{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:22:50Z","timestamp":1790374970333,"version":"4.1.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005153","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"publisher","award":["81903937"],"award-info":[{"award-number":["81903937"]}],"id":[{"id":"10.13039\/501100005153","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005153","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"publisher","award":["82305208"],"award-info":[{"award-number":["82305208"]}],"id":[{"id":"10.13039\/501100005153","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.phymed.2025.156786","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T16:08:25Z","timestamp":1746547705000},"page":"156786","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Deoxypodophyllotoxin inhibited the growth of malignant pleural mesothelioma by inducing necroptosis and mitotic catastrophe"],"prefix":"10.1016","volume":"143","author":[{"given":"Cheng","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqiong","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongle","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6345-5228","authenticated-orcid":false,"given":"Rong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.156786_b1","article-title":"Perspectives and mechanisms for targeting mitotic catastrophe in cancer treatment","author":"Bai","year":"2023","journal-title":"BBA- Rev. Cancer"},{"issue":"5","key":"10.1016\/j.phymed.2025.156786_b2","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1038\/s41423-020-00630-3","article-title":"Necroptosis, pyroptosis and apoptosis: an intricate game of cell death","volume":"18","author":"Bertheloot","year":"2021","journal-title":"Cell. Mol. Immunol."},{"issue":"4","key":"10.1016\/j.phymed.2025.156786_b3","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/ng.3520","article-title":"Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations","volume":"48","author":"Bueno","year":"2016","journal-title":"Nat. Genet."},{"issue":"12","key":"10.1016\/j.phymed.2025.156786_b4","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1016\/S1470-2045(19)30532-7","article-title":"Tumour treating fields in combination with pemetrexed and cisplatin or carboplatin as first-line treatment for unresectable malignant pleural mesothelioma (STELLAR): A multicentre, single-arm phase 2 trial","volume":"20","author":"Ceresoli","year":"2019","journal-title":"Lancet Oncol."},{"issue":"4","key":"10.1016\/j.phymed.2025.156786_b5","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejcb.2020.151075","article-title":"Microtubule-targeting agents and their impact on cancer treatment","volume":"99","author":"\u010cerm\u00e1k","year":"2020","journal-title":"Eur. J. Cell Biol."},{"issue":"17","key":"10.1016\/j.phymed.2025.156786_b6","doi-asserted-by":"crossref","first-page":"4105","DOI":"10.3390\/cancers14174105","article-title":"Correlation between BAP1 localization, driver mutations, and patient survival in uveal melanoma","volume":"14","author":"Cole","year":"2022","journal-title":"Cancers"},{"issue":"4","key":"10.1016\/j.phymed.2025.156786_b7","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1080\/15548627.2016.1147670","article-title":"Inhibition of BMI1 induces autophagy-mediated necroptosis","volume":"12","author":"Dey","year":"2016","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.phymed.2025.156786_b8","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.tranon.2014.12.002","article-title":"Changing pattern in malignant mesothelioma survival","volume":"8","author":"Faig","year":"2015","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.phymed.2025.156786_b9","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2022.101432","article-title":"Active symptom control with or without oral vinorelbine in patients with relapsed malignant pleural mesothelioma (VIM): A randomised, phase 2 trial","volume":"48","author":"Fennell","year":"2022","journal-title":"EClinicalMedicine"},{"issue":"23","key":"10.1016\/j.phymed.2025.156786_b10","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020105753","article-title":"Pore formation in regulated cell death","volume":"39","author":"Flores-Romero","year":"2020","journal-title":"EMBO J."},{"issue":"6","key":"10.1016\/j.phymed.2025.156786_b11","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.pathol.2018.05.002","article-title":"Nuclear grading, BAP1, mesothelin and PD-L1 expression in malignant pleural mesothelioma: prognostic implications","volume":"50","author":"Forest","year":"2018","journal-title":"Pathology"},{"issue":"10","key":"10.1016\/j.phymed.2025.156786_b12","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1038\/s41418-019-0298-5","article-title":"Cell cycle arrest in mitosis promotes interferon-induced necroptosis","volume":"26","author":"Frank","year":"2019","journal-title":"Cell Death & Differ."},{"issue":"12","key":"10.1016\/j.phymed.2025.156786_b13","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/ncb3064","article-title":"Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice","volume":"16","author":"Friedmann Angeli","year":"2014","journal-title":"Nat. Cell Biol."},{"issue":"3","key":"10.1016\/j.phymed.2025.156786_b14","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","article-title":"Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018","volume":"25","author":"Galluzzi","year":"2018","journal-title":"Cell Death & Differ."