{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T14:02:47Z","timestamp":1774965767462,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003345","name":"Chinese Academy of Meteorological Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003345","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019018","name":"CIFMS","doi-asserted-by":"publisher","award":["2021-I2M-1-026"],"award-info":[{"award-number":["2021-I2M-1-026"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019018","name":"CIFMS","doi-asserted-by":"publisher","award":["2023-I2M-2-006"],"award-info":[{"award-number":["2023-I2M-2-006"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019018","name":"CIFMS","doi-asserted-by":"publisher","award":["2024-I2M-ZH-012"],"award-info":[{"award-number":["2024-I2M-ZH-012"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.phymed.2025.156517","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T16:11:55Z","timestamp":1739549515000},"page":"156517","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Berberine protects against dysentery by targeting both Shigella filamentous temperature sensitive protein Z and host pyroptosis: Resolving in vitro\u2013vivo effect discrepancy"],"prefix":"10.1016","volume":"139","author":[{"given":"Xiangyin","family":"Chi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinwen","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanxing","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiandong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.156517_bib0001","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.ccm.2023.07.004","article-title":"Host-directed therapy in nontuberculous mycobacterial pulmonary disease: preclinical and clinical data review","volume":"44","author":"Anidi","year":"2023","journal-title":"Clin. Chest Med."},{"key":"10.1016\/j.phymed.2025.156517_bib0002","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1021\/acsinfecdis.0c00889","article-title":"Target product profile and development path for shigellosis treatment with antibacterials","volume":"7","author":"Arnold","year":"2021","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.phymed.2025.156517_bib0003","doi-asserted-by":"crossref","first-page":"dmm049414","DOI":"10.1242\/dmm.049414","article-title":"Pyroptosis in host defence against bacterial infection","volume":"15","author":"Brokatzky","year":"2022","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.phymed.2025.156517_bib0004","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1016\/j.apsb.2021.02.006","article-title":"Gasdermin D in pyroptosis","volume":"11","author":"Burdette","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phymed.2025.156517_bib0006","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/S1473-3099(17)30276-1","article-title":"Estimates of global, regional, and national morbidity, mortality, and aetiologies of diarrhoeal diseases: a systematic analysis for the global burden of disease study 2015","volume":"17","year":"2017","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.phymed.2025.156517_bib0007","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1021\/bi7018546","article-title":"Berberine targets assembly of Escherichia coli cell division protein FtsZ","volume":"47","author":"Domadia","year":"2008","journal-title":"Biochemistry"},{"key":"10.1016\/j.phymed.2025.156517_bib0008","doi-asserted-by":"crossref","first-page":"4971","DOI":"10.1021\/acs.est.2c08766","article-title":"Monitoring longitudinal trends and assessment of the health risk of Shigella flexneri antimicrobial resistance","volume":"57","author":"Fang","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.phymed.2025.156517_bib0009","article-title":"Immunometabolism of macrophages in bacterial infections","volume":"10","author":"Galli","year":"2020","journal-title":"Front. Cell Infect. Microbiol."},{"key":"10.1016\/j.phymed.2025.156517_bib0010","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/jb\/mvad114","article-title":"Unusual weak and delayed GTPase activity of FtsZ from human pathogenic bacteria Helicobacter pylori","volume":"175","author":"Gurung","year":"2023","journal-title":"J. Biochem."},{"key":"10.1016\/j.phymed.2025.156517_bib0011","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1043236","article-title":"Pharmacological effects of berberine on models of ulcerative colitis: a meta-analysis and systematic review of animal studies","volume":"13","author":"Hu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156517_bib0012","doi-asserted-by":"crossref","first-page":"6975","DOI":"10.1021\/acs.jmedchem.5b01098","article-title":"Targeting the bacterial division protein FtsZ","volume":"59","author":"Hurley","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.phymed.2025.156517_bib0013","article-title":"Exploring the mechanism of berberine intervention in ulcerative colitis from the perspective of inflammation and immunity based on systemic pharmacology","volume":"2021","author":"Jiang","year":"2021","journal-title":"Evid. Complement. Alternat. Med."},{"key":"10.1016\/j.phymed.2025.156517_bib0014","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1186\/s13054-021-03775-3","article-title":"Exosomal miR-30d-5p of neutrophils induces M1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury","volume":"25","author":"Jiao","year":"2021","journal-title":"Crit. Care"},{"key":"10.1016\/j.phymed.2025.156517_bib0015","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/s41419-022-04966-8","article-title":"Novel role for caspase 1 inhibitor VX765 in suppressing NLRP3 inflammasome assembly and atherosclerosis via promoting mitophagy and efferocytosis","volume":"13","author":"Jin","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phymed.2025.156517_bib0016","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1146\/annurev-immunol-073119-095439","article-title":"Caspases in cell death, inflammation, and pyroptosis","volume":"38","author":"Kesavardhana","year":"2020","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.phymed.2025.156517_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112531","article-title":"A review of the berberine natural polysaccharide nanostructures as potential anticancer and antibacterial agents","volume":"146","author":"Khan","year":"2022","journal-title":"Biomed. PharmacOther"},{"key":"10.1016\/j.phymed.2025.156517_bib0018","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.chom.2012.03.008","article-title":"Host cell autophagy activated by antibiotics is required for their