{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:32:52Z","timestamp":1793298772370,"version":"4.5.0"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["7232279"],"award-info":[{"award-number":["7232279"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004846","name":"Beijing University of Chinese Medicine","doi-asserted-by":"publisher","award":["2024-JYB-JBZD-043"],"award-info":[{"award-number":["2024-JYB-JBZD-043"]}],"id":[{"id":"10.13039\/501100004846","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004846","name":"Beijing University of Chinese Medicine","doi-asserted-by":"publisher","award":["2022-JYB-JBZR-004"],"award-info":[{"award-number":["2022-JYB-JBZR-004"]}],"id":[{"id":"10.13039\/501100004846","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104560"],"award-info":[{"award-number":["82104560"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U21A20400"],"award-info":[{"award-number":["U21A20400"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.phymed.2025.156607","type":"journal-article","created":{"date-parts":[[2025,3,9]],"date-time":"2025-03-09T16:18:26Z","timestamp":1741537106000},"page":"156607","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Huang-Lian-Jie-Du decoction inhibits CD4+ T cell infiltration into CNS in MCAO rats by regulating BBB"],"prefix":"10.1016","volume":"141","author":[{"given":"Congai","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changxiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilin","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiao","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxiu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youxiang","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fafeng","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingguo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.156607_bib0001","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.neuron.2017.03.043","article-title":"Blood-brain barrier permeability is regulated by lipid transport-dependent suppression of caveolae-mediated transcytosis","volume":"94","author":"Andreone","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.phymed.2025.156607_bib0002","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.molmed.2014.10.003","article-title":"Regulation of T cell trafficking by the T cell immunoglobulin and mucin domain 1 glycoprotein","volume":"20","author":"Angiari","year":"2014","journal-title":"Trend. Mol. Med."},{"key":"10.1016\/j.phymed.2025.156607_bib0003","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41572-019-0118-8","article-title":"Ischaemic stroke","volume":"5","author":"Campbell","year":"2019","journal-title":"Nat. Rev. Dis. Primer."},{"key":"10.1016\/j.phymed.2025.156607_bib0004","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0140-6736(20)31179-X","article-title":"Stroke","volume":"396","author":"Campbell","year":"2020","journal-title":"Lancet (Lond., Engl.)"},{"key":"10.1016\/j.phymed.2025.156607_bib0005","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1161\/STROKEAHA.122.036946","article-title":"Neuroinflammation, stroke, blood-brain barrier dysfunction, and imaging modalities","volume":"53","author":"Candelario-Jalil","year":"2022","journal-title":"Stroke"},{"key":"10.1016\/j.phymed.2025.156607_bib0006","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1242\/jcs.047522","article-title":"Mechanisms for transcellular diapedesis: probing and pathfinding by 'invadosome-like protrusions","volume":"122","author":"Carman","year":"2009","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.phymed.2025.156607_bib0007","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.4103\/1673-5374.386398","article-title":"Activation of the wnt\/\u03b2-catenin\/CYP1B1 pathway alleviates oxidative stress and protects the blood-brain barrier under cerebral ischemia\/reperfusion conditions","volume":"19","author":"Chen","year":"2024","journal-title":"Neural Regenerat. Res."},{"key":"10.1016\/j.phymed.2025.156607_bib0008","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.neuron.2017.02.043","article-title":"Gradual suppression of transcytosis governs functional blood-retinal barrier formation","volume":"93","author":"Chow","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.phymed.2025.156607_bib0009","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1111\/cns.13381","article-title":"Early neutrophil count relates to infarct size and fatal outcome after large hemispheric infarction","volume":"26","author":"Cui","year":"2020","journal-title":"CNS Neurosci. Therapeut."},{"key":"10.1016\/j.phymed.2025.156607_bib0010","doi-asserted-by":"crossref","first-page":"e18528","DOI":"10.1111\/jcmm.18528","article-title":"Huanglian Jiedu decoction alleviates ischemia-induced cerebral injury in rats by mitigating NET formation and activiting GABAergic synapses","volume":"28","author":"Cui","year":"2024","journal-title":"J. Cell. Molecul. Med."},{"key":"10.1016\/j.phymed.2025.156607_bib0011","doi-asserted-by":"crossref","DOI":"10.1172\/JCI154225","article-title":"Neutrophil extracellular traps regulate ischemic stroke brain injury","volume":"132","author":"Denorme","year":"2022","journal-title":"J. Clin. Investigat."