{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T03:49:23Z","timestamp":1789616963958,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073980"],"award-info":[{"award-number":["82073980"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.phymed.2025.156807","type":"journal-article","created":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T14:42:50Z","timestamp":1745678570000},"page":"156807","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Psoralen alleviates acute lung injury by covalently targeting Cys106 of HMGB1 in macrophages to inhibit inflammatory responses"],"prefix":"10.1016","volume":"142","author":[{"given":"Yixu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4935-315X","authenticated-orcid":false,"given":"Min","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.156807_bib0001","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s10020-020-00172-4","article-title":"Extracellular HMGB1: a therapeutic target in severe pulmonary inflammation including COVID-19?","volume":"26","author":"Andersson","year":"2020","journal-title":"Mol. Med."},{"key":"10.1016\/j.phymed.2025.156807_bib0002","doi-asserted-by":"crossref","DOI":"10.1002\/ddr.22132","article-title":"Covalent inhibitors: an ambitious approach for the discovery of newer oncotherapeutics","volume":"85","author":"Cheke","year":"2024","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.phymed.2025.156807_bib0003","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1007\/s11033-012-2256-x","article-title":"The melanocortin 1 receptor (MC1R) inhibits the inflammatory response in Raw 264.7 cells and atopic dermatitis (AD) mouse model","volume":"40","author":"Chen","year":"2013","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.phymed.2025.156807_bib0004","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/s41401-021-00676-7","article-title":"Targeting HMGB1 for the treatment of sepsis and sepsis-induced organ injury","volume":"43","author":"Deng","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2025.156807_bib0005","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1111\/jcmm.13048","article-title":"Emerging role of HMGB1 in lung diseases: friend or foe","volume":"21","author":"Ding","year":"2017","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.phymed.2025.156807_bib0006","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/cbin.11205","article-title":"Psoralen attenuates bleomycin-induced pulmonary fibrosis in mice through inhibiting myofibroblast activation and collagen deposition","volume":"44","author":"Du","year":"2020","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.phymed.2025.156807_bib0007","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/17512433.2024.2306223","article-title":"Metformin adverse event profile: a pharmacovigilance study based on the FDA Adverse Event Reporting System (FAERS) from 2004 to 2022","volume":"17","author":"Du","year":"2024","journal-title":"Expert Rev. Clin. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156807_bib0008","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.redox.2014.01.013","article-title":"Inhibition of extracellular HMGB1 attenuates hyperoxia-induced inflammatory acute lung injury","volume":"2","author":"Entezari","year":"2014","journal-title":"Redox Biol."},{"key":"10.1016\/j.phymed.2025.156807_bib0009","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1056\/NEJMra2026131","article-title":"Cytokine storm","volume":"383","author":"Fajgenbaum","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phymed.2025.156807_bib0010","first-page":"2526","article-title":"Acute respiratory distress syndrome: the Berlin definition","volume":"307","author":"Force","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.phymed.2025.156807_bib0011","doi-asserted-by":"crossref","first-page":"8436","DOI":"10.1074\/jbc.M116.769380","article-title":"Metformin directly binds the alarmin HMGB1 and inhibits its proinflammatory activity","volume":"292","author":"Horiuchi","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2025.156807_bib0012","doi-asserted-by":"crossref","first-page":"7225","DOI":"10.2147\/JIR.S334043","article-title":"Acute Respiratory Distress Syndrome and COVID-19: a literature review","volume":"14","author":"Hussain","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.phymed.2025.156807_bib0013","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231911740","article-title":"Cytokine storm-definition, causes, and implications","volume":"23","author":"Jarczak","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2025.156807_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154165","article-title":"Psoralen induces hepatotoxicity by covalently binding to glutathione-S-transferases and the hepatic cytochrome P450","volume":"104","author":"Jiang","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.156807_bib0015","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1142\/S0192415X14500438","article-title":"Effects of Psoraleae fructus and its major component psoralen on Th2 response in allergic asthma","volume":"42","author":"Jin","year":"2014","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.phymed.2025.156807_bib0016","doi-asserted-by":"crossref","first-page":"4906","DOI":"10.1021\/jm00025a008","article-title":"Structure-activity relationship of omeprazole and analogues as Helicobacter pylori urease inhibitors","volume":"38","author":"Kuhler","year":"1995","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.phymed.2025.156807_bib0017","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1021\/ja5112964","article-title":"Mechanistic insights into a classic wonder drug\u2013aspirin","volume":"137","author":"Lei","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.phymed.2025.156807_bib0018","first-page":"406","article-title":"Inhalable and bioactive lipid-nanomedicine based on bergapten for targeted acute lung injury therapy via orchestrating macrophage polarization","volume":"43","author":"Liao","year":"2025","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.phymed.2025.156807_bib0019","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nri1594","article-title":"High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal","volume":"5","author":"Lotze","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.phymed.2025.156807_bib0020","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1002\/hep.28736","article-title":"A novel high mobility group box 1 neutralizing chimeric antibody attenuates drug-induced liver injury and postinjury inflammation in mice","volume":"64","author":"Lundback","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2025.156807_bib0021","doi-asserted-by":"crossref","first-page":"138","DOI":"10.2119\/molmed.2013.00164","article-title":"The role of HMGB1 in the pathogenesis of inflammatory and autoimmune diseases","volume":"20","author":"Magna","year":"2014","journal-title":"Mol. Med."