{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:35:07Z","timestamp":1791930907499,"version":"4.3.4"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170549"],"award-info":[{"award-number":["82170549"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.phymed.2025.156671","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T05:39:05Z","timestamp":1742449145000},"page":"156671","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Diosmin alleviates colitis by inhibiting PANoptosis of intestinal epithelial cells and regulating gut microbiota and metabolites"],"prefix":"10.1016","volume":"141","author":[{"given":"Cheng","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixuan","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haodong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingzhou","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5403-8473","authenticated-orcid":false,"given":"Yu","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhai","family":"Zhen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4228-6508","authenticated-orcid":false,"given":"Weiguo","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.156671_bib0001","doi-asserted-by":"crossref","first-page":"6743","DOI":"10.3748\/wjg.v28.i47.6743","article-title":"Role of the combination of biologics and\/or small molecules in the treatment of patients with inflammatory bowel disease","volume":"28","author":"Balderramo","year":"2022","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.phymed.2025.156671_bib0002","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/s41580-020-0270-8","article-title":"Emerging connectivity of programmed cell death pathways and its physiological implications","volume":"21","author":"Bedoui","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2025.156671_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115705","article-title":"Zhenwu decoction ameliorates cardiac hypertrophy through activating sGC (soluble guanylate cyclase) - cGMP (cyclic guanosine monophosphate) - PKG (protein kinase G) pathway","volume":"300","author":"Chen","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.156671_bib0004","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1053\/j.gastro.2020.01.006","article-title":"AGA Clinical Practice guidelines on the management of moderate to severe ulcerative colitis","volume":"158","author":"Feuerstein","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phymed.2025.156671_bib0005","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.ijbiomac.2021.03.137","article-title":"Crataegus pinnatifida polysaccharide alleviates colitis via modulation of gut microbiota and SCFAs metabolism","volume":"181","author":"Guo","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2025.156671_bib0006","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/j.apsb.2021.08.030","article-title":"High-throughput screening for amyloid-\u03b2 binding natural small-molecules based on the combinational use of biolayer interferometry and UHPLC-DAD-Q\/TOF-MS\/MS","volume":"12","author":"Guo","year":"2022","journal-title":"Acta Pharmaceut. Sinica B"},{"key":"10.1016\/j.phymed.2025.156671_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153412","article-title":"Naringenin alleviates nonalcoholic steatohepatitis in middle-aged Apoe(-\/-)mice: role of SIRT1","volume":"81","author":"Hua","year":"2021","journal-title":"Phytomed.: Int. J. Phytother. Phytopharmacol."},{"key":"10.1016\/j.phymed.2025.156671_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155795","article-title":"PRM1201 effectively inhibits colorectal cancer metastasis via shaping gut microbiota and short- chain fatty acids","volume":"132","author":"Jia","year":"2024","journal-title":"Phytomed.: Int. J. Phytother. Phytopharmacol."},{"key":"10.1016\/j.phymed.2025.156671_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.124150","article-title":"Oyster polysaccharides relieve DSS-induced colitis via anti-inflammatory and maintaining the physiological hypoxia","volume":"238","author":"Jiang","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2025.156671_bib0010","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/s41401-021-00726-0","article-title":"Diosmetin has therapeutic efficacy in colitis regulating gut microbiota, inflammation, and oxidative stress via the circ-Sirt1\/Sirt1 axis","volume":"43","author":"Li","year":"2022","journal-title":"Acta. Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2025.156671_bib0011","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1007\/s10753-023-01849-8","article-title":"Kaempferol attenuates gouty arthritis by regulating the balance of Th17\/treg cells and secretion of IL-17","volume":"46","author":"Li","year":"2023","journal-title":"Inflammation"},{"key":"10.1016\/j.phymed.2025.156671_bib0012","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.2147\/JIR.S455862","article-title":"PANoptosis and autophagy-related molecular signature and immune landscape in ulcerative colitis: integrated analysis and experimental validation","volume":"17","author":"Lu","year":"2024","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.phymed.2025.156671_bib0013","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/s41564-021-01050-3","article-title":"Multi-omics analyses of the ulcerative colitis gut microbiome link Bacteroides vulgatus proteases with disease