{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:40:30Z","timestamp":1791549630617,"version":"4.3.4"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074054"],"award-info":[{"award-number":["82074054"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.phymed.2025.156621","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T12:58:49Z","timestamp":1741611529000},"page":"156621","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Stachydrine hydrochloride reduces NOX2 activity to suppress oxidative stress levels to improve cardiac insufficiency"],"prefix":"10.1016","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9744-8116","authenticated-orcid":false,"given":"Mengwei","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuting","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songru","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaijing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongshan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3040-5781","authenticated-orcid":false,"given":"Rong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.156621_bib0001","doi-asserted-by":"crossref","first-page":"142","DOI":"10.4103\/ijpvm.IJPVM_5_19","article-title":"Vinpocetine Improves Oxidative Stress and Pro-Inflammatory Mediators in Acute Kidney Injury","volume":"10","author":"Al-Kuraishy","year":"2019","journal-title":"Int. J. Prev. Med."},{"key":"10.1016\/j.phymed.2025.156621_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113673","article-title":"Investigation of the impact of rosuvastatin and telmisartan in doxorubicin-induced acute cardiotoxicity","volume":"154","author":"Al-Kuraishy","year":"2022","journal-title":"Biomed. PharmacOther"},{"key":"10.1016\/j.phymed.2025.156621_bib0003","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.905828","article-title":"Combination of Panax ginseng C. A. Mey and Febuxostat Boasted Cardioprotective Effects Against Doxorubicin-Induced Acute Cardiotoxicity in Rats","volume":"13","author":"Al-Kuraishy","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156621_bib0004","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1007\/s10787-022-01082-z","article-title":"The role of ivabradine in doxorubicin-induced cardiotoxicity: exploring of underlying argument","volume":"30","author":"Al-Kuraishy","year":"2022","journal-title":"Inflammopharmacology."},{"key":"10.1016\/j.phymed.2025.156621_bib0005","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1161\/01.RES.86.4.396","article-title":"Enhanced dispersion of repolarization and refractoriness in transgenic mouse hearts promotes reentrant ventricular tachycardia","volume":"86","author":"Baker","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.phymed.2025.156621_bib0006","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/cvr\/cvt024","article-title":"Ryanopathy': causes and manifestations of RyR2 dysfunction in heart failure","volume":"98","author":"Belevych","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.phymed.2025.156621_bib0007","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3389\/fphar.2014.00101","article-title":"CaMKII regulation of cardiac ryanodine receptors and inositol triphosphate receptors","volume":"5","author":"Camors","year":"2014","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156621_bib0008","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1159\/000477119","article-title":"Stachydrine Protects Against Pressure Overload-Induced Cardiac Hypertrophy by Suppressing Autophagy","volume":"42","author":"Cao","year":"2017","journal-title":"Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry, and pharmacology"},{"key":"10.1016\/j.phymed.2025.156621_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112306","article-title":"Stachydrine hydrochloride alleviates pressure overload-induced heart failure and calcium mishandling on mice","volume":"248","author":"Chen","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.156621_bib0010","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1016\/j.apsb.2023.02.005","article-title":"The traditional Chinese medicines treat chronic heart failure and their main bioactive constituents and mechanisms","volume":"13","author":"Chen","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phymed.2025.156621_bib0011","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1161\/CIRCULATIONAHA.111.038919","article-title":"Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease","volume":"125","author":"Cunnington","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.phymed.2025.156621_bib0012","article-title":"The Role of Oxidative Stress in Cardiac Disease: From Physiological Response to Injury Factor","volume":"2020","author":"D'Oria","year":"2020","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.phymed.2025.156621_bib0013","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2174\/157340641202160209094548","article-title":"Calcium Homeostasis and Kinetics in Heart Failure","volume":"12","author":"Davlouros","year":"2016","journal-title":"Med. Chem."},{"key":"10.1016\/j.phymed.2025.156621_bib0014","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.cell.2008.02.048","article-title":"A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation","volume":"133","author":"Erickson","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2025.156621_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176585","article-title":"Stachydrine hydrochloride protects the ischemic heart by ameliorating endoplasmic reticulum stress through a SERCA2a dependent way and maintaining intracellular Ca(2+) homeostasis","volume":"973","author":"Feng","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156621_bib0016","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nbt.1515","article-title":"Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes","volume":"27","author":"Foust","year":"2009","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.phymed.2025.156621_bib0017","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1042\/BJ20130282","article-title":"ROS inhibitor N-acetyl-L-cysteine antagonizes the activity of proteasome inhibitors","volume":"454","author":"Halasi","year":"2013","journal-title":"Biochem. J."