-induced severe cutaneous adverse reactions: insights into clinical presentation, immunopathogenesis, diagnostic methods, treatment, and pharmacogenomics","volume":"13","author":"Tempark","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2024.156273_bib0036","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.jaad.2020.08.122","article-title":"Treating toxic epidermal necrolysis with systemic immunomodulating therapies: a systematic review and network meta-analysis","volume":"84","author":"Tsai","year":"2021","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.phymed.2024.156273_bib0037","article-title":"Stevens-Johnson syndrome and toxic epidermal necrolysis: a systematic review of PubMed\/MEDLINE case reports from 1980 to 2020","volume":"9","author":"Wang","year":"2022","journal-title":"Front. Med."},{"key":"10.1016\/j.phymed.2024.156273_bib0038","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.2215\/CJN.02140215","article-title":"Epidemiology and clinical correlates of AKI in Chinese hospitalized adults","volume":"10","author":"Xu","year":"2015","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.phymed.2024.156273_bib0039","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/s41397-018-0051-3","article-title":"HLA-C*12:02 is strongly associated with Xuesaitong-induced cutaneous adverse drug reactions","volume":"19","author":"Yan","year":"2018","journal-title":"Pharmacogenom. J."},{"key":"10.1016\/j.phymed.2024.156273_bib0040","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/s41397-019-0121-1","article-title":"HLA-A*02:01 allele is associated with tanshinone-induced cutaneous drug reactions in Chinese population","volume":"20","author":"Zhu","year":"2019","journal-title":"Pharmacogenom. J."},{"key":"10.1016\/j.phymed.2024.156273_bib0041","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13293-020-00308-5","article-title":"Sex differences in pharmacokinetics predict adverse drug reactions in women","volume":"11","author":"Zucker","year":"2020","journal-title":"Biol. Sex. Differ."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324009292?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324009292?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T04:16:27Z","timestamp":1778559387000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711324009292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":41,"alternative-id":["S0944711324009292"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2024.156273","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unveiling the impact of traditional Chinese herbal medicines on cutaneous adverse drug reactions: A landmark 15-year nationwide study","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2024.156273","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156273"}}