{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:43:10Z","timestamp":1793644990091,"version":"4.5.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006462","name":"Anhui Agricultural University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006462","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.phymed.2025.156792","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T19:11:30Z","timestamp":1745349090000},"page":"156792","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Tea residue protein-derived oligopeptides attenuate DSS-induced acute colitis complicated with hepatic injury in C57BL\/6J mice by regulating the gut-microbiome-liver axis"],"prefix":"10.1016","volume":"142","author":[{"given":"Fengxue","family":"Qi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simeng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaru","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqun","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongwen","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daxiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7321-3790","authenticated-orcid":false,"given":"Huifang","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.phymed.2025.156792_bib0001","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.cgh.2018.07.022","article-title":"Association between intestinal microbiota collected at hospital admission and outcomes of patients with cirrhosis","volume":"17","author":"Bajaj","year":"2019","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"5","key":"10.1016\/j.phymed.2025.156792_bib0002","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1007\/s10787-021-00856-1","article-title":"A review of the biological and pharmacological activities of mesalazine or 5-aminosalicylic acid (5-ASA): an anti-ulcer and anti-oxidant drug","volume":"29","author":"Beiranvand","year":"2021","journal-title":"Inflammopharmacology"},{"issue":"2","key":"10.1016\/j.phymed.2025.156792_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.phyplu.2022.100264","article-title":"A review of the most common in vivo models of stomach ulcers and natural and synthetic anti-ulcer compounds: a comparative systematic study","volume":"2","author":"Beiranvand","year":"2022","journal-title":"Phytomed. Plus"},{"key":"10.1016\/j.phymed.2025.156792_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2022.108238","article-title":"Bile acid metabolism and signaling, the microbiota, and metabolic disease","volume":"237","author":"Cai","year":"2022","journal-title":"Pharmacol. Ther."},{"issue":"S1","key":"10.1016\/j.phymed.2025.156792_bib0005","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/cns.14044","article-title":"Gut microbial signatures and differences in bipolar disorder and schizophrenia of emerging adulthood","volume":"29","author":"Chen","year":"2023","journal-title":"CNS Neurosci. Ther."},{"issue":"suppl_1","key":"10.1016\/j.phymed.2025.156792_bib0006","first-page":"D691","article-title":"Reactome: a database of reactions, pathways and biological processes","volume":"39","author":"Croft","year":"2010","journal-title":"Nucleic. Acids. Res."},{"issue":"4","key":"10.1016\/j.phymed.2025.156792_bib0007","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/apt.16753","article-title":"Randomised clinical trial: a phase 1b study of GB004, an oral HIF-1\u03b1 stabiliser, for treatment of ulcerative colitis","volume":"55","author":"Danese","year":"2022","journal-title":"Aliment. Pharm. Ther."},{"key":"10.1016\/j.phymed.2025.156792_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.139936","article-title":"Large-leaf yellow tea protein derived-peptides alleviated dextran sodium sulfate-induced acute colitis and restored intestinal microbiota balance in C57BL\/6J mice","volume":"456","author":"Ge","year":"2024","journal-title":"Food Chem."},{"key":"10.1016\/j.phymed.2025.156792_bib0009","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.foodchem.2018.12.066","article-title":"Aroma compositions of large-leaf yellow tea and potential effect of theanine on volatile formation in tea","volume":"280","author":"Guo","year":"2019","journal-title":"Food Chem."},{"issue":"8","key":"10.1016\/j.phymed.2025.156792_bib0010","doi-asserted-by":"crossref","first-page":"3834","DOI":"10.7150\/thno.70668","article-title":"Orally administered titanium carbide nanosheets as anti-inflammatory therapy for colitis","volume":"12","author":"Hou","year":"2022","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.phymed.2025.156792_bib0011","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s13073-020-00796-5","article-title":"Integrated analysis of microbiome and host transcriptome reveals correlations between gut microbiota and clinical outcomes in HBV-related hepatocellular carcinoma","volume":"12","author":"Huang","year":"2020","journal-title":"Genome Med."