{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T22:06:16Z","timestamp":1793484376312,"version":"4.5.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7232,279"],"award-info":[{"award-number":["7232,279"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004846","name":"Beijing University of Chinese Medicine","doi-asserted-by":"publisher","award":["2024-JYB-JBZD-043"],"award-info":[{"award-number":["2024-JYB-JBZD-043"]}],"id":[{"id":"10.13039\/501100004846","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004846","name":"Beijing University of Chinese Medicine","doi-asserted-by":"publisher","award":["2022-JYB-JBZR-004"],"award-info":[{"award-number":["2022-JYB-JBZR-004"]}],"id":[{"id":"10.13039\/501100004846","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82,104,560"],"award-info":[{"award-number":["82,104,560"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U21A20400"],"award-info":[{"award-number":["U21A20400"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.phymed.2025.156696","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T13:40:32Z","timestamp":1743082832000},"page":"156696","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Refined qingkailing attenuates reactive astrocytes and glial scar formation after ischemia stroke via the EGFR\/PLC\u03b3 pathway"],"prefix":"10.1016","volume":"142","author":[{"given":"Zi-Lin","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu-Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Xiao","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong-Ai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Dan-Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Hui","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Lin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Hua","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Guo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fa-Feng","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Xiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.156696_bib0001","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1523\/JNEUROSCI.14-02-00846.1994","article-title":"Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines","volume":"14","author":"Balasingam","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phymed.2025.156696_bib0002","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/nn.3371","article-title":"Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation","volume":"16","author":"Bardehle","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.phymed.2025.156696_bib0003","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.cmet.2016.08.023","article-title":"Mitochondrial transfer from astrocytes to neurons following ischemic insult: guilt by association?","volume":"24","author":"Berridge","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.phymed.2025.156696_bib0004","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1007\/s11064-007-9312-2","article-title":"Role of cell cycle proteins in CNS injury","volume":"32","author":"Byrnes","year":"2007","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.phymed.2025.156696_bib0005","doi-asserted-by":"crossref","DOI":"10.1038\/celldisc.2017.44","article-title":"A role for ErbB signaling in the induction of reactive astrogliosis","volume":"3","author":"Chen","year":"2017","journal-title":"Cell Discov."},{"key":"10.1016\/j.phymed.2025.156696_bib0006","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.nbd.2015.05.003","article-title":"Reactive astrocytes and therapeutic potential in focal ischemic stroke","volume":"85","author":"Choudhury","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.phymed.2025.156696_bib0007","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.974890","article-title":"More than a marker: potential pathogenic functions of MAP2","volume":"15","author":"DeGiosio","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.phymed.2025.156696_bib0008","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1083\/jcb.125.3.669","article-title":"The neuronal chondroitin sulfate proteoglycan neurocan binds to the neural cell adhesion molecules Ng-CAM\/L1\/NILE and N-CAM, and inhibits neuronal adhesion and neurite outgrowth","volume":"125","author":"Friedlander","year":"1994","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.phymed.2025.156696_bib0009","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1159\/000514951","article-title":"Valproic acid inhibits glial scar formation after ischemic stroke","volume":"107","author":"Gao","year":"2022","journal-title":"Pharmacology"},{"key":"10.1016\/j.phymed.2025.156696_bib0010","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S1474-4422(21)00252-0","article-title":"Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"20","year":"2021","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.phymed.2025.156696_bib0011","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1111\/jnc.13730","article-title":"Nucleolin inhibitor GroA triggers reduction in epidermal growth factor receptor activation: pharmacological implication for glial scarring after spinal cord injury","volume":"138","author":"Goldshmit","year":"2016","journal-title":"J. Neurochem."},{"key":"10.1016\/j.phymed.2025.156696_bib0012","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1083\/jcb.120.3.815","article-title":"Functional characterization of chondroitin sulfate proteoglycans of brain: interactions with neurons and neural cell adhesion molecules","volume":"120","author":"Grumet","year":"1993","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.phymed.2025.156696_bib0013","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nature18928","article-title":"Transfer of mitochondria from astrocytes to neurons after stroke","volume":"535","author":"Hayakawa","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2025.156696_bib0014","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/s12031-019-01417-6","article-title":"Glial scar-a promising target for improving outcomes after CNS injury","volume":"70","author":"He","year":"2020","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.phymed.2025.156696_bib0015","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neulet.2013.10.012","article-title":"Astrocyte loss and astrogliosis in neuroinflammatory disorders","volume":"565","author":"Hostenbach","year":"2014","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.phymed.2025.156696_bib0016","doi-asserted-by":"crossref","first-page":"344","DOI":"10.7150\/ijms.8140","article-title":"Glial scar formation occurs in the Human brain after ischemic stroke","volume":"11","author":"Huang","year":"2014","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.phymed.2025.156696_bib0017","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jbior.2017.11.003","article-title":"PLC\u03b31: potential arbitrator of cancer progression","volume":"67","author":"Jang","year":"2018","journal-title":"Adv. Biol. Regul."