{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:56:03Z","timestamp":1790873763423,"version":"4.1.0"},"reference-count":117,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012562","name":"Gansu University of Chinese Medicine","doi-asserted-by":"publisher","award":["2022)003"],"award-info":[{"award-number":["2022)003"]}],"id":[{"id":"10.13039\/501100012562","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004001","name":"Guizhou Province Science and Technology Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018555","name":"Science and Technology Program of Guizhou Province","doi-asserted-by":"publisher","award":["ZK[2022]505"],"award-info":[{"award-number":["ZK[2022]505"]}],"id":[{"id":"10.13039\/501100018555","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010828","name":"Guizhou Province Department of Education","doi-asserted-by":"publisher","award":["Qian-jiao-ji (2023)071"],"award-info":[{"award-number":["Qian-jiao-ji (2023)071"]}],"id":[{"id":"10.13039\/501100010828","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.phymed.2025.156761","type":"journal-article","created":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T11:46:54Z","timestamp":1745063214000},"page":"156761","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["A comprehensive pharmacology study reveals the molecular mechanisms underlying the antidepressant effects of Gastrodiae Rhizoma"],"prefix":"10.1016","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9306-6261","authenticated-orcid":false,"given":"Pei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihuang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haili","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghong","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meidan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-e","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyan","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7776-6229","authenticated-orcid":false,"given":"Zili","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1563-827X","authenticated-orcid":false,"given":"Jinqiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.156761_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.110206","article-title":"Calycosin ameliorates advanced glycation end product-induced neurodegenerative changes in cellular and rat models of diabetes-related Alzheimer's disease","volume":"368","author":"An","year":"2022","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.phymed.2025.156761_bib0002","doi-asserted-by":"crossref","first-page":"15737","DOI":"10.1073\/pnas.1509045112","article-title":"Neurotrophic-priming of glucocorticoid receptor signaling is essential for neuronal plasticity to stress and antidepressant treatment","volume":"112","author":"Arango-Lievano","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phymed.2025.156761_bib0003","first-page":"398","article-title":"Expression of c-fos and c-jun proteins in the marginal division of the rat striatum during learning and memory training","volume":"118","author":"Bao","year":"2005","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.phymed.2025.156761_bib0004","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.bbi.2020.11.009","article-title":"Minocycline alleviates depression-like symptoms by rescuing decrease in neurogenesis in dorsal hippocampus via blocking microglia activation\/phagocytosis","volume":"91","author":"Bassett","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.phymed.2025.156761_bib0005","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ajp.2014.09.001","article-title":"Emerging antidepressants to treat major depressive disorder","volume":"12","author":"Block","year":"2014","journal-title":"Asian J. Psychiatr."},{"key":"10.1016\/j.phymed.2025.156761_bib0006","doi-asserted-by":"crossref","first-page":"6773","DOI":"10.1038\/s41380-021-01160-8","article-title":"Omega-3 polyunsaturated fatty acids protect against inflammation through production of LOX and CYP450 lipid mediators: relevance for major depression and for human hippocampal neurogenesis","volume":"26","author":"Borsini","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.phymed.2025.156761_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.140525","article-title":"Association between rare earth elements and depression: evidence from pilot mice model of chronic unpredictable mild stress-induced depression and human studies of major depressive disorder","volume":"345","author":"Cao","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.phymed.2025.156761_bib0008","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1142\/S0192415X08005618","article-title":"The antidepressant effect of Gastrodia elata Bl. On the forced-swimming test in rats","volume":"36","author":"Chen","year":"2008","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.phymed.2025.156761_bib0009","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S2225-4110(16)30054-2","article-title":"Gastrodiae Rhizoma (tian ma): a review of biological activity and antidepressant mechanisms","volume":"1","author":"Chen","year":"2011","journal-title":"J. Tradit. Complement. Med."