{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:30:30Z","timestamp":1787751030770,"version":"build-2784847793"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971329"],"award-info":[{"award-number":["81971329"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200821"],"award-info":[{"award-number":["82200821"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32341004"],"award-info":[{"award-number":["32341004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371758"],"award-info":[{"award-number":["82371758"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515140075"],"award-info":[{"award-number":["2022A1515140075"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515010600"],"award-info":[{"award-number":["2024A1515010600"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515012922"],"award-info":[{"award-number":["2024A1515012922"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515010528"],"award-info":[{"award-number":["2022A1515010528"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515012838"],"award-info":[{"award-number":["2023A1515012838"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021B1515130004"],"award-info":[{"award-number":["2021B1515130004"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515140062"],"award-info":[{"award-number":["2022A1515140062"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20240813154919025"],"award-info":[{"award-number":["JCYJ20240813154919025"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.phymed.2025.156846","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T02:30:12Z","timestamp":1747362612000},"page":"156846","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["18\u03b2-glycyrrhetinic acid mitigates lipotoxicity-induced premature senescence of tubular epithelial cells by activating SIRT1-TFEB signaling"],"prefix":"10.1016","volume":"143","author":[{"given":"Meng","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihui","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengquan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiheng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haochang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiting","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suidong","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3851-8553","authenticated-orcid":false,"given":"Min","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonghua","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinguang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.156846_bib0001","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1080\/0886022X.2016.1216722","article-title":"18beta-Glycyrrhetinic acid protects against methotrexate-induced kidney injury by up-regulating the Nrf2\/ARE\/HO-1 pathway and endogenous antioxidants","volume":"38","author":"Abd El-Twab","year":"2016","journal-title":"Ren. Fail."},{"key":"10.1016\/j.phymed.2025.156846_bib0002","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1002\/jsfa.10215","article-title":"The effects of hydroalcoholic extract of spinach on prevention and treatment of some metabolic and histologic features in a rat model of nonalcoholic fatty liver disease","volume":"100","author":"Amirinejad","year":"2020","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.phymed.2025.156846_bib0003","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/s12906-021-03396-x","article-title":"Administration of hydro-alcoholic extract of spinach improves oxidative stress and inflammation in high-fat diet-induced NAFLD rats","volume":"21","author":"Amirinejad","year":"2021","journal-title":"BMC. Complement. Med. Ther."},{"key":"10.1016\/j.phymed.2025.156846_bib0004","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s13238-016-0269-2","article-title":"Deacetylation of TFEB promotes fibrillar Abeta degradation by upregulating lysosomal biogenesis in microglia","volume":"7","author":"Bao","year":"2016","journal-title":"Protein Cell"},{"key":"10.1016\/j.phymed.2025.156846_bib0005","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nrd3738","article-title":"Are sirtuins viable targets for improving healthspan and lifespan?","volume":"11","author":"Baur","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.phymed.2025.156846_bib0006","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3389\/fphar.2018.00034","article-title":"HDAC6 inhibition promotes transcription factor EB activation and is protective in experimental kidney disease","volume":"9","author":"Brijmohan","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156846_bib0007","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1007\/s11011-022-01027-z","article-title":"Neuroprotective effects of 18beta-glycyrrhetinic acid against bisphenol A-induced neurotoxicity in rats: involvement of neuronal apoptosis, endoplasmic reticulum stress and JAK1\/STAT1 signaling pathway","volume":"37","author":"Caglayan","year":"2022","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.phymed.2025.156846_bib0008","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3389\/fnagi.2014.00103","article-title":"SIRT1 ameliorates age-related senescence of mesenchymal stem cells via modulating telomere shelterin","volume":"6","author":"Chen","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.phymed.2025.156846_bib0009","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s00204-017-2048-0","article-title":"Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity","volume":"92","author":"Cheng","year":"2018","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.phymed.2025.156846_bib0010","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.cmet.2019.08.003","article-title":"Mitochondrial