{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:16:03Z","timestamp":1793661363763,"version":"4.5.1"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100009004","name":"Anhui University of Chinese Medicine","doi-asserted-by":"publisher","award":["2024277"],"award-info":[{"award-number":["2024277"]}],"id":[{"id":"10.13039\/501100009004","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.phymed.2025.156477","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T03:06:29Z","timestamp":1738897589000},"page":"156477","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Dual role of Baimao-Longdan-Congrong-Fang in inhibiting Staphylococcus aureus virulence factors and regulating TNF-\u03b1\/TNFR1\/NF-\u03baB\/MMP9 axis"],"prefix":"10.1016","volume":"139","author":[{"given":"Tao","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixin","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenhao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianting","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2194-5698","authenticated-orcid":false,"given":"Xin","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.156477_bib0001","doi-asserted-by":"crossref","first-page":"3543","DOI":"10.4049\/jimmunol.180.5.3543","article-title":"Mast cell-fibroblast interactions induce matrix metalloproteinase-9 release from fibroblasts: role for IgE-mediated mast cell activation","volume":"180","author":"Abel","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.phymed.2025.156477_bib0002","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s43141-021-00288-y","article-title":"Missense variants in the TNFA epitopes and their effects on interaction with therapeutic antibodies-in silico analysis","volume":"20","author":"Ahsan","year":"2022","journal-title":"J. Genet. Eng. Biotechnol."},{"key":"10.1016\/j.phymed.2025.156477_bib0003","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1038\/s41564-019-0480-z","article-title":"Antibiotic combinations that exploit heteroresistance to multiple drugs effectively control infection","volume":"4","author":"Band","year":"2019","journal-title":"Nat. Microbiol."},{"issue":"Suppl 4","key":"10.1016\/j.phymed.2025.156477_bib0004","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/1469-0691.12463","volume":"20","author":"Bassetti","year":"2014","journal-title":"Eur. Soc. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.phymed.2025.156477_bib0005","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.3390\/toxins5061140","article-title":"Staphylococcus aureus \u03b1-toxin: nearly a century of intrigue","volume":"5","author":"Berube","year":"2013","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.phymed.2025.156477_bib0006","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s11274-022-03378-2","article-title":"7,8-Dihydroxyflavone attenuates the virulence of Staphylococcus aureus by inhibiting alpha-hemolysin","volume":"38","author":"Bian","year":"2022","journal-title":"World J. Microbiol. Biotechnol."},{"key":"10.1016\/j.phymed.2025.156477_bib0007","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/nrmicro1818","article-title":"The biology and future prospects of antivirulence therapies","volume":"6","author":"Cegelski","year":"2008","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.phymed.2025.156477_bib0008","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.bcp.2017.06.123","article-title":"Major achievements of evidence-based traditional Chinese medicine in treating major diseases","volume":"139","author":"Chao","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156477_bib0009","doi-asserted-by":"crossref","first-page":"e67994","DOI":"10.1371\/journal.pone.0067994","article-title":"Linezolid exerts greater bacterial clearance but No modification of host lung gene expression profiling: a mouse MRSA pneumonia model","volume":"8","author":"Chen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2025.156477_bib0010","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1021\/acs.jcim.6b00672","article-title":"Discovery of novel ligands for TNF-\u03b1 and TNF receptor-1 through structure-based virtual screening and biological assay","volume":"57","author":"Chen","year":"2017","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.phymed.2025.156477_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114892","article-title":"Research progress on polysaccharide components of Cistanche deserticola as potential pharmaceutical agents","volume":"245","author":"Cheng","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.phymed.2025.156477_bib0012","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.cca.2014.03.031","article-title":"Matrix metalloproteinases in pneumonia","volume":"433","author":"Chiang","year":"2014","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.phymed.2025.156477_bib0013","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41579-022-00820-y","article-title":"Molecular mechanisms of antibiotic resistance revisited","volume":"21","author":"Darby","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.phymed.2025.156477_bib0014","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrd.2017.23","article-title":"Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance","volume":"16","author":"Dickey","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.phymed.2025.156477_bib0015","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1016\/j.apsb.2024.02.002","article-title":"Spirohypertones