{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:49:39Z","timestamp":1793663379419,"version":"4.5.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Jiangsu Province Natural Science Foundation","doi-asserted-by":"publisher","award":["24KJB320011"],"award-info":[{"award-number":["24KJB320011"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Jiangsu Province Natural Science Foundation","doi-asserted-by":"publisher","award":["BK20242070"],"award-info":[{"award-number":["BK20242070"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2632023TD03"],"award-info":[{"award-number":["2632023TD03"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011360","name":"State Key Laboratory of Natural Medicines","doi-asserted-by":"publisher","award":["SKLNMKF202301"],"award-info":[{"award-number":["SKLNMKF202301"]}],"id":[{"id":"10.13039\/501100011360","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82474375"],"award-info":[{"award-number":["82474375"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374322"],"award-info":[{"award-number":["82374322"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81961128020"],"award-info":[{"award-number":["81961128020"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82004124"],"award-info":[{"award-number":["82004124"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104184"],"award-info":[{"award-number":["82104184"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.phymed.2025.156495","type":"journal-article","created":{"date-parts":[[2025,2,16]],"date-time":"2025-02-16T10:56:30Z","timestamp":1739703390000},"page":"156495","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Yinzhihuang formula modulates the microbe\u2012gut\u2012liver axis and bile acid excretion to attenuate cholestatic liver injury"],"prefix":"10.1016","volume":"139","author":[{"given":"Xin","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feihui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6954-364X","authenticated-orcid":false,"given":"Yunlong","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1733-6331","authenticated-orcid":false,"given":"Zhonghong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.phymed.2025.156495_bib0001","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.jhep.2019.10.003","article-title":"The gut-liver axis in liver disease: pathophysiological basis for therapy","volume":"72","author":"Albillos","year":"2020","journal-title":"J. Hepatol."},{"issue":"3","key":"10.1016\/j.phymed.2025.156495_bib0002","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.chom.2020.12.004","article-title":"A microbial metabolite remodels the gut-liver axis following bariatric surgery","volume":"29","author":"Chaudhari","year":"2021","journal-title":"Cell Host. Microbe"},{"key":"10.1016\/j.phymed.2025.156495_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106643","article-title":"Capsaicin shapes gut microbiota and pre-metastatic niche to facilitate cancer metastasis to liver","volume":"188","author":"Cheng","year":"2023","journal-title":"Pharmacol. Res."},{"issue":"5","key":"10.1016\/j.phymed.2025.156495_bib0004","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.cell.2016.10.043","article-title":"A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility","volume":"167","author":"Desai","year":"2016","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.phymed.2025.156495_bib0005","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1002\/hep.31017","article-title":"Liver injury in patients with cholestatic liver disease treated with obeticholic acid","volume":"71","author":"Eaton","year":"2020","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.phymed.2025.156495_bib0006","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.apsb.2022.10.016","article-title":"Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice","volume":"13","author":"Fan","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"issue":"6","key":"10.1016\/j.phymed.2025.156495_bib0007","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/s41575-019-0132-z","article-title":"Neonatal cholestasis: emerging molecular diagnostics and potential novel therapeutics","volume":"16","author":"Feldman","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"7","key":"10.1016\/j.phymed.2025.156495_bib31","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/s41575-021-00566-7","article-title":"Role of bile acids and their receptors in gastrointestinal and hepatic pathophysiology","volume":"19","author":"Fuchs","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phymed.2025.156495_bib0008","first-page":"1","article-title":"The gut\u2013liver axis and gut microbiota in health and liver disease","author":"Hsu","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"issue":"2","key":"10.1016\/j.phymed.2025.156495_bib0009","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1002\/hep.28965","article-title":"The ascending pathophysiology of cholestatic liver disease","volume":"65","author":"Jansen","year":"2017","journal-title":"Hepatology"},{"issue":"36","key":"10.1016\/j.phymed.2025.156495_bib0010","doi-asserted-by":"crossref","first-page":"13580","DOI":"10.1073\/pnas.0804437105","article-title":"Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome","volume":"105","author":"Jones","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U S. A"},{"issue":"3","key":"10.1016\/j.phymed.2025.156495_bib0011","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1172\/JCI22996","article-title":"Toll-like receptor 9\u2013induced type I IFN protects mice from experimental colitis","volume":"115","author":"Katakura","year":"2005","journal-title":"J. Clin. Invest."