{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:50:40Z","timestamp":1790142640164,"version":"4.0.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013061","name":"Jilin Scientific and Technological Development Program","doi-asserted-by":"publisher","award":["YDZJ202402017CXJD"],"award-info":[{"award-number":["YDZJ202402017CXJD"]}],"id":[{"id":"10.13039\/501100013061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013061","name":"Jilin Scientific and Technological Development Program","doi-asserted-by":"publisher","award":["20240401048YY"],"award-info":[{"award-number":["20240401048YY"]}],"id":[{"id":"10.13039\/501100013061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011789","name":"Department of Science and Technology of Jilin Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010905","name":"Major Research Plan","doi-asserted-by":"publisher","award":["U20A20402"],"award-info":[{"award-number":["U20A20402"]}],"id":[{"id":"10.13039\/501100010905","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.phymed.2025.156590","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T08:20:14Z","timestamp":1741162814000},"page":"156590","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Deoxyshikonin from Arnebiae Radix promotes hair growth by targeting the Wnt\/\u03b2-catenin signaling pathway"],"prefix":"10.1016","volume":"140","author":[{"given":"Yingna","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlei","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangbing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.phymed.2025.156590_bib0001","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1111\/jocd.16319","article-title":"Trichoscopic findings in children and adults with alopecia areata: a comparative study","volume":"23","author":"Aryanian","year":"2024","journal-title":"J. Cosmet. Dermatol."},{"issue":"3","key":"10.1016\/j.phymed.2025.156590_bib0002","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1080\/10717540500455975","article-title":"Dermal and transdermal drug delivery systems: current and future prospects","volume":"13","author":"Brown","year":"2006","journal-title":"Drug. Deliv."},{"issue":"10","key":"10.1016\/j.phymed.2025.156590_bib0003","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1093\/stcltm\/szac059","article-title":"The emergent power of Human cellular vs mouse models in translational hair research","volume":"11","author":"Castro","year":"2022","journal-title":"Stem. Cells Transl. Med."},{"issue":"1","key":"10.1016\/j.phymed.2025.156590_bib0004","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s13287-020-01650-6","article-title":"PI3K\/Akt signaling pathway is essential for de novo hair follicle regeneration","volume":"11","author":"Chen","year":"2020","journal-title":"Stem. Cell. Res. Ther."},{"issue":"6","key":"10.1016\/j.phymed.2025.156590_bib0005","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.stem.2013.10.003","article-title":"Distinct functions for wnt\/\u03b2-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis","volume":"13","author":"Choi","year":"2013","journal-title":"Cell. Stem. Cell."},{"issue":"3","key":"10.1016\/j.phymed.2025.156590_bib0006","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1517\/14712598.2013.739601","article-title":"Therapeutic strategy for hair regeneration: hair cycle activation, niche environment modulation, wound-induced follicle neogenesis, and stem cell engineering","volume":"13","author":"Chueh","year":"2013","journal-title":"Expert. Opin. Biol. Ther."},{"issue":"1","key":"10.1016\/j.phymed.2025.156590_bib0007","doi-asserted-by":"crossref","first-page":"92","DOI":"10.2174\/1872208316666220718154341","article-title":"Current status and medicinal prominence of arnebia euchroma (Ratanjot): a critically endangered plant of Trans-Himalayan region","volume":"17","author":"Devi","year":"2023","journal-title":"Recent. Pat Biotechnol."},{"issue":"1","key":"10.1016\/j.phymed.2025.156590_bib0008","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s13020-023-00807-8","article-title":"Correction: traditional Chinese Medicine Shi-Bi-Man regulates lactic acid metabolism and drives hair follicle stem cell activation to promote hair regeneration","volume":"18","author":"Du","year":"2023","journal-title":"Chin. Med."},{"issue":"1","key":"10.1016\/j.phymed.2025.156590_bib0009","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s12929-015-0172-9","article-title":"Investigating the potential of Shikonin as a novel hypertrophic scar treatment","volume":"22","author":"Fan","year":"2015","journal-title":"J. Biomed. Sci."