},{"issue":"1","key":"10.1016\/j.phymed.2025.156786_b15","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/s41392-022-01046-3","article-title":"Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy","volume":"7","author":"Gao","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2025.156786_b16","article-title":"Apoptosis, necroptosis, and pyroptosis as alternative cell death pathways induced by chemotherapeutic agents?","author":"Gieleci\u0144ska","year":"2023","journal-title":"BBA- Rev Cancer"},{"issue":"7","key":"10.1016\/j.phymed.2025.156786_b17","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1038\/cdd.2017.65","article-title":"Initiation and execution mechanisms of necroptosis: an overview","volume":"24","author":"Grootjans","year":"2017","journal-title":"Cell Death & Differ."},{"key":"10.1016\/j.phymed.2025.156786_b18","first-page":"63","article-title":"Docetaxel in the treatment of non-small cell lung carcinoma: An update and analysis","author":"Gubens","year":"2010","journal-title":"Lung Cancer: Targets Ther."},{"issue":"5","key":"10.1016\/j.phymed.2025.156786_b19","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.4049\/jimmunol.1601757","article-title":"MLKL activation triggers NLRP3-mediated processing and release of IL-1\u03b2 independently of gasdermin-d","volume":"198","author":"Gutierrez","year":"2017","journal-title":"J. Immunol."},{"issue":"11","key":"10.1016\/j.phymed.2025.156786_b20","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1038\/s41416-022-01979-0","article-title":"Genomic landscape of pleural and peritoneal mesothelioma tumours","volume":"127","author":"Hiltbrunner","year":"2022","journal-title":"Br. J. Cancer"},{"issue":"12","key":"10.1016\/j.phymed.2025.156786_b21","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1158\/1535-7163.MCT-21-0195","article-title":"Paclitaxel induces micronucleation and activates pro-inflammatory cGAS\u2013STING signaling in triple-negative breast cancer","volume":"20","author":"Hu","year":"2021","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.phymed.2025.156786_b22","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.humpath.2021.02.007","article-title":"TRAF7 mutations and immunohistochemical study of uterine adenomatoid tumor compared with malignant mesothelioma","volume":"111","author":"Itami","year":"2021","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.phymed.2025.156786_b23","series-title":"Semin. Cancer Biol.","first-page":"93","article-title":"Autoimmunity, checkpoint inhibitor therapy and immune-related adverse events: A review","volume":"vol. 64","author":"Khan","year":"2020"},{"issue":"8","key":"10.1016\/j.phymed.2025.156786_b24","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.3390\/cancers14082020","article-title":"Feasibility of tumor treating fields with pemetrexed and platinum-based chemotherapy for unresectable malignant pleural mesothelioma: Single-center, real-world data","volume":"14","author":"Kutuk","year":"2022","journal-title":"Cancers"},{"issue":"18","key":"10.1016\/j.phymed.2025.156786_b25","doi-asserted-by":"crossref","first-page":"6854","DOI":"10.3390\/ijms21186854","article-title":"Deoxypodophyllotoxin, a lignan from anthriscus sylvestris, induces apoptosis and cell cycle arrest by inhibiting the EGFR signaling pathways in esophageal squamous cell carcinoma cells","volume":"21","author":"Kwak","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.phymed.2025.156786_b26","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1038\/s41401-023-01109-3","article-title":"Activated SIRT1 contributes to DPT-induced glioma cell parthanatos by upregulation of NOX2 and NAT10","volume":"44","author":"Liang","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"issue":"3","key":"10.1016\/j.phymed.2025.156786_b27","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.21037\/tlcr-20-1027","article-title":"Low-level expression of necroptosis factors indicates a poor prognosis of the squamous cell carcinoma subtype of non-small-cell lung cancer","volume":"10","author":"Lim","year":"2021","journal-title":"Transl. Lung Cancer Res."},{"key":"10.1016\/j.phymed.2025.156786_b28","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.108714","article-title":"Extracellular HMGB1 prevents necroptosis in acute myeloid leukemia cells","volume":"112","author":"Liu","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2025.156786_b29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40659-019-0243-6","article-title":"Berberine in combination with cisplatin induces necroptosis and apoptosis in ovarian cancer cells","volume":"52","author":"Liu","year":"2019","journal-title":"Biol. Res."},{"issue":"1","key":"10.1016\/j.phymed.2025.156786_b30","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.tcb.2021.07.001","article-title":"Cell cycle on the crossroad of tumorigenesis and cancer therapy","volume":"32","author":"Liu","year":"2022","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.phymed.2025.156786_b31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13073-021-00931-w","article-title":"Multi-site tumor sampling highlights molecular intra-tumor heterogeneity in malignant pleural mesothelioma","volume":"13","author":"Meiller","year":"2021","journal-title":"Genome Med."