},{"key":"10.1016\/j.phymed.2025.156761_bib0010","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jep.2016.02.001","article-title":"Anti-depressant effects of Gastrodia elata Blume and its compounds gastrodin and 4-hydroxybenzyl alcohol, via the monoaminergic system and neuronal cytoskeletal remodeling","volume":"182","author":"Chen","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.156761_bib0011","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jep.2016.02.001","article-title":"Anti-depressant effects of Gastrodia elata Blume and its compounds gastrodin and 4-hydroxybenzyl alcohol, via the monoaminergic system and neuronal cytoskeletal remodeling","volume":"182","author":"Chen","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.156761_bib0012","doi-asserted-by":"crossref","first-page":"4305","DOI":"10.1007\/s12035-020-02016-y","article-title":"Proteomics-Guided study on buyang huanwu decoction for its neuroprotective and neurogenic mechanisms for transient ischemic stroke: involvements of EGFR\/PI3K\/Akt\/Bad\/14-3-3 and Jak2\/Stat3\/Cyclin D1 signaling cascades","volume":"57","author":"Chen","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phymed.2025.156761_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155369","article-title":"Gastrodin alleviates mitochondrial dysfunction by regulating SIRT3-mediated TFAM acetylation in vascular dementia","volume":"128","author":"Chen","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.156761_bib0014","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1092693","article-title":"A novel alcohol steamed preparation from Gastrodia elata Blume: pharmacological assessment of a functional food","volume":"14","author":"Cheng","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156761_bib0015","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.621076","article-title":"Manipulation of EGFR-induced signaling for the recruitment of quiescent neural stem cells in the adult mouse forebrain","volume":"15","author":"Cochard","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.phymed.2025.156761_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101636","article-title":"Neurogenesis in aging and age-related neurodegenerative diseases","volume":"78","author":"Culig","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.phymed.2025.156761_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2019.108843","article-title":"Involvement of PI3K\/Akt\/GSK-3\u03b2 signaling pathway in the antidepressant-like and neuroprotective effects of Morus nigra and its major phenolic, syringic acid","volume":"314","author":"Dalmagro","year":"2019","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.phymed.2025.156761_bib0018","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.neuron.2009.04.017","article-title":"Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety\/depression","volume":"62","author":"David","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.phymed.2025.156761_bib0019","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1007\/s11064-016-1901-5","article-title":"Vanillin attenuated behavioural impairments, neurochemical deficts, oxidative stress and apoptosis against rotenone induced rat model of parkinson's disease","volume":"41","author":"Dhanalakshmi","year":"2016","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.phymed.2025.156761_bib0020","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.biopsych.2006.05.047","article-title":"A role for MAP kinase signaling in behavioral models of depression and antidepressant treatment","volume":"61","author":"Duman","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phymed.2025.156761_bib0021","article-title":"Effects of ketamine on GABAergic and glutamatergic activity in the mPFC: biphasic recruitment of GABA function in antidepressant-like responses","author":"Fogaca","year":"2024","journal-title":"Neuropsychopharmacol"},{"key":"10.1016\/j.phymed.2025.156761_bib0022","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3389\/fncel.2013.00258","article-title":"The role of EGFR and ErbB family related proteins in the oligodendrocyte specification in germinal niches of the adult mammalian brain","volume":"7","author":"Galvez-Contreras","year":"2013","journal-title":"Front. Cell Neurosci."