},{"issue":"5","key":"10.1016\/j.phymed.2025.156590_bib0010","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1096\/fasebj.14.5.752","article-title":"Control of murine hair follicle regression (catagen) by TGF-beta1 in vivo","volume":"14","author":"Foitzik","year":"2000","journal-title":"FASEB J."},{"key":"10.1016\/j.phymed.2025.156590_bib0011","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2022.894380","article-title":"Identification of genes related to hair follicle cycle development in Inner Mongolia cashmere goat by WGCNA","volume":"9","author":"Gong","year":"2022","journal-title":"Front. Vet. Sci."},{"issue":"2","key":"10.1016\/j.phymed.2025.156590_bib0012","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.stem.2008.12.009","article-title":"A two-step mechanism for stem cell activation during hair regeneration","volume":"4","author":"Greco","year":"2009","journal-title":"Cell. Stem. Cell."},{"key":"10.1016\/j.phymed.2025.156590_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104463","article-title":"Pharmacological properties and derivatives of shikonin-A review in recent years","volume":"149","author":"Guo","year":"2019","journal-title":"Pharmacol. Res."},{"issue":"12","key":"10.1016\/j.phymed.2025.156590_bib0014","doi-asserted-by":"crossref","first-page":"e83922","DOI":"10.1371\/journal.pone.0083922","article-title":"Combining machine learning systems and multiple docking simulation packages to improve docking prediction reliability for network pharmacology","volume":"8","author":"Hsin","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.phymed.2025.156590_bib0015","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0092-8674(01)00336-1","article-title":"beta-catenin controls hair follicle morphogenesis and stem cell differentiation in the skin","volume":"105","author":"Huelsken","year":"2001","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.phymed.2025.156590_bib0016","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1159\/000505151","article-title":"Finasteride and suicide: a postmarketing case series","volume":"236","author":"Irwig","year":"2020","journal-title":"Dermatol. (Basel)"},{"issue":"8","key":"10.1016\/j.phymed.2025.156590_bib0017","doi-asserted-by":"crossref","first-page":"e15155","DOI":"10.1111\/exd.15155","article-title":"Irisin promotes hair growth and hair cycle transition by activating the GSK-3\u03b2\/\u03b2-catenin pathway","volume":"33","author":"Kim","year":"2024","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.phymed.2025.156590_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.113896","article-title":"Phytochemical constituents, distributions and traditional usages of Arnebia euchroma: a review","volume":"271","author":"Kumar","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.phymed.2025.156590_bib0019","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jdermsci.2011.01.013","article-title":"Minoxidil activates \u03b2-catenin pathway in human dermal papilla cells: a possible explanation for its anagen prolongation effect","volume":"62","author":"Kwack","year":"2011","journal-title":"J. Dermatol. Sci."},{"issue":"1","key":"10.1016\/j.phymed.2025.156590_bib0020","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1182\/blood-2007-04-085092","article-title":"PKC zeta mTOR pathway: a new target for rituximab therapy in follicular lymphoma","volume":"111","author":"Leseux","year":"2008","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.phymed.2025.156590_bib0021","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/ncb2903","article-title":"In vivo transcriptional governance of hair follicle stem cells by canonical wnt regulators","volume":"16","author":"Lien","year":"2014","journal-title":"Nat. Cell Biol."},{"issue":"W1","key":"10.1016\/j.phymed.2025.156590_bib0022","doi-asserted-by":"crossref","first-page":"W159","DOI":"10.1093\/nar\/gkac394","article-title":"CB-Dock2: improved protein-ligand blind docking by integrating cavity detection, docking and homologous template fitting","volume":"50","author":"Liu","year":"2022","journal-title":"Nucleic. Acids. Res."},{"issue":"8","key":"10.1016\/j.phymed.2025.156590_bib0023","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1142\/S0192415X21500889","article-title":"Therapeutic effects of Shikonin on skin diseases: a review","volume":"49","author":"Mu","year":"2021","journal-title":"Am. J. Chin. Med0 (Gard City N Y)"},{"issue":"12","key":"10.1016\/j.phymed.2025.156590_bib0024","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1007\/s00109-016-1475-3","article-title":"Cyclin D1, cancer progression, and opportunities in cancer treatment","volume":"94","author":"Qie","year":"2016","journal-title":"J. Mol. Med."