{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:45:10Z","timestamp":1792086310207,"version":"4.4.0"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32402936"],"award-info":[{"award-number":["32402936"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.phymed.2025.156747","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T11:36:46Z","timestamp":1744285006000},"page":"156747","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Hesperidin mitigated deoxynivalenol-induced liver injury by inhibiting ROS\/ P53\/ PGC-1\u03b1-mediated disruption of mitochondrial dynamics and PANoptosis"],"prefix":"10.1016","volume":"142","author":[{"given":"Xin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aqun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2686-5673","authenticated-orcid":false,"given":"Jun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.phymed.2025.156747_bib0001","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.tox.2008.03.005","article-title":"Tissue distribution and proinflammatory cytokine induction by the trichothecene deoxynivalenol in the mouse: comparison of nasal vs. oral exposure","volume":"248","author":"Amuzie","year":"2008","journal-title":"Toxicology"},{"issue":"7","key":"10.1016\/j.phymed.2025.156747_bib0002","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1080\/19440049.2017.1321149","article-title":"Tissue distribution and elimination of deoxynivalenol and ochratoxin A in dietary-exposed Atlantic salmon (Salmo salar)","volume":"34","author":"Bernhoft","year":"2017","journal-title":"Food Addit Contam Part A Chem Anal Control Expo Risk Assess"},{"issue":"8628","key":"10.1016\/j.phymed.2025.156747_bib0003","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0140-6736(89)91684-X","article-title":"Outbreak of trichothecene mycotoxicosis associated with consumption of mould-damaged wheat production in Kashmir Valley, India","volume":"1","author":"Bhat","year":"1989","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.phymed.2025.156747_bib0004","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0215466","article-title":"Glyphosate, but not its metabolite AMPA, alters the honeybee gut microbiota","volume":"14","author":"Blot","year":"2019","journal-title":"PloS one"},{"key":"10.1016\/j.phymed.2025.156747_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.133854","article-title":"Low-dose deoxynivalenol exposure inhibits hepatic mitophagy and hesperidin reverses this phenomenon by activating SIRT1","volume":"468","author":"Chen","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.phymed.2025.156747_bib0006","article-title":"Low-dose deoxynivalenol exposure triggers hepatic excessive ferritinophagy and mitophagy mitigated by hesperidin modulated O-GlcNAcylation","volume":"480","author":"Chen","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.phymed.2025.156747_bib0007","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3389\/fcimb.2020.00237","article-title":"Identification of the PANoptosome: a molecular platform triggering pyroptosis, apoptosis, and necroptosis (PANoptosis)","volume":"10","author":"Christgen","year":"2020","journal-title":"Front Cell Infect Microbiol"},{"issue":"10","key":"10.1016\/j.phymed.2025.156747_bib0008","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1002\/mnfr.200500050","article-title":"On the effects of graded levels of fusarium toxin contaminated wheat in diets for gilts on feed intake, growth performance and metabolism of deoxynivalenol and zearalenone","volume":"49","author":"D\u00e4nicke","year":"2005","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.phymed.2025.156747_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108525","article-title":"Novel mechanism by which extracellular vesicles derived from Lactobacillus murinus alleviates deoxynivalenol-induced intestinal barrier disruption","volume":"185","author":"Fan","year":"2024","journal-title":"Environ Int"},{"key":"10.1016\/j.phymed.2025.156747_bib0010","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.freeradbiomed.2024.04.228","article-title":"Selenium maintains intestinal epithelial cells to activate M2 macrophages against deoxynivalenol injury","volume":"219","author":"Fan","year":"2024","journal-title":"Free Radic. Biol. Med."