{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T04:09:36Z","timestamp":1784606976127,"version":"3.55.0"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.phymed.2024.156359","type":"journal-article","created":{"date-parts":[[2024,12,29]],"date-time":"2024-12-29T22:32:20Z","timestamp":1735511540000},"page":"156359","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Recent advances in phytocompounds as potential Chikungunya virus non-structural protein 2 protease antagonists: A systematic review"],"prefix":"10.1016","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5727-165X","authenticated-orcid":false,"given":"Jarmani","family":"Dansana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Purohit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhusmita","family":"Panda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0519-9074","authenticated-orcid":false,"given":"Biswa Ranjan","family":"Meher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2024.156359_bib0001","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3390\/v10020071","article-title":"Non-structural proteins of alphavirus-potential targets for drug development","volume":"10","author":"Abu Bakar","year":"2018","journal-title":"Viruses"},{"key":"10.1016\/j.phymed.2024.156359_bib0002","doi-asserted-by":"crossref","first-page":"453","DOI":"10.4103\/0250-474X.164769","article-title":"Molecular modeling and docking study to elucidate novel Chikungunya virus nsP2 protease inhibitors","volume":"77","author":"Agarwal","year":"2015","journal-title":"Indian J. Pharm. Sci."},{"key":"10.1016\/j.phymed.2024.156359_bib0003","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1073\/pnas.92.2.507","article-title":"Reaction in alphavirus mRNA capping: formation of a covalent complex of nonstructural protein nsP1 with 7-methyl-GMP","volume":"92","author":"Ahola","year":"1995","journal-title":"P. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.phymed.2024.156359_bib0004","doi-asserted-by":"crossref","first-page":"7180","DOI":"10.1128\/JVI.00541-12","article-title":"Evasion of the innate immune response: the Old World alphavirus nsP2 protein induces rapid degradation of Rpb1, a catalytic subunit of RNA polymerase II","volume":"86","author":"Akhrymuk","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.phymed.2024.156359_bib0005","doi-asserted-by":"crossref","first-page":"5046","DOI":"10.1128\/JVI.02746-06","article-title":"Development of Sindbis viruses encoding nsP2\/GFP chimeric proteins and their application for studying nsP2 functioning","volume":"81","author":"Atasheva","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.phymed.2024.156359_bib0006","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.antiviral.2013.01.002","article-title":"Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus","volume":"98","author":"Bassetto","year":"2013","journal-title":"Antiviral. Res."},{"key":"10.1016\/j.phymed.2024.156359_bib0007","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.ejmech.2014.10.010","article-title":"A perspective on targeting non-structural proteins to combat neglected tropical diseases: dengue, West Nile and Chikungunya viruses","volume":"87","author":"Bhakat","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.phymed.2024.156359_bib0008","doi-asserted-by":"crossref","first-page":"8677","DOI":"10.1128\/JVI.02411-06","article-title":"Semliki Forest virus nonstructural protein 2 is involved insuppression of the type I interferon response","volume":"81","author":"Breakwell","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.phymed.2024.156359_bib0009","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.compbiolchem.2016.06.005","article-title":"Alphavirus protease inhibitors from natural sources: a homology modeling and molecular docking investigation","volume":"64","author":"Byler","year":"2016","journal-title":"Comput. Biol. Chem."},{"key":"10.1016\/j.phymed.2024.156359_bib0068","article-title":"Tomatidine reduces Chikungunya virus progeny release by controlling viral protein expression","volume":"15","author":"Troost","year":"2021","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.phymed.2024.156359_bib0010","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.antiviral.2017.04.001","article-title":"Chikungunya virus nsP4 RNA-dependent RNA polymerase core domain displays detergent-sensitive primer extension and terminal adenylyltransferase activities","volume":"143","author":"Chen","year":"2017","journal-title":"Antiviral. Res."