},{"issue":"3","key":"10.1016\/j.phymed.2025.156786_b32","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.cell.2010.01.028","article-title":"Methods in mammalian autophagy research","volume":"140","author":"Mizushima","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2025.156786_b33","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175089","article-title":"A comprehensive insight into the antineoplastic activities and molecular mechanisms of deoxypodophyllotoxin: Recent trends, challenges, and future outlook","volume":"928","author":"Mottaghi","year":"2022","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.phymed.2025.156786_b34","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1158\/1078-0432.CCR-21-1466","article-title":"FDA approval summary: nivolumab in combination with ipilimumab for the treatment of unresectable malignant pleural mesothelioma","volume":"28","author":"Nakajima","year":"2022","journal-title":"Clin. Cancer Res."},{"issue":"6571","key":"10.1016\/j.phymed.2025.156786_b35","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1126\/science.abi5934","article-title":"Dying cells fan the flames of inflammation","volume":"374","author":"Newton","year":"2021","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.phymed.2025.156786_b36","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s12943-021-01399-3","article-title":"RIPK3 activation induces TRIM28 derepression in cancer cells and enhances the anti-tumor microenvironment","volume":"20","author":"Park","year":"2021","journal-title":"Mol. Cancer"},{"issue":"5","key":"10.1016\/j.phymed.2025.156786_b37","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.annonc.2022.01.074","article-title":"First-line nivolumab plus ipilimumab versus chemotherapy in patients with unresectable malignant pleural mesothelioma: 3-year outcomes from CheckMate 743","volume":"33","author":"Peters","year":"2022","journal-title":"Ann. Oncol."},{"issue":"5","key":"10.1016\/j.phymed.2025.156786_b38","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1073\/pnas.1416418112","article-title":"Microtubule-targeting agents augment the toxicity of DNA-damaging agents by disrupting intracellular trafficking of DNA repair proteins","volume":"112","author":"Poruchynsky","year":"2015","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.phymed.2025.156786_b39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41388-019-0980-6","article-title":"The DNA-damage response and nuclear events as regulators of nonapoptotic forms of cell death","volume":"39","author":"Prokhorova","year":"2020","journal-title":"Oncogene"},{"issue":"4","key":"10.1016\/j.phymed.2025.156786_b40","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/modpathol.2017.170","article-title":"Nuclear grade and necrosis predict prognosis in malignant epithelioid pleural mesothelioma: a multi-institutional study","volume":"31","author":"Rosen","year":"2018","journal-title":"Mod. Pathol."},{"issue":"3","key":"10.1016\/j.phymed.2025.156786_b41","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1183\/09031936.00063109","article-title":"Guidelines of the European respiratory society and the European society of thoracic surgeons for the management of malignant pleural mesothelioma","volume":"35","author":"Scherpereel","year":"2010","journal-title":"Eur. Respir. J."},{"issue":"08","key":"10.1016\/j.phymed.2025.156786_b42","first-page":"544","article-title":"Cytotoxic deoxypodophyllotoxin can be extracted in high purity from anthriscus sylvestris roots by supercritical carbon dioxide","volume":"50","author":"Seegers","year":"2018","journal-title":"Planta Med."},{"issue":"9","key":"10.1016\/j.phymed.2025.156786_b43","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.4014\/jmb.2207.07012","article-title":"Deoxypodophyllotoxin induces ROS-mediated apoptosis by modulating the PI3k\/AKT and p38 MAPK-dependent signaling in oral squamous cell carcinoma","volume":"32","author":"Seo","year":"2022","journal-title":"J. Microbiol. Biotechnol."},{"issue":"5","key":"10.1016\/j.phymed.2025.156786_b44","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/s41419-020-2567-0","article-title":"Exploiting immune-dependent effects of microtubule-targeting agents to improve efficacy and tolerability of cancer treatment","volume":"11","author":"Serpico","year":"2020","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.phymed.2025.156786_b45","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.canlet.2017.06.032","article-title":"Suppression of angiogenesis and tumour progression by combretastatin and derivatives","volume":"403","author":"Sherbet","year":"2017","journal-title":"Cancer Lett."},{"issue":"8","key":"10.1016\/j.phymed.2025.156786_b46","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/s41388-022-02577-3","article-title":"BAP1 loss induces mitotic defects in mesothelioma cells through BRCA1-dependent and independent mechanisms","volume":"42","author":"Singh","year":"2023","journal-title":"Oncogene"},{"issue":"10","key":"10.1016\/j.phymed.2025.156786_b47","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.tcb.2018.05.001","article-title":"Microtubule-targeting agents: strategies to hijack the cytoskeleton","volume":"28","author":"Steinmetz","year":"2018","journal-title":"Trends Cell Biol."