A and B as potent antipsoriatics: tumor necrosis factor-\u03b1 inhibitors with unprecedented chemical architectures","volume":"14","author":"Duan","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phymed.2025.156477_bib0016","article-title":"Antivirulence strategies for the treatment of Staphylococcus aureus infections: a mini review","volume":"11","author":"Ford","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.phymed.2025.156477_bib0017","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1007\/s00134-018-5229-2","article-title":"Safety and tolerability of a single administration of AR-301, a human monoclonal antibody, in ICU patients with severe pneumonia caused by Staphylococcus aureus: first-in-human trial","volume":"44","author":"Fran\u00e7ois","year":"2018","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.phymed.2025.156477_bib0018","doi-asserted-by":"crossref","first-page":"W60","DOI":"10.1093\/nar\/gky311","article-title":"GeneMANIA update 2018","volume":"46","author":"Franz","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.phymed.2025.156477_bib0019","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1111\/bph.13912","article-title":"Isoacteoside, a dihydroxyphenylethyl glycoside, exhibits anti-inflammatory effects through blocking toll-like receptor 4 dimerization","volume":"174","author":"Gao","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156477_bib0020","first-page":"171","article-title":"Antimicrobial resistance. Its importance and efforts to control it","volume":"156","author":"Giono-Cerezo","year":"2020","journal-title":"Gac. Med. Mex."},{"issue":"Suppl 5","key":"10.1016\/j.phymed.2025.156477_bib0021","doi-asserted-by":"crossref","first-page":"S350","DOI":"10.1086\/533591","article-title":"Pathogenesis of methicillin-resistant Staphylococcus aureus infection","volume":"46","author":"Gordon","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.phymed.2025.156477_bib0022","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.2147\/DDDT.S164515","article-title":"Linezolid: a review of its properties, function, and use in critical care","volume":"12","author":"Hashemian","year":"2018","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.phymed.2025.156477_bib0023","doi-asserted-by":"crossref","first-page":"384","DOI":"10.3390\/molecules23020384","article-title":"Wogonin suppresses the activity of matrix metalloproteinase-9 and inhibits migration and invasion in human hepatocellular carcinoma","volume":"23","author":"Hong","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2025.156477_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113391","article-title":"Genus Gentiana: a review on phytochemistry, pharmacology and molecular mechanism","volume":"264","author":"Jiang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.156477_bib0025","article-title":"Multi-omics and bioinformatics for the investigation of therapeutic mechanism of roucongrong pill against postmenopausal osteoporosis","volume":"337","author":"Jiang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.156477_bib0026","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00430-023-00782-9","article-title":"Echinacoside, a promising sortase A inhibitor, combined with vancomycin against murine models of MRSA-induced pneumonia","volume":"212","author":"Jiang","year":"2023","journal-title":"Med. Microbiol. Immunol."},{"key":"10.1016\/j.phymed.2025.156477_bib0027","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrrheum.2015.169","article-title":"TNF biology, pathogenic mechanisms and emerging therapeutic strategies","volume":"12","author":"Kalliolias","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.phymed.2025.156477_bib0028","doi-asserted-by":"crossref","first-page":"697","DOI":"10.3390\/antibiotics12040697","article-title":"Effectiveness and safety of linezolid versus vancomycin, teicoplanin, or Daptomycin against methicillin-resistant Staphylococcus aureus bacteremia: a systematic review and meta-analysis","volume":"12","author":"Kawasuji","year":"2023","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.phymed.2025.156477_bib0029","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3390\/toxins8030072","article-title":"Targeting Staphylococcus aureus toxins: a potential form of anti-virulence therapy","volume":"8","author":"Kong","year":"2016","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.phymed.2025.156477_bib0030","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.bbrc.2007.01.072","article-title":"Staphylococcus aureus protein A induced inflammatory response in human corneal epithelial cells","volume":"354","author":"Kumar","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phymed.2025.156477_bib0031","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.cmi.2020.12.018","article-title":"Antibiotic prescribing in patients with COVID-19: rapid review and meta-analysis","volume":"27","author":"Langford","year":"2021","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.phymed.2025.156477_bib0032","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1016\/j.cmi.2020.07.016","article-title":"Bacterial