},{"issue":"3","key":"10.1016\/j.phymed.2025.156590_bib0025","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.jaad.2020.06.1009","article-title":"Oral minoxidil treatment for hair loss: a review of efficacy and safety","volume":"84","author":"Randolph","year":"2021","journal-title":"J. Am. Acad. Dermatol."},{"issue":"4","key":"10.1016\/j.phymed.2025.156590_bib0026","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.jaad.2019.02.050","article-title":"Pressure alopecia in pediatric and adult patients: clinical and trichoscopic findings in 12 cases","volume":"81","author":"Ravaioli","year":"2019","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.phymed.2025.156590_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.reactfunctpolym.2022.105440","article-title":"Fabrication and development of PVA\/alginate nanofibrous mats containing Arnebia Euchroma extract as a burn wound dressing","volume":"181","author":"Sadeghi-Aghbash","year":"2022","journal-title":"React. Funct. Polym."},{"issue":"7","key":"10.1016\/j.phymed.2025.156590_bib0028","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1021\/acs.orglett.1c00360","article-title":"CYP82AR Subfamily proteins catalyze C-1\u2032 Hydroxylations of deoxyshikonin in the biosynthesis of Shikonin and Alkannin","volume":"23","author":"Song","year":"2021","journal-title":"Org. Lett."},{"key":"10.1016\/j.phymed.2025.156590_bib0029","article-title":"Retinoic acid drives hair follicle stem cell activation via wnt\/\u03b2-catenin signalling in androgenetic alopecia","author":"Wen","year":"2024","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"41","key":"10.1016\/j.phymed.2025.156590_bib0030","doi-asserted-by":"crossref","first-page":"8424","DOI":"10.1039\/D0OB01934H","article-title":"Archromones A-F, unusual polycyclic dearomatic geranylquinol derivatives from the roots of Arnebia euchroma","volume":"18","author":"Yan","year":"2020","journal-title":"Org. Biomol. Chem."},{"issue":"4","key":"10.1016\/j.phymed.2025.156590_bib0031","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1172\/JCI11317","article-title":"Control of hair growth and follicle size by VEGF-mediated angiogenesis","volume":"107","author":"Yano","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2025.156590_bib0032","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.lfs.2019.05.033","article-title":"Ginsenoside Rb1 promotes the growth of mink hair follicle via PI3K\/AKT\/GSK-3\u03b2 signaling pathway","volume":"229","author":"Zhang","year":"2019","journal-title":"Life Sci."},{"issue":"2","key":"10.1016\/j.phymed.2025.156590_bib0033","doi-asserted-by":"crossref","first-page":"164","DOI":"10.2174\/1389557517666170228114809","article-title":"Advance in anti-tumor mechanisms of Shikonin, Alkannin and their derivatives","volume":"18","author":"Zhang","year":"2018","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.phymed.2025.156590_bib0034","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1073392","article-title":"Stimulation of hair growth by Tianma Gouteng decoction: identifying mechanisms based on chemical analysis, systems biology approach, and experimental evaluation","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.phymed.2025.156590_bib0035","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1080\/13880209.2020.1818793","article-title":"Pharmacology, toxicity and pharmacokinetics of acetylshikonin: a review","volume":"58","author":"Zhang","year":"2020","journal-title":"Pharm. Biol."},{"issue":"16","key":"10.1016\/j.phymed.2025.156590_bib0036","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27165242","article-title":"Identification of hair growth promoting components in the kernels of Prunus mira Koehne and their mechanism of action","volume":"27","author":"Zhou","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2025.156590_bib0037","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2022.1012553","article-title":"Screening and characterization estrogen receptor ligands from Arnebia euchroma (Royle) Johnst. Via affinity ultrafiltration LC-MS and molecular docking","volume":"13","author":"Zhu","year":"2022","journal-title":"Front. Plant Sci."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325002302?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325002302?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T15:31:13Z","timestamp":1763047873000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325002302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":37,"alternative-id":["S0944711325002302"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156590","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deoxyshikonin from Arnebiae Radix promotes hair growth by targeting the Wnt\/\u03b2-catenin signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156590","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156590"}}