},{"issue":"9","key":"10.1016\/j.phymed.2025.156495_bib0012","doi-asserted-by":"crossref","first-page":"3949","DOI":"10.1016\/j.apsb.2024.05.014","article-title":"Schisanhenol ameliorates non-alcoholic fatty liver disease via inhibiting miR-802 activation of AMPK-mediated modulation of hepatic lipid metabolism","volume":"14","author":"Li","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"issue":"7","key":"10.1016\/j.phymed.2025.156495_bib0013","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.chom.2023.05.026","article-title":"Intestinal mucus and their glycans: a habitat for thriving microbiota","volume":"31","author":"Luis","year":"2023","journal-title":"Cell Host. Microbe"},{"issue":"6391","key":"10.1016\/j.phymed.2025.156495_bib0014","doi-asserted-by":"crossref","first-page":"eaan5931","DOI":"10.1126\/science.aan5931","article-title":"Gut microbiome\u2013mediated bile acid metabolism regulates liver cancer via NKT cells","volume":"360","author":"Ma","year":"2018","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.phymed.2025.156495_bib0015","doi-asserted-by":"crossref","first-page":"729","DOI":"10.4161\/19490976.2014.972223","article-title":"Serratia marcescens is injurious to intestinal epithelial cells","volume":"5","author":"Ochieng","year":"2014","journal-title":"Gut. Microbes."},{"issue":"7","key":"10.1016\/j.phymed.2025.156495_bib0016","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/s41575-023-00771-6","article-title":"Gut\u2013liver axis: barriers and functional circuits","volume":"20","author":"Pabst","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phymed.2025.156495_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113658","article-title":"Metabolomics analysis delineates the therapeutic effects of Huangqi decoction and astragalosides on \u03b1-naphthylisothiocyanate (ANIT) -induced cholestasis in rats","volume":"268","author":"Qiu","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.phymed.2025.156495_bib0018","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-003725","article-title":"Optimizing therapeutic outcomes of immune checkpoint blockade by a microbial tryptophan metabolite","volume":"10","author":"Renga","year":"2022","journal-title":"J. ImmunOther Cancer"},{"issue":"3","key":"10.1016\/j.phymed.2025.156495_bib0019","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1097\/MOG.0000000000000057","article-title":"Bile acids and the gut microbiome","volume":"30","author":"Ridlon","year":"2014","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.phymed.2025.156495_bib0020","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41467-018-07859-7","article-title":"Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway","volume":"10","author":"Singh","year":"2019","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.phymed.2025.156495_bib0021","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/hep.27927","article-title":"Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis","volume":"63","author":"Tabibian","year":"2016","journal-title":"Hepatol. Baltim. Md"},{"issue":"3","key":"10.1016\/j.phymed.2025.156495_bib0022","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1136\/gutjnl-2016-313332","article-title":"Gut microbial profile is altered in primary biliary cholangitis and partially restored after UDCA therapy","volume":"67","author":"Tang","year":"2018","journal-title":"Gut"},{"issue":"4","key":"10.1016\/j.phymed.2025.156495_bib0023","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nrmicro.2016.10","article-title":"The genomic signatures of Shigella evolution, adaptation and geographical spread","volume":"14","author":"The","year":"2016","journal-title":"Nat. Rev. Microbiol."},{"issue":"11","key":"10.1016\/j.phymed.2025.156495_bib0024","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/j.cmet.2022.09.017","article-title":"Gut-liver axis: pathophysiological concepts and clinical implications","volume":"34","author":"Tilg","year":"2022","journal-title":"Cell Metab."},{"issue":"7","key":"10.1016\/j.phymed.2025.156495_bib0025","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/s41575-018-0011-z","article-title":"The gut-liver axis and the intersection with the microbiome","volume":"15","author":"Tripathi","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"2","key":"10.1016\/j.phymed.2025.156495_bib0026","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1136\/gutjnl-2017-315458","article-title":"Gut commensal Parabacteroides goldsteinii plays a predominant role in the anti-obesity effects of polysaccharides isolated from Hirsutella sinensis","volume":"68","author":"Wu","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.phymed.2025.156495_bib0027","doi-asserted-by":"crossref","first-page":"9291","DOI":"10.1038\/s41467-024-53144-1","article-title":"Galactooligosaccharides and Limosilactobacillus reuteri synergistically alleviate gut inflammation and barrier dysfunction by enriching Bacteroides acidifaciens for pentadecanoic acid biosynthesis","volume":"15","author":"Wu","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2025.156495_bib0028","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2024.1434582","article-title":"Causal associations between gut microbiota and Cholestatic liver diseases: a Mendelian randomization study","volume":"11","author":"Yang","year":"2024","journal-title":"Front. Med."},{"issue":"1","key":"10.1016\/j.phymed.2025.156495_bib0029","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2181930","article-title":"Cholestasis: exploring the triangular relationship of gut microbiota-bile acid-cholestasis and the potential probiotic strategies","volume":"15","author":"Yu","year":"2023","journal-title":"Gut. Microbes."},{"issue":"1","key":"10.1016\/j.phymed.2025.156495_bib0030","first-page":"1","article-title":"Mechanisms of cholestasis","volume":"12","author":"Zollner","year":"2008","journal-title":"Clin. Liver Dis., Recent Adv. Cholestatic Liver Dis."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325001369?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325001369?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T13:11:21Z","timestamp":1774962681000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325001369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":31,"alternative-id":["S0944711325001369"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156495","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Yinzhihuang formula modulates the microbe\u2012gut\u2012liver axis and bile acid excretion to attenuate cholestatic liver injury","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156495","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"156495"}}