{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:16:40Z","timestamp":1787062600360,"version":"build-2736575974"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32202853"],"award-info":[{"award-number":["32202853"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013142","name":"Key Research and Development Project of Hainan Province","doi-asserted-by":"publisher","award":["ZDYF2023XDNY038"],"award-info":[{"award-number":["ZDYF2023XDNY038"]}],"id":[{"id":"10.13039\/501100013142","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.phymed.2025.156549","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T03:09:54Z","timestamp":1740452994000},"page":"156549","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Procyanidins inhibit alphacoronavirus infection by reducing interferon antagonism"],"prefix":"10.1016","volume":"140","author":[{"given":"Yi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wensai","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujing","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0183-5611","authenticated-orcid":false,"given":"Jiufeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.156549_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102508","article-title":"SARS-CoV-2 mitochondriopathy in COVID-19 pneumonia exacerbates hypoxemia","volume":"58","author":"Archer","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.phymed.2025.156549_bib0002","doi-asserted-by":"crossref","first-page":"9148","DOI":"10.1021\/jf4024728","article-title":"Distribution and quantification of Flavan-3-ols and procyanidins with low degree of polymerization in nuts, cereals, and legumes","volume":"61","author":"Bittner","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2025.156549_bib0004","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.chom.2016.07.008","article-title":"Dengue virus perturbs mitochondrial morphodynamics to dampen innate immune responses","volume":"20","author":"Chatel-Chaix","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.phymed.2025.156549_bib0005","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.foodchem.2018.08.090","article-title":"Structure-activity relationship of procyanidins on advanced glycation end products formation and corresponding mechanisms","volume":"272","author":"Chen","year":"2019","journal-title":"Food Chem."},{"issue":"853\u2013866","key":"10.1016\/j.phymed.2025.156549_bib0006","first-page":"e855","article-title":"Integrative imaging reveals SARS-CoV-2-Iinduced reshaping of subcellular morphologies","volume":"28","author":"Cortese","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.phymed.2025.156549_bib0007","doi-asserted-by":"crossref","first-page":"8936","DOI":"10.1128\/JVI.00700-14","article-title":"Porcine epidemic diarrhea virus nucleocapsid protein antagonizes beta interferon production by sequestering the interaction between IRF3 and TBK1","volume":"88","author":"Ding","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.phymed.2025.156549_bib0008","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1002\/jmv.27673","article-title":"TET2 is required for Type I IFN-mediated inhibition of bat-origin swine acute diarrhea syndrome coronavirus","volume":"94","author":"Duan","year":"2022","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.phymed.2025.156549_bib0009","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.antiviral.2019.05.008","article-title":"Virucidal activity of proanthocyanidin against Mayaro virus","volume":"168","author":"Ferraz","year":"2019","journal-title":"Antiviral Res."},{"key":"10.1016\/j.phymed.2025.156549_bib0010","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/s41580-020-0210-7","article-title":"The cell biology of mitochondrial membrane dynamics","volume":"21","author":"Giacomello","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2025.156549_bib0011","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/s41423-023-01086-x","article-title":"Mitochondrial DNA-triggered innate immune response: mechanisms and diseases","volume":"20","author":"Hu","year":"2023","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.phymed.2025.156549_bib0012","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1038\/s41477-018-0292-9","article-title":"Proanthocyanidin subunit composition determined by functionally diverged dioxygenases","volume":"4","author":"Jun","year":"2018","journal-title":"Nat. Plants"},{"key":"10.1016\/j.phymed.2025.156549_bib0013","doi-asserted-by":"crossref","first-page":"6413","DOI":"10.1073\/pnas.1321114111","article-title":"Hepatitis C virus triggers mitochondrial fission and attenuates apoptosis to promote viral persistence","volume":"111","author":"Kim","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phymed.2025.156549_bib0014","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41392-022-01249-8","article-title":"Small molecules in the treatment of COVID-19","volume":"7","author":"Lei","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2025.156549_bib0015","doi-asserted-by":"crossref","first-page":"3810","DOI":"10.1038\/s41467-020-17665-9","article-title":"Activation and evasion of type I interferon responses by SARS-CoV-2","volume":"11","author":"Lei","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2025.156549_bib0016","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.03739-21","article-title":"Molecular