},{"key":"10.1016\/j.phymed.2025.156807_bib0022","doi-asserted-by":"crossref","DOI":"10.1172\/JCI170501","article-title":"Alveolar macrophages in tissue homeostasis, inflammation, and infection: evolving concepts of therapeutic targeting","volume":"133","author":"Malainou","year":"2023","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2025.156807_bib0023","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/S0140-6736(21)00439-6","article-title":"Acute respiratory distress syndrome","volume":"398","author":"Meyer","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2025.156807_bib0024","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.chembiol.2007.03.007","article-title":"Glycyrrhizin binds to high-mobility group box 1 protein and inhibits its cytokine activities","volume":"14","author":"Mollica","year":"2007","journal-title":"Chem. Biol."},{"key":"10.1016\/j.phymed.2025.156807_bib0025","doi-asserted-by":"crossref","first-page":"e74","DOI":"10.1097\/CCM.0b013e3181cc5373","article-title":"Nonventilatory strategies for patients with life-threatening 2009 H1N1 influenza and severe respiratory failure","volume":"38","author":"Napolitano","year":"2010","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.phymed.2025.156807_bib0026","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1056\/NEJMoa062200","article-title":"Comparison of two fluid-management strategies in acute lung injury","volume":"354","author":"National Heart","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phymed.2025.156807_bib0027","first-page":"129","article-title":"Cytokine storm plays a direct role in the morbidity and mortality from influenza virus infection and is chemically treatable with a single sphingosine-1-phosphate agonist molecule","volume":"378","author":"Oldstone","year":"2014","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.phymed.2025.156807_bib0028","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.12659\/MSM.912867","article-title":"High-mobility group box 1 (HMGB1) and autophagy in acute lung injury (ALI): a review","volume":"25","author":"Qu","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.phymed.2025.156807_bib0029","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.3390\/cells10112921","article-title":"The role of glucocorticoids in inflammatory diseases","volume":"10","author":"Reichardt","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.phymed.2025.156807_bib0030","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.571535","article-title":"A review of the pharmacological properties of Psoralen","volume":"11","author":"Ren","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156807_bib0031","doi-asserted-by":"crossref","first-page":"663","DOI":"10.3390\/ph16050663","article-title":"Recent advances in covalent drug discovery","volume":"16","author":"Schaefer","year":"2023","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.phymed.2025.156807_bib0033","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nrd3410","article-title":"The resurgence of covalent drugs","volume":"10","author":"Singh","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.phymed.2025.156807_bib0034","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1056\/NEJMoa0708638","article-title":"Mechanical ventilation guided by esophageal pressure in acute lung injury","volume":"359","author":"Talmor","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phymed.2025.156807_bib0035","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1089\/ars.2015.6409","article-title":"Regulation of posttranslational modifications of HMGB1 during immune responses","volume":"24","author":"Tang","year":"2016","journal-title":"Antioxid. Redox. Signal."},{"key":"10.1016\/j.phymed.2025.156807_bib0036","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202300867","article-title":"Phytochemical and pharmacological aspects of Psoralen - A bioactive furanocoumarin from Psoralea corylifolia Linn","volume":"20","author":"Tripathi","year":"2023","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.phymed.2025.156807_bib0037","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/imm.13623","article-title":"The role of HMGB1 in COVID-19-induced cytokine storm and its potential therapeutic targets: a review","volume":"169","author":"Wulandari","year":"2023","journal-title":"Immunology"},{"key":"10.1016\/j.phymed.2025.156807_bib0038","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1038\/s41401-022-01040-z","article-title":"Tabersonine, a natural NLRP3 inhibitor, suppresses inflammasome activation in macrophages and attenuate NLRP3-driven diseases in mice","volume":"44","author":"Xu","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2025.156807_bib0039","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1073\/pnas.76.6.2730","article-title":"Mechanism of penicillin action: penicillin and substrate bind covalently to the same active site serine in two bacterial d-alanine carboxypeptidases","volume":"76","author":"Yocum","year":"1979","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phymed.2025.156807_bib0040","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1021\/acscentsci.2c01424","article-title":"Macrophage inactivation by small molecule wedelolactone via targeting sEH for the treatment of LPS-induced acute lung injury","volume":"9","author":"Zhang","year":"2023","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.phymed.2025.156807_bib0041","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.bcp.2015.08.109","article-title":"Toll-like receptor 4 signaling: a common pathway for interactions between prooxidants and extracellular disulfide high mobility group box 1 (HMGB1) protein-coupled activation","volume":"98","author":"Zhang","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156807_bib0042","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.697071","article-title":"Roles of RAGE\/ROCK1 pathway in HMGB1-induced early changes in barrier permeability of Human pulmonary microvascular endothelial cell","volume":"12","author":"Zhao","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2025.156807_bib0043","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/jcmm.14703","article-title":"Glycyrrhizin mitigates radiation-induced acute lung injury by inhibiting the HMGB1\/TLR4 signalling pathway","volume":"24","author":"Zheng","year":"2020","journal-title":"J. Cell Mol. Med."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325004453?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325004453?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T21:45:21Z","timestamp":1773351921000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325004453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":42,"alternative-id":["S0944711325004453"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156807","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Psoralen alleviates acute lung injury by covalently targeting Cys106 of HMGB1 in macrophages to inhibit inflammatory responses","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156807","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156807"}}