},{"issue":"21","key":"10.1016\/j.phymed.2025.156747_bib0011","doi-asserted-by":"crossref","first-page":"5903","DOI":"10.1080\/10408398.2021.1895056","article-title":"Mechanisms of deoxynivalenol (DON) degradation during different treatments: a review","volume":"62","author":"Feizollahi","year":"2022","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"25","key":"10.1016\/j.phymed.2025.156747_bib0012","article-title":"PXR activation relieves deoxynivalenol-induced liver oxidative stress via Malat1 LncRNA m(6)A demethylation","volume":"11","author":"Feng","year":"2024","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.phymed.2025.156747_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154836","article-title":"Progress of research on the role of active ingredients of Citri Reticulatae Pericarpium in liver injury","volume":"115","author":"Gao","year":"2023","journal-title":"Phytomedicine: international journal of phytotherapy and phytopharmacology"},{"issue":"6","key":"10.1016\/j.phymed.2025.156747_bib0014","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1080\/19440040903567232","article-title":"Fusarium head blight and associated mycotoxin occurrence on winter wheat in Luxembourg in 2007\/2008","volume":"27","author":"Giraud","year":"2010","journal-title":"Food Addit Contam Part A Chem Anal Control Expo Risk Assess"},{"key":"10.1016\/j.phymed.2025.156747_bib0015","doi-asserted-by":"crossref","DOI":"10.1038\/s41556-024-01429-4","article-title":"Mitochondria and cell death","author":"Glover","year":"2024","journal-title":"Nat. Cell Biol."},{"issue":"29","key":"10.1016\/j.phymed.2025.156747_bib0016","doi-asserted-by":"crossref","first-page":"16276","DOI":"10.1021\/acs.jafc.4c02265","article-title":"Hesperidin alleviated intestinal barrier injury, mitochondrial dysfunction, and disorder of endoplasmic reticulum mitochondria contact sites under oxidative stress","volume":"72","author":"Gou","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2025.156747_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2019.134619","article-title":"Hesperidin improves motor disability in rat spinal cord injury through anti-inflammatory and antioxidant mechanism via nrf-2\/HO-1 pathway","volume":"715","author":"Heo","year":"2020","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.phymed.2025.156747_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2023.153707","article-title":"DON induced DNA damage triggers absence of p53-mediated G2 arrest and apoptosis in IPEC-1 cells","volume":"501","author":"Hou","year":"2024","journal-title":"Toxicology"},{"key":"10.1016\/j.phymed.2025.156747_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.136095","article-title":"AHR activation relieves deoxynivalenol-induced disruption of porcine intestinal epithelial barrier functions","volume":"480","author":"Hu","year":"2024","journal-title":"J. Hazard. Mater."},{"issue":"1","key":"10.1016\/j.phymed.2025.156747_bib0020","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s40104-024-01012-9","article-title":"Hesperidin ameliorates H(2)O(2)-induced bovine mammary epithelial cell oxidative stress via the Nrf2 signaling pathway","volume":"15","author":"Huang","year":"2024","journal-title":"J Anim Sci Biotechnol"},{"issue":"11","key":"10.1016\/j.phymed.2025.156747_bib0021","doi-asserted-by":"crossref","first-page":"5734","DOI":"10.1021\/acs.jafc.3c06337","article-title":"Folic acid rescues dopaminergic neurons in MPTP-induced mice by inhibiting the NLRP3 inflammasome and ameliorating mitochondrial impairment","volume":"72","author":"Jia","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2025.156747_bib0022","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.envpol.2019.05.026","article-title":"Deoxynivalenol induced apoptosis and inflammation of IPEC-J2 cells by promoting ROS production","volume":"251","author":"Kang","year":"2019","journal-title":"Environmental pollution (Barking, Essex: 1987)"},{"issue":"2\u20133","key":"10.1016\/j.phymed.2025.156747_bib0023","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.tox.2006.06.018","article-title":"Beneficial effect of hesperidin on lipopolysaccharide-induced hepatotoxicity","volume":"226","author":"Kaur","year":"2006","journal-title":"Toxicology"},{"issue":"1","key":"10.1016\/j.phymed.2025.156747_bib0024","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3892\/mmr.2020.11121","article-title":"p53\/PGC\u20111\u03b1\u2011mediated mitochondrial dysfunction promotes PC3 prostate cancer cell apoptosis","volume":"22","author":"Li","year":"2020","journal-title":"Mol Med Rep"},{"issue":"9","key":"10.1016\/j.phymed.2025.156747_bib0025","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.1039\/D0FO02736G","article-title":"Hesperetin ameliorates hepatic oxidative stress and inflammation via the PI3K\/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat diet-induced