{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T04:02:30Z","timestamp":1793764950018,"version":"4.6.1"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004712","name":"Tianjin University of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004712","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.phymed.2025.156561","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T11:29:43Z","timestamp":1740482983000},"page":"156561","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Polysaccharide from Pyrus pashia Buch ameliorates DSS-induced colitis in mice via MAPKP38\/NF-\u03baB P65 and SCFAs\/ERK\/MSK signaling pathways"],"prefix":"10.1016","volume":"140","author":[{"given":"Yan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.156561_bib0001","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1007\/s11894-007-0067-3","article-title":"Innate and adaptive immune responses related to IBD pathogenesis","volume":"9","author":"Arseneau","year":"2007","journal-title":"Curr. Gastroenterol. Rep."},{"issue":"12","key":"10.1016\/j.phymed.2025.156561_bib0003","doi-asserted-by":"crossref","first-page":"7180","DOI":"10.4049\/jimmunol.165.12.7180","article-title":"Vitamin C inhibits NF-kappa B activation by TNF via the activation of p38 mitogen-activated protein kinase","volume":"165","author":"Bowie","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.phymed.2025.156561_bib0004","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.dld.2020.10.033","article-title":"IBDs and the pediatric age: their peculiarities and the involvement of the microbiota","volume":"53","author":"Cococcioni","year":"2021","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.phymed.2025.156561_bib0005","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2016.01475","article-title":"Beyond 16S rRNA community profiling: intra-species diversity in the gut microbiota","volume":"7","author":"Ellegaard","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.phymed.2025.156561_bib0006","article-title":"The Function of Natural Polysaccharides in the Treatment of Ulcerative Colitis","volume":"13","author":"Guo","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156561_bib0007","article-title":"Applications of infrared spectroscopy in polysaccharide structural analysis: progress, challenge, and perspective","volume":"12","author":"Hong","year":"2021","journal-title":"Food Chem: X"},{"key":"10.1016\/j.phymed.2025.156561_bib0008","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/9275083","article-title":"Angelica acutiloba Kitagawa extract attenuates DSS-induced murine colitis","volume":"2016","author":"Jang","year":"2016","journal-title":"Mediator. Inflamm."},{"key":"10.1016\/j.phymed.2025.156561_bib0009","doi-asserted-by":"crossref","first-page":"4701","DOI":"10.3390\/jcm10204701","article-title":"Fecal levels of lactic, succinic and short-chain fatty acids in patients with ulcerative colitis and Crohn disease: a pilot study","volume":"10","author":"Kaczmarczyk","year":"2021","journal-title":"J. Clin. Med"},{"key":"10.1016\/j.phymed.2025.156561_bib0010","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1134\/S1068162019060219","article-title":"Application of Natural Polysaccharides in Pharmaceutics","volume":"45","author":"Khvostov","year":"2019","journal-title":"Russ J Bioorg Chem"},{"key":"10.1016\/j.phymed.2025.156561_bib0011","doi-asserted-by":"crossref","first-page":"11","DOI":"10.5217\/ir.2015.13.1.11","article-title":"Intestinal permeability regulation by tight junction: implication on inflammatory bowel diseases","volume":"13","author":"Lee","year":"2015","journal-title":"Intest Res"},{"key":"10.1016\/j.phymed.2025.156561_bib0012","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1007\/s10787-022-01007-w","article-title":"Aromatic-turmerone ameliorates DSS-induced ulcerative colitis via modulating gut microbiota in mice","volume":"30","author":"Li","year":"2022","journal-title":"Inflammopharmacol"},{"key":"10.1016\/j.phymed.2025.156561_bib0013","article-title":"Prickly Ash Seeds improve immunity of Hu sheep by changing the diversity and structure of gut microbiota","volume":"14","author":"Li","year":"2023","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.phymed.2025.156561_bib0014","first-page":"1","article-title":"Quzhou Fructus Aurantii Extract suppresses inflammation via regulation of MAPK, NF-\u03baB, and AMPK signaling pathway","volume":"10","author":"Li","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.phymed.2025.156561_bib0015","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1213383","article-title":"Analysis of the interferon-\u03b3-induced secretome of intestinal endothelial cells: putative impact on epithelial barrier dysfunction in IBD","volume":"11","author":"Naschberger","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.phymed.2025.156561_bib0016","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1093\/alcalc\/agw098","article-title":"The Role of NFkB in Drug Addiction: beyond