effective antimycobacterial drug action","volume":"11","author":"Kim","year":"2012","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.phymed.2025.156517_bib0019","doi-asserted-by":"crossref","first-page":"6770","DOI":"10.1021\/acsnano.9b01346","article-title":"Natural berberine-based Chinese herb medicine assembled nanostructures with modified antibacterial application","volume":"13","author":"Li","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.phymed.2025.156517_bib0020","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/j.chom.2021.08.010","article-title":"Shigella ubiquitin ligase IpaH7.8 targets gasdermin D for degradation to prevent pyroptosis and enable infection","volume":"29","author":"Luchetti","year":"2021","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.phymed.2025.156517_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155909","article-title":"Berberine alleviates ulcerative colitis by inhibiting inflammation through targeting IRGM1","volume":"133","author":"Meng","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.156517_bib0022","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1016\/j.immuni.2023.10.004","article-title":"Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis","volume":"56","author":"Miao","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.phymed.2025.156517_bib0023","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.cell.2016.08.064","article-title":"Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages","volume":"167","author":"Mills","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2025.156517_bib0024","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.ijbiomac.2022.07.241","article-title":"Screening of plant-based natural compounds as an inhibitor of FtsZ from Salmonella Typhi using the computational, biochemical and in vitro cell-based studies","volume":"219","author":"Naz","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2025.156517_bib0025","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.04711-22","article-title":"Baicalein suppresses NLRP3 and AIM2 inflammasome-mediated pyroptosis in macrophages infected by mycobacterium tuberculosis via induced autophagy","volume":"11","author":"Ning","year":"2023","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.phymed.2025.156517_bib0026","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s00253-005-0040-8","article-title":"Inhibition of sortase-mediated Staphylococcus aureus adhesion to fibronectin via fibronectin-binding protein by sortase inhibitors","volume":"70","author":"Oh","year":"2006","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.phymed.2025.156517_bib0027","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3390\/antibiotics9070381","article-title":"Synthesis and evaluation of the antibacterial activities of 13-substituted berberine derivatives","volume":"9","author":"Olleik","year":"2020","journal-title":"Antibiotics"},{"key":"10.1016\/j.phymed.2025.156517_bib0028","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1098\/rstb.2000.0599","article-title":"The pathogenesis of Shigella flexneri infection: lessons from in vitro and in vivo studies","volume":"355","author":"Philpott","year":"2000","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.phymed.2025.156517_bib0029","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2012.124","article-title":"Spontaneous formation of IpaB ion channels in host cell membranes reveals how Shigella induces pyroptosis in macrophages","volume":"3","author":"Senerovic","year":"2012","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phymed.2025.156517_bib0030","doi-asserted-by":"crossref","first-page":"e97514","DOI":"10.1371\/journal.pone.0097514","article-title":"Rational design of berberine-based FtsZ inhibitors with broad-spectrum antibacterial activity","volume":"9","author":"Sun","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2025.156517_bib0031","doi-asserted-by":"crossref","first-page":"656","DOI":"10.3390\/md20110656","article-title":"Equisetin targets intracellular Staphylococcus aureus through a host acting strategy","volume":"20","author":"Tian","year":"2022","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.phymed.2025.156517_bib0032","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00284-005-4569-7","article-title":"Berberine inhibits arylamine N-acetyltransferase activity and gene expression in Salmonella typhi","volume":"51","author":"Wu","year":"2005","journal-title":"Curr. Microbiol."},{"key":"10.1016\/j.phymed.2025.156517_bib0033","first-page":"744","article-title":"GTPase activity-coupled treadmilling of the bacterial tubulin FtsZ organizes septal cell wall synthesis","volume":"355","author":"Yang","year":"2017","journal-title":"Science (1979)"},{"key":"10.1016\/j.phymed.2025.156517_bib0034","doi-asserted-by":"crossref","first-page":"23374","DOI":"10.1038\/s41598-021-00932-0","article-title":"Meteorological and social conditions contribute to infectious diarrhea in China","volume":"11","author":"Yang","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2025.156517_bib0035","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.3892\/etm.2017.4402","article-title":"Berberine alleviates dextran sodium sulfate-induced colitis by improving intestinal barrier function and reducing inflammation and oxidative stress","volume":"13","author":"Zhang","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.phymed.2025.156517_bib0036","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1142\/S0192415X23500945","article-title":"Coptis chinensis and berberine ameliorate chronic ulcerative colitis: an integrated microbiome-metabolomics study","volume":"51","author":"Zhou","year":"2023","journal-title":"Am. J. Chin. Med."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325001588?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325001588?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T13:15:08Z","timestamp":1774962908000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325001588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":35,"alternative-id":["S0944711325001588"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156517","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Berberine protects against dysentery by targeting both Shigella filamentous temperature sensitive protein Z and host pyroptosis: Resolving in vitro\u2013vivo effect discrepancy","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156517","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"156517"}}