NAFLD","volume":"12","author":"Li","year":"2021","journal-title":"Food Funct"},{"issue":"6","key":"10.1016\/j.phymed.2025.156747_bib0026","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1093\/toxres\/tfad094","article-title":"Molecular mechanisms underlying mitochondrial damage, endoplasmic reticulum stress, and oxidative stress induced by environmental pollutants","volume":"12","author":"Li","year":"2023","journal-title":"Toxicol Res (Camb)"},{"issue":"1","key":"10.1016\/j.phymed.2025.156747_bib0027","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11010006","article-title":"Survey of deoxynivalenol contamination in agricultural products in the Chinese market using an ELISA kit","volume":"11","author":"Li","year":"2018","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.phymed.2025.156747_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113595","article-title":"Arsenic induces ferroptosis and acute lung injury through mtROS-mediated mitochondria-associated endoplasmic reticulum membrane dysfunction","volume":"238","author":"Li","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.phymed.2025.156747_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.169642","article-title":"Gut microbiota disorders aggravate terbuthylazine-induced mitochondrial quality control disturbance and PANoptosis in chicken hepatocyte through gut-liver axis","volume":"913","author":"Li","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"23","key":"10.1016\/j.phymed.2025.156747_bib0030","doi-asserted-by":"crossref","first-page":"13039","DOI":"10.1021\/acs.jafc.3c09132","article-title":"Elevated PINK1\/Parkin-dependent mitophagy and boosted mitochondrial function mediate protection of HepG2 cells from excess palmitic acid by hesperetin","volume":"72","author":"Li","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2025.156747_bib0031","article-title":"Qishen Granule protects against doxorubicin-induced cardiotoxicity by coordinating MDM2-p53-mediated mitophagy and mitochondrial biogenesis","volume":"2022","author":"Li","year":"2022","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.phymed.2025.156747_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114222","article-title":"The benefits of hesperidin in central nervous system disorders, based on the neuroprotective effect","volume":"159","author":"Li","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"9","key":"10.1016\/j.phymed.2025.156747_bib0033","article-title":"Hesperidin protects SH-SY5Y neuronal cells against high glucose-induced apoptosis via regulation of MAPK signaling","volume":"11","author":"Lim","year":"2022","journal-title":"Antioxidants (Basel, Switzerland)"},{"issue":"8","key":"10.1016\/j.phymed.2025.156747_bib0034","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/j.freeradbiomed.2008.01.011","article-title":"ROS and p53: a versatile partnership","volume":"44","author":"Liu","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2025.156747_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.133719","article-title":"Sodium sulfite triggered hepatic apoptosis, necroptosis, and pyroptosis by inducing mitochondrial damage in mice and AML-12 cells","volume":"467","author":"Liu","year":"2024","journal-title":"J. Hazard. Mater."},{"issue":"1","key":"10.1016\/j.phymed.2025.156747_bib0036","doi-asserted-by":"crossref","DOI":"10.1080\/13510002.2024.2341470","article-title":"Hesperidin activates Nrf2 to protect cochlear hair cells from cisplatin-induced damage","volume":"29","author":"Lou","year":"2024","journal-title":"Redox report: communications in free radical research"},{"key":"10.1016\/j.phymed.2025.156747_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.169730","article-title":"Selenium deficiency exacerbated Bisphenol A-induced intestinal toxicity in chickens: apoptosis and cell cycle arrest mediated by ROS\/P53","volume":"913","author":"Luo","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.phymed.2025.156747_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112759","article-title":"Hesperidin PLGA nanoparticles potentiate the efficacy of aPD-1 in treating triple negative breast cancer by regulating CCL2 and ADPN expression in cancer-associated adipocytes","volume":"140","author":"Luo","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.phymed.2025.156747_bib0039","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0278-6915(02)00228-4","article-title":"Development of a urinary biomarker of human exposure to deoxynivalenol","volume":"41","author":"Meky","year":"2003","journal-title":"Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association"},{"issue":"1","key":"10.1016\/j.phymed.2025.156747_bib0040","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.toxlet.2014.06.032","article-title":"Metabolism of the masked mycotoxin deoxynivalenol-3-glucoside in pigs","volume":"229","author":"Nagl","year":"2014","journal-title":"Toxicol. Lett."