{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:49:38Z","timestamp":1793832578596,"version":"4.6.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82030124"],"award-info":[{"award-number":["82030124"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003345","name":"Chinese Academy of Meteorological Sciences","doi-asserted-by":"publisher","award":["2021-I2M-1-031"],"award-info":[{"award-number":["2021-I2M-1-031"]}],"id":[{"id":"10.13039\/501100003345","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.phymed.2025.156736","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T08:55:23Z","timestamp":1744188923000},"page":"156736","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Formononetin attenuates myocardial ischemia\/reperfusion injury by regulating neutrophil extracellular traps formation and platelet activation via platelet CD36"],"prefix":"10.1016","volume":"141","author":[{"given":"Shuang","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-xue","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruo-yun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-lu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-chen","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-bo","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.156736_bib0001","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1055\/s-0043-1768935","article-title":"The role of CD36\/GPIV in platelet biology","volume":"50","author":"Bendas","year":"2024","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/j.phymed.2025.156736_bib0002","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1161\/CIRCRESAHA.108.172064","article-title":"A specific CD36-dependent signaling pathway is required for platelet activation by oxidized low-density lipoprotein","volume":"102","author":"Chen","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.phymed.2025.156736_bib0003","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1161\/CIRCGENETICS.115.001249","article-title":"CD36 Is a matrix metalloproteinase-9 substrate that stimulates neutrophil apoptosis and removal during cardiac remodeling","volume":"9","author":"DeLeon-Pennell","year":"2016","journal-title":"Circ. Cardiovasc. Genet."},{"key":"10.1016\/j.phymed.2025.156736_bib0004","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1182\/blood-2015-01-624023","article-title":"P-selectin promotes neutrophil extracellular trap formation in mice","volume":"126","author":"Etulain","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.phymed.2025.156736_bib0005","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1161\/CIRCULATIONAHA.118.036044","article-title":"Dectin-1 contributes to myocardial ischemia\/reperfusion injury by regulating macrophage polarization and neutrophil infiltration","volume":"139","author":"Fan","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.phymed.2025.156736_bib0006","doi-asserted-by":"crossref","first-page":"512","DOI":"10.4103\/1673-5374.380821","article-title":"Role of CD36 in central nervous system diseases","volume":"19","author":"Feng","year":"2024","journal-title":"Neural. Regen. Res."},{"key":"10.1016\/j.phymed.2025.156736_bib0007","doi-asserted-by":"crossref","first-page":"15880","DOI":"10.1073\/pnas.1005743107","article-title":"Extracellular DNA traps promote thrombosis","volume":"107","author":"Fuchs","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.phymed.2025.156736_bib0008","doi-asserted-by":"crossref","first-page":"H500","DOI":"10.1152\/ajpheart.00381.2014","article-title":"Neutrophil extracellular traps in ischemia-reperfusion injury-induced myocardial no-reflow: therapeutic potential of DNase-based reperfusion strategy","volume":"308","author":"Ge","year":"2015","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"key":"10.1016\/j.phymed.2025.156736_bib0009","doi-asserted-by":"crossref","DOI":"10.3390\/cells11193009","article-title":"Platelets and the cybernetic regulation of ischemic inflammatory responses through PNC formation regulated by extracellular nucleotide metabolism and signaling","volume":"11","author":"Granja","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.phymed.2025.156736_bib0010","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s00395-016-0588-8","article-title":"Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery","volume":"111","author":"Hausenloy","year":"2016","journal-title":"Basic. Res. Cardiol."},{"key":"10.1016\/j.phymed.2025.156736_bib0011","doi-asserted-by":"crossref","DOI":"10.1172\/JCI151268","article-title":"Gasdermin D inhibition confers antineutrophil-mediated cardioprotection in acute myocardial infarction","volume":"132","author":"Jiang","year":"2022","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2025.156736_bib0012","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1161\/CIRCULATIONAHA.110.014555","article-title":"Phosphorylation of vasodilator-stimulated phosphoprotein prevents platelet-neutrophil complex formation and dampens myocardial ischemia-reperfusion injury","volume":"123","author":"K\u00f6hler","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.phymed.2025.156736_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.129975","article-title":"Formononetin: biological effects and uses - a review","volume":"359","author":"Machado Dutra","year":"2021","journal-title":"Food. Chem."