{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:16:17Z","timestamp":1792707377342,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011798","name":"Ministry of Agriculture and Rural Affairs of the People's Republic of China","doi-asserted-by":"publisher","award":["CARS-35"],"award-info":[{"award-number":["CARS-35"]}],"id":[{"id":"10.13039\/501100011798","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010203","name":"Agriculture Research System of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010203","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD1800903-2"],"award-info":[{"award-number":["2023YFD1800903-2"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32072908"],"award-info":[{"award-number":["32072908"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["OEP003793"],"award-info":[{"award-number":["OEP003793"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.phymed.2025.156821","type":"journal-article","created":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T11:37:53Z","timestamp":1746099473000},"page":"156821","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Effect of emodin on Streptococcus suis by targeting \u03b2-ketoacyl-acyl carrier protein synthase \u2161"],"prefix":"10.1016","volume":"143","author":[{"given":"Jun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongxiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sikai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijia","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunliu","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianwei","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3645-7024","authenticated-orcid":false,"given":"Yanhua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.156821_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.ultsonch.2023.106733","article-title":"Ultrasound-assisted extraction of emodin from Rheum officinale Baill and its antibacterial mechanism against Streptococcus suis based on CcpA","volume":"102","author":"Bai","year":"2024","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.phymed.2025.156821_bib0002","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1038\/s41564-023-01369-z","article-title":"Inhibiting fatty acid synthesis overcomes colistin resistance","volume":"8","author":"Carfrae","year":"2023","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.phymed.2025.156821_bib0003","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1471-2180-9-91","article-title":"Emodin targets the beta-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: enzymatic inhibition assay with crystal structural and thermodynamic characterization","volume":"9","author":"Chen","year":"2009","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.phymed.2025.156821_bib0004","series-title":"CLSI Supplement M100","article-title":"Performance standards for antimicrobial susceptibility testing","year":"2024"},{"key":"10.1016\/j.phymed.2025.156821_bib0005","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0005-2728(89)80219-1","article-title":"On the nature of ion leaks in energy-transducing membranes","volume":"976","author":"Garlid","year":"1989","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.phymed.2025.156821_bib0006","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1021\/acs.accounts.0c00687","article-title":"LAURDAN since weber: the quest for visualizing membrane heterogeneity","volume":"54","author":"Gunther","year":"2021","journal-title":"Account Chem. Res."},{"key":"10.1016\/j.phymed.2025.156821_bib0007","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1038\/nprot.2014.138","article-title":"The cellular thermal shift assay for evaluating drug target interactions in cells","volume":"9","author":"Jafari","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.phymed.2025.156821_bib0008","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1128\/AAC.42.5.1207","article-title":"Influence of test conditions on antifungal time-kill curve results: proposal for standardized methods","volume":"42","author":"Klepser","year":"1998","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.phymed.2025.156821_bib0009","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00676-21","article-title":"Active efflux leads to heterogeneous dissipation of proton motive force by protonophores in bacteria","volume":"12","author":"Le","year":"2021","journal-title":"mBio"},{"key":"10.1016\/j.phymed.2025.156821_bib0010","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cell.2020.02.056","article-title":"The science of antibiotic discovery","volume":"181","author":"Lewis","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2025.156821_bib0011","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.micres.2016.03.008","article-title":"The antibacterial activity and action mechanism of emodin from Polygonum cuspidatum against Haemophilus parasuis in vitro","volume":"186-187","author":"Li","year":"2016","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.phymed.2025.156821_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.128645","article-title":"Sodium dehydroacetate confers broad antibiotic tolerance by remodeling bacterial metabolism","volume":"432","author":"Liu","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.phymed.2025.156821_bib0014","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.chembiol.2016.12.015","article-title":"Carbon sources tune antibiotic susceptibility in Pseudomonas aeruginosa via tricarboxylic acid cycle control","volume":"24","author":"Meylan","year":"2017","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.phymed.2025.156821_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155400","article-title":"Discovery of gambogic acid as an antibacterial adjuvant against vancomycin-resistant enterococci in vitro and in