damage and activation of the STING pathway lead to renal inflammation and fibrosis","volume":"30","author":"Chung","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.phymed.2025.156846_bib0011","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1681\/ASN.2017070802","article-title":"Impairment of PPARalpha and the fatty acid oxidation pathway aggravates renal fibrosis during aging","volume":"29","author":"Chung","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.phymed.2025.156846_bib0012","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1002\/ptr.6972","article-title":"Effect of Portulaca Oleracea (purslane) extract on liver enzymes, lipid profile, and glycemic status in nonalcoholic fatty liver disease: a randomized, double-blind clinical trial","volume":"35","author":"Darvish Damavandi","year":"2021","journal-title":"PhytOther Res."},{"key":"10.1016\/j.phymed.2025.156846_bib0013","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1053\/j.gastro.2010.07.041","article-title":"Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice","volume":"139","author":"Ding","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phymed.2025.156846_bib0014","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1681\/ASN.2018121251","article-title":"Cellular senescence in the kidney","volume":"30","author":"Docherty","year":"2019","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.phymed.2025.156846_bib0015","first-page":"12","article-title":"Klotho, oxidative stress, and mitochondrial damage in kidney disease","author":"Donate-Correa","year":"2023","journal-title":"Antioxid. (Basel)"},{"key":"10.1016\/j.phymed.2025.156846_bib0016","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S0140-6736(13)60439-0","article-title":"Evolving importance of kidney disease: from subspecialty to global health burden","volume":"382","author":"Eckardt","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2025.156846_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.hermed.2021.100525","article-title":"Effects of sumac (Rhus coriaria) on lipid profile, leptin and steatosis in patients with non-alcoholic fatty liver disease: a randomized double-blind placebo-controlled trial","volume":"31","author":"Ehsani","year":"2022","journal-title":"J. Herb. Med."},{"key":"10.1016\/j.phymed.2025.156846_bib0018","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1161\/CIRCRESAHA.118.312672","article-title":"Endothelial TFEB (transcription factor EB) positively regulates postischemic angiogenesis","volume":"122","author":"Fan","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.phymed.2025.156846_bib0019","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/nrneph.2018.9","article-title":"Mitochondrial dysfunction in diabetic kidney disease","volume":"14","author":"Forbes","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.phymed.2025.156846_bib0020","doi-asserted-by":"crossref","DOI":"10.3390\/nu11040722","article-title":"Lipid accumulation and chronic kidney disease","volume":"11","author":"Gai","year":"2019","journal-title":"Nutrients."},{"key":"10.1016\/j.phymed.2025.156846_bib0021","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.83353","article-title":"Empagliflozin reduces podocyte lipotoxicity in experimental Alport syndrome","volume":"12","author":"Ge","year":"2023","journal-title":"Elife"},{"key":"10.1016\/j.phymed.2025.156846_bib0022","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1038\/ki.2015.300","article-title":"Chinese herbal medicines and chronic kidney disease: a positive outcome in a large patient study in Taiwan","volume":"88","author":"Gobe","year":"2015","journal-title":"Kidney Int."},{"key":"10.1016\/j.phymed.2025.156846_bib0023","doi-asserted-by":"crossref","first-page":"7458","DOI":"10.1093\/nar\/gkq609","article-title":"SIRT1 is regulated by a PPARgamma-SIRT1 negative feedback loop associated with senescence","volume":"38","author":"Han","year":"2010","journal-title":"Nucleic. Acids. Res."},{"key":"10.1016\/j.phymed.2025.156846_bib0024","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1038\/s41419-021-04326-y","article-title":"Lipophagy deficiency exacerbates ectopic lipid accumulation and tubular cells injury in diabetic nephropathy","volume":"12","author":"Han","year":"2021","journal-title":"Cell Death. Dis."},{"key":"10.1016\/j.phymed.2025.156846_bib0025","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.immuni.2015.01.012","article-title":"DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity","volume":"42","author":"Hartlova","year":"2015","journal-title":"Immunity."},{"key":"10.1016\/j.phymed.2025.156846_bib0026","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/ncomms1001","article-title":"Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer","volume":"1","author":"Herranz","year":"2010","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2025.156846_bib0027","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.dsx.2020.01.002","article-title":"The effects of curcumin supplementation on oxidative stress, Sirtuin-1 and peroxisome proliferator activated receptor gamma coactivator 1alpha gene expression in polycystic ovarian syndrome (PCOS) patients: a randomized placebo-controlled clinical trial","volume":"14","author":"Heshmati","year":"2020","journal-title":"Diabetes. Metab. Syndr."