{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:29:17Z","timestamp":1793834957535,"version":"4.6.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["cstc2022ycjh-bgzxm0145"],"award-info":[{"award-number":["cstc2022ycjh-bgzxm0145"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2023TIAD-STX0007"],"award-info":[{"award-number":["CSTB2023TIAD-STX0007"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["cstc2021jcyj-cxtt0005"],"award-info":[{"award-number":["cstc2021jcyj-cxtt0005"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.phymed.2025.156789","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T13:13:36Z","timestamp":1745500416000},"page":"156789","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Mori Folium ethanol extracts induce ferroptosis and suppress gastric cancer progression by inhibiting the AKT\/GSK3\u03b2\/NRF2 axis"],"prefix":"10.1016","volume":"142","author":[{"given":"Xin","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0028-8988","authenticated-orcid":false,"given":"Lang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bili","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangzhao","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhan","family":"L\u00fc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjuan","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.156789_bib0001","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221910317","article-title":"Role of HSP90 in cancer","volume":"22","author":"Birbo","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2025.156789_bib0002","first-page":"17","article-title":"Phytochemistry, pharmacology, and clinical trials of Morus alba","volume":"14","author":"Chan","year":"2016","journal-title":"Chin J. Nat. Med."},{"key":"10.1016\/j.phymed.2025.156789_bib0003","doi-asserted-by":"crossref","first-page":"e281","DOI":"10.1002\/mco2.281","article-title":"Sanggenon C inhibits cell proliferation and induces apoptosis by regulating the MIB1\/DAPK1 axis in glioblastoma","volume":"4","author":"Chang","year":"2023","journal-title":"Medcomm"},{"key":"10.1016\/j.phymed.2025.156789_bib0004","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1080\/01635581.2013.748924","article-title":"Antioxidant rich Morus alba leaf extract induces apoptosis in human colon and breast cancer cells by the downregulation of nitric oxide produced by inducible nitric oxide synthase","volume":"65","author":"Deepa","year":"2013","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.phymed.2025.156789_bib0005","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41580-024-00703-5","article-title":"The cell biology of ferroptosis","volume":"25","author":"Dixon","year":"2024","journal-title":"Nat. Rev. Mol. Cell. Bio."},{"key":"10.1016\/j.phymed.2025.156789_bib0006","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12951-023-02286-3","article-title":"Natural lipid nanoparticles extracted from Morus nigra L. leaves for targeted treatment of hepatocellular carcinoma via the oral route","volume":"22","author":"Gao","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.phymed.2025.156789_bib0007","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s12943-023-01827-6","article-title":"PI3K\/AKT\/mTOR signaling transduction pathway and targeted therapies in cancer","volume":"22","author":"Glaviano","year":"2023","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.phymed.2025.156789_bib0008","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/s41419-023-05779-z","article-title":"Combination treatment with FAAH inhibitors\/URB597 and ferroptosis inducers significantly decreases the growth and metastasis of renal cell carcinoma cells via the PI3K-AKT signaling pathway","volume":"14","author":"Hao","year":"2023","journal-title":"Cell. Death. Dis."},{"key":"10.1016\/j.phymed.2025.156789_bib0009","doi-asserted-by":"crossref","first-page":"6794","DOI":"10.1080\/21655979.2022.2036909","article-title":"Bupivacaine modulates the apoptosis and ferroptosis in bladder cancer via phosphatidylinositol 3-kinase (PI3K)\/AKT pathway","volume":"13","author":"Hao","year":"2022","journal-title":"Bioengineered"},{"key":"10.1016\/j.phymed.2025.156789_bib0010","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/s41392-021-00828-5","article-title":"Targeting PI3K\/akt signal transduction for cancer therapy","volume":"6","author":"He","year":"2021","journal-title":"Signal. Transduct. Tar."