},{"key":"10.1016\/j.phymed.2025.156621_bib0018","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s00395-021-00900-9","article-title":"Cardiomyocyte Na(+) and Ca(2+) mishandling drives vicious cycle involving CaMKII, ROS, and ryanodine receptors","volume":"116","author":"Hegyi","year":"2021","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.phymed.2025.156621_bib0019","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1089\/ars.2014.6202","article-title":"Discovery of GSK2795039, a Novel Small Molecule NADPH Oxidase 2 Inhibitor","volume":"23","author":"Hirano","year":"2015","journal-title":"Antioxid. Redox. Signal."},{"key":"10.1016\/j.phymed.2025.156621_bib0020","doi-asserted-by":"crossref","unstructured":"Hu D, Li R, Li Y, Wang M, Wang L, Wang S, Cheng H, Zhang Q, Fu C, Qian Z. 2024. Inflammation-Targeted Nanomedicines Alleviate Oxidative Stress and Reprogram Macrophages Polarization for Myocardial Infarction Treatment. 11: e2308910.","DOI":"10.1002\/advs.202308910"},{"key":"10.1016\/j.phymed.2025.156621_bib0021","article-title":"Stachytine Hydrochloride Improves Cardiac Function in Mice with ISO-Induced Heart Failure by Inhibiting the \u03b1-1,6-Fucosylation on N-Glycosylation of \u03b21AR","volume":"12","author":"Hu","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156621_bib0022","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1093\/eurheartj\/ehv126","article-title":"Redox biomarkers in cardiovascular medicine","volume":"36","author":"Karimi Galougahi","year":"2015","journal-title":"Eur. Heart. J."},{"key":"10.1016\/j.phymed.2025.156621_bib0023","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.yjmcc.2014.03.001","article-title":"Reactive oxygen species and excitation-contraction coupling in the context of cardiac pathology","volume":"73","author":"K\u00f6hler","year":"2014","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.phymed.2025.156621_bib0024","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nri1312","article-title":"NOX enzymes and the biology of reactive oxygen","volume":"4","author":"Lambeth","year":"2004","journal-title":"Nature reviews Immunology"},{"key":"10.1016\/j.phymed.2025.156621_bib0025","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1161\/CIRCRESAHA.117.310083","article-title":"Calcium Signaling and Cardiac Arrhythmias","volume":"120","author":"Landstrom","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.phymed.2025.156621_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.113853","article-title":"Ophiopogonin D alleviates diabetic myocardial injuries by regulating mitochondrial dynamics","volume":"271","author":"Li","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.156621_bib0027","first-page":"3840","article-title":"Stachydrine hydrochloride ameliorates cardiac hypertrophy through CaMKII\/HDAC4\/MEF2C signal pathway","volume":"14","author":"Li","year":"2022","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.phymed.2025.156621_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175881","article-title":"A new mechanism of therapeutic effect of stachydrine on heart failure by inhibiting myocardial ferroptosis","volume":"954","author":"Liang","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156621_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114489","article-title":"Stachydrine, a potential drug for the treatment of cardiovascular system and central nervous system diseases","volume":"161","author":"Liao","year":"2023","journal-title":"Biomed. PharmacOther"},{"key":"10.1016\/j.phymed.2025.156621_bib0030","doi-asserted-by":"crossref","first-page":"538","DOI":"10.3389\/fphar.2019.00538","article-title":"Stachydrine Ameliorates Cardiac Fibrosis Through Inhibition of Angiotensin II\/Transformation Growth Factor \u03b21 Fibrogenic Axis","volume":"10","author":"Liu","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156621_bib0031","first-page":"24","article-title":"Stachydrine Hydrochloride Regulates the NOX2-ROS-Signaling Axis in Pressure-Overload-Induced Heart Failure","author":"Lu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2025.156621_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101678","article-title":"Interrelation between ROS and Ca(2+) in aging and age-related diseases","volume":"36","author":"Madreiter-Sokolowski","year":"2020","journal-title":"Redox. Biol."},{"key":"10.1016\/j.phymed.2025.156621_bib0033","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1093\/eurheartj\/ehq396","article-title":"Is oxidative stress a therapeutic target in cardiovascular disease?","volume":"31","author":"M\u00fcnzel","year":"2010","journal-title":"Eur. Heart. J."},{"key":"10.1016\/j.phymed.2025.156621_bib0034","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pharmthera.2018.12.006","article-title":"Mechanisms of cardiac ethanol toxicity and novel treatment options","volume":"197","author":"Mustroph","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2025.156621_bib0035","first-page":"f10","article-title":"Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials","volume":"346","author":"Myung","year":"2013","journal-title":"BMJ (Clinical research ed)"},{"key":"10.1016\/j.phymed.2025.156621_bib0036","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1002\/ejhf.592","volume":"18","author":"Ponikowski","year":"2016","journal-title":"Eur. J. Heart. Fail."