},{"key":"10.1016\/j.phymed.2025.156761_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115832","article-title":"Anti-depressant-like effect of fermented Gastrodia elata Bl. By regulating monoamine levels and BDNF\/NMDAR pathways in mice","volume":"301","author":"Gao","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.156761_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117128","article-title":"Traditional uses, phytochemistry, pharmacology, applications, and quality control of Gastrodia elata Blume: a comprehensive review","volume":"319","author":"Gong","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.156761_bib0025","doi-asserted-by":"crossref","first-page":"4916","DOI":"10.1093\/brain\/awad303","article-title":"Microbiota from Alzheimer's patients induce deficits in cognition and hippocampal neurogenesis","volume":"146","author":"Grabrucker","year":"2023","journal-title":"Brain"},{"key":"10.1016\/j.phymed.2025.156761_bib0026","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/nrendo.2014.201","article-title":"Neuroendocrinology: role for adiponectin in effects of exercise in depression","volume":"11","author":"Greenhill","year":"2015","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.phymed.2025.156761_bib0027","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12974-019-1474-8","article-title":"Baicalin ameliorates neuroinflammation-induced depressive-like behavior through inhibition of toll-like receptor 4 expression via the PI3K\/AKT\/FoxO1 pathway","volume":"16","author":"Guo","year":"2019","journal-title":"J. Neuroinflammation."},{"key":"10.1016\/j.phymed.2025.156761_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107300","article-title":"PI3K\/AKT signaling pathway: molecular mechanisms and therapeutic potential in depression","volume":"206","author":"Guo","year":"2024","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2025.156761_bib0029","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1038\/npp.2011.220","article-title":"Depression, antidepressants, and neurogenesis: a critical reappraisal","volume":"36","author":"Hanson","year":"2011","journal-title":"Neuropsychopharmacol"},{"key":"10.1016\/j.phymed.2025.156761_bib0030","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1124\/pr.57.2.4","article-title":"The blood-brain barrier\/neurovascular unit in health and disease","volume":"57","author":"Hawkins","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.phymed.2025.156761_bib0031","doi-asserted-by":"crossref","first-page":"7816","DOI":"10.1039\/D1FO00847A","article-title":"Gastrodin extends the lifespan and protects against neurodegeneration in the Drosophila PINK1 model of Parkinson's disease","volume":"12","author":"He","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2025.156761_bib0032","doi-asserted-by":"crossref","first-page":"5107","DOI":"10.1002\/ptr.8314","article-title":"The role of gastrodin in the management of CNS-related diseases: underlying mechanisms to therapeutic perspectives","volume":"38","author":"He","year":"2024","journal-title":"PhytOther Res."},{"key":"10.1016\/j.phymed.2025.156761_bib0033","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s12888-018-1983-5","article-title":"The dynamical signature of anhedonia in major depressive disorder: positive emotion dynamics, reactivity, and recovery","volume":"19","author":"Heininga","year":"2019","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.phymed.2025.156761_bib0034","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1021\/ci100275a","article-title":"Assessing the performance of the MM\/PBSA and MM\/GBSA methods. 1. The accuracy of binding free energy calculations based on molecular dynamics simulations","volume":"51","author":"Hou","year":"2011","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.phymed.2025.156761_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153576","article-title":"Gastrodiae rhizoma attenuates brain aging via promoting neuritogenesis and neurodifferentiation","volume":"87","author":"Hsu","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.156761_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115872","article-title":"Anti-depressive-like and cognitive impairment alleviation effects of Gastrodia elata Blume water extract is related to gut microbiome remodeling in ApoE-\/- mice exposed to unpredictable chronic mild stress","volume":"302","author":"Huang","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.156761_bib0037","doi-asserted-by":"crossref","first-page":"5133","DOI":"10.1002\/ptr.7091","article-title":"Gastrodia elata Blume water extract modulates neurotransmitters and alters the gut microbiota in a mild social defeat stress-induced depression mouse model","volume":"35","author":"Huang","year":"2021","journal-title":"PhytOther Res."},{"key":"10.1016\/j.phymed.2025.156761_bib0038","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/sj.mp.4000712","article-title":"Adult brain neurogenesis and psychiatry: a novel theory of depression","volume":"5","author":"Jacobs","year":"2000","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.phymed.2025.156761_bib0039","doi-asserted-by":"crossref","first-page":"e40","DOI":"10.1038\/tp.2011.33","article-title":"Enriched environment treatment reverses depression-like behavior and restores reduced hippocampal neurogenesis and protein levels of brain-derived neurotrophic factor in mice lacking its expression through promoter IV","volume":"1","author":"Jha","year":"2011","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.phymed.2025.156761_bib0040","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/9501427","article-title":"2,3,5,4\u2032-Tetrahydroxystilbene-2-O-beta-D-glucoside