},{"key":"10.1016\/j.phymed.2025.156696_bib0018","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0014-4886(03)00087-6","article-title":"The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, and versican are differentially regulated following spinal cord injury","volume":"182","author":"Jones","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.phymed.2025.156696_bib0019","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/(SICI)1098-1136(199703)19:3<227::AID-GLIA5>3.0.CO;2-W","article-title":"Impaired neuroglial activation in interleukin-6 deficient mice","volume":"19","author":"Klein","year":"1997","journal-title":"Glia"},{"key":"10.1016\/j.phymed.2025.156696_bib0020","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3390\/ijms21010275","article-title":"On the modulatory roles of neuregulins\/ErbB signaling on synaptic plasticity","volume":"21","author":"Ledonne","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2025.156696_bib0021","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.4103\/1673-5374.259617","article-title":"Hyodeoxycholic acid protects the neurovascular unit against oxygen-glucose deprivation and reoxygenation-induced injury in vitro","volume":"14","author":"Li","year":"2019","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.phymed.2025.156696_bib0022","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/1742-2094-11-71","article-title":"Epidermal growth factor receptor inhibitor ameliorates excessive astrogliosis and improves the regeneration microenvironment and functional recovery in adult rats following spinal cord injury","volume":"11","author":"Li","year":"2014","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.phymed.2025.156696_bib0023","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.immuni.2017.06.006","article-title":"Reactive astrocytes: production, function, and therapeutic potential","volume":"46","author":"Liddelow","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.phymed.2025.156696_bib0024","doi-asserted-by":"crossref","first-page":"7532","DOI":"10.1523\/JNEUROSCI.1004-06.2006","article-title":"Epidermal growth factor receptor activation: an upstream signal for transition of quiescent astrocytes into reactive astrocytes after neural injury","volume":"26","author":"Liu","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phymed.2025.156696_bib0025","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.pneurobio.2015.09.008","article-title":"Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke","volume":"144","author":"Liu","year":"2016","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.phymed.2025.156696_bib0026","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1096\/fj.10-163790","article-title":"Reactive glial cells: increased stiffness correlates with increased intermediate filament expression","volume":"25","author":"Lu","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.phymed.2025.156696_bib0027","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.00519","article-title":"An integrative pharmacology-based analysis of refined qingkailing injection against cerebral ischemic stroke: a novel combination of baicalin, geniposide, cholic acid, and hyodeoxycholic acid","volume":"11","author":"Ma","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156696_bib0028","doi-asserted-by":"crossref","first-page":"10778","DOI":"10.1523\/JNEUROSCI.19-24-10778.1999","article-title":"The chondroitin sulfate proteoglycans neurocan and phosphacan are expressed by reactive astrocytes in the chronic CNS glial scar","volume":"19","author":"McKeon","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phymed.2025.156696_bib0029","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1083\/jcb.109.5.2353","article-title":"Schwannoma cell-derived inhibitor of the neurite-promoting activity of laminin","volume":"109","author":"Muir","year":"1989","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.phymed.2025.156696_bib0030","doi-asserted-by":"crossref","first-page":"4280","DOI":"10.3390\/ijms22084280","article-title":"Astrocyte activation in neurovascular damage and repair following ischaemic stroke","volume":"22","author":"Patabendige","year":"2021","journal-title":"IJMS"},{"key":"10.1016\/j.phymed.2025.156696_bib0031","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1152\/physrev.00041.2013","article-title":"Astrocyte reactivity and reactive astrogliosis: costs and benefits","volume":"94","author":"Pekny","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.phymed.2025.156696_bib0032","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/(SICI)1098-1136(199806)23:2<120::AID-GLIA3>3.0.CO;2-A","article-title":"Epidermal growth factor receptor in proliferating reactive glia following transient focal ischemia in the rat brain","volume":"23","author":"Planas","year":"1998","journal-title":"Glia"},{"key":"10.1016\/j.phymed.2025.156696_bib0033","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/s41401-018-0166-8","article-title":"CID1067700, a late endosome GTPase Rab7 receptor antagonist, attenuates brain atrophy, improves neurologic deficits and inhibits reactive astrogliosis in rat ischemic stroke","volume":"40","author":"Qin","year":"2019","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2025.156696_bib0034","doi-asserted-by":"crossref","first-page":"10541","DOI":"10.1523\/JNEUROSCI.18-24-10541.1998","article-title":"A role for transforming growth factor alpha as an inducer of astrogliosis","volume":"18","author":"Rabchevsky","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phymed.2025.156696_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115580","article-title":"Refined Qingkailing protects the in vitro neurovascular unit against oxygen-glucose deprivation and re-oxygenation-induced injury","volume":"167","author":"Ren","year":"2023","journal-title":"Biomed. PharmacOther"},{"key":"10.1016\/j.phymed.2025.156696_bib0036","doi-asserted-by":"crossref","first-page":"19936","DOI":"10.1074\/jbc.M309304200","volume":"279","author":"Sriram","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2025.156696_bib0037","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/glia.440150204","article-title":"The role of intracellular calcium and protein kinase C in endothelin-stimulated proliferation of rat type I astrocytes","volume":"15","author":"Stanimirovic","year":"1995","journal-title":"Glia"},{"key":"10.1016\/j.phymed.2025.156696_bib0038","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1080\/02699052.2018.1531311","article-title":"The roles of astrocyte in the brain pathologies following ischemic stroke","volume":"33","author":"Sun","year":"2019","journal-title":"Brain Inj."