},{"key":"10.1016\/j.phymed.2025.156607_bib0012","doi-asserted-by":"crossref","first-page":"13573","DOI":"10.1111\/jcmm.16049","article-title":"Anti-inflammatory and immune-modulatory impacts of berberine on activation of autoreactive T cells in autoimmune inflammation","volume":"24","author":"Ehteshamfar","year":"2020","journal-title":"J. Cell. Molecul. Med."},{"key":"10.1016\/j.phymed.2025.156607_bib0013","article-title":"Inflammation within the neurovascular unit: focus on microglia for stroke injury and recovery","volume":"147","author":"Eldahshan","year":"2019","journal-title":"Pharmacolog. Res."},{"key":"10.1016\/j.phymed.2025.156607_bib0014","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.it.2012.07.004","article-title":"Capture, crawl, cross: the T cell code to breach the blood-brain barriers","volume":"33","author":"Engelhardt","year":"2012","journal-title":"Trend. Immunol."},{"key":"10.1016\/j.phymed.2025.156607_bib0015","doi-asserted-by":"crossref","first-page":"2955","DOI":"10.1002\/eji.200425327","article-title":"Mini-review: transendothelial migration of leukocytes: through the front door or around the side of the house?","volume":"34","author":"Engelhardt","year":"2004","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.phymed.2025.156607_bib0016","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1124\/pr.117.014647","article-title":"Neuroimmune axes of the blood-brain barriers and blood-brain interfaces: bases for physiological regulation, disease states, and pharmacological interventions","volume":"70","author":"Erickson","year":"2018","journal-title":"Pharmacolog. Rev."},{"key":"10.1016\/j.phymed.2025.156607_bib0017","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1161\/STROKEAHA.111.635250","article-title":"A rat model of studying tissue-type plasminogen activator thrombolysis in ischemic stroke with diabetes","volume":"43","author":"Fan","year":"2012","journal-title":"Stroke"},{"key":"10.1016\/j.phymed.2025.156607_bib0018","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0165-5728(02)00098-X","article-title":"Interferon-beta directly influences monocyte infiltration into the central nervous system","volume":"127","author":"Floris","year":"2002","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.phymed.2025.156607_bib0019","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1161\/STROKEAHA.120.029440","article-title":"Sustained increases in immune transcripts and immune cell trafficking during the recovery of experimental brain ischemia","volume":"51","author":"Fury","year":"2020","journal-title":"Stroke"},{"key":"10.1016\/j.phymed.2025.156607_bib0020","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s11910-018-0869-8","article-title":"Thrombectomy for acute ischemic stroke: recent insights and future directions","volume":"18","author":"Ganesh","year":"2018","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.phymed.2025.156607_bib0021","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1161\/01.STR.26.4.627","article-title":"Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats. Statistical validation","volume":"26","author":"Garcia","year":"1995","journal-title":"Stroke"},{"key":"10.1016\/j.phymed.2025.156607_bib0022","first-page":"408","article-title":"Lymphocyte adhesion and transendothelial migration in the central nervous system: the role of LFA-1, ICAM-1, VLA-4 and VCAM-1. off","volume":"86","author":"Greenwood","year":"1995","journal-title":"Immunology"},{"key":"10.1016\/j.phymed.2025.156607_bib0023","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.255653","article-title":"Neutrophil transendothelial migration hotspots - mechanisms and implications","volume":"134","author":"Gr\u00f6nloh","year":"2021","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.phymed.2025.156607_bib0024","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1177\/0271678X16629976","article-title":"The blood-brain barrier after stroke: structural studies and the role of transcytotic vesicles","volume":"37","author":"Haley","year":"2017","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.phymed.2025.156607_bib0025","article-title":"Explore of the beneficial effects of Huang-Lian-Jie-Du Decoction on diabetic encephalopathy in db\/db mice by UPLC-Q-Orbitrap HRMS\/MS based untargeted metabolomics analysis","volume":"192","author":"He","year":"2021","journal-title":"J. Pharmaceut. Biomed. Analy."},{"key":"10.1016\/j.phymed.2025.156607_bib0026","article-title":"Protective effect of Huanglianjiedu Decoction on microcystin-LR induced nerve injury. Comparative biochemistry and physiology","volume":"272","author":"Hu","year":"2023","journal-title":"Toxicol. Pharmacol.: CBP"},{"key":"10.1016\/j.phymed.2025.156607_bib0027","article-title":"Endothelial \u03b2-catenin deficiency causes blood-brain barrier breakdown via enhancing the paracellular and transcellular permeability","volume":"15","author":"Hussain","year":"2022","journal-title":"Front. Molecul. Neurosci."