reverses stress-induced depression via inflammatory and oxidative stress pathways","author":"Jiang","year":"2018","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.phymed.2025.156761_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117891","article-title":"Antidepressant effects of Parishin C in chronic social defeat stress-induced depressive mice","volume":"325","author":"Jiang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.156761_bib0042","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1248\/bpb.29.261","article-title":"Anxiolytic-like effects of Gastrodia elata and its phenolic constituents in mice","volume":"29","author":"Jung","year":"2006","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.phymed.2025.156761_bib0043","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/1028415X.2023.2187510","article-title":"Impaired brain equanimity and neurogenesis in the diet-induced overweight mouse: a preventive role by syringic acid treatment","volume":"27","author":"Khatun","year":"2024","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.phymed.2025.156761_bib0044","doi-asserted-by":"crossref","first-page":"e759","DOI":"10.1038\/tp.2016.25","article-title":"Is increased antidepressant exposure a contributory factor to the obesity pandemic?","volume":"6","author":"Lee","year":"2016","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.phymed.2025.156761_bib0045","doi-asserted-by":"crossref","first-page":"8477","DOI":"10.1523\/JNEUROSCI.3881-16.2017","article-title":"N1-Src Kinase is required for primary neurogenesis in Xenopus tropicalis","volume":"37","author":"Lewis","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phymed.2025.156761_bib0046","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.biopsych.2008.07.014","article-title":"Vaccination as a novel approach for treating depressive behavior","volume":"65","author":"Lewitus","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phymed.2025.156761_bib0047","doi-asserted-by":"crossref","first-page":"955","DOI":"10.7150\/thno.76553","article-title":"Phloretin decreases microglia-mediated synaptic engulfment to prevent chronic mild stress-induced depression-like behaviors in the mPFC","volume":"13","author":"Li","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.phymed.2025.156761_bib0048","article-title":"Unraveling the potential mechanisms of the anti-osteoporotic effects of the Achyranthes bidentata-Dipsacus asper herb pair: a network pharmacology and experimental study","volume":"14","author":"Li","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156761_bib0049","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.ijbiomac.2021.09.173","article-title":"Syringic acid demonstrates promising protective effect against tau fibrillization and cytotoxicity through regulation of endoplasmic reticulum stress-mediated pathway as a prelude to Alzheimer's disease","volume":"192","author":"Li","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2025.156761_bib0050","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jep.2017.12.044","article-title":"Antidepressant-like effects of water extract of Gastrodia elata Blume on neurotrophic regulation in a chronic social defeat stress model","volume":"215","author":"Lin","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.156761_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2022.109488","article-title":"Calycosin decreases cerebral ischemia\/reperfusion injury by suppressing ACSL4-dependent ferroptosis","volume":"734","author":"Liu","year":"2023","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.phymed.2025.156761_bib0052","article-title":"Akebia saponin D protects hippocampal neurogenesis from microglia-mediated inflammation and ameliorates depressive-like behaviors and cognitive impairment in mice through the PI3K-Akt pathway","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156761_bib0053","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114378","article-title":"Study on the experimental verification and regulatory mechanism of Rougui-Ganjiang herb-pair for the actions of thermogenesis in brown adipose tissue based on network pharmacology","volume":"279","author":"Liu","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.156761_bib0054","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.963327","article-title":"The effects of bioactive components from the rhizome of gastrodia elata blume (Tianma) on the characteristics of Parkinson's disease","volume":"13","author":"Lu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156761_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2021.135803","article-title":"Nrg1\/ErbB2 regulates differentiation and apoptosis of neural stem cells in the cochlear nucleus through PI3K\/Akt pathway","volume":"751","author":"Lu","year":"2021","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.phymed.2025.156761_bib0056","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s13020-020-00399-7","article-title":"The study of neuroprotective effects and underlying mechanism of Naoshuantong capsule on ischemia stroke mice","volume":"15","author":"Luo","year":"2020","journal-title":"Chin. Med."