co-infection and secondary infection in patients with COVID-19: a living rapid review and meta-analysis","volume":"26","author":"Langford","year":"2020","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.phymed.2025.156477_bib0033","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.cmi.2022.12.006","article-title":"Antibiotic resistance associated with the COVID-19 pandemic: a systematic review and meta-analysis","volume":"29","author":"Langford","year":"2023","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.phymed.2025.156477_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116863","article-title":"Protective effects of Angelica decursiva Franchet & Savatier on allergic responses through enhancement of Nrf2 and suppression of NF-kB\/MMP-9 in ovalbumin-exposed mice","volume":"318","author":"Lee","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.156477_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2024.113823","article-title":"Biocompatible formulation of a hydrophobic antimicrobial peptide L30 through nanotechnology principles and its potential role in mouse pneumonia model infected with Staphylococcus aureus","volume":"236","author":"Li","year":"2024","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.phymed.2025.156477_bib0036","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3724\/SP.J.1009.2013.00110","article-title":"Traditional Chinese medicine network pharmacology: theory, methodology and application","volume":"11","author":"Li","year":"2013","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.phymed.2025.156477_bib0037","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.antiviral.2012.10.006","article-title":"Traditional Chinese herbal medicine as a source of molecules with antiviral activity","volume":"97","author":"Li","year":"2013","journal-title":"Antiviral Res."},{"key":"10.1016\/j.phymed.2025.156477_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154475","article-title":"Compound 511 ameliorates MRSA-induced lung injury by attenuating morphine-induced immunosuppression in mice via PI3K\/AKT\/mTOR pathway","volume":"108","author":"Li","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.156477_bib0039","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(00)00129-0","article-title":"Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings","volume":"46","author":"Lipinski","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.phymed.2025.156477_bib0040","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.7150\/ijms.33723","article-title":"Yunnan Baiyao reduces hospital-acquired pressure ulcers via suppressing virulence gene expression and biofilm formation of Staphylococcus aureus","volume":"16","author":"Liu","year":"2019","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.phymed.2025.156477_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115842","article-title":"Network and experimental pharmacology on mechanism of Si-Wu-tang improving ovarian function in a mouse model of premature ovarian failure induced by cyclophosphamide","volume":"301","author":"Liu","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.156477_bib0042","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1259004","article-title":"Nuclease activity and protein A release of Staphylococcus aureus clinical isolates determine the virulence in a murine model of acute lung infection","volume":"14","author":"Ludwig","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2025.156477_bib0043","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/14787210.2023.2154653","article-title":"Escalation of antimicrobial resistance among MRSA part 1: focus on global spread","volume":"21","author":"Lynch","year":"2023","journal-title":"Expert Rev. Anti. Infect. Ther."},{"key":"10.1016\/j.phymed.2025.156477_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155006","article-title":"Combining transcriptomic analysis and network pharmacology to explore the mechanism by which Shaofu Zhuyu decoction improves diabetes mellitus erectile dysfunction","volume":"119","author":"Mao","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.156477_bib0045","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bcp.2016.12.018","article-title":"Antileishmanial activity of verbascoside: selective arginase inhibition of intracellular amastigotes of Leishmania (Leishmania) amazonensis with resistance induced by LPS plus IFN-\u03b3","volume":"127","author":"Maquiaveli","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156477_bib0046","doi-asserted-by":"crossref","first-page":"e15177","DOI":"10.1371\/journal.pone.0015177","article-title":"Importance of the global regulators Agr and SaeRS in the pathogenesis of CA-MRSA USA300 infection","volume":"5","author":"Montgomery","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2025.156477_bib0047","doi-asserted-by":"crossref","first-page":"4717","DOI":"10.3390\/molecules26164717","article-title":"Prenylated flavonoids and C-15 isoprenoid analogues with antibacterial properties from the whole plant of Imperata cylindrica (L.) Raeusch (Gramineae)","volume":"26","author":"Nago","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2025.156477_bib0048","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1186\/s12906-020-03064-6","article-title":"A botanical from the antiproliferative Cameroonian spice, Imperata cylindrica is safe at lower doses, as demonstrated by oral acute and sub-chronic toxicity screenings","volume":"20","author":"Nayim","year":"2020","journal-title":"BMC Complement. Med. Ther."