},{"issue":"4","key":"10.1016\/j.phymed.2025.156786_b48","doi-asserted-by":"crossref","first-page":"543","DOI":"10.21037\/tlcr-21-765","article-title":"Picropodophyllin inhibits the growth of pemetrexed-resistant malignant pleural mesothelioma via microtubule inhibition and IGF-1R-, caspase-independent pathways","volume":"11","author":"Sun","year":"2022","journal-title":"Transl Lung Cancer Res."},{"issue":"6","key":"10.1016\/j.phymed.2025.156786_b49","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1093\/annonc\/mdu127","article-title":"Expression profiling stratifies mesothelioma tumors and signifies deregulation of spindle checkpoint pathway and microtubule network with therapeutic implications","volume":"25","author":"Suraokar","year":"2014","journal-title":"Ann. Oncol."},{"issue":"23","key":"10.1016\/j.phymed.2025.156786_b50","doi-asserted-by":"crossref","first-page":"5962","DOI":"10.3390\/cancers14235962","article-title":"The microtubule destabilizer eribulin synergizes with STING agonists to promote antitumor efficacy in triple-negative breast cancer models","volume":"14","author":"Takahashi-Ruiz","year":"2022","journal-title":"Cancers"},{"issue":"19","key":"10.1016\/j.phymed.2025.156786_b51","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1042\/BCJ20210724","article-title":"Mechanisms of TNF-independent RIPK3-mediated cell death","volume":"479","author":"Tummers","year":"2022","journal-title":"Biochem. J."},{"issue":"14","key":"10.1016\/j.phymed.2025.156786_b52","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1200\/JCO.2003.11.136","article-title":"Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma","volume":"21","author":"Vogelzang","year":"2003","journal-title":"J. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.phymed.2025.156786_b53","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1186\/s12951-024-02568-4","article-title":"NIR-responsive CN-Pt-GEM hydrogel induces necroptosis and immunotherapeutic responses prevent postoperative recurrence and wound infection in lung carcinoma","volume":"22","author":"Wang","year":"2024","journal-title":"J. Nanobiotechnology"},{"issue":"8","key":"10.1016\/j.phymed.2025.156786_b54","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.biopha.2013.06.002","article-title":"Deoxypodophyllotoxin triggers necroptosis in human non-small cell lung cancer NCI-h460 cells","volume":"67","author":"Wu","year":"2013","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2025.156786_b55","article-title":"Deoxypodophyllotoxin inhibits non-small cell lung cancer cell growth by reducing HIF-1\u03b1-mediated glycolysis","volume":"11","author":"Yang","year":"2021","journal-title":"Front. Oncol."},{"issue":"11","key":"10.1016\/j.phymed.2025.156786_b56","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113377","article-title":"Triggering endogenous Z-RNA sensing for anti-tumor therapy through ZBP1-dependent necroptosis","volume":"42","author":"Yang","year":"2023","journal-title":"Cell Rep."},{"issue":"3","key":"10.1016\/j.phymed.2025.156786_b57","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1097\/PAS.0000000000001416","article-title":"Utility of nuclear grading system in epithelioid malignant pleural mesothelioma in biopsy-heavy setting: an external validation study of 563 cases","volume":"44","author":"Zhang","year":"2020","journal-title":"Am. J. Surg. Pathol."},{"issue":"5","key":"10.1016\/j.phymed.2025.156786_b58","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1038\/s41418-019-0441-3","article-title":"Membrane-bound TNF mediates microtubule-targeting chemotherapeutics-induced cancer cytolysis via juxtacrine inter-cancer-cell death signaling","volume":"27","author":"Zhang","year":"2020","journal-title":"Cell Death & Differ."},{"issue":"7914","key":"10.1016\/j.phymed.2025.156786_b59","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/s41586-022-04753-7","article-title":"ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis","volume":"606","author":"Zhang","year":"2022","journal-title":"Nature"},{"issue":"19","key":"10.1016\/j.phymed.2025.156786_b60","doi-asserted-by":"crossref","first-page":"13354","DOI":"10.1021\/acs.jmedchem.3c00517","article-title":"Recent progress on microtubule degradation agents","volume":"66","author":"Zhang","year":"2023","journal-title":"J. Med. Chem."},{"issue":"4","key":"10.1016\/j.phymed.2025.156786_b61","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/jmcb\/mjy072","article-title":"Mutant p53 in cancer therapy\u2014the barrier or the path","volume":"11","author":"Zhou","year":"2019","journal-title":"J. Mol. Cell Biol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325004246?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325004246?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:21:01Z","timestamp":1751588461000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325004246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":61,"alternative-id":["S0944711325004246"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156786","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deoxypodophyllotoxin inhibited the growth of malignant pleural mesothelioma by inducing necroptosis and mitotic catastrophe","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156786","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156786"}}