},{"key":"10.1016\/j.phymed.2025.156761_bib0057","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.neubiorev.2013.11.009","article-title":"Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects","volume":"38","author":"Mahar","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.phymed.2025.156761_bib0058","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2024.105836","article-title":"Unlocking the potential of low-molecular-weight (Poly)phenol metabolites: protectors at the blood-brain barrier frontier","volume":"179","author":"Marques","year":"2024","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.phymed.2025.156761_bib0059","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2021.104560","article-title":"Entry-inhibitory role of catechins against SARS-CoV-2 and its UK variant","volume":"135","author":"Mhatre","year":"2021","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.phymed.2025.156761_bib0060","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.tips.2021.11.004","article-title":"Network pharmacology: curing causal mechanisms instead of treating symptoms","volume":"43","author":"Nogales","year":"2022","journal-title":"Trends. Pharmacol. Sci."},{"key":"10.1016\/j.phymed.2025.156761_bib0061","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1038\/msb4100014","article-title":"A comprehensive pathway map of epidermal growth factor receptor signaling","volume":"1","author":"Oda","year":"2005","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.phymed.2025.156761_bib0062","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.4103\/1673-5374.211174","article-title":"Impact of glucocorticoid on neurogenesis","volume":"12","author":"Odaka","year":"2017","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.phymed.2025.156761_bib0063","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ijbiomac.2021.03.186","article-title":"Antioxidant activity of calycosin against alpha-synuclein amyloid fibrils-induced oxidative stress in neural-like cells as a model of preventive care studies in Parkinson's disease","volume":"182","author":"Pan","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2025.156761_bib0064","doi-asserted-by":"crossref","first-page":"556","DOI":"10.3109\/13550289909021285","article-title":"Blood-brain barrier biology and methodology","volume":"5","author":"Pardridge","year":"1999","journal-title":"J. Neurovirol."},{"key":"10.1016\/j.phymed.2025.156761_bib0065","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14444","article-title":"Gastrodin improves nerve cell injury and behaviors of depressed mice through Caspase-3-mediated apoptosis","volume":"30","author":"Pei","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.phymed.2025.156761_bib0066","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2023.106660","article-title":"Fu-Huang ointment ameliorates impaired wound healing associated with diabetes through PI3K-AKT signalling pathway activation","volume":"155","author":"Qu","year":"2023","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.phymed.2025.156761_bib0067","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/978-3-030-74046-7_7","article-title":"An overview of adult neurogenesis","volume":"1331","author":"Ribeiro","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.phymed.2025.156761_bib0068","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/j.1440-1681.1987.tb02425.x","article-title":"Facilitation of drug entry into brain by osmotic opening of the blood-brain barrier","volume":"14","author":"Robinson","year":"1987","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.phymed.2025.156761_bib0069","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.1083328","article-title":"Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants","volume":"301","author":"Santarelli","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.phymed.2025.156761_bib0070","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1038\/mp.2010.34","article-title":"Environmental enrichment requires adult neurogenesis to facilitate the recovery from psychosocial stress","volume":"15","author":"Schloesser","year":"2010","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.phymed.2025.156761_bib0071","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neubiorev.2015.11.012","article-title":"Neurobiological effects of exercise on major depressive disorder: a systematic review","volume":"61","author":"Schuch","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.phymed.2025.156761_bib0072","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1038\/mp.2016.118","article-title":"Cellular and molecular basis for stress-induced depression","volume":"22","author":"Seo","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.phymed.2025.156761_bib0073","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jad.2024.05.083","article-title":"Astrocyte atrophy induced by