},{"key":"10.1016\/j.phymed.2025.156621_bib0037","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/cvr\/cvaa033","article-title":"Junctophilin-2 tethers T-tubules and recruits functional L-type calcium channels to lipid rafts in adult cardiomyocytes","volume":"117","author":"Poulet","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.phymed.2025.156621_bib0038","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.122.009570","article-title":"Inflammatory Glycoprotein 130 Signaling Links Changes in Microtubules and Junctophilin-2 to Altered Mitochondrial Metabolism and Right Ventricular Contractility","volume":"15","author":"Prisco","year":"2022","journal-title":"Circ. Heart. Fail."},{"key":"10.1016\/j.phymed.2025.156621_bib0039","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s12906-022-03594-1","article-title":"Trans-cinnamaldehyde protects against phenylephrine-induced cardiomyocyte hypertrophy through the CaMKII\/ERK pathway","volume":"22","author":"Qian","year":"2022","journal-title":"BMC. Complement. Med. Ther."},{"key":"10.1016\/j.phymed.2025.156621_bib0040","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1146\/annurev-pharmtox-051421-111814","article-title":"CaMKII as a Therapeutic Target in Cardiovascular Disease","volume":"63","author":"Reyes Gaido","year":"2023","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.phymed.2025.156621_bib0041","doi-asserted-by":"crossref","first-page":"e13757","DOI":"10.1111\/jfbc.13757","article-title":"Astragaloside IV prevents acute myocardial infarction by inhibiting the TLR4\/MyD88\/NF-\u03baB signaling pathway","volume":"45","author":"Shi","year":"2021","journal-title":"J. Food Biochem."},{"key":"10.1016\/j.phymed.2025.156621_bib0042","doi-asserted-by":"crossref","first-page":"153","DOI":"10.21037\/cdt.2020.01.02","article-title":"Ginsenoside Rg3 protects heart against isoproterenol-induced myocardial infarction by activating AMPK mediated autophagy","volume":"10","author":"Sun","year":"2020","journal-title":"Cardiovasc. Diagn. Ther."},{"key":"10.1016\/j.phymed.2025.156621_bib0043","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1254\/jjp.79.447","article-title":"Naftopidil, a novel alpha1-adrenoceptor antagonist, displays selective inhibition of canine prostatic pressure and high affinity binding to cloned human alpha1-adrenoceptors","volume":"79","author":"Takei","year":"1999","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156621_bib0044","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.freeradbiomed.2023.03.001","article-title":"Activation of neuronal NADPH oxidase NOX2 promotes inflammatory neurodegeneration","volume":"200","author":"Tu","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2025.156621_bib0045","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/ejhf.1320","article-title":"Treating oxidative stress in heart failure: past, present and future","volume":"21","author":"van der Pol","year":"2019","journal-title":"Eur. J. Heart. Fail."},{"key":"10.1016\/j.phymed.2025.156621_bib0046","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1161\/CIRCULATIONAHA.123.065767","article-title":"Ptpn23 Controls Cardiac T-Tubule Patterning by Promoting the Assembly of Dystrophin-Glycoprotein Complex","volume":"149","author":"Xu","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.phymed.2025.156621_bib0047","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1080\/13880209.2024.2354335","article-title":"Network pharmacology integrated with experimental validation to elucidate the mechanisms of action of the Guizhi-Gancao Decoction in the treatment of phenylephrine-induced cardiac hypertrophy","volume":"62","author":"Yang","year":"2024","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.phymed.2025.156621_bib0048","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1186\/1472-6882-14-474","article-title":"Effects of stachydrine on norepinephrine-induced neonatal rat cardiac myocytes hypertrophy and intracellular calcium transients","volume":"14","author":"Zhang","year":"2014","journal-title":"BMC. Complement. Altern. Med."},{"key":"10.1016\/j.phymed.2025.156621_bib0049","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1093\/cvr\/cvt050","article-title":"ROS regulation of microdomain Ca(2+) signalling at the dyads","volume":"98","author":"Zhang","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.phymed.2025.156621_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2023.116412","article-title":"GSK2795039 prevents RIP1-RIP3-MLKL-mediated cardiomyocyte necroptosis in doxorubicin-induced heart failure through inhibition of NADPH oxidase-derived oxidative stress","volume":"463","author":"Zhang","year":"2023","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156621_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173386","article-title":"Stachydrine hydrochloride suppresses phenylephrine-induced pathological cardiac hypertrophy by inhibiting the calcineurin\/nuclear factor of activated T-cell signalling pathway","volume":"883","author":"Zheng","year":"2020","journal-title":"Eur. J. Pharmacol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325002612?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325002612?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T15:22:33Z","timestamp":1763047353000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325002612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":51,"alternative-id":["S0944711325002612"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156621","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stachydrine hydrochloride reduces NOX2 activity to suppress oxidative stress levels to improve cardiac insufficiency","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156621","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156621"}}