},{"key":"10.1016\/j.phymed.2025.156789_bib0011","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.7150\/ijbs.80324","article-title":"Polyphyllin B suppresses gastric tumor growth by modulating iron metabolism and inducing ferroptosis","volume":"19","author":"Hu","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.phymed.2025.156789_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117759","article-title":"Screening of anti-melanoma compounds from Morus alba L.: sanggenon C promotes melanoma cell apoptosis by disrupting intracellular Ca2+ homeostasis","volume":"324","author":"Hu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.156789_bib0013","doi-asserted-by":"crossref","first-page":"13768","DOI":"10.1021\/acs.jafc.3c02257","article-title":"Kuwanon H inhibits melanoma growth through cytotoxic endoplasmic reticulum stress and impaired autophagy flux","volume":"71","author":"Hu","year":"2023","journal-title":"J. Agr. Food. Chem."},{"key":"10.1016\/j.phymed.2025.156789_bib0014","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ijbiomac.2021.07.193","article-title":"The identification of nuclear factor Akirin with immune defense role in silkworm, bombyx mori","volume":"188","author":"Hu","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2025.156789_bib0015","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1007279","article-title":"Cortex Mori extracts induce apoptosis and inhibit tumor invasion via blockage of the PI3K\/AKT signaling in melanoma cells","volume":"13","author":"Hu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156789_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155220","article-title":"Yi-qi-hua-yu-jie-du decoction induces ferroptosis in cisplatin-resistant gastric cancer via the AKT\/GSK3\u03b2\/NRF2\/GPX4 axis","volume":"123","author":"Huang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.156789_bib0017","doi-asserted-by":"crossref","first-page":"144","DOI":"10.15430\/JCP.2016.21.3.144","article-title":"The immunomodulatory activity of Mori folium, the leaf of Morus alba L., in RAW 264.7 macrophages In vitro","volume":"21","author":"Kwon","year":"2016","journal-title":"J. Cancer Prev."},{"key":"10.1016\/j.phymed.2025.156789_bib0018","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/imr.13280","article-title":"Targeting ferroptosis in gastric cancer: strategies and opportunities","volume":"321","author":"Le","year":"2024","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.phymed.2025.156789_bib0019","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/s41568-022-00459-0","article-title":"Targeting ferroptosis as a vulnerability in cancer","volume":"22","author":"Lei","year":"2022","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.phymed.2025.156789_bib0020","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.ccell.2024.03.011","article-title":"The roles of ferroptosis in cancer: tumor suppression, tumor microenvironment, and therapeutic interventions","volume":"42","author":"Lei","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.phymed.2025.156789_bib0021","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/mco2.73","article-title":"Demethylzeylasteral inhibits proliferation, migration, and invasion through FBXW7\/c-myc axis in gastric cancer","volume":"2","author":"Li","year":"2021","journal-title":"Medcomm"},{"key":"10.1016\/j.phymed.2025.156789_bib0022","doi-asserted-by":"crossref","DOI":"10.3390\/metabo13111151","article-title":"The mechanism of Mori Folium and Eucommiae Cortex against cyclophosphamide-induced immunosuppression integrating network pharmacology, molecular docking, molecular dynamics simulations, and experimental validation","volume":"13","author":"Liu","year":"2023","journal-title":"Metabolites"},{"key":"10.1016\/j.phymed.2025.156789_bib0023","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.canlet.2021.04.007","article-title":"SIRT3 inhibits gallbladder cancer by induction of AKT-dependent ferroptosis and blockade of epithelial-mesenchymal transition","volume":"510","author":"Liu","year":"2021","journal-title":"Cancer Lett."},{"key":"10.1016\/j.phymed.2025.156789_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155351","article-title":"Xie-Bai-San increases NSCLC cells sensitivity to gefitinib by inhibiting beclin-1 mediated autophagosome formation","volume":"125","author":"Ma","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.156789_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113302","article-title":"Fucoxanthin extracted from Laminaria Japonica inhibits metastasis and enhances the sensitivity of lung cancer to Gefitinib","volume":"265","author":"Ming","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.156789_bib0026","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.freeradbiomed.2013.02.008","article-title":"Regulation of Nrf2-an update","volume":"66","author":"Niture","year":"2014","journal-title":"Free Radical. Bio. Med."