L-PGDS\/PGD2\/Src signaling dysfunction in the central amygdala mediates postpartum depression","volume":"359","author":"Sheng","year":"2024","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.phymed.2025.156761_bib0074","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1515\/rns.2011.032","article-title":"C-Jun N-terminal kinases in memory and synaptic plasticity","volume":"22","author":"Sherrin","year":"2011","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.phymed.2025.156761_bib0075","doi-asserted-by":"crossref","first-page":"3656","DOI":"10.7150\/thno.70370","article-title":"Requirement of hippocampal DG nNOS-CAPON dissociation for the anxiolytic and antidepressant effects of fluoxetine","volume":"12","author":"Shi","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.phymed.2025.156761_bib0076","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12974-023-02765-2","article-title":"Stellate ganglion block ameliorated central post-stroke pain with comorbid anxiety and depression through inhibiting HIF-1alpha\/NLRP3 signaling following thalamic hemorrhagic stroke","volume":"20","author":"Shi","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.phymed.2025.156761_bib0077","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/978-1-61779-145-1_4","article-title":"Isolation and characterization of adult neural stem cells","volume":"750","author":"Siebzehnrubl","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.phymed.2025.156761_bib0078","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/nature10287","article-title":"Adult hippocampal neurogenesis buffers stress responses and depressive behaviour","volume":"476","author":"Snyder","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2025.156761_bib0079","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1044375","article-title":"Gastrodin ameliorates the lipopolysaccharide-induced neuroinflammation in mice by downregulating miR-107-3p","volume":"13","author":"Song","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156761_bib0080","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s00213-021-05982-w","article-title":"Chronic mild stress paradigm as a rat model of depression: facts, artifacts, and future perspectives","volume":"239","author":"Strekalova","year":"2022","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.phymed.2025.156761_bib0081","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114991","article-title":"Chronic exposure to aflatoxin B1 increases hippocampal microglial pyroptosis and vulnerability to stress in mice","volume":"258","author":"Su","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.phymed.2025.156761_bib0082","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116467","article-title":"The processing methods, phytochemistry and pharmacology of Gastrodia elata Bl.: a comprehensive review","volume":"314","author":"Su","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.156761_bib0083","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.biopsych.2008.02.022","article-title":"Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversal","volume":"64","author":"Surget","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phymed.2025.156761_bib0084","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1009578","article-title":"Implementation of residue-level coarse-grained models in GENESIS for large-scale molecular dynamics simulations","volume":"18","author":"Tan","year":"2022","journal-title":"PLoS. Comput. Biol."},{"key":"10.1016\/j.phymed.2025.156761_bib0085","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1038\/s41593-023-01397-2","article-title":"The medial preoptic area mediates depressive-like behaviors induced by ovarian hormone withdrawal through distinct GABAergic projections","volume":"26","author":"Tao","year":"2023","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.phymed.2025.156761_bib0086","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jare.2022.02.015","article-title":"A natural carotenoid crocin exerts antidepressant action by promoting adult hippocampal neurogenesis through Wnt\/beta-catenin signaling","volume":"43","author":"Tao","year":"2023","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.phymed.2025.156761_bib0087","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF01742530","article-title":"Epidermal growth factor receptor expression in human gliomas","volume":"33","author":"Torp","year":"1991","journal-title":"Cancer Immunol. Immunther."