},{"key":"10.1016\/j.phymed.2024.156359_bib0011","doi-asserted-by":"crossref","first-page":"30269","DOI":"10.1074\/jbc.M603980200","article-title":"Tracking and elucidating alphavirus-host protein interactions","volume":"281","author":"Cristea","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2024.156359_bib0012","doi-asserted-by":"crossref","first-page":"7382","DOI":"10.1128\/AAC.01421-16","article-title":"Design and validation of novel Chikungunya virus protease inhibitors","volume":"60","author":"Das","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.phymed.2024.156359_bib0013","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/nrd2424","article-title":"The design of drugs for HIV and HCV","volume":"6","author":"De Clercq","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.phymed.2024.156359_bib0014","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1080\/07391102.2016.1261046","article-title":"Conformer and pharmacophore based identification of peptidomimetic inhibitors of chikungunya virus nsP2 protease","volume":"35","author":"Dhindwal","year":"2017","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.phymed.2024.156359_bib0042","article-title":"In silico drug repurposing for the identification of potential candidate molecules against arboviruses infection","volume":"173","author":"Montes","year":"2020","journal-title":"Antiviral. Res."},{"key":"10.1016\/j.phymed.2024.156359_bib0015","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s13659-022-00366-9","article-title":"Alkaloids as potential antivirals. A comprehensive review","volume":"13","author":"Faisal","year":"2023","journal-title":"Nat. Prod. Bioprospect."},{"key":"10.1016\/j.phymed.2024.156359_bib0016","doi-asserted-by":"crossref","first-page":"9031","DOI":"10.1128\/JVI.00850-09","article-title":"Random insertion mutagenesis of sindbis virus nonstructural protein 2 and selection of variants incapable of downregulating cellular transcription","volume":"83","author":"Frolov","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.phymed.2024.156359_bib0017","doi-asserted-by":"crossref","first-page":"4122","DOI":"10.1128\/JVI.80.8.4122-4134.2006","article-title":"Formation of nsP3-specific protein complexes during Sindbis virus replication","volume":"80","author":"Frolova","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.phymed.2024.156359_bib0018","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3390\/v10030105","article-title":"The enigmatic alphavirus non-structural protein 3 (nsP3) revealing its secrets at last","volume":"10","author":"G\u00f6tte","year":"2018","journal-title":"Viruses"},{"key":"10.1016\/j.phymed.2024.156359_bib0019","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1007\/s11224-020-01507-x","article-title":"Computer-aided study of selective flavonoids against chikungunya virus replication using molecular docking and DFT-based approach","volume":"31","author":"Hussain","year":"2020","journal-title":"Struct. Chem."},{"key":"10.1016\/j.phymed.2024.156359_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.jksus.2022.102157","article-title":"Exploring potential anti-chikungunya virus activity of phytocompounds: computational docking and in vitro studies","volume":"34","author":"Indu","year":"2022","journal-title":"J. King Saud. Univ. Sci"},{"key":"10.1016\/j.phymed.2024.156359_bib0021","first-page":"1363","article-title":"Computer-aided study of selective flavonoids against Chikungunya virus replication using molecular docking and DFT-based approach","volume":"8","author":"Intayot","year":"2019","journal-title":"Pathogens"},{"key":"10.1016\/j.phymed.2024.156359_bib0022","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ejmech.2014.10.042","article-title":"Thiazolidone derivatives as inhibitors of chikungunya virus","volume":"89","author":"Jadav","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.phymed.2024.156359_bib0023","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.12688\/f1000research.12301.2","article-title":"In silico analysis of natural compounds targeting structural and nonstructural proteins of chikungunya virus","volume":"6","author":"Jain","year":"2017","journal-title":"F1000Res"},{"key":"10.1016\/j.phymed.2024.156359_bib0024","doi-asserted-by":"crossref","first-page":"e22336","DOI":"10.1371\/journal.pone.0022336","article-title":"NTPase and 5\u2032-RNA triphosphatase activities of Chikungunya virus nsP2 protein","volume":"6","author":"Karpe","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2024.156359_bib0025","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.drudis.2013.05.002","article-title":"Chikungunya virus: an update on antiviral development and challenges","volume":"18","author":"Kaur","year":"2013","journal-title":"Drug. Discov. Today"},{"key":"10.1016\/j.phymed.2024.156359_bib0026","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1128\/AAC.01467-12","article-title":"Inhibition of Chikungunya virus replication by harringtonine, a novel antiviral that suppresses viral protein expression","volume":"57","author":"Kaur","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.phymed.2024.156359_bib0027","doi-asserted-by":"crossref","first-page":"9296","DOI":"10.1093\/nar\/gkz640","article-title":"Structural and phenotypic analysis of Chikungunya virus RNA replication elements","volume":"47","author":"Kendall","year":"2019","journal-title":"Nucleic. Acids. Res."