},{"key":"10.1016\/j.phymed.2025.156607_bib0028","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0006-8993(98)00498-3","article-title":"Affinity-purification and characterization of caveolins from the brain: differential expression of caveolin-1, -2, and -3 in brain endothelial and astroglial cell types","volume":"804","author":"Ikezu","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.phymed.2025.156607_bib0029","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.3389\/fimmu.2019.02167","article-title":"The involvement and therapy target of immune cells after ischemic stroke","volume":"10","author":"Jian","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2025.156607_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113508","article-title":"CNS and peripheral immunity in cerebral ischemia: partition and interaction","volume":"335","author":"Kim","year":"2021","journal-title":"Exper. Neurol."},{"key":"10.1016\/j.phymed.2025.156607_bib0031","doi-asserted-by":"crossref","first-page":"155","DOI":"10.5607\/en20062","article-title":"Dynamics of T lymphocyte between the periphery and the brain from the acute to the chronic phase following ischemic stroke in mice","volume":"30","author":"Kim","year":"2021","journal-title":"Exper. Neurobiol."},{"key":"10.1016\/j.phymed.2025.156607_bib0032","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.neuron.2014.03.003","article-title":"Stepwise recruitment of transcellular and paracellular pathways underlies blood-brain barrier breakdown in stroke","volume":"82","author":"Knowland","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.phymed.2025.156607_bib0033","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.yexcr.2016.01.001","article-title":"Stress-induced upregulation of VLDL receptor alters wnt-signaling in neurons","volume":"340","author":"Kysenius","year":"2016","journal-title":"Exper. Cell Res."},{"key":"10.1016\/j.phymed.2025.156607_bib0034","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1146\/annurev-cellbio-100617-062608","article-title":"Development and cell biology of the blood-brain barrier","volume":"35","author":"Langen","year":"2019","journal-title":"Ann. Rev. Cell Develop. Biol."},{"key":"10.1016\/j.phymed.2025.156607_bib0035","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1023\/B:CEMN.0000012726.43842.d2","article-title":"Neuronal and glial expression of the multidrug resistance gene product in an experimental epilepsy model","volume":"24","author":"Lazarowski","year":"2004","journal-title":"Cell. Molecul. Neurobiol."},{"key":"10.1016\/j.phymed.2025.156607_bib0036","article-title":"Endothelial wnt\/\u03b2-catenin signaling reduces immune cell infiltration in multiple sclerosis","volume":"114","author":"Lengfeld","year":"2017","journal-title":"Proceed. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.phymed.2025.156607_bib0037","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ejphar.2019.04.021","article-title":"Geniposide protects against hypoxia\/reperfusion-induced blood-brain barrier impairment by increasing tight junction protein expression and decreasing inflammation, oxidative stress, and apoptosis in an in vitro system","volume":"854","author":"Li","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156607_bib0038","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00401-018-1815-1","article-title":"Functional morphology of the blood-brain barrier in health and disease","volume":"135","author":"Liebner","year":"2018","journal-title":"Acta neuropathologica"},{"key":"10.1016\/j.phymed.2025.156607_bib0039","doi-asserted-by":"crossref","first-page":"7762","DOI":"10.1007\/s12035-016-0249-9","article-title":"Th17 Cells induce dopaminergic neuronal death via LFA-1\/ICAM-1 interaction in a mouse model of Parkinson's Disease","volume":"54","author":"Liu","year":"2017","journal-title":"Molecul. Neurobiol."},{"key":"10.1016\/j.phymed.2025.156607_bib0040","article-title":"Brain targeted borneol-baicalin liposome improves blood-brain barrier integrity after cerebral ischemia-reperfusion injury via inhibiting HIF-1\u03b1\/VEGF\/eNOS\/NO signal pathway","volume":"160","author":"Long","year":"2023","journal-title":"Biomed. Pharmacother. = Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2025.156607_bib0041","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","article-title":"Reversible middle cerebral artery occlusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke"},{"key":"10.1016\/j.phymed.2025.156607_bib0042","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.bbadis.2015.10.018","article-title":"Immune cell trafficking across the barriers of the central nervous system in multiple sclerosis and stroke","volume":"1862","author":"Lopes Pinheiro","year":"2016","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.phymed.2025.156607_bib0043","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.jep.2011.01.049","article-title":"Anti-inflammatory effects of Huang-Lian-Jie-Du decoction, its two fractions and four typical compounds","volume":"134","author":"Lu","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.156607_bib0044","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/imcb.12191","article-title":"The immune system and stroke: from current targets to future