{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:05:01Z","timestamp":1792037101013,"version":"4.4.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2024-JYB-JBZD-053"],"award-info":[{"award-number":["2024-JYB-JBZD-053"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.phymed.2025.156754","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T11:15:15Z","timestamp":1744370115000},"page":"156754","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Xiongshao Zhitong granules alleviate nitroglycerin-induced migraine by regulating the TRPV1-mediated NLRP3 inflammatory pathway in rats"],"prefix":"10.1016","volume":"142","author":[{"given":"Yuxi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2029-3408","authenticated-orcid":false,"given":"Cong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7272-599X","authenticated-orcid":false,"given":"Yao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.156754_bib0001","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.redox.2015.01.008","article-title":"NLRP3 inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases","volume":"4","author":"Abderrazak","year":"2015","journal-title":"Redox. Biol."},{"issue":"1","key":"10.1016\/j.phymed.2025.156754_bib0002","doi-asserted-by":"crossref","first-page":"6304","DOI":"10.1038\/s41467-022-33835-3","article-title":"TRPM8 contributes to sex dimorphism by promoting recovery of normal sensitivity in a mouse model of chronic migraine","volume":"13","author":"Alarcon-Alarcon","year":"2022","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.phymed.2025.156754_bib0003","doi-asserted-by":"crossref","first-page":"339","DOI":"10.5114\/ceji.2016.65132","article-title":"Ellagic acid alleviates adjuvant induced arthritis by modulation of pro- and anti-inflammatory cytokines","volume":"41","author":"Allam","year":"2016","journal-title":"Cent. Eur. J. Immunol."},{"issue":"12","key":"10.1016\/j.phymed.2025.156754_bib0004","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1177\/0333102412454947","article-title":"Influence of sex, estrous cycle, and estrogen on intracranial dural mast cells","volume":"32","author":"Boes","year":"2012","journal-title":"Cephalalgia"},{"issue":"5","key":"10.1016\/j.phymed.2025.156754_bib0005","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/00001503-200410000-00018","article-title":"Neurogenic painful inflammation","volume":"17","author":"Brack","year":"2004","journal-title":"Curr. Opin. Anaesthesiol."},{"issue":"1","key":"10.1016\/j.phymed.2025.156754_bib0006","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s10194-023-01559-4","article-title":"A study on the correlation of the asymmetric regulation between the periaqueductal gray and the bilateral trigeminal nucleus caudalis in migraine male rats","volume":"24","author":"Cao","year":"2023","journal-title":"J. Headache Pain."},{"issue":"7","key":"10.1016\/j.phymed.2025.156754_bib0007","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1093\/brain\/awad045","article-title":"Neuronal NLRP3 inflammasome mediates spreading depolarization-evoked trigeminovascular activation","volume":"146","author":"Chen","year":"2023","journal-title":"Brain"},{"key":"10.1016\/j.phymed.2025.156754_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156069","article-title":"SIRT1 activation by Ligustrazine ameliorates migraine via the paracrine interaction of microglia and neurons","volume":"135","author":"Chen","year":"2024","journal-title":"Phytomedicine"},{"issue":"13","key":"10.1016\/j.phymed.2025.156754_bib0009","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1177\/03331024221114773","article-title":"The effects of certain TRP channels and voltage-gated KCNQ\/Kv7 channel opener retigabine on calcitonin gene-related peptide release in the trigeminovascular system","volume":"42","author":"Citak","year":"2022","journal-title":"Cephalalgia"},{"issue":"5","key":"10.1016\/j.phymed.2025.156754_bib0010","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S1474-4422(18)30499-X","article-title":"Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"18","year":"2019","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.phymed.2025.156754_bib0011","article-title":"Gut microbiota and migraine","volume":"11","author":"Crawford","year":"2022","journal-title":"Neurobiol. Pain."