},{"key":"10.1016\/j.phymed.2024.156359_bib0028","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1099\/0022-1317-83-12-3075","article-title":"Complete nucleotide sequence of chikungunya virus and evidence for an internal polyadenylation site","volume":"83","author":"Khan","year":"2002","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.phymed.2024.156359_bib0029","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1080\/07391102.2020.1731602","article-title":"Discovery of small molecule inhibitors of chikungunya virus proteins (nsP2 and E1) using in silico approaches","volume":"39","author":"Khan","year":"2021","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.phymed.2024.156359_bib0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005810","article-title":"New world and old-world alphaviruses have evolved to exploit different components of stress granules, FXR and G3BP proteins, for assembly of viral replication complexes","volume":"12","author":"Kim","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.phymed.2024.156359_bib0031","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3390\/pathogens8030128","article-title":"Targeting the nsp2 cysteine protease of Chikungunya virus using FDA approved library and selected cysteine protease inhibitors","volume":"8","author":"Kumar","year":"2019","journal-title":"Pathogens"},{"key":"10.1016\/j.phymed.2024.156359_bib0032","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1038\/s41598-018-19295-0","article-title":"Chikungunya virus nsP1 interacts directly with nsP2 and modulates its ATPase activity","volume":"8","author":"Kumar","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2024.156359_bib0033","doi-asserted-by":"crossref","first-page":"37853","DOI":"10.1074\/jbc.M004865200","article-title":"Membrane binding mechanism of an RNA virus-capping enzyme","volume":"275","author":"Lampio","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2024.156359_bib0034","doi-asserted-by":"crossref","first-page":"11421","DOI":"10.1038\/srep11421","article-title":"Antiviral activity of silymarin against chikungunya virus","volume":"5","author":"Lani","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2024.156359_bib0035","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.antiviral.2016.07.009","article-title":"Antiviral activity of selected flavonoids against Chikungunya virus","volume":"133","author":"Lani","year":"2016","journal-title":"Antiviral Res."},{"key":"10.1016\/j.phymed.2024.156359_bib0036","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1177\/1087057112460091","article-title":"A phenotypic assay to identify Chikungunya virus inhibitors targeting the nonstructural protein nsP2","volume":"18","author":"Lucas","year":"2013","journal-title":"J. Biomol. Screen."},{"key":"10.1016\/j.phymed.2024.156359_bib0037","article-title":"Presence of autoimmune antibody in chikungunya infection","volume":"2009","author":"Maek","year":"2009","journal-title":"Case Rep. Med."},{"key":"10.1016\/j.phymed.2024.156359_bib0038","doi-asserted-by":"crossref","first-page":"6534","DOI":"10.1128\/JVI.00189-09","article-title":"The crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket","volume":"83","author":"Malet","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.phymed.2024.156359_bib0039","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/nrd4050","article-title":"Novel therapies for hepatitis C \u2014 One pill fits all?","volume":"12","author":"Manns","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.phymed.2024.156359_bib0040","doi-asserted-by":"crossref","first-page":"5827","DOI":"10.1080\/07391102.2021.1873863","article-title":"Promising inhibitors of nsp2 of CHIKV using molecular docking and temperature-dependent molecular dynamics simulations","volume":"40","author":"Meena","year":"2022","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.phymed.2024.156359_bib0041","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1099\/0022-1317-82-4-765","article-title":"Proteolytic processing of Semliki Forest virus-specific non-structural polyprotein by nsP2 protease","volume":"82","author":"Merits","year":"2001","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.phymed.2024.156359_bib0043","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.antiviral.2017.03.014","article-title":"Curcumin inhibits Zika and chikungunya virus infection by inhibiting cell binding","volume":"142","author":"Mounce","year":"2017","journal-title":"Antiviral. Res."},{"key":"10.1016\/j.phymed.2024.156359_bib0044","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jmgm.2015.01.001","article-title":"Identification of chikungunya virus nsP2 protease inhibitors using structure-base approaches","volume":"57","author":"Nguyen","year":"2015","journal-title":"J. Mol. Graph. Model."},{"key":"10.1016\/j.phymed.2024.156359_bib0045","doi-asserted-by":"crossref","first-page":"3712","DOI":"10.1021\/jp994072s","article-title":"Modification of the generalized born model suitable for macromolecules","volume":"104","author":"Onufriev","year":"2000","journal-title":"J. Phys. Chem."},{"key":"10.1016\/j.phymed.2024.156359_bib0046","doi-asserted-by":"crossref","first-page":"221","DOI":"10.5455\/jabet.2024.d19","article-title":"Antiviral potential of terpenoids against major viral infections: rece nt advances, challenges, and opportunities","volume":"7","author":"Orosco","year":"2024","journal-title":"J. Adv. Biotechnol. Exp. Ther."