},{"issue":"6","key":"10.1016\/j.phymed.2025.156792_bib0012","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1002\/hep.31228","article-title":"Intestinal ntestinal microbiome-macrophage crosstalk contributes to cholestatic liver disease by promoting intestinal permeability in mice","volume":"72","author":"Isaacs-Ten","year":"2020","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.phymed.2025.156792_bib0013","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1093\/ibd\/izac219","article-title":"Colonic epithelial circadian disruption worsens dextran sulfate sodium-induced colitis","volume":"29","author":"Jochum","year":"2023","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.phymed.2025.156792_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2023.136783","article-title":"Tea (Camellia sinensis (L.) Kuntze) as an emerging source of protein and bioactive peptides: a narrative review","volume":"428","author":"Kumar","year":"2023","journal-title":"Food Chem."},{"issue":"Supplement_1","key":"10.1016\/j.phymed.2025.156792_bib0015","doi-asserted-by":"crossref","first-page":"i2101","DOI":"10.1093\/ecco-jcc\/jjad212.1308","article-title":"Detection of occult liver disease in patients with inflammatory bowel disease","volume":"18","author":"Ladr\u00f3n Abia","year":"2024","journal-title":"J. Crohns. Colitis"},{"issue":"1","key":"10.1016\/j.phymed.2025.156792_bib0016","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s40168-019-0637-2","article-title":"Sequence and cultivation study of muribaculaceae reveals novel species, host preference, and functional potential of this yet undescribed family","volume":"7","author":"Lagkouvardos","year":"2019","journal-title":"Microbiome"},{"issue":"7","key":"10.1016\/j.phymed.2025.156792_bib0017","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1136\/gutjnl-2020-321565","article-title":"Microbiota tryptophan metabolism induces aryl hydrocarbon receptor activation and improves alcohol-induced liver injury","volume":"70","author":"Laura","year":"2021","journal-title":"Gut"},{"issue":"10401","key":"10.1016\/j.phymed.2025.156792_bib0018","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0140-6736(23)00966-2","article-title":"Ulcerative colitis","volume":"402","author":"Le Berre","year":"2023","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.phymed.2025.156792_bib0019","first-page":"446","article-title":"The intestinal microbiome and paediatric liver disease","volume":"2","author":"Leung","year":"2017","journal-title":"Lancet Gastroenterol."},{"issue":"2","key":"10.1016\/j.phymed.2025.156792_bib0020","article-title":"Gut microbiota-derived 12-ketolithocholic acid suppresses the IL-17A secretion from colonic group 3 innate lymphoid cells to prevent the acute exacerbation of ulcerative colitis","volume":"15","author":"Li","year":"2023","journal-title":"Gut Microb."},{"issue":"1","key":"10.1016\/j.phymed.2025.156792_bib0021","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s40168-021-01064-3","article-title":"Enlightening the taxonomy darkness of human gut microbiomes with a cultured biobank","volume":"9","author":"Liu","year":"2021","journal-title":"Microbiome"},{"issue":"4","key":"10.1016\/j.phymed.2025.156792_bib0022","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR","volume":"25","author":"Livak","year":"2002","journal-title":"Methods"},{"issue":"11","key":"10.1016\/j.phymed.2025.156792_bib0023","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.4254\/wjh.v13.i11.1534","article-title":"Liver involvement in inflammatory bowel disease: what should the clinician know?","volume":"13","author":"Losurdo","year":"2021","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.phymed.2025.156792_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117990","article-title":"Banxia Xiexin decoction modulates gut microbiota and gut microbiota metabolism to alleviate DSS-induced ulcerative colitis","volume":"326","author":"Luo","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"12","key":"10.1016\/j.phymed.2025.156792_bib0025","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1111\/apt.16949","article-title":"Systematic review-pancreatic involvement in inflammatory bowel disease","volume":"55","author":"Massironi","year":"2022","journal-title":"Aliment. Pharm. Ther."},{"issue":"6","key":"10.1016\/j.phymed.2025.156792_bib0026","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.jhep.2020.01.014","article-title":"FXR-dependent Rubicon induction impairs autophagy in models of human cholestasis","volume":"72","author":"Panzitt","year":"2020","journal-title":"J. Hepatol."},{"issue":"3","key":"10.1016\/j.phymed.2025.156792_bib0027","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.cmet.2020.02.008","article-title":"When rhythms meet the blues: circadian interactions with the microbiota-gut-brain axis","volume":"31","author":"Teichman","year":"2020","journal-title":"Cell Metab."},{"issue":"15","key":"10.1016\/j.phymed.2025.156792_bib0028","doi-asserted-by":"crossref","first-page":"eade5041","DOI":"10.1126\/sciadv.ade5041","article-title":"Milk-derived extracellular vesicles protect intestinal barrier integrity in the gut-liver axis","volume":"9","author":"Tong","year":"2023","journal-title":"Sci. Adv."},{"issue":"3","key":"10.1016\/j.phymed.2025.156792_bib0029","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.cels.2020.02.008","article-title":"Gut-liver physiomimetics reveal paradoxical modulation of IBD-related inflammation by short-chain fatty acids","volume":"10","author":"Trapecar","year":"2020","journal-title":"Cell Syst."