mechanism of porcine epidemic diarrhea virus cell tropism","volume":"13","author":"Li","year":"2022","journal-title":"mBio"},{"key":"10.1016\/j.phymed.2025.156549_bib0017","article-title":"A comparative analysis of coronavirus nucleocapsid (N) proteins reveals the SADS-CoV N protein antagonizes IFN-\u03b2 production by inducing ubiquitination of RIG-I","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2025.156549_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107825","article-title":"SARS-CoV-2 and other coronaviruses negatively influence mitochondrial quality control: beneficial effects of melatonin","volume":"224","author":"Mehrzadi","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2025.156549_bib0019","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1080\/15548627.2020.1817280","article-title":"Coronavirus interactions with the cellular autophagy machinery","volume":"16","author":"Miller","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2025.156549_bib0020","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1038\/s41564-024-01765-z","article-title":"SARS-CoV-2-related bat viruses evade human intrinsic immunity but lack efficient transmission capacity","volume":"9","author":"Pe\u00f1a-Hern\u00e1ndez","year":"2024","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.phymed.2025.156549_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101915","article-title":"Understanding the involvement of innate immunity and the Nrf2-NLRP3 axis on mitochondrial health in Parkinson's disease","volume":"87","author":"Rajan","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.phymed.2025.156549_bib0022","doi-asserted-by":"crossref","first-page":"4356","DOI":"10.1038\/s41467-023-40043-0","article-title":"Targeting an allosteric site in dynamin-related protein 1 to inhibit Fis1-mediated mitochondrial dysfunction","volume":"14","author":"Rios","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2025.156549_bib0023","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11101-017-9507-3","article-title":"Procyanidins: a comprehensive review encompassing structure elucidation via mass spectrometry","volume":"17","author":"Rue","year":"2018","journal-title":"Phytochem. Rev."},{"key":"10.1016\/j.phymed.2025.156549_bib0024","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1080\/15548627.2023.2274205","article-title":"The NLRX1-SLC39A7 complex orchestrates mitochondrial dynamics and mitophagy to rejuvenate intervertebral disc by modulating mitochondrial Zn2+ trafficking","volume":"20","author":"Song","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2025.156549_bib0025","doi-asserted-by":"crossref","first-page":"16024","DOI":"10.1038\/celldisc.2016.24","article-title":"MAVS maintains mitochondrial homeostasis via autophagy","volume":"2","author":"Sun","year":"2016","journal-title":"Cell Discov."},{"key":"10.1016\/j.phymed.2025.156549_bib0026","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1093\/cid\/ciab456","article-title":"Novel canine coronavirus isolated from a hospitalized patient with pneumonia in East Malaysia","volume":"74","author":"Vlasova","year":"2022","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.phymed.2025.156549_bib0027","doi-asserted-by":"crossref","first-page":"14499","DOI":"10.3390\/ijms232314499","article-title":"Triacetyl Resveratrol inhibits PEDV by inducing the early apoptosis in vitro","volume":"23","author":"Wang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2025.156549_bib0028","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1011702","article-title":"Broad antagonism of coronaviruses nsp5 to evade the host antiviral responses by cleaving POLDIP3","volume":"19","author":"Wu","year":"2023","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.phymed.2025.156549_bib0029","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s40168-022-01348-2","article-title":"Chicken intestinal microbiota modulation of resistance to nephropathogenic infectious bronchitis virus infection through IFN-I","volume":"10","author":"Yin","year":"2022","journal-title":"Microbiome"},{"key":"10.1016\/j.phymed.2025.156549_bib0030","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1038\/s41467-020-16312-7","article-title":"Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics","volume":"11","author":"Yu","year":"2020","journal-title":"Nat. Commun."},{"issue":"4380\u20134391","key":"10.1016\/j.phymed.2025.156549_bib0031","first-page":"e4314","article-title":"Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses","volume":"184","author":"Zhou","year":"2021","journal-title":"Cell"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325001898?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325001898?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T15:30:53Z","timestamp":1763047853000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325001898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":30,"alternative-id":["S0944711325001898"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156549","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Procyanidins inhibit alphacoronavirus infection by reducing interferon antagonism","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156549","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156549"}}