},{"key":"10.1016\/j.phymed.2024.156359_bib0047","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.virusres.2007.09.009","article-title":"Expression and biochemical characterization of nsP2 cysteine protease of Chikungunya virus","volume":"131","author":"Pastorino","year":"2008","journal-title":"Virus Res."},{"key":"10.1016\/j.phymed.2024.156359_bib0048","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12985-021-01517-z","article-title":"In vitro and in vivo studies reveal \u03b1-Mangostin, a xanthonoid from Garcinia mangostana, as a promising natural antiviral compound against chikungunya virus","volume":"18","author":"Patil","year":"2021","journal-title":"Virol. J."},{"key":"10.1016\/j.phymed.2024.156359_bib0049","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.3390\/v1031209","article-title":"Current and novel inhibitors of HIV protease","volume":"1","author":"Pokorna","year":"2009","journal-title":"Viruses"},{"key":"10.1016\/j.phymed.2024.156359_bib0050","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1111\/cbdd.12901","article-title":"Structure-function relationship of Chikungunya nsP2 protease: a comparative study with papain","volume":"89","author":"Ramakrishnan","year":"2017","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.phymed.2024.156359_bib0051","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1002\/prot.24602","article-title":"Network mapping among the functional domains of Chikungunya virus nonstructural proteins","volume":"82","author":"Rana","year":"2014","journal-title":"Proteins"},{"key":"10.1016\/j.phymed.2024.156359_bib0052","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1021\/jm400460d","article-title":"Chikungunya virus: emerging targets and new opportunities for medicinal chemistry","volume":"57","author":"Rashad","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.phymed.2024.156359_bib0053","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.antiviral.2013.12.010","article-title":"Chikungunya virus nsP3 & nsP4 interacts with HSP-90 to promote virus replication: HSP-90 inhibitors reduce CHIKV infection and inflammation in vivo","volume":"103","author":"Rathore","year":"2014","journal-title":"Antiviral Res."},{"key":"10.1016\/j.phymed.2024.156359_bib0054","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2020.104558","article-title":"Indole alkaloids: 2012 until now, highlighting the new chemical structures and biological activities","volume":"143","author":"Rosales","year":"2020","journal-title":"Fitoterapia"},{"key":"10.1016\/j.phymed.2024.156359_bib0055","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1017\/S0022172400044442","article-title":"The Newala epidemic. III. The virus: isolation, pathogenic properties and relationship to the epidemic","volume":"54","author":"Ross","year":"1956","journal-title":"J. Hyg."},{"key":"10.1016\/j.phymed.2024.156359_bib0056","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1099\/jgv.0.000249","article-title":"Alphavirus RNA synthesis and non-structural protein functions","volume":"96","author":"Rupp","year":"2015","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.phymed.2024.156359_bib0057","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nrmicro2368","article-title":"Biology and pathogenesis of chikungunya virus","volume":"8","author":"Schwartz","year":"2010","journal-title":"Nat. Rev. Micro."},{"key":"10.1016\/j.phymed.2024.156359_bib0058","doi-asserted-by":"crossref","first-page":"21","DOI":"10.20535\/ibb.2023.7.3.285245","article-title":"Potential alphavirus inhibitors from phytocompounds\u2013molecular docking and dynamics based approach","volume":"7","author":"Sharma","year":"2023","journal-title":"Innov. Biosyst. Bioeng"},{"key":"10.1016\/j.phymed.2024.156359_bib0059","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/s13337-021-00685-4","article-title":"In-vitro and in-silico evaluation of the anti-chikungunya potential of Psidium guajava leaf extract and their synthesized silver nanoparticles","volume":"32","author":"Sharma","year":"2021","journal-title":"VirusDis"},{"key":"10.1016\/j.phymed.2024.156359_bib0060","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.biochi.2018.04.004","article-title":"Chikungunya virus inhibition by peptidomimetic inhibitors targeting virus-specific cysteine protease","volume":"149","author":"Singh","year":"2018","journal-title":"Biochimie"},{"key":"10.1016\/j.phymed.2024.156359_bib0061","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00894-011-1018-3","article-title":"Homology modeling, molecular dynamics, e-pharmacophore mapping and docking study of Chikungunya virus nsP2 protease","volume":"18","author":"Singh","year":"2012","journal-title":"J. Mol. Model."},{"key":"10.1016\/j.phymed.2024.156359_bib0062","doi-asserted-by":"crossref","first-page":"e89","DOI":"10.1371\/journal.ppat.0030089","article-title":"Characterization of reemerging chikungunya virus","volume":"3","author":"Sourisseau","year":"2007","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.phymed.2024.156359_bib0063","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.virusres.2012.08.006","article-title":"Mapping interactions of Chikungunya virus nonstructural proteins","volume":"169","author":"Sreejith","year":"2012","journal-title":"Virus Res."