},{"issue":"1","key":"10.1016\/j.phymed.2025.156747_bib0041","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1039\/D3FO04348G","article-title":"The promotion of fatty acid \u03b2-oxidation by hesperidin via activating SIRT1\/PGC1\u03b1 to improve NAFLD induced by a high-fat diet","volume":"15","author":"Nie","year":"2024","journal-title":"Food Funct"},{"issue":"2","key":"10.1016\/j.phymed.2025.156747_bib0042","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.pharep.2015.09.007","article-title":"Hesperidin alleviates cisplatin-induced hepatotoxicity in rats without inhibiting its antitumor activity","volume":"68","author":"Omar","year":"2016","journal-title":"Pharmacological reports: PR"},{"issue":"1","key":"10.1016\/j.phymed.2025.156747_bib0043","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.molmed.2023.10.001","article-title":"Therapeutic potential of PANoptosis: innate sensors, inflammasomes, and RIPKs in PANoptosomes","volume":"30","author":"Pandeya","year":"2024","journal-title":"Trends Mol Med"},{"issue":"12","key":"10.1016\/j.phymed.2025.156747_bib0044","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1007\/s00204-016-1826-4","article-title":"Toxicology of deoxynivalenol and its acetylated and modified forms","volume":"90","author":"Payros","year":"2016","journal-title":"Arch. Toxicol."},{"issue":"11\u201312","key":"10.1016\/j.phymed.2025.156747_bib0045","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1007\/s10495-024-02014-8","article-title":"BH3-mimetics or DNA-damaging agents in combination with RG7388 overcome p53 mutation-induced resistance to MDM2 inhibition","volume":"29","author":"Pervushin","year":"2024","journal-title":"Apoptosis: an international journal on programmed cell death"},{"issue":"8","key":"10.1016\/j.phymed.2025.156747_bib0046","doi-asserted-by":"crossref","DOI":"10.3390\/toxins9080240","article-title":"Sex is a determinant for deoxynivalenol metabolism and elimination in the mouse","volume":"9","author":"Pestka","year":"2017","journal-title":"Toxins (Basel)"},{"issue":"12","key":"10.1016\/j.phymed.2025.156747_bib0047","doi-asserted-by":"crossref","DOI":"10.3390\/nu14122387","article-title":"Hesperidin: a review on extraction methods, stability and biological activities","volume":"14","author":"Pyrzynska","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2025.156747_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155568","article-title":"Natural plant medications for the treatment of retinal diseases: the blood-retinal barrier as a clue","volume":"130","author":"Ren","year":"2024","journal-title":"Phytomedicine: international journal of phytotherapy and phytopharmacology"},{"issue":"7","key":"10.1016\/j.phymed.2025.156747_bib0049","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1089\/fpd.2019.2710","article-title":"Food poisoning caused by Deoxynivalenol at a school in Zhuhai, Guangdong, China, in 2019","volume":"17","author":"Ruan","year":"2020","journal-title":"Foodborne Pathog. Dis."},{"issue":"7334","key":"10.1016\/j.phymed.2025.156747_bib0050","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nature09787","article-title":"Telomere dysfunction induces metabolic and mitochondrial compromise","volume":"470","author":"Sahin","year":"2011","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.phymed.2025.156747_bib0051","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.phymed.2012.12.001","article-title":"Hesperidin attenuates cisplatin-induced acute renal injury by decreasing oxidative stress, inflammation and DNA damage","volume":"20","author":"Sahu","year":"2013","journal-title":"Phytomedicine: international journal of phytotherapy and phytopharmacology"},{"issue":"12","key":"10.1016\/j.phymed.2025.156747_bib0052","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1038\/s41419-020-03238-7","article-title":"Telomeric injury by KML001 in human T cells induces mitochondrial dysfunction through the p53-PGC-1\u03b1 pathway","volume":"11","author":"Schank","year":"2020","journal-title":"Cell Death Dis"},{"issue":"12","key":"10.1016\/j.phymed.2025.156747_bib0053","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.1007\/s00204-017-2012-z","article-title":"Glucuronidation of deoxynivalenol (DON) by different animal species: identification of iso-DON glucuronides and iso-deepoxy-DON glucuronides as novel DON metabolites in pigs, rats, mice, and cows","volume":"91","author":"Schwartz-Zimmermann","year":"2017","journal-title":"Arch. Toxicol."