therapy","volume":"97","author":"Malone","year":"2019","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.phymed.2025.156607_bib0045","series-title":"Effect of Berberine On the Hippocampal structure, Biochemical factors, memory, and Blood-Brain Barrier in Rat Model of Transient Global Cerebral Ischemia","author":"Mehboodi","year":"2024"},{"key":"10.1016\/j.phymed.2025.156607_bib0046","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.565667","article-title":"Wnt pathway: an emerging player in vascular and traumatic mediated brain injuries","volume":"11","author":"Menet","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.phymed.2025.156607_bib0047","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1177\/0271678X15608396","article-title":"Ultrastructural analysis of blood-brain barrier breakdown in the peri-infarct zone in young adult and aged mice","volume":"36","author":"Nahirney","year":"2016","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.phymed.2025.156607_bib0048","doi-asserted-by":"crossref","first-page":"e02179","DOI":"10.1002\/brb3.2179","article-title":"The emerging role of FTY720 as a sphingosine 1-phosphate analog for the treatment of ischemic stroke: The cellular and molecular mechanisms","volume":"11","author":"Naseh","year":"2021","journal-title":"Brain Behav."},{"key":"10.1016\/j.phymed.2025.156607_bib0049","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nature13241","article-title":"Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid","volume":"509","author":"Nguyen","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2025.156607_bib0050","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.676621","article-title":"Immune response in neurological pathology: emerging role of Central and peripheral Immune crosstalk","volume":"12","author":"Passaro","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.phymed.2025.156607_bib0051","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20190062","article-title":"The blood-brain barrier in health and disease: important unanswered questions","volume":"217","author":"Profaci","year":"2020","journal-title":"J. Exper. Med."},{"key":"10.1016\/j.phymed.2025.156607_bib0052","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.678744","article-title":"Immune cells in the BBB disruption after acute ischemic stroke: targets for Immune therapy?","volume":"12","author":"Qiu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2025.156607_bib0053","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.expneurol.2012.12.009","article-title":"Fingolimod reduces cerebral lymphocyte infiltration in experimental models of rodent intracerebral hemorrhage","volume":"241","author":"Rolland","year":"2013","journal-title":"Exper. Neurol."},{"key":"10.1016\/j.phymed.2025.156607_bib0054","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000012781","article-title":"Global epidemiology of stroke and access to acute ischemic stroke interventions","volume":"97","author":"Saini","year":"2021","journal-title":"Neurology"},{"key":"10.1016\/j.phymed.2025.156607_bib0055","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1002\/JLB.1RU1117-428R","article-title":"Blood-brain barrier and its function during inflammation and autoimmunity","volume":"103","author":"Sonar","year":"2018","journal-title":"J. Leukocyt. Biol."},{"key":"10.1016\/j.phymed.2025.156607_bib0056","first-page":"189","article-title":"Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL\/J mouse","volume":"145","author":"Steffen","year":"1994","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.phymed.2025.156607_bib0057","doi-asserted-by":"crossref","first-page":"4846","DOI":"10.4049\/jimmunol.0903732","article-title":"Differential roles for endothelial ICAM-1, ICAM-2, and VCAM-1 in shear-resistant T cell arrest, polarization, and directed crawling on blood-brain barrier endothelium","volume":"185","author":"Steiner","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.phymed.2025.156607_bib0058","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.4049\/jimmunol.1402691","article-title":"Canonical wnt signaling in dendritic cells regulates Th1\/Th17 responses and suppresses autoimmune neuroinflammation","volume":"194","author":"Suryawanshi","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.phymed.2025.156607_bib0059","doi-asserted-by":"crossref","DOI":"10.1161\/CIR.0000000000001052","article-title":"Heart Disease and Stroke statistics-2022 update: A report from the American Heart Association","volume":"145","author":"Tsao","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.phymed.2025.156607_bib0060","doi-asserted-by":"crossref","DOI":"10.1161\/CIR.0000000000000950","article-title":"Heart Disease and Stroke statistics-2021 update: A report from the American Heart Association","volume":"143","author":"Virani","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.phymed.2025.156607_bib0061","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0306-4522(02)00374-3","article-title":"Expression of caveolin-1 in human brain microvessels","volume":"115","author":"Virgintino","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.phymed.2025.156607_bib0062","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.3389\/fphar.2019.01288","article-title":"Intermodule