{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:01:34Z","timestamp":1793390494426,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M723514"],"award-info":[{"award-number":["2022M723514"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404997"],"award-info":[{"award-number":["82404997"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204340"],"award-info":[{"award-number":["82204340"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.phymed.2025.156490","type":"journal-article","created":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T01:48:32Z","timestamp":1739065712000},"page":"156490","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Sea buckthorn berries alleviate ulcerative colitis via regulating gut Faecalibaculum rodentium-mediated butyrate biosynthesis"],"prefix":"10.1016","volume":"139","author":[{"given":"Zhe","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingfei","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.156490_bib0001","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2024.2382324","article-title":"Enhancing recovery from gut microbiome dysbiosis and alleviating DSS-induced colitis in mice with a consortium of rare short-chain fatty acid-producing bacteria","volume":"16","author":"Ambat","year":"2024","journal-title":"Gut Microbes"},{"key":"10.1016\/j.phymed.2025.156490_bib0002","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.cmi.2023.12.007","article-title":"Update on microbiota-derived therapies for recurrent infections","volume":"30","author":"Benech","year":"2024","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.phymed.2025.156490_bib0003","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0140-6736(23)00966-2","article-title":"Ulcerative colitis","volume":"402","author":"Berre","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2025.156490_bib0004","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1053\/j.gastro.2024.05.036","article-title":"Targeting the interleukin 23 pathway in inflammatory bowel disease","volume":"168","author":"Bourgonje","year":"2025","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phymed.2025.156490_bib0005","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/j.chom.2022.07.015","article-title":"Faecalibaculum rodentium remodels retinoic acid signaling to govern eosinophil-dependent intestinal epithelial homeostasis","volume":"30","author":"Cao","year":"2022","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.phymed.2025.156490_bib0006","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.ebiom.2018.03.030","article-title":"Sodium butyrate inhibits inflammation and maintains epithelium barrier integrity in a TNBS-induced inflammatory bowel disease mice model","volume":"30","author":"Chen","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.phymed.2025.156490_bib0007","article-title":"Flavonoids from Seabuckthorn (Hippophae rhamnoides L.) mimic neurotrophic functions in inducing neurite outgrowth in cultured neurons: signaling PI3K\/Akt and ERK pathways","volume":"115","author":"Chen","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.156490_bib0008","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature11225","article-title":"Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-\/- mice","volume":"487","author":"Devkota","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2025.156490_bib0009","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41564-018-0306-4","article-title":"Gut microbiome structure and metabolic activity in inflammatory bowel disease","volume":"4","author":"Franzosa","year":"2019","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.phymed.2025.156490_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2023.135598","article-title":"Metabolomics provide a novel interpretation of the changes in flavonoids during sea buckthorn (Hippophae rhamnoides L.) drying","volume":"413","author":"Geng","year":"2023","journal-title":"Food Chem."},{"key":"10.1016\/j.phymed.2025.156490_bib0011","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/s41573-024-00953-0","article-title":"Navigating the complexities of drug development for inflammatory bowel disease","volume":"23","author":"Honap","year":"2024","journal-title":"Nat. Rev. Drug. Discov."},{"key":"10.1016\/j.phymed.2025.156490_bib0012","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41467-020-20673-4","article-title":"A diet-microbial metabolism feedforward loop modulates intestinal stem cell renewal in the stressed gut","volume":"12","author":"Hou","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2025.156490_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113394","article-title":"Qingchang Huashi Formula attenuates DSS-induced colitis in mice by restoring gut microbiota-metabolism homeostasis and goblet cell function","volume":"266","author":"Hu","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.156490_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2022.108273","article-title":"Short-chain fatty acid receptors and gut microbiota as therapeutic targets in metabolic, immune, and neurological diseases","volume":"239","author":"Ikeda","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2025.156490_bib0015","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2232137","article-title":"Advancing therapeutics for recurrent clostridioides difficile infections: an overview of vowst\u2019s FDA approval and implications","volume":"15","author":"Jain","year":"2023","journal-title":"Gut Microbes"},{"key":"10.1016\/j.phymed.2025.156490_bib0016","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","article-title":"From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites","volume":"165","author":"Koh","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2025.156490_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.123797","article-title":"Sea buckthorn polysaccharide ameliorates high-fat diet induced mice neuroinflammation and synaptic dysfunction via regulating gut dysbiosis","volume":"236","author":"Lan","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2025.156490_bib0018","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41575-019-0258-z","article-title":"Gut microbiota-derived metabolites as key actors in inflammatory bowel disease","volume":"17","author":"Lavelle","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phymed.2025.156490_bib0019","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1093\/ecco-jcc\/jjz025","article-title":"CD1d modulates colonic inflammation in NOD2-\/- mice by altering the intestinal microbial composition comprising Acetatifactor muris","volume":"13","author":"Lee","year":"2019","journal-title":"J. Crohns. Colitis"},{"key":"10.1016\/j.phymed.2025.156490_bib0020","doi-asserted-by":"crossref","first-page":"4769","DOI":"10.1021\/acs.jafc.2c06916","article-title":"Hippophae rhamnoides L.: a comprehensive review on the botany, traditional Uses, phytonutrients, health benefits, quality markers, and applications","volume":"71","author":"Ma","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2025.156490_bib0021","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1136\/gutjnl-2013-304833","article-title":"A decrease of the butyrate-producing species and defines dysbiosis in patients with ulcerative