},{"issue":"4","key":"10.1016\/j.phymed.2025.156747_bib0054","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.molcel.2011.08.044","article-title":"PGC-1\u03b1, a key modulator of p53, promotes cell survival upon metabolic stress","volume":"44","author":"Sen","year":"2011","journal-title":"Mol. Cell"},{"key":"10.1016\/j.phymed.2025.156747_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.109146","article-title":"Alleviative effects of quercetin of Botrytis cinerea-induced toxicity in zebrafish (Danio rerio) larvae","volume":"142","author":"Shi","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.phymed.2025.156747_bib0056","first-page":"1","article-title":"A comprehensive review on the impact of hesperidin and its aglycone hesperetin on metabolic dysfunction-associated steatotic liver disease and other liver disorders","author":"Sivaslioglu","year":"2024","journal-title":"Nutr Res Rev"},{"key":"10.1016\/j.phymed.2025.156747_bib0057","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116854","article-title":"Hesperetin alleviates aflatoxin B1 induced liver toxicity in mice: modulating lipid peroxidation and ferritin autophagy","volume":"284","author":"Song","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"31","key":"10.1016\/j.phymed.2025.156747_bib0058","doi-asserted-by":"crossref","first-page":"9619","DOI":"10.1021\/acs.jafc.2c03690","article-title":"The Deoxynivalenol Challenge","volume":"70","author":"Sumarah","year":"2022","journal-title":"J. Agric. Food Chem."},{"issue":"10","key":"10.1016\/j.phymed.2025.156747_bib0059","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1007\/s00204-022-03337-8","article-title":"Toxicokinetics and metabolism of deoxynivalenol in animals and humans","volume":"96","author":"Sun","year":"2022","journal-title":"Arch. Toxicol."},{"issue":"1","key":"10.1016\/j.phymed.2025.156747_bib0060","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s40199-020-00344-x","article-title":"A review of the hepatoprotective effects of hesperidin, a flavanon glycoside in citrus fruits, against natural and chemical toxicities","volume":"28","author":"Tabeshpour","year":"2020","journal-title":"Daru: journal of Faculty of Pharmacy, Tehran University of Medical Sciences"},{"issue":"2","key":"10.1016\/j.phymed.2025.156747_bib0061","first-page":"96","article-title":"Mycotoxin contamination in Japanese domestic feed","volume":"6","author":"Uegaki","year":"2018","journal-title":"Food safety (Tokyo, Japan)"},{"issue":"25","key":"10.1016\/j.phymed.2025.156747_bib0062","doi-asserted-by":"crossref","first-page":"14349","DOI":"10.1021\/acs.jafc.4c02039","article-title":"Hesperidin alleviates hepatic injury caused by deoxynivalenol exposure through activation of mTOR and AKT\/GSK3\u03b2\/TFEB pathways","volume":"72","author":"Wang","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2025.156747_bib0063","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102494","article-title":"Lycopene attenuates the inflammation and apoptosis in aristolochic acid nephropathy by targeting the Nrf2 antioxidant system","volume":"57","author":"Wang","year":"2022","journal-title":"Redox Biol"},{"issue":"Suppl 1","key":"10.1016\/j.phymed.2025.156747_bib0064","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/BF03036710","article-title":"Monitoring of deoxynivalenol and zearalenone in cereals and cereal products from the state of Saxony-Anhalt, Germany","volume":"17","author":"Woese","year":"2001","journal-title":"Mycotoxin Res"},{"key":"10.1016\/j.phymed.2025.156747_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.161962","article-title":"Polystyrene-microplastics and DEHP co-exposure induced DNA damage, cell cycle arrest and necroptosis of ovarian granulosa cells in mice by promoting ROS production","volume":"871","author":"Wu","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.phymed.2025.156747_bib0066","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.169260","article-title":"Polystyrene nanoplastics-induced lung apoptosis and ferroptosis via ROS-dependent endoplasmic reticulum stress","volume":"912","author":"Wu","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"4","key":"10.1016\/j.phymed.2025.156747_bib0067","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12828","article-title":"Anti-PANoptosis is involved in neuroprotective effects of melatonin in acute ocular hypertension model","volume":"73","author":"Ye","year":"2022","journal-title":"J. Pineal Res."