},{"key":"10.1016\/j.phymed.2025.156736_bib0014","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1681\/ASN.2016080925","article-title":"Histones and neutrophil extracellular traps enhance tubular necrosis and remote organ injury in ischemic AKI","volume":"28","author":"Nakazawa","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.phymed.2025.156736_bib0015","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/j.jvs.2013.02.241","article-title":"Reduced hind limb ischemia-reperfusion injury in toll-like receptor-4 mutant mice is associated with decreased neutrophil extracellular traps","volume":"58","author":"Oklu","year":"2013","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.phymed.2025.156736_bib0016","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1161\/CIRCULATIONAHA.120.046290","article-title":"PCSK9 (Proprotein Convertase Subtilisin\/Kexin 9) Enhances platelet activation, thrombosis, and myocardial infarct expansion by binding to platelet CD36","volume":"143","author":"Qi","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.phymed.2025.156736_bib0017","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/cvr\/cvaa319","article-title":"The role of CD36 in cardiovascular disease","volume":"118","author":"Shu","year":"2022","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.phymed.2025.156736_bib0018","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1093\/eurheartj\/ehv007","article-title":"Expression of functional tissue factor by neutrophil extracellular traps in culprit artery of acute myocardial infarction","volume":"36","author":"Stakos","year":"2015","journal-title":"Eur. Heart. J."},{"key":"10.1016\/j.phymed.2025.156736_bib0019","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/s41569-021-00552-1","article-title":"Interplay between inflammation and thrombosis in cardiovascular pathology","volume":"18","author":"Stark","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.phymed.2025.156736_bib0020","doi-asserted-by":"crossref","DOI":"10.1172\/JCI147191","article-title":"KLF2 regulates neutrophil activation and thrombosis in cardiac hypertrophy and heart failure progression","volume":"132","author":"Tang","year":"2022","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2025.156736_bib0021","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s11883-020-00870-8","article-title":"CD36 in atherosclerosis: pathophysiological mechanisms and therapeutic implications","volume":"22","author":"Tian","year":"2020","journal-title":"Curr. Atheroscler. Rep."},{"key":"10.1016\/j.phymed.2025.156736_bib0022","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.cardiores.2003.10.011","article-title":"Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury","volume":"61","author":"Vinten-Johansen","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.phymed.2025.156736_bib0023","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1084\/jem.20112322","article-title":"Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo","volume":"209","author":"von Br\u00fchl","year":"2012","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.phymed.2025.156736_bib0024","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.bbrc.2020.02.147","article-title":"Formononetin ameliorates myocardial ischemia\/reperfusion injury in rats by suppressing the ROS-TXNIP-NLRP3 pathway","volume":"525","author":"Wang","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phymed.2025.156736_bib0025","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.thromres.2023.06.022","article-title":"What do we know about platelets in myocardial ischemia-reperfusion injury and why is it important?","volume":"229","author":"Wang","year":"2023","journal-title":"Thromb. Res."},{"key":"10.1016\/j.phymed.2025.156736_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118211","article-title":"Qilong capsule prevents myocardial ischemia\/reperfusion injury by inhibiting platelet activation via the platelet CD36 signaling pathway","volume":"330","author":"Wang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.156736_bib0027","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jare.2020.10.005","article-title":"Calenduloside E suppresses calcium overload by promoting the interaction between l-type calcium channels and Bcl2-associated athanogene 3 to alleviate myocardial ischemia\/reperfusion injury","volume":"34","author":"Wang","year":"2021","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.phymed.2025.156736_bib0028","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1182\/blood-2016-11-750133","article-title":"Platelet CD36 promotes thrombosis by activating redox sensor ERK5 in hyperlipidemic conditions","volume":"129","author":"Yang","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.phymed.2025.156736_bib0029","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1056\/NEJMra071667","article-title":"Myocardial reperfusion injury","volume":"357","author":"Yellon","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phymed.2025.156736_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.123110","article-title":"Formononetin alleviates no reflow after myocardial ischemia-reperfusion via modulation of gut microbiota to inhibit inflammation","volume":"358","author":"Zhang","year":"2024","journal-title":"Life. Sci."},{"key":"10.1016\/j.phymed.2025.156736_bib0031","doi-asserted-by":"crossref","DOI":"10.1177\/03946320221111117","article-title":"Formononetin regulates endothelial nitric oxide synthase to protect vascular endothelium in deep vein thrombosis rats","volume":"36","author":"Zhou","year":"2022","journal-title":"Int. J. Immunopathol. Pharmacol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325003757?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325003757?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T11:58:35Z","timestamp":1745582315000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325003757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":31,"alternative-id":["S0944711325003757"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156736","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Formononetin attenuates myocardial ischemia\/reperfusion injury by regulating neutrophil extracellular traps formation and platelet activation via platelet CD36","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156736","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156736"}}