},{"key":"10.1016\/j.phymed.2025.156477_bib0049","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.tim.2014.09.002","article-title":"What role does the quorum-sensing accessory gene regulator system play during Staphylococcus aureus bacteremia?","volume":"22","author":"Painter","year":"2014","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.phymed.2025.156477_bib0050","doi-asserted-by":"crossref","first-page":"4331","DOI":"10.3390\/ijms20184331","article-title":"Molecular docking: shifting paradigms in drug discovery","volume":"20","author":"Pinzi","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2025.156477_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijfoodmicro.2024.110925","article-title":"Antibiofilm mechanism of 2R,3R-dihydromyricetin by targeting sortase A and its application against Staphylococcus aureus adhesion on eggshell","volume":"426","author":"Ran","year":"2025","journal-title":"Int. J. Food Microbiol."},{"key":"10.1016\/j.phymed.2025.156477_bib0052","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nrd3013","article-title":"Anti-virulence strategies to combat bacteria-mediated disease","volume":"9","author":"Rasko","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.phymed.2025.156477_bib0053","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.bjorl.2016.03.008","article-title":"Surveillance of bacteria Pseudomonas aeruginosa and MRSA associated with chronic suppurative otitis media","volume":"83","author":"Rath","year":"2017","journal-title":"Braz. J. Otorhinolaryngol."},{"key":"10.1016\/j.phymed.2025.156477_bib0054","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/s41579-020-0395-y","article-title":"Antimicrobial use, drug-resistant infections and COVID-19","volume":"18","author":"Rawson","year":"2020","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.phymed.2025.156477_bib0055","doi-asserted-by":"crossref","first-page":"6020","DOI":"10.3892\/mmr.2017.7316","article-title":"Staphylococcus aureus Protein A induces osteoclastogenesis via the NF\u2011\u03baB signaling pathway","volume":"16","author":"Ren","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.phymed.2025.156477_bib0056","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1432334","article-title":"Aconitate decarboxylase 1 mediates the acute airway inflammatory response to environmental exposures","volume":"15","author":"Schwab","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2025.156477_bib0057","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2023.105452","article-title":"Revisiting Licorice as a functional food in the management of neurological disorders: bench to trend","volume":"155","author":"Sharma","year":"2023","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.phymed.2025.156477_bib0058","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2022.104795","article-title":"Role of Shankhpushpi (Convolvulus pluricaulis) in neurological disorders: an umbrella review covering evidence from ethnopharmacology to clinical studies","volume":"140","author":"Sharma","year":"2022","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.phymed.2025.156477_bib0059","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115653","article-title":"Lianhuaqingwen capsule inhibits non-lethal doses of influenza virus-induced secondary Staphylococcus aureus infection in mice","volume":"298","author":"Song","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.156477_bib0060","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1126\/science.274.5294.1859","article-title":"Structure of staphylococcal alpha-hemolysin, a heptameric transmembrane pore","volume":"274","author":"Song","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.phymed.2025.156477_bib0061","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.106086","article-title":"The key role of macrophage depolarization in the treatment of COPD with ergosterol both in vitro and in vivo","volume":"79","author":"Sun","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2025.156477_bib0062","first-page":"893","article-title":"Bleomycin-induced interstitial pulmonary disease in the nude, athymic mouse","volume":"120","author":"Szapiel","year":"1979","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.phymed.2025.156477_bib0063","doi-asserted-by":"crossref","DOI":"10.1080\/21505594.2023.2260675","article-title":"Exploring the modulatory impact of isosakuranetin on Staphylococcus aureus: inhibition of sortase A activity and \u03b1-haemolysin expression","volume":"14","author":"Tian","year":"2023","journal-title":"Virulence"},{"key":"10.1016\/j.phymed.2025.156477_bib0064","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.4014\/jmb.2206.06007","article-title":"Isovitexin protects mice from methicillin-resistant Staphylococcus aureus-induced pneumonia by targeting Sortase