vivo","volume":"128","author":"Pang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.156821_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.133284","article-title":"Preparation of polyclonal antibody against thrombospondin 2 recombinant protein and its functional verification in pulmonary hypertension syndrome in broilers","volume":"274","author":"Peng","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2025.156821_bib0017","doi-asserted-by":"crossref","first-page":"6894","DOI":"10.1021\/acs.jafc.2c06991","article-title":"Gallic scid restores the sulfonamide sensitivity of multidrug-resistant Streptococcus suis via polypharmaceology mechanism","volume":"71","author":"Qu","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2025.156821_bib0018","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1146\/annurev-micro-041320-110408","article-title":"Mining fatty acid biosynthesis for new antimicrobials","volume":"76","author":"Radka","year":"2022","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.phymed.2025.156821_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.104799","article-title":"AdipoR2 recruits protein interactors to promote fatty acid elongation and membrane fluidity","volume":"299","author":"Ruiz","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2025.156821_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113555","article-title":"Recent advances in the therapeutic potential of emodin for human health","volume":"154","author":"Sharifi-Rad","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2025.156821_bib0021","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1038\/s41564-020-0723-z","article-title":"A broad-spectrum antibiotic adjuvant reverses multidrug-resistant gram-negative pathogens","volume":"5","author":"Song","year":"2020","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.phymed.2025.156821_bib0022","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s13567-022-01111-3","article-title":"How Streptococcus suis escapes antibiotic treatments","volume":"53","author":"Uru\u00e9n","year":"2022","journal-title":"Vet. Res."},{"key":"10.1016\/j.phymed.2025.156821_bib0023","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.768890","article-title":"Effects of antibacterial peptide F1 on bacterial liposome membrane integrity","volume":"8","author":"Wang","year":"2021","journal-title":"Front. Nutr."},{"key":"10.1016\/j.phymed.2025.156821_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155421","article-title":"Gramine sensitizes Klebsiella pneumoniae to tigecycline killing","volume":"126","author":"Xiao","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.156821_bib0025","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.3892\/etm.2014.1857","article-title":"Effect of emodin on the cariogenic properties of Streptococcus mutans and the development of caries in rats","volume":"8","author":"Xu","year":"2014","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.phymed.2025.156821_bib0026","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1007\/s00203-017-1396-8","article-title":"The effect of emodin on Staphylococcus aureus strains in planktonic form and biofilm formation in vitro","volume":"199","author":"Yan","year":"2017","journal-title":"Arch. Microbiol."},{"key":"10.1016\/j.phymed.2025.156821_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155732","article-title":"In vitro and in vivo enhancement effect of glabridin on the antibacterial activity of colistin, against multidrug resistant Escherichia coli strains","volume":"130","author":"Yang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.156821_bib0028","doi-asserted-by":"crossref","first-page":"5940","DOI":"10.1074\/jbc.R114.636241","article-title":"How bacterial pathogens eat host lipids: implications for the development of fatty acid synthesis therapeutics","volume":"290","author":"Yao","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2025.156821_bib0030","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2118566119","article-title":"A broadly applicable, stress-mediated bacterial death pathway regulated by the phosphotransferase system (PTS) and the cAMP-crp cascade","volume":"119","author":"Zeng","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.phymed.2025.156821_bib0031","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/5026103","article-title":"Emodin ameliorates intestinal dysfunction by maintaining intestinal barrier integrity and modulating the microbiota in septic mice","volume":"2022","author":"Zhang","year":"2022","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.phymed.2025.156821_bib0032","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nrmicro1839","article-title":"Membrane lipid homeostasis in bacteria","volume":"6","author":"Zhang","year":"2008","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.phymed.2025.156821_bib0033","doi-asserted-by":"crossref","DOI":"10.1080\/21505594.2024.2367647","article-title":"Exogenous NADH promotes the bactericidal effect of aminoglycoside antibiotics against Edwardsiella tarda","volume":"15","author":"Zhong","year":"2024","journal-title":"Virulence"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325004593?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325004593?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T04:17:57Z","timestamp":1778559477000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325004593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":31,"alternative-id":["S0944711325004593"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156821","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of emodin on Streptococcus suis by targeting \u03b2-ketoacyl-acyl carrier protein synthase \u2161","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156821","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156821"}}