},{"key":"10.1016\/j.phymed.2025.156761_bib0088","doi-asserted-by":"crossref","first-page":"9799","DOI":"10.1038\/s41598-024-58877-z","article-title":"Network pharmacology combined with molecular docking and experimental verification to elucidate the effect of flavan-3-ols and aromatic resin on anxiety","volume":"14","author":"Vikhar","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2025.156761_bib0089","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s12974-022-02492-0","article-title":"Microglia in depression: an overview of microglia in the pathogenesis and treatment of depression","volume":"19","author":"Wang","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.phymed.2025.156761_bib0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115018","article-title":"Ameliorative effect of Gastrodia elata Blume extracts on depression in zebrafish and cellular models through modulating reticulon 4 receptors and apoptosis","volume":"289","author":"Wang","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.156761_bib0091","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.cytogfr.2004.01.004","article-title":"The role of epidermal growth factor and its receptors in mammalian CNS","volume":"15","author":"Wong","year":"2004","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.phymed.2025.156761_bib0092","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/5606021","article-title":"Gastrodia elata BI.:a comprehensive review of its traditional use, botany, phytochemistry, pharmacology, and pharmacokinetics","author":"Wu","year":"2023","journal-title":"Evid. Based. Complement. Alternat. Med."},{"key":"10.1016\/j.phymed.2025.156761_bib0093","first-page":"25","article-title":"Metabolomics-based study of the protective effect of 4-hydroxybenzyl alcohol on ischemic astrocytes","author":"Xiao","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2025.156761_bib0094","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.phymed.2015.09.004","article-title":"Antidepressant-like effect of the water extract of the fixed combination of Gardenia jasminoides, Citrus aurantium and Magnolia officinalis in a rat model of chronic unpredictable mild stress","volume":"22","author":"Xing","year":"2015","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.156761_bib0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113751","article-title":"Gastrodin alleviates seizure severity and neuronal excitotoxicities in the rat lithium-pilocarpine model of temporal lobe epilepsy via enhancing GABAergic transmission","volume":"269","author":"Yang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.156761_bib0096","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.bbi.2023.10.006","article-title":"The role of the Toll like receptor 4 signaling in sex-specific persistency of depression-like behavior in response to chronic stress","volume":"115","author":"Yang","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.phymed.2025.156761_bib0097","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12974-023-02715-y","article-title":"Morinda officinalis oligosaccharides mitigate depression-like behaviors in hypertension rats by regulating Mfn2-mediated mitophagy","volume":"20","author":"Yang","year":"2023","journal-title":"J. Neuroinfl."},{"key":"10.1016\/j.phymed.2025.156761_bib0098","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118887","article-title":"Screening the effective components of Lysionotus pauciflorus Maxim. On the treatment of LPS induced acute lung injury mice by integrated UHPLC-Q-TOF-MS\/MS and network pharmacology","volume":"337","author":"Yang","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.156761_bib0099","doi-asserted-by":"crossref","first-page":"15810","DOI":"10.1073\/pnas.1415219111","article-title":"Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin","volume":"111","author":"Yau","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phymed.2025.156761_bib0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117355","article-title":"Zhi-Zi-Hou-Po decoction alleviates depressive-like behavior and promotes hippocampal neurogenesis in chronic unpredictable mild stress induced mice via activating the BDNF\/TrkB\/CREB pathway","volume":"319","author":"Ye","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.156761_bib0101","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1080\/1028415X.2023.2296165","article-title":"The impact of flavonoids and BDNF on neurogenic process in various physiological\/pathological conditions including ischemic insults: a narrative review","volume":"27","author":"Yilmaz","year":"2024","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.phymed.2025.156761_bib0102","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13387","article-title":"Role of Adiponectin-Notch pathway in cognitive dysfunction associated with depression and in the therapeutic effect of physical exercise","volume":"20","author":"You","year":"2021","journal-title":"Aging Cell"},{"key":"10.1016\/j.phymed.2025.156761_bib0103","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2020.106012","article-title":"Computational screening of antagonists against the SARS-CoV-2 (COVID-19) coronavirus by molecular docking","volume":"56","author":"Yu","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.phymed.2025.156761_bib0104","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115005","article-title":"Xiaoyaosan ethyl acetate fraction alleviates depression-like behaviors in CUMS mice by promoting hippocampal neurogenesis via modulating the IGF-1R\u03b2\/PI3K\/Akt signaling