severity","volume":"7","author":"Mills","year":"2022","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.phymed.2025.156671_bib0014","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/S0140-6736(12)60150-0","article-title":"Ulcerative colitis","volume":"380","author":"Ord\u00e1s","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2025.156671_bib0015","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.molmed.2023.10.001","article-title":"Therapeutic potential of PANoptosis: innate sensors, inflammasomes, and RIPKs in PANoptosomes","volume":"30","author":"Pandeya","year":"2024","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.phymed.2025.156671_bib0016","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/ecco-jcc\/jjab178","article-title":"ECCO Guidelines on therapeutics in ulcerative colitis: medical treatment","volume":"16","author":"Raine","year":"2022","journal-title":"J. Crohns. Colitis."},{"key":"10.1016\/j.phymed.2025.156671_bib0017","doi-asserted-by":"crossref","first-page":"e27527","DOI":"10.1016\/j.heliyon.2024.e27527","article-title":"Diosmin alleviates ulcerative colitis in mice by increasing Akkermansia muciniphila abundance, improving intestinal barrier function, and modulating the NF-\u03bab and Nrf2 pathways","volume":"10","author":"Salem","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.phymed.2025.156671_bib0018","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1177\/0960327117694075","article-title":"Anti-inflammatory, antioxidant and anti-apoptotic activity of diosmin in acetic acid-induced ulcerative colitis","volume":"37","author":"Shalkami","year":"2018","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.phymed.2025.156671_bib0019","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0014-2999(02)02949-7","article-title":"Effects of dosmalfate, a new cytoprotective agent, on acute and chronic trinitrobenzene sulphonic acid-induced colitis in rats","volume":"460","author":"Villegas","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156671_bib0020","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25010348","article-title":"Comprehensive analysis of PANoptosis-related gene signature of ulcerative colitis","volume":"25","author":"Wang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2025.156671_bib0021","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.1016\/j.csbj.2021.07.038","article-title":"From pyroptosis, apoptosis and necroptosis to PANoptosis: a mechanistic compendium of programmed cell death pathways","volume":"19","author":"Wang","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.phymed.2025.156671_bib0022","doi-asserted-by":"crossref","first-page":"11731","DOI":"10.1038\/s41598-024-62259-w","article-title":"Characterization of PANoptosis-related genes in Crohn's disease by integrated bioinformatics, machine learning and experiments","volume":"14","author":"Yang","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2025.156671_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.127335","article-title":"Bergamot polysaccharides relieve DSS-induced ulcerative colitis via regulating the gut microbiota and metabolites","volume":"253","author":"Yang","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2025.156671_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.133794","article-title":"Synbiotics containing sea buckthorn polysaccharides ameliorate DSS-induced colitis in mice via regulating Th17\/Treg homeostasis through intestinal microbiota and their production of BA metabolites and SCFAs","volume":"276","author":"Yuan","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2025.156671_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2019.107452","article-title":"Anti-inflammatory and immunoregulatory effects of paeoniflorin and total glucosides of paeony","volume":"207","author":"Zhang","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2025.156671_bib0026","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12906-023-04330-z","article-title":"Diosmin ameliorates renal fibrosis through inhibition of inflammation by regulating SIRT3-mediated NF-\u03bab p65 nuclear translocation","volume":"24","author":"Zhao","year":"2024","journal-title":"BMC Complem. Med. Ther."},{"key":"10.1016\/j.phymed.2025.156671_bib0027","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s12906-023-03976-z","article-title":"Analysis of the potential biological mechanisms of diosmin against renal fibrosis based on network pharmacology and molecular docking approach","volume":"23","author":"Zhao","year":"2023","journal-title":"BMC Complem. Med. Ther."},{"key":"10.1016\/j.phymed.2025.156671_bib0028","article-title":"Advances in mechanism and regulation of PANoptosis: prospects in disease treatment","volume":"14","author":"Zhu","year":"2023","journal-title":"Front. Immunol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325003113?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325003113?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T07:56:43Z","timestamp":1745567803000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325003113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":28,"alternative-id":["S0944711325003113"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156671","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diosmin alleviates colitis by inhibiting PANoptosis of intestinal epithelial cells and regulating gut microbiota and metabolites","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156671","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156671"}}