},{"key":"10.1016\/j.phymed.2025.156696_bib0039","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/5251236","article-title":"Expression of MicroRNA-29a regulated by yes-associated protein modulates the neurite outgrowth in N2a cells","author":"Tan","year":"2017","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.phymed.2025.156696_bib0040","doi-asserted-by":"crossref","first-page":"6289","DOI":"10.1523\/JNEUROSCI.0008-11.2011","article-title":"Integrin activation promotes axon growth on inhibitory chondroitin sulfate proteoglycans by enhancing integrin signaling","volume":"31","author":"Tan","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phymed.2025.156696_bib0041","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/jnr.10523","article-title":"Changes in distribution, cell associations, and protein expression levels of NG2, neurocan, phosphacan, brevican, versican V2, and tenascin-C during acute to chronic maturation of spinal cord scar tissue","volume":"71","author":"Tang","year":"2003","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.phymed.2025.156696_bib0042","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2017.11.016","article-title":"Reduced post-stroke glial scarring in the infant primate brain reflects age-related differences in the regulation of astrogliosis","volume":"111","author":"Teo","year":"2018","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.phymed.2025.156696_bib0043","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1056\/NEJMoa1804492","article-title":"Global, regional, and country-specific lifetime risks of stroke, 1990 and 2016","volume":"379","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phymed.2025.156696_bib0044","doi-asserted-by":"crossref","DOI":"10.1177\/2058738418801406","article-title":"Portrait of glial scar in neurological diseases","volume":"31","author":"Wang","year":"2018","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156696_bib0045","doi-asserted-by":"crossref","first-page":"5865","DOI":"10.1073\/pnas.92.13.5865","article-title":"A role for ciliary neurotrophic factor as an inducer of reactive gliosis, the glial response to central nervous system injury","volume":"92","author":"Winter","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U S. A."},{"key":"10.1016\/j.phymed.2025.156696_bib0046","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/sj.cr.7290318","article-title":"The interaction of versican with its binding partners","volume":"15","author":"Wu","year":"2005","journal-title":"Cell Res."},{"key":"10.1016\/j.phymed.2025.156696_bib0047","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41419-017-0260-8","article-title":"Neuroglobin boosts axon regeneration during ischemic reperfusion via p38 binding and activation depending on oxygen signal","volume":"9","author":"Xiong","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phymed.2025.156696_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114773","article-title":"Identification of potential regulating effect of baicalin on nf\u03bab\/CCL2\/CCR2 signaling pathway in rats with cerebral ischemia by antibody-based array and bioinformatics analysis","volume":"284","author":"Xu","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.156696_bib0049","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1002\/jcp.30649","article-title":"Melatonin attenuates reactive astrogliosis and glial scar formation following cerebral ischemia and reperfusion injury mediated by GSK-3\u03b2 and RIP1K","volume":"237","author":"Yawoot","year":"2022","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.phymed.2025.156696_bib0050","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.1007\/s11064-021-03266-5","article-title":"Glial cell line-derived neurotrophic factor and focal ischemic stroke","volume":"46","author":"Zhang","year":"2021","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.phymed.2025.156696_bib0051","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.nurt.2010.07.004","article-title":"Targeting astrocytes for stroke therapy","volume":"7","author":"Zhao","year":"2010","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.phymed.2025.156696_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110041","article-title":"Neuroprotective effects of saffron on the late cerebral ischemia injury through inhibiting astrogliosis and glial scar formation in rats","volume":"126","author":"Zhong","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2025.156696_bib0053","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.neuroscience.2017.05.004","article-title":"Sevoflurane postconditioning attenuates reactive astrogliosis and glial scar formation after ischemia\u2013reperfusion brain injury","volume":"356","author":"Zhu","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.phymed.2025.156696_bib0054","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1007\/s12975-021-00888-3","article-title":"The key regulator of necroptosis, RIP1 kinase, contributes to the formation of astrogliosis and glial scar in ischemic stroke","volume":"12","author":"Zhu","year":"2021","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.phymed.2025.156696_bib0055","doi-asserted-by":"crossref","first-page":"5203","DOI":"10.1523\/JNEUROSCI.18-14-05203.1998","article-title":"Neuronal matrix metalloproteinase-2 degrades and inactivates a neurite-inhibiting chondroitin sulfate proteoglycan","volume":"18","author":"Zuo","year":"1998","journal-title":"J. Neurosci."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325003368?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325003368?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T21:49:51Z","timestamp":1773352191000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325003368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":55,"alternative-id":["S0944711325003368"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156696","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Refined qingkailing attenuates reactive astrocytes and glial scar formation after ischemia stroke via the EGFR\/PLC\u03b3 pathway","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156696","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156696"}}