pathway","volume":"288","author":"Zeng","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.156761_bib0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154725","article-title":"Gastrodin programs an Arg-1+ microglial phenotype in hippocampus to ameliorate depression- and anxiety-like behaviors via the Nrf2 pathway in mice","volume":"113","author":"Zhang","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.156761_bib0106","article-title":"IL4-driven microglia modulate stress resilience through BDNF-dependent neurogenesis","volume":"7","author":"Zhang","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.phymed.2025.156761_bib0107","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bbi.2017.07.012","article-title":"Salvianolic acid B promotes microglial M2-polarization and rescues neurogenesis in stress-exposed mice","volume":"66","author":"Zhang","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.phymed.2025.156761_bib0108","doi-asserted-by":"crossref","first-page":"3825","DOI":"10.1002\/jssc.201500739","article-title":"Approach based on high-performance liquid chromatography fingerprint coupled with multivariate statistical analysis for the quality evaluation of Gastrodia Rhizoma","volume":"38","author":"Zhang","year":"2015","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.phymed.2025.156761_bib0109","first-page":"312","article-title":"Research progress on mechanism of gastrodin and p-hydroxybenzyl alcohol on central nervous system","volume":"45","author":"Zhang","year":"2020","journal-title":"Zhongguo Zhong. Yao Za Zhi."},{"key":"10.1016\/j.phymed.2025.156761_bib0110","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.aca.2018.11.011","article-title":"Stable isotope labeling derivatization and magnetic dispersive solid phase extraction coupled with UHPLC-MS\/MS for the measurement of brain neurotransmitters in post-stroke depression rats administrated with gastrodin","volume":"1051","author":"Zhao","year":"2019","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.phymed.2025.156761_bib0111","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.4161\/cbt.8.11.8539","article-title":"ADAM17 promotes breast cancer cell malignant phenotype through EGFR-PI3K-AKT activation","volume":"8","author":"Zheng","year":"2009","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.phymed.2025.156761_bib0112","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155251","article-title":"Mechanisms for the biological activity of Gastrodia elata Blume and its constituents: a comprehensive review on sedative-hypnotic, and antidepressant properties","volume":"123","author":"Zhou","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.156761_bib0113","doi-asserted-by":"crossref","first-page":"14520","DOI":"10.1021\/acsomega.4c00436","article-title":"Isolation, bioactivity, and molecular docking of a rare gastrodin isocitrate and diverse parishin derivatives from Gastrodia elata blume","volume":"9","author":"Zhou","year":"2024","journal-title":"ACS Omega"},{"key":"10.1016\/j.phymed.2025.156761_bib0114","doi-asserted-by":"crossref","first-page":"12258","DOI":"10.1523\/JNEUROSCI.0805-11.2011","article-title":"Hippocampal telomerase is involved in the modulation of depressive behaviors","volume":"31","author":"Zhou","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phymed.2025.156761_bib0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153837","article-title":"Network pharmacology to unveil the mechanism of Moluodan in the treatment of chronic atrophic gastritis","volume":"95","author":"Zhou","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.156761_bib0116","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1080\/07853890.2022.2034931","article-title":"The mechanism of triptolide in the treatment of connective tissue disease-related interstitial lung disease based on network pharmacology and molecular docking","volume":"54","author":"Zhu","year":"2022","journal-title":"Ann. Med."},{"key":"10.1016\/j.phymed.2025.156761_bib0117","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118906","article-title":"Amino acid metabolites profiling in unpredictable chronic mild stress-induced depressive rats and the protective effects of Gastrodia elata Blume and gastrodin","volume":"337","author":"Zumbi","year":"2025","journal-title":"J. Ethnopharmacol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325004003?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325004003?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T21:38:55Z","timestamp":1773351535000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325004003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":117,"alternative-id":["S0944711325004003"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156761","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A comprehensive pharmacology study reveals the molecular mechanisms underlying the antidepressant effects of Gastrodiae Rhizoma","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156761","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156761"}}