},{"key":"10.1016\/j.phymed.2025.156789_bib0027","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/cac2.12197","article-title":"Cancer incidence, mortality, and burden in China: a time-trend analysis and comparison with the United States and United Kingdom based on the global epidemiological data released in 2020","volume":"41","author":"Qiu","year":"2021","journal-title":"Cancer Commun."},{"key":"10.1016\/j.phymed.2025.156789_bib0028","article-title":"Baicalin enhances the chemotherapy sensitivity of oxaliplatin-resistant gastric cancer cells by activating p53-mediated ferroptosis","volume":"14","author":"Shao","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2025.156789_bib0029","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1139\/bcb-2022-0361","article-title":"AKT1 participates in ferroptosis vulnerability by driving autophagic degradation of FTH1 in cisplatin-resistant ovarian cancer","volume":"101","author":"Shi","year":"2023","journal-title":"Biochem. Cell. Biol."},{"key":"10.1016\/j.phymed.2025.156789_bib0030","first-page":"207","article-title":"Research progress on chemical constituents, pharmacological effects and applications of Sangye (Mori Folium)","volume":"25","author":"Shuying","year":"2023","journal-title":"J. Liaon. Univ. Tradit. Chinese Med."},{"key":"10.1016\/j.phymed.2025.156789_bib0031","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21654","article-title":"Cancer statistics, 2021","volume":"71","author":"Siegel","year":"2021","journal-title":"CA-Cancer J. Clin."},{"key":"10.1016\/j.phymed.2025.156789_bib0032","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1158\/0008-5472.CAN-18-2738","article-title":"AKT as a therapeutic target for cancer","volume":"79","author":"Song","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.phymed.2025.156789_bib0033","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1372330","article-title":"Regulation of ferroptosis by PI3K\/Akt signaling pathway: a promising therapeutic axis in cancer","volume":"12","author":"Su","year":"2024","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.phymed.2025.156789_bib0034","article-title":"Comprehensive overview of different medicinal parts from Morus alba L.: chemical compositions and pharmacological activities","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156789_bib0035","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12943-022-01530-y","article-title":"Ferroptosis in cancer therapy: a novel approach to reversing drug resistance","volume":"21","author":"Zhang","year":"2022","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.phymed.2025.156789_bib0036","article-title":"Editorial: the roles of ion-induced cell death in cancer treatment: volume II","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156789_bib0037","doi-asserted-by":"crossref","first-page":"999","DOI":"10.3390\/ijms25020999","article-title":"Gastrointestinal cancer therapeutics via triggering unfolded protein response and endoplasmic reticulum stress by 2-arylbenzofuran","volume":"25","author":"Zhang","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2025.156789_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.prmcm.2025.100611","article-title":"Cathepsin-K targeted by Sanggenol L induces lethal autophagy through ROS-dependent AMPK\/mTOR signaling in gastric cancer","author":"Zhang","year":"2025","journal-title":"Pharmacolog. Res. - Modern Chinese Med."},{"key":"10.1016\/j.phymed.2025.156789_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.106029","article-title":"Mulberry leaf (Morus alba L.): a review of its potential influences in mechanisms of action on metabolic diseases","volume":"175","author":"Zhang","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2025.156789_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155527","article-title":"Moracin D suppresses cell growth and induces apoptosis via targeting the XIAP\/PARP1 axis in pancreatic cancer","volume":"128","author":"Zhong","year":"2024","journal-title":"Phytomedicine"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325004271?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325004271?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T21:50:31Z","timestamp":1773352231000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325004271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":40,"alternative-id":["S0944711325004271"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156789","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mori Folium ethanol extracts induce ferroptosis and suppress gastric cancer progression by inhibiting the AKT\/GSK3\u03b2\/NRF2 axis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156789","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156789"}}