colitis","volume":"63","author":"Machiels","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.phymed.2025.156490_bib0022","doi-asserted-by":"crossref","first-page":"6734","DOI":"10.1038\/ncomms7734","article-title":"Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome","volume":"6","author":"Macia","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2025.156490_bib0023","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/s41577-024-01014-8","article-title":"Short-chain fatty acids: linking diet, the microbiome and immunity","volume":"24","author":"Mann","year":"2024","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.phymed.2025.156490_bib0024","doi-asserted-by":"crossref","DOI":"10.3390\/nu16091280","article-title":"Sea buckthorn polysaccharide ameliorates colitis","volume":"16","author":"Ouyang","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2025.156490_bib0025","doi-asserted-by":"crossref","first-page":"7139","DOI":"10.1038\/s41598-017-07280-y","article-title":"Effect of niacin on inflammation and angiogenesis in a murine model of ulcerative colitis","volume":"7","author":"Salem","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2025.156490_bib0026","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.chom.2017.11.004","article-title":"Bifidobacteria or fiber protects against diet-induced microbiota-mediated colonic mucus deterioration","volume":"23","author":"Schroeder","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.phymed.2025.156490_bib0027","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.immuni.2013.12.007","article-title":"Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis","volume":"40","author":"Singh","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.phymed.2025.156490_bib0028","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.chom.2012.09.012","article-title":"Mycobacterium tuberculosis-driven targeted recalibration of macrophage lipid homeostasis promotes the foamy phenotype","volume":"12","author":"Singh","year":"2012","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.phymed.2025.156490_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155378","article-title":"Phenolic acids from Chicory roots ameliorate dextran sulfate sodium-induced colitis in mice by targeting TRP signaling pathways and the gut microbiota","volume":"128","author":"Tian","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.156490_bib0030","doi-asserted-by":"crossref","first-page":"3728","DOI":"10.1038\/s41467-018-06125-0","article-title":"NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease","volume":"9","author":"Tye","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2025.156490_bib0031","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1080\/19490976.2018.1526583","article-title":"Inulin-type fructans improve active ulcerative colitis associated with microbiota changes and increased short-chain fatty acids levels","volume":"10","author":"Valcheva","year":"2019","journal-title":"Gut Microbes"},{"key":"10.1016\/j.phymed.2025.156490_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122004","article-title":"Niacin modulates depressive-like behavior in experimental colitis through GPR109A-dependent mechanisms","volume":"330","author":"Wadie","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2025.156490_bib0033","doi-asserted-by":"crossref","first-page":"11648","DOI":"10.1073\/pnas.1917597117","article-title":"Microbiota-derived butyrate dynamically regulates intestinal homeostasis through regulation of actin-associated protein synaptopodin","volume":"117","author":"Wang","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.phymed.2025.156490_bib0034","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.phymed.2017.11.007","article-title":"Seabuckthorn berry polysaccharide extracts protect against acetaminophen induced hepatotoxicity in mice via activating the Nrf-2\/HO-1-SOD-2 signaling pathway","volume":"38","author":"Wang","year":"2018","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.156490_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155868","article-title":"Linderae Radix extract attenuates ulcerative colitis by inhibiting the JAK\/STAT signaling pathway","volume":"132","author":"Wang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.156490_bib0036","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.1067813","article-title":"Sea buckthorn pulp and seed oils ameliorate lipid metabolism disorders and modulate gut microbiota in C57BL\/6J mice on high-fat diet","volume":"9","author":"Wang","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.phymed.2025.156490_bib0037","doi-asserted-by":"crossref","first-page":"7426","DOI":"10.1039\/D3FO01332D","article-title":"Flavonoids from Seabuckthorn (Hippophae rhamnoides L.) restore CUMS-induced depressive disorder and regulate the gut microbiota in mice","volume":"14","author":"Xia","year":"2023","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2025.156490_bib0038","doi-asserted-by":"crossref","first-page":"e65","DOI":"10.1093\/nutrit\/nuae022","article-title":"Efficacy of probiotic supplementation and impact on fecal microbiota in patients with inflammatory bowel disease: a systematic review and meta-analysis of randomized controlled trials","volume":"83","author":"Xu","year":"2025","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.phymed.2025.156490_bib0039","doi-asserted-by":"crossref","first-page":"4703","DOI":"10.1039\/D3FO04140A","article-title":"Medicinal and edible polysaccharides from ancient plants: extraction, isolation, purification, structure, biological activity and market trends of sea buckthorn polysaccharides","volume":"15","author":"Xu","year":"2024","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2025.156490_bib0040","doi-asserted-by":"crossref","first-page":"4457","DOI":"10.1038\/s41467-020-18262-6","article-title":"Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity","volume":"11","author":"Yang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2025.156490_bib0041","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2024.2363020","article-title":"Microbial metabolite butyrate modulates granzyme B in tolerogenic IL-10 producing Th1 cells to regulate intestinal inflammation","volume":"16","author":"Yang","year":"2024","journal-title":"Gut Microbes"},{"key":"10.1016\/j.phymed.2025.156490_bib0042","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/s41564-019-0649-5","article-title":"Endogenous murine microbiota member and its human homologue protect from intestinal tumour growth","volume":"5","author":"Zagato","year":"2020","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.phymed.2025.156490_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104959","article-title":"Enteral nutrition promotes the remission of colitis by gut bacteria-mediated histidine biosynthesis","volume":"100","author":"Zeng","year":"2024","journal-title":"EBioMedicine"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132500131X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132500131X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T13:17:50Z","timestamp":1774963070000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S094471132500131X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":43,"alternative-id":["S094471132500131X"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156490","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sea buckthorn berries alleviate ulcerative colitis via regulating gut Faecalibaculum rodentium-mediated butyrate biosynthesis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156490","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156490"}}