coupling analysis of Huang-Lian-Jie-Du decoction on stroke","volume":"10","author":"Wang","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156607_bib0063","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107725","article-title":"Baicalin protects LPS-induced blood-brain barrier damage and activates Nrf2-mediated antioxidant stress pathway","volume":"96","author":"Wang","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2025.156607_bib0064","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.2174\/0929867326666190308133732","article-title":"FTY720 (Fingolimod) Ameliorates brain injury through multiple mechanisms and is a strong candidate for stroke treatment","volume":"27","author":"Wang","year":"2020","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.phymed.2025.156607_bib0065","doi-asserted-by":"crossref","first-page":"6303","DOI":"10.1007\/s11033-022-07438-6","article-title":"Geniposide attenuates early brain injury by inhibiting oxidative stress and neurocyte apoptosis after subarachnoid hemorrhage in rats","volume":"49","author":"Xiao","year":"2022","journal-title":"Molecul. Biol. Rep."},{"key":"10.1016\/j.phymed.2025.156607_bib0066","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2023.114301","article-title":"Baicalin facilitates remyelination and suppresses neuroinflammation in rats with chronic cerebral hypoperfusion by activating wnt\/\u03b2-catenin and inhibiting NF-\u03bab signaling","volume":"442","author":"Xiao","year":"2023","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.phymed.2025.156607_bib0067","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1177\/0271678X18792372","article-title":"Experimental ischemic stroke induces long-term T cell activation in the brain","volume":"39","author":"Xie","year":"2019","journal-title":"J. Cerebr. Blood Flow Metabol.: Off. J. Int. Soc. Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.phymed.2025.156607_bib0068","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/2582843","article-title":"Systematic understanding of the mechanism of Baicalin against ischemic stroke through a network pharmacology approach","author":"Xu","year":"2018","journal-title":"Evidence-Base. Complement. Alternat. Med.: eCAM 2018"},{"key":"10.1016\/j.phymed.2025.156607_bib0069","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1002\/acn3.51453","article-title":"Role of cellular prion protein in splenic CD4(+) T cell differentiation in cerebral ischaemic\/reperfusion","volume":"8","author":"Zhang","year":"2021","journal-title":"Ann. Clin. Translat. Neurol."},{"key":"10.1016\/j.phymed.2025.156607_bib0070","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.jep.2014.04.022","article-title":"Preconditioning with the traditional Chinese medicine Huang-Lian-Jie-Du-Tang initiates HIF-1\u03b1-dependent neuroprotection against cerebral ischemia in rats","volume":"154","author":"Zhang","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.156607_bib0071","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13020-021-00486-3","article-title":"The emerging possibility of the use of geniposide in the treatment of cerebral diseases: a review","volume":"16","author":"Zhang","year":"2021","journal-title":"Chin. Med."},{"key":"10.1016\/j.phymed.2025.156607_bib0072","article-title":"Rapid screening of neuroprotective components from Huang-Lian-Jie-Du Decoction by living cell biospecific extraction coupled with HPLC-Q-Orbitrap-HRMS\/MS analysis","volume":"1176","author":"Zhang","year":"2021","journal-title":"J. Chromatogr. B, Analyt. Technolog. Biomed. Life Sci."},{"key":"10.1016\/j.phymed.2025.156607_bib0073","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.bcp.2018.04.006","article-title":"Baicalin modulates the Treg\/Teff balance to alleviate uveitis by activating the aryl hydrocarbon receptor","volume":"154","author":"Zhu","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156607_bib0074","article-title":"CD4 T helper cell subsets and related Human immunological disorders","volume":"21","author":"Zhu","year":"2020","journal-title":"Int. J. Molecul. Sci."},{"key":"10.1016\/j.phymed.2025.156607_bib0075","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jep.2015.12.001","article-title":"Induced cortical neurogenesis after focal cerebral ischemia\u2013three active components from Huang-Lian-Jie-Du Decoction","volume":"178","author":"Zou","year":"2016","journal-title":"J. Ethnopharmacol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325002478?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325002478?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T11:55:44Z","timestamp":1745582144000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325002478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":75,"alternative-id":["S0944711325002478"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156607","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Huang-Lian-Jie-Du decoction inhibits CD4+ T cell infiltration into CNS in MCAO rats by regulating BBB","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156607","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156607"}}