},{"key":"10.1016\/j.phymed.2024.156359_bib0064","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1017\/S0950268807008424","article-title":"Retrospective survey of Chikungunya disease in Reunion Island hospital staff","volume":"136","author":"Staikowsky","year":"2008","journal-title":"Epidemiol. Infect."},{"key":"10.1016\/j.phymed.2024.156359_bib0065","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1128\/mr.58.3.491-562.1994","article-title":"The alphaviruses: gene expression, replication, and evolution","volume":"58","author":"Strauss","year":"1994","journal-title":"Microbiol. Rev."},{"key":"10.1016\/j.phymed.2024.156359_bib0066","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.ijbiomac.2020.05.165","article-title":"In-silico and biophysical investigation of biomolecular interaction between naringin and nsP2 of the chikungunya virus","volume":"160","author":"Tripathi","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2024.156359_bib0067","doi-asserted-by":"crossref","first-page":"6364","DOI":"10.1038\/s41598-020-63397-7","article-title":"Tomatidine, a natural steroidal alkaloid shows antiviral activity towards chikungunya virus in vitro","volume":"10","author":"Troost","year":"2020","journal-title":"Sci Rep."},{"key":"10.1016\/j.phymed.2024.156359_bib0069","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.antiviral.2015.12.012","article-title":"Discovery of berberine, abamectin and ivermectin as antivirals against chikungunya and other alphaviruses","volume":"126","author":"Varghese","year":"2016","journal-title":"Antiviral. Res."},{"key":"10.1016\/j.phymed.2024.156359_bib0070","doi-asserted-by":"crossref","first-page":"9743","DOI":"10.1128\/JVI.01382-16","article-title":"The antiviral alkaloid Berberine reduces Chikungunya virus-induced mitogen-activated protein kinase signaling","volume":"90","author":"Varghese","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.phymed.2024.156359_bib0071","doi-asserted-by":"crossref","first-page":"30786","DOI":"10.1074\/jbc.M104786200","article-title":"Site-specific protease activity of the carboxyl-terminal domain of Semliki Forest virus replicase protein nsP2","volume":"276","author":"Vasiljeva","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2024.156359_bib0072","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1080\/07391102.2018.1509732","article-title":"Structure based virtual screening, 3D-QSAR, molecular dynamics and ADMET studies for selection of natural inhibitors against structural and non-structural targets of Chikungunya","volume":"37","author":"Vora","year":"2019","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.phymed.2024.156359_bib0073","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.virol.2017.02.014","article-title":"Discovery of a novel antiviral agent targeting the nonstructural protein 4 (nsP4) of chikungunya virus","volume":"505","author":"Wada","year":"2017","journal-title":"Virology"},{"key":"10.1016\/j.phymed.2024.156359_bib0074","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01382-20","article-title":"Berberine chloride is an alphavirus inhibitor that targets nucleocapsid assembly","volume":"11","author":"Wan","year":"2020","journal-title":"mBio"},{"key":"10.1016\/j.phymed.2024.156359_bib0075","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1006\/viro.1996.0147","article-title":"Mutagenesis of the Sindbis virus nsP1 protein: effects on methyltransferase activity and viral infectivity","volume":"217","author":"Wang","year":"1996","journal-title":"Virology"},{"key":"10.1016\/j.phymed.2024.156359_bib0076","doi-asserted-by":"crossref","first-page":"14179","DOI":"10.1038\/srep14179","article-title":"Activity of andrographolide against chikungunya virus infection","volume":"5","author":"Wintachai","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2024.156359_bib0077","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/v10060294","article-title":"The interplay of viral and host factors in Chikungunya virus infection: targets for antiviral strategies","volume":"10","author":"Wong","year":"2018","journal-title":"Viruses"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324010146?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324010146?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:12:03Z","timestamp":1740355923000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711324010146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":77,"alternative-id":["S0944711324010146"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2024.156359","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recent advances in phytocompounds as potential Chikungunya virus non-structural protein 2 protease antagonists: A systematic review","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2024.156359","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156359"}}