Inflammation","volume":"52","author":"Nennig","year":"2017","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.phymed.2025.156561_bib0018","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1093\/ibd\/izz075","article-title":"Challenges in IBD Research: preclinical Human IBD Mechanisms","volume":"25","author":"Pizarro","year":"2019","journal-title":"Inflamm. Bowel Dis"},{"key":"10.1016\/j.phymed.2025.156561_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2021.101119","article-title":"Chemical composition and in vitro antihyperglycemic potential of Kainth fruit (Pyrus pashia Buch-Ham ex D. Don)","volume":"42","author":"Prakash","year":"2021","journal-title":"Food Biosci"},{"key":"10.1016\/j.phymed.2025.156561_bib0020","doi-asserted-by":"crossref","unstructured":"Sharma, D, Sharma, P, 2022. Taguchi design-based synthesis and structural analysis of Cassia galactomannan hydroxypropyl derivative. Carbohydrate Polym 292, 119672. https:\/\/doi.org\/10.1016\/j.carbpol.2022.119672.","DOI":"10.1016\/j.carbpol.2022.119672"},{"key":"10.1016\/j.phymed.2025.156561_bib0021","article-title":"Extraction Optimization, Structural Characterization, and Anti-Hepatoma Activity of Acidic Polysaccharides From Scutellaria barbata D","volume":"13","author":"Su","year":"2022","journal-title":"Don. Front. Pharmacol"},{"key":"10.1016\/j.phymed.2025.156561_bib0022","doi-asserted-by":"crossref","first-page":"S00","DOI":"10.1093\/ibd\/izae020.046","article-title":"Exploring the relationship between patient symptoms and provider goals for mucosal healing in IBD: insights from the IBD qorus survey data","volume":"30","author":"Troia","year":"2024","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.phymed.2025.156561_bib0023","doi-asserted-by":"crossref","DOI":"10.1099\/ijsem.0.005635","article-title":"Allobaculum mucilyticum sp. nov. and Allobaculum fili sp. nov., isolated from the human intestinal tract","volume":"73","author":"van Muijlwijk","year":"2023","journal-title":"Int. J. Syst. Evol.Microbiol"},{"key":"10.1016\/j.phymed.2025.156561_bib0024","doi-asserted-by":"crossref","first-page":"4852","DOI":"10.1158\/0008-5472.CAN-05-2957","article-title":"Attenuation of Mitogen- and Stress-Activated Protein Kinase-1\u2013Driven Nuclear Factor-\u03baB Gene Expression by Soy Isoflavones Does Not Require Estrogenic Activity","volume":"66","author":"Vanden Berghe","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.phymed.2025.156561_bib0025","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/jsfa.12145","article-title":"Isolation, structure identification, and immunostimulatory effects in vitro and in vivo of polysaccharides from Onosma hookeri Clarke var. longiforum Duthie","volume":"103","author":"Wu","year":"2023","journal-title":"J. Sci. Food Agric"},{"key":"10.1016\/j.phymed.2025.156561_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115868","article-title":"Licorice flavonoid alleviates gastric ulcers by producing changes in gut microbiota and promoting mucus cell regeneration","volume":"169","author":"Wu","year":"2023","journal-title":"Biomed. Pharmacother"},{"key":"10.1016\/j.phymed.2025.156561_bib0027","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12014-023-09396-y","article-title":"Integrating the serum proteomic and fecal metaproteomic to analyze the impacts of overweight\/obesity on IBD: a pilot investigation","volume":"20","author":"Yan","year":"2023","journal-title":"Clin. Proteomics"},{"key":"10.1016\/j.phymed.2025.156561_bib0028","doi-asserted-by":"crossref","DOI":"10.1099\/ijsem.0.004819","article-title":"New human-associated species of the family Atopobiaceae and proposal to reclassify members of the genus Olsenella","volume":"71","author":"Zgheib","year":"2021","journal-title":"Int. J. Syst. Evol. Microbiol"},{"key":"10.1016\/j.phymed.2025.156561_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2023.102788","article-title":"Rheum tanguticum polysaccharide alleviates DSS-induced ulcerative colitis and regulates intestinal microbiota in mice","volume":"53","author":"Zhang","year":"2023","journal-title":"Food Biosci"},{"key":"10.1016\/j.phymed.2025.156561_bib0030","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.777218","article-title":"Analysis of Intestinal Microflora and Metabolites From Mice With DSS-Induced IBD Treated With Schistosoma Soluble Egg Antigen","volume":"9","author":"Zhu","year":"2021","journal-title":"Front. Cell Dev. Biol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325002016?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325002016?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T15:22:41Z","timestamp":1763047361000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325002016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":28,"alternative-id":["S0944711325002016"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156561","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polysaccharide from Pyrus pashia Buch ameliorates DSS-induced colitis in mice via MAPKP38\/NF-\u03baB P65 and SCFAs\/ERK\/MSK signaling pathways","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156561","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156561"}}