},{"key":"10.1016\/j.phymed.2025.156846_bib0028","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1111\/cns.13114","article-title":"Exercise activates lysosomal function in the brain through AMPK-SIRT1-TFEB pathway","volume":"25","author":"Huang","year":"2019","journal-title":"CNS. Neurosci. Ther."},{"key":"10.1016\/j.phymed.2025.156846_bib0029","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/s41392-023-01379-7","article-title":"Kidney fibrosis: from mechanisms to therapeutic medicines","volume":"8","author":"Huang","year":"2023","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2025.156846_bib0030","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1194\/jlr.R067520","article-title":"Lipids, lysosomes, and autophagy","volume":"57","author":"Jaishy","year":"2016","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.phymed.2025.156846_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.134319","article-title":"18beta-Glycyrrhetinic acid protects against deoxynivalenol-induced liver injury via modulating ferritinophagy and mitochondrial quality control","volume":"471","author":"Jiang","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.phymed.2025.156846_bib0032","article-title":"Dual peroxisome-proliferator-activated-receptor-alpha\/gamma activation inhibits SIRT1-PGC1alpha axis and causes cardiac dysfunction","volume":"5","author":"Kalliora","year":"2019","journal-title":"JCI. Insight."},{"key":"10.1016\/j.phymed.2025.156846_bib0033","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nm.3762","article-title":"Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development","volume":"21","author":"Kang","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.phymed.2025.156846_bib0034","doi-asserted-by":"crossref","first-page":"284","DOI":"10.7762\/cnr.2020.9.4.284","article-title":"Effect of selenium supplementation on expression of SIRT1 and PGC-1alpha genes in ulcerative colitis patients: a double blind randomized clinical trial","volume":"9","author":"Khazdouz","year":"2020","journal-title":"Clin. Nutr. Res."},{"key":"10.1016\/j.phymed.2025.156846_bib0035","doi-asserted-by":"crossref","first-page":"E268","DOI":"10.1210\/jc.2010-1681","article-title":"Altered autophagy in human adipose tissues in obesity","volume":"96","author":"Kovsan","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.phymed.2025.156846_bib0036","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1681\/ASN.2007010089","article-title":"Role of altered renal lipid metabolism in the development of renal injury induced by a high-fat diet","volume":"18","author":"Kume","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.phymed.2025.156846_bib0037","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/s41420-023-01504-z","article-title":"The regulatory role of lipophagy in central nervous system diseases","volume":"9","author":"Lan","year":"2023","journal-title":"Cell Death. Discov."},{"key":"10.1016\/j.phymed.2025.156846_bib0038","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/s41419-022-04515-3","article-title":"STAT6 contributes to renal fibrosis by modulating PPARalpha-mediated tubular fatty acid oxidation","volume":"13","author":"Li","year":"2022","journal-title":"Cell Death. Dis."},{"key":"10.1016\/j.phymed.2025.156846_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.102649","article-title":"TFEB acetylation promotes lysosome biogenesis and ameliorates Alzheimer's disease-relevant phenotypes in mice","volume":"298","author":"Li","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2025.156846_bib0040","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1038\/ki.2015.226","article-title":"Association of prescribed Chinese herbal medicine use with risk of end-stage renal disease in patients with chronic kidney disease","volume":"88","author":"Lin","year":"2015","journal-title":"Kidney Int."},{"key":"10.1016\/j.phymed.2025.156846_bib0041","article-title":"A potential adjuvant chemotherapeutics, 18beta-glycyrrhetinic acid, inhibits renal tubular epithelial cells apoptosis via enhancing BMP-7 epigenetically through targeting HDAC2","volume":"6","author":"Ma","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2025.156846_bib0042","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cbi.2017.04.009","article-title":"Methotrexate hepatotoxicity is associated with oxidative stress, and down-regulation of PPARgamma and Nrf2: protective effect of 18beta-Glycyrrhetinic acid","volume":"270","author":"Mahmoud","year":"2017","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.phymed.2025.156846_bib0043","first-page":"195","article-title":"Docosahexaenoic acid-rich fish oil supplementation improves body composition without influence of the PPARgamma Pro12Ala polymorphism in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled clinical trial","volume":"8","author":"Mansoori","year":"2015","journal-title":"J Nutr. Nutr."},{"key":"10.1016\/j.phymed.2025.156846_bib0044","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.jacl.2015.08.007","article-title":"Effect of DHA-rich fish oil on PPARgamma target genes related to lipid metabolism in type 2 diabetes: a randomized, double-blind, placebo-controlled clinical trial","volume":"9","author":"Mansoori","year":"2015","journal-title":"J. Clin. Lipidol."},{"key":"10.1016\/j.phymed.2025.156846_bib0045","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/s41581-023-00741-w","article-title":"Kidney lipid dysmetabolism and lipid droplet accumulation in chronic kidney disease","volume":"19","author":"Mitrofanova","year":"2023