A","volume":"32","author":"Tian","year":"2022","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1016\/j.phymed.2025.156477_bib0065","doi-asserted-by":"crossref","first-page":"12424","DOI":"10.1073\/pnas.96.22.12424","article-title":"Purification and characterization of sortase, the transpeptidase that cleaves surface proteins of Staphylococcus aureus at the LPXTG motif","volume":"96","author":"Ton-That","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.phymed.2025.156477_bib0066","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1128\/CMR.00134-14","article-title":"Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management","volume":"28","author":"Tong","year":"2015","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.phymed.2025.156477_bib0067","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.chembiol.2016.01.004","article-title":"Regulation of virulence in Staphylococcus aureus: molecular mechanisms and remaining puzzles","volume":"23","author":"Wang","year":"2016","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.phymed.2025.156477_bib0068","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1038\/s41467-021-23659-y","article-title":"Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistance","volume":"12","author":"Wang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2025.156477_bib0069","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2022.105454","article-title":"Mechanisms underlying the therapeutic effects of Qingfeiyin in treating acute lung injury based on GEO datasets, network pharmacology and molecular docking","volume":"145","author":"Wang","year":"2022","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.phymed.2025.156477_bib0070","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.3390\/antiox12111925","article-title":"Sirtuin1 Mediates the protective effects of echinacoside against sepsis-induced acute lung injury via regulating the NOX4-Nrf2 axis","volume":"12","author":"Xie","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.phymed.2025.156477_bib0071","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.14336\/AD.2021.0906","article-title":"Effectiveness and safety of traditional Chinese medicine in treating COVID-19: clinical evidence from China","volume":"12","author":"Xing","year":"2021","journal-title":"Aging Dis."},{"key":"10.1016\/j.phymed.2025.156477_bib0072","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1086\/508210","article-title":"Regulation of Staphylococcus aureus alpha-toxin gene (hla) expression by agr, sarA, and sae in vitro and in experimental infective endocarditis","volume":"194","author":"Xiong","year":"2006","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.phymed.2025.156477_bib0073","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41586-020-2757-z","article-title":"Modulating TRADD to restore cellular homeostasis and inhibit apoptosis","volume":"587","author":"Xu","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2025.156477_bib0074","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114575","article-title":"Targeting the TNF-\u03b1-TNFR interaction with EGCG to block NF-\u03baB signaling in human synovial fibroblasts","volume":"161","author":"Xu","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2025.156477_bib0075","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1074\/mcp.M111.014191","article-title":"Proteomic and transcriptomic profiling of Staphylococcus aureus surface LPXTG-proteins: correlation with agr genotypes and adherence phenotypes","volume":"11","author":"Ythier","year":"2012","journal-title":"Mol. Cell Proteomics."},{"key":"10.1016\/j.phymed.2025.156477_bib0076","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155808","article-title":"Chemical composition, pharmacological effects, and parasitic mechanisms of Cistanche deserticola: an update","volume":"132","author":"Zhang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.156477_bib0077","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114066","article-title":"Liu Shen Wan inhibits influenza virus-induced secondary Staphylococcus aureus infection in vivo and in vitro","volume":"277","author":"Zhao","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.156477_bib0078","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.2147\/IJN.S406649","article-title":"Gentiopicroside-loaded chitosan nanoparticles inhibit TNF-\u03b1-induced proliferation and inflammatory response in HaCaT keratinocytes and ameliorate imiquimod-induced dermatitis lesions in mice","volume":"18","author":"Zhao","year":"2023","journal-title":"Int. J. Nanomed."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325001187?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325001187?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T13:15:27Z","timestamp":1774962927000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325001187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":78,"alternative-id":["S0944711325001187"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156477","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dual role of Baimao-Longdan-Congrong-Fang in inhibiting Staphylococcus aureus virulence factors and regulating TNF-\u03b1\/TNFR1\/NF-\u03baB\/MMP9 axis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156477","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156477"}}