},{"issue":"3","key":"10.1016\/j.phymed.2025.156747_bib0068","doi-asserted-by":"crossref","first-page":"655","DOI":"10.2527\/jas1983.573655x","article-title":"Vomitoxin in corn fed to young pigs","volume":"57","author":"Young","year":"1983","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.phymed.2025.156747_bib0069","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.foodchem.2016.11.101","article-title":"A rapid Raman detection of deoxynivalenol in agricultural products","volume":"221","author":"Yuan","year":"2017","journal-title":"Food Chem"},{"key":"10.1016\/j.phymed.2025.156747_bib0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112710","article-title":"Scutellarin inhibits inflammatory PANoptosis by diminishing mitochondrial ROS generation and blocking PANoptosome formation","volume":"139","author":"Yuan","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"8","key":"10.1016\/j.phymed.2025.156747_bib0071","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1038\/s41401-024-01239-2","article-title":"Neutrophil extracellular traps promote acetaminophen-induced acute liver injury in mice via AIM2","volume":"45","author":"Zeng","year":"2024","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2025.156747_bib0072","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102687","article-title":"Pathologically high intraocular pressure induces mitochondrial dysfunction through Drp1 and leads to retinal ganglion cell PANoptosis in glaucoma","volume":"62","author":"Zeng","year":"2023","journal-title":"Redox Biol"},{"issue":"4","key":"10.1016\/j.phymed.2025.156747_bib0073","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/ki.2012.441","article-title":"Mitochondrial dynamics: regulatory mechanisms and emerging role in renal pathophysiology","volume":"83","author":"Zhan","year":"2013","journal-title":"Kidney Int."},{"key":"10.1016\/j.phymed.2025.156747_bib0074","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103402","article-title":"Promising tools into oxidative stress: a review of non-rodent model organisms","volume":"77","author":"Zhang","year":"2024","journal-title":"Redox Biol"},{"issue":"6","key":"10.1016\/j.phymed.2025.156747_bib0075","first-page":"341","article-title":"Newly identified function of caspase-6 in ZBP1-mediated innate immune responses, NLRP3 inflammasome activation, PANoptosis, and host defense","volume":"2","author":"Zheng","year":"2020","journal-title":"Journal of cellular immunology"},{"issue":"3","key":"10.1016\/j.phymed.2025.156747_bib0076","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.cell.2020.03.040","article-title":"Caspase-6 is a key regulator of innate immunity, inflammasome activation, and host defense","volume":"181","author":"Zheng","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2025.156747_bib0077","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.134601","article-title":"Necroptosis contributes to the intestinal toxicity of deoxynivalenol and is mediated by methyltransferase SETDB1","volume":"474","author":"Zhou","year":"2024","journal-title":"J. Hazard. Mater."},{"issue":"16","key":"10.1016\/j.phymed.2025.156747_bib0078","doi-asserted-by":"crossref","first-page":"11516","DOI":"10.1021\/acs.est.2c02712","article-title":"Niclosamide exposure at environmentally relevant concentrations efficaciously inhibited the growth and disturbed the liver-gut axis of adult male zebrafish","volume":"56","author":"Zhu","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.phymed.2025.156747_bib0079","article-title":"Advances in mechanism and regulation of PANoptosis: prospects in disease treatment","volume":"14","author":"Zhu","year":"2023","journal-title":"Front Immunol"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325003861?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325003861?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T21:42:14Z","timestamp":1773351734000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325003861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":79,"alternative-id":["S0944711325003861"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156747","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hesperidin mitigated deoxynivalenol-induced liver injury by inhibiting ROS\/ P53\/ PGC-1\u03b1-mediated disruption of mitochondrial dynamics and PANoptosis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156747","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156747"}}