},{"issue":"19","key":"10.1016\/j.phymed.2025.156792_bib0030","doi-asserted-by":"crossref","first-page":"12117","DOI":"10.1021\/acsnano.3c11257","article-title":"Inhibiting the cGAS-STING pathway in ulcerative colitis with programmable micelles","volume":"18","author":"Uthaman","year":"2024","journal-title":"Acs Nano"},{"issue":"9","key":"10.1016\/j.phymed.2025.156792_bib0031","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/s41419-020-02959-z","article-title":"Matrix metalloproteinase 9 (MMP9) limits reactive oxygen species (ROS) accumulation and DNA damage in colitis-associated cancer","volume":"11","author":"Walter","year":"2020","journal-title":"Cell Death. Dis."},{"issue":"20","key":"10.1016\/j.phymed.2025.156792_bib0032","doi-asserted-by":"crossref","first-page":"9337","DOI":"10.1039\/D3FO01691A","article-title":"Large yellow tea polysaccharides ameliorate obesity-associated metabolic syndrome by promoting M2 polarization of adipose tissue macrophages","volume":"14","author":"Wang","year":"2023","journal-title":"Food Funct."},{"issue":"4","key":"10.1016\/j.phymed.2025.156792_bib0033","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1039\/D1FO03405G","article-title":"Large-leaf yellow tea attenuates high glucose-induced vascular endothelial cell injury by up-regulating autophagy and down-regulating oxidative stress","volume":"13","author":"Wang","year":"2022","journal-title":"Food Funct."},{"issue":"1","key":"10.1016\/j.phymed.2025.156792_bib0034","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41423-020-00592-6","article-title":"Gut microbiome, liver immunology, and liver diseases","volume":"18","author":"Wang","year":"2021","journal-title":"Cell Mol. Immunol."},{"issue":"1","key":"10.1016\/j.phymed.2025.156792_bib0035","doi-asserted-by":"crossref","first-page":"4246","DOI":"10.1038\/s41467-018-06568-5","article-title":"REV-erb\u03b1 integrates colon clock with experimental colitis through regulation of NF-\u03bab\/NLRP3 axis","volume":"9","author":"Wang","year":"2018","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.phymed.2025.156792_bib0036","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.7150\/ijbs.80441","article-title":"Olfactomedin-4 deletion exacerbates DSS-induced colitis through a matrix metalloproteinase-9-dependent mechanism","volume":"19","author":"Wang","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.phymed.2025.156792_bib0037","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.eng.2023.10.016","article-title":"Procyanidin C1 modulates the microbiome to increase FOXO1 signaling and valeric acid levels to protect the mucosal barrier in inflammatory bowel disease","volume":"42","author":"Wang","year":"2024","journal-title":"Engineering"},{"issue":"8049","key":"10.1016\/j.phymed.2025.156792_bib0038","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/s41586-024-08379-9","article-title":"Host metabolism balances microbial regulation of bile acid signalling","volume":"638","author":"Won","year":"2025","journal-title":"Nature"},{"issue":"suppl_2","key":"10.1016\/j.phymed.2025.156792_bib0039","doi-asserted-by":"crossref","first-page":"W720","DOI":"10.1093\/nar\/gkl167","article-title":"KOBAS server: a web-based platform for automated annotation and pathway identification","volume":"34","author":"Wu","year":"2006","journal-title":"Nucleic. Acids. Res."},{"issue":"10","key":"10.1016\/j.phymed.2025.156792_bib0040","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1111\/pbi.13111","article-title":"Tea plant information archive: a comprehensive genomics and bioinformatics platform for tea plant","volume":"17","author":"Xia","year":"2019","journal-title":"Plant Biotechnol. J."},{"issue":"10","key":"10.1016\/j.phymed.2025.156792_bib0041","doi-asserted-by":"crossref","first-page":"5466","DOI":"10.1039\/D3FO04413K","article-title":"Wheat peptide alleviates DSS-induced colitis by activating the Keap1-Nrf2 signaling pathway and maintaining the integrity of the gut barrier","volume":"15","author":"Xie","year":"2024","journal-title":"Food Funct."},{"issue":"1","key":"10.1016\/j.phymed.2025.156792_bib0042","article-title":"Oscillospira - a candidate for the next-generation probiotics","volume":"13","author":"Yang","year":"2021","journal-title":"Gut. Microb."},{"issue":"23","key":"10.1016\/j.phymed.2025.156792_bib0043","doi-asserted-by":"crossref","first-page":"8894","DOI":"10.1021\/acs.jafc.2c08897","article-title":"Integrated microbiome and metabolomic analysis reveal the repair mechanisms of ovalbumin on the intestine barrier of colitis mice","volume":"71","author":"Yang","year":"2023","journal-title":"J. Agric. Food Chem."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325004301?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325004301?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T21:48:23Z","timestamp":1773352103000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325004301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":43,"alternative-id":["S0944711325004301"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156792","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tea residue protein-derived oligopeptides attenuate DSS-induced acute colitis complicated with hepatic injury in C57BL\/6J mice by regulating the gut-microbiome-liver axis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156792","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156792"}}