},{"issue":"1","key":"10.1016\/j.phymed.2025.156754_bib0012","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s10194-023-01657-3","article-title":"European Headache Federation (EHF) critical re-appraisal and meta-analysis of oral drugs in migraine prevention-part 2: flunarizine","volume":"24","author":"Deligianni","year":"2023","journal-title":"J. Headache Pain."},{"issue":"51","key":"10.1016\/j.phymed.2025.156754_bib0013","doi-asserted-by":"crossref","first-page":"18345","DOI":"10.1073\/pnas.1420252111","article-title":"alphaCGRP is essential for algesic exocytotic mobilization of TRPV1 channels in peptidergic nociceptors","volume":"111","author":"Devesa","year":"2014","journal-title":"Proc. Natl. Acad. Sci. u S. a"},{"issue":"6","key":"10.1016\/j.phymed.2025.156754_bib0014","doi-asserted-by":"crossref","first-page":"e1455","DOI":"10.1002\/cti2.1455","article-title":"A novel dual NLRP1 and NLRP3 inflammasome inhibitor for the treatment of inflammatory diseases","volume":"12","author":"Docherty","year":"2023","journal-title":"Clin. Transl. Immunology."},{"issue":"17","key":"10.1016\/j.phymed.2025.156754_bib0015","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27175428","article-title":"Identification of a partial and selective TRPV1 agonist CPIPC for alleviation of inflammatory pain","volume":"27","author":"Dong","year":"2022","journal-title":"Molecules."},{"issue":"12","key":"10.1016\/j.phymed.2025.156754_bib0016","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0050898","article-title":"Application of ICHD-II criteria in a headache clinic of China","volume":"7","author":"Dong","year":"2012","journal-title":"PLoS. One"},{"issue":"5","key":"10.1016\/j.phymed.2025.156754_bib0017","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/j.1526-4610.2011.02053.x","article-title":"Sumatriptan inhibits TRPV1 channels in trigeminal neurons","volume":"52","author":"Evans","year":"2012","journal-title":"Headache"},{"issue":"1","key":"10.1016\/j.phymed.2025.156754_bib0018","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1186\/s12974-024-03313-2","article-title":"Metformin attenuates central sensitization by regulating neuroinflammation through the TREM2-SYK signaling pathway in a mouse model of chronic migraine","volume":"21","author":"Fan","year":"2024","journal-title":"J. Neuroinflammation."},{"issue":"11","key":"10.1016\/j.phymed.2025.156754_bib0019","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1177\/0333102417748563","article-title":"Ghrelin attenuated hyperalgesia induced by chronic nitroglycerin: CGRP and TRPV1 as targets for migraine management","volume":"38","author":"Farajdokht","year":"2018","journal-title":"Cephalalgia"},{"issue":"23","key":"10.1016\/j.phymed.2025.156754_bib0020","doi-asserted-by":"crossref","first-page":"4626","DOI":"10.1111\/bph.15641","article-title":"Involvement of P2Y(12) receptors in a nitroglycerin-induced model of migraine in male mice","volume":"178","author":"Goloncser","year":"2021","journal-title":"Br. J. Pharmacol."},{"issue":"10","key":"10.1016\/j.phymed.2025.156754_bib0021","doi-asserted-by":"crossref","first-page":"6590","DOI":"10.1007\/s12035-022-02998-x","article-title":"Glibenclamide directly prevents neuroinflammation by targeting SUR1-TRPM4-mediated NLRP3 inflammasome activation In microglia","volume":"59","author":"He","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phymed.2025.156754_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2021.136380","article-title":"The role of TRP ion channels in migraine and headache","volume":"768","author":"Iannone","year":"2022","journal-title":"Neurosci. Lett."},{"issue":"1\u20132","key":"10.1016\/j.phymed.2025.156754_bib0023","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.neures.2013.08.001","article-title":"Activation of extracellular signal-regulated kinase in the trigeminal ganglion following both treatment of the dura mater with capsaicin and cortical spreading depression","volume":"77","author":"Iwashita","year":"2013","journal-title":"Neurosci. Res."},{"issue":"1","key":"10.1016\/j.phymed.2025.156754_bib0024","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1186\/s12974-019-1603-4","article-title":"P2Y12 receptor mediates microglial activation via RhoA\/ROCK pathway in the trigeminal nucleus caudalis in a mouse model of chronic migraine","volume":"16","author":"Jing","year":"2019","journal-title":"J. Neuroinflammation."},{"issue":"6","key":"10.1016\/j.phymed.2025.156754_bib0025","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/1440-1681.12915","article-title":"Salmon calcitonin ameliorates migraine pain through modulation of CGRP release and dural mast cell degranulation in rats","volume":"45","author":"Kilinc","year":"2018","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"1","key":"10.1016\/j.phymed.2025.156754_bib0026","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s10753-019-01115-w","article-title":"Thymoquinone inhibits neurogenic inflammation underlying migraine through modulation of calcitonin gene-related peptide release and stabilization of meningeal mast cells in glyceryltrinitrate-induced migraine model in rats","volume":"43","author":"Kilinc","year":"2020","journal-title":"Inflammation"},{"issue":"9","key":"10.1016\/j.phymed.2025.156754_bib0027","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1111\/ejn.15888","article-title":"Meningeal mast cell-mediated mechanisms of cholinergic system modulation in neurogenic inflammation underlying the pathophysiology of migraine","volume":"59","author":"Kilinc","year":"2024","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.phymed.2025.156754_bib0028","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.bbi.2017.03.007","article-title":"Modulation of neuroinflammation: role and therapeutic potential of TRPV1 in the neuro-immune axis","volume":"64","author":"Kong","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.phymed.2025.156754_bib0029","article-title":"A preliminary inquiry into the potential mechanism of Huang-Lian-Jie-Du decoction in treating rheumatoid arthritis via network pharmacology and molecular docking","volume":"9","author":"Li","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"4","key":"10.1016\/j.phymed.2025.156754_bib0030","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1002\/ptr.8158","article-title":"Quercetin as a promising intervention for rat osteoarthritis by decreasing M1-polarized macrophages via blocking the TRPV1-mediated P2X7\/NLRP3 signaling pathway","volume":"38","author":"Li","year":"2024","journal-title":"PhytOther Res."},{"issue":"1","key":"10.1016\/j.phymed.2025.156754_bib0031","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s10194-024-01778-3","article-title":"Alleviation of migraine related pain and anxiety by inhibiting calcium-stimulating AC1-dependent CGRP in the insula of adult rats","volume":"25","author":"Li","year":"2024","journal-title":"J. Headache Pain."},{"key":"10.1016\/j.phymed.2025.156754_bib0032","article-title":"Effect of Xiongmatang Extract on behavioral and TRPV1-CGRP\/CGRP-R pathway in rats with migraine","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156754_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155766","article-title":"Exploring the anti-migraine effects of Tianshu capsule: chemical profile, metabolic behavior, and therapeutic mechanisms","volume":"131","author":"Liu","year":"2024","journal-title":"Phytomedicine"},{"issue":"4","key":"10.1016\/j.phymed.2025.156754_bib0034","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.molmed.2010.02.004","article-title":"TRPV1 in migraine pathophysiology","volume":"16","author":"Meents","year":"2010","journal-title":"Trends. Mol. Med."},{"issue":"15","key":"10.1016\/j.phymed.2025.156754_bib0035","doi-asserted-by":"crossref","first-page":"4981","DOI":"10.1523\/JNEUROSCI.5490-08.2009","article-title":"Activation of TRPV1 mediates calcitonin gene-related peptide release, which excites trigeminal sensory neurons and is attenuated by a retargeted botulinum toxin with anti-nociceptive potential","volume":"29","author":"Meng","year":"2009","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.phymed.2025.156754_bib0036","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1468-2982.2007.01448.x","article-title":"Ethanol causes neurogenic vasodilation by TRPV1 activation and CGRP release in the trigeminovascular system of the guinea pig","volume":"28","author":"Nicoletti","year":"2008","journal-title":"Cephalalgia"},{"key":"10.1016\/j.phymed.2025.156754_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2022.114255","article-title":"NLRP3 upregulation related to sleep deprivation-induced memory and emotional behavior changes in TRPV1(-\/-) mice","volume":"440","author":"Ozathaley","year":"2023","journal-title":"Behav. Brain Res."},{"issue":"2","key":"10.1016\/j.phymed.2025.156754_bib0038","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.pain.2013.10.004","article-title":"Characterization of a novel model of chronic migraine","volume":"155","author":"Pradhan","year":"2014","journal-title":"Pain."},{"issue":"1","key":"10.1016\/j.phymed.2025.156754_bib0039","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s10194-022-01461-5","article-title":"Gradually shifting clinical phenomics in migraine spectrum: a cross-sectional, multicenter study of 5438 patients","volume":"23","author":"Ran","year":"2022","journal-title":"J. Headache Pain."},{"issue":"2","key":"10.1016\/j.phymed.2025.156754_bib0040","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1526-4610.2006.00337.x","article-title":"Proinflammatory cytokines, adhesion molecules, and lymphocyte integrin expression in the internal jugular blood of migraine patients without aura assessed ictally","volume":"46","author":"Sarchielli","year":"2006","journal-title":"Headache"},{"issue":"12","key":"10.1016\/j.phymed.2025.156754_bib0041","first-page":"1702","article-title":"Summary of the experience of QIN Yue-hao on the treatment of women's migraine based on wind, phlegm and blood stasis","volume":"22","author":"Su","year":"2016","journal-title":"Journal of Basic Chinese Medicine"},{"issue":"3","key":"10.1016\/j.phymed.2025.156754_bib0042","doi-asserted-by":"crossref","first-page":"e125","DOI":"10.1111\/j.1365-2982.2011.01848.x","article-title":"Lesioning of TRPV1 expressing primary afferent neurons prevents PAR-2 induced motility, but not mechanical hypersensitivity in the rat colon","volume":"24","author":"Suckow","year":"2012","journal-title":"Neurogastroenterol. Motil."},{"issue":"1","key":"10.1016\/j.phymed.2025.156754_bib0043","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s10194-023-01707-w","article-title":"Microglia TREM1-mediated neuroinflammation contributes to central sensitization via the NF-kappaB pathway in a chronic migraine model","volume":"25","author":"Sun","year":"2024","journal-title":"J. Headache Pain."},{"issue":"6","key":"10.1016\/j.phymed.2025.156754_bib0044","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1007\/s12031-020-01745-y","article-title":"Differential expression of cytokine-coding genes among migraine patients with and without aura and normal subjects","volume":"71","author":"Taheri","year":"2021","journal-title":"J. Mol. Neurosci."},{"issue":"1","key":"10.1016\/j.phymed.2025.156754_bib0045","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s12035-019-01721-7","article-title":"Gut microbiota dysbiosis enhances migraine-like pain via TNFalpha upregulation","volume":"57","author":"Tang","year":"2020","journal-title":"Mol. Neurobiol."},{"issue":"4","key":"10.1016\/j.phymed.2025.156754_bib0046","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.jhep.2022.12.031","article-title":"Capsaicin receptor TRPV1 maintains quiescence of hepatic stellate cells in the liver via recruitment of SARM1","volume":"78","author":"Tao","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2025.156754_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.123091","article-title":"TRESK channel activation ameliorates migraine-like pain via modulation of CGRP release from the trigeminovascular system and meningeal mast cells in experimental migraine models","volume":"357","author":"Torun","year":"2024","journal-title":"Life Sci."},{"issue":"7","key":"10.1016\/j.phymed.2025.156754_bib0048","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22073712","article-title":"Hypersensitivity induced by intrathecal Bradykinin administration is enhanced by N-oleoyldopamine (OLDA) and prevented by TRPV1 antagonist","volume":"22","author":"Uchytilova","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.phymed.2025.156754_bib0049","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s10194-024-01730-5","article-title":"Lipopolysaccharide, VE-cadherin, HMGB1, and HIF-1alpha levels are elevated in the systemic circulation in chronic migraine patients with medication overuse headache: evidence of leaky gut and inflammation","volume":"25","author":"Vuralli","year":"2024","journal-title":"J. Headache Pain."},{"key":"10.1016\/j.phymed.2025.156754_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156146","article-title":"Lignans of Schisandra chinensis (Turcz.) Baill inhibits Parkinson's disease progression through mediated neuroinflammation-TRPV1 expression in microglia","volume":"135","author":"Wang","year":"2024","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.phymed.2025.156754_bib0051","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s10194-022-01442-8","article-title":"P2X7R\/NLRP3 signaling pathway-mediated pyroptosis and neuroinflammation contributed to cognitive impairment in a mouse model of migraine","volume":"23","author":"Wang","year":"2022","journal-title":"J. Headache Pain."},{"issue":"5","key":"10.1016\/j.phymed.2025.156754_bib0052","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.explore.2020.05.006","article-title":"Efficacy and safety of the classic Chinese herbal prescription Sanpian decoction on migraine: a meta-analysis","volume":"16","author":"Wu","year":"2020","journal-title":"Explore (NY)"},{"issue":"2","key":"10.1016\/j.phymed.2025.156754_bib0053","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/s41401-022-00941-3","article-title":"Roxadustat alleviates nitroglycerin-induced migraine in mice by regulating HIF-1alpha\/NF-kappaB\/inflammation pathway","volume":"44","author":"Yang","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2025.156754_bib0054","article-title":"Xiongshao Zhitong recipe attenuates nitroglycerin-induced migraine-like behaviors via the inhibition of inflammation mediated by nitric oxide synthase","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156754_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175931","article-title":"Research progress of NLRP3 inflammasome and its inhibitors with aging diseases","volume":"957","author":"Yuan","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156754_bib0056","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3389\/fncel.2015.00287","article-title":"Hunting for origins of migraine pain: cluster analysis of spontaneous and capsaicin-induced firing in meningeal trigeminal nerve fibers","volume":"9","author":"Zakharov","year":"2015","journal-title":"Front. Cell Neurosci."},{"issue":"2","key":"10.1016\/j.phymed.2025.156754_bib0057","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.18632\/aging.205379","article-title":"TRPV1 modulated NLRP3 inflammasome activation via calcium in experimental subarachnoid hemorrhage","volume":"16","author":"Zhang","year":"2024","journal-title":"Aging (Albany. NY)"},{"issue":"1","key":"10.1016\/j.phymed.2025.156754_bib0058","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s10194-023-01603-3","article-title":"PACAP6-38 improves nitroglycerin-induced central sensitization by modulating synaptic plasticity at the trigeminal nucleus caudalis in a male rat model of chronic migraine","volume":"24","author":"Zhang","year":"2023","journal-title":"J. Headache Pain."},{"issue":"3","key":"10.1016\/j.phymed.2025.156754_bib0059","doi-asserted-by":"crossref","first-page":"279","DOI":"10.5021\/ad.2019.31.3.279","article-title":"Inhibition of poly(I:c)-induced inflammation by Salvianolic acid A in skin keratinocytes","volume":"31","author":"Zhang","year":"2019","journal-title":"Ann. Dermatol."},{"issue":"12","key":"10.1016\/j.phymed.2025.156754_bib0060","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/s41419-021-04450-9","article-title":"TRPV1 channel mediates NLRP3 inflammasome-dependent neuroinflammation in microglia","volume":"12","author":"Zhang","year":"2021","journal-title":"Cell Death. Dis."},{"issue":"1","key":"10.1016\/j.phymed.2025.156754_bib0061","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s10194-022-01416-w","article-title":"FKN\/CX3CR1 axis facilitates migraine-like behaviour by activating thalamic-cortical network microglia in status epilepticus model rats","volume":"23","author":"Zhou","year":"2022","journal-title":"J. Headache Pain."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325003939?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325003939?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T21:42:48Z","timestamp":1773351768000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325003939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":61,"alternative-id":["S0944711325003939"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156754","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Xiongshao Zhitong granules alleviate nitroglycerin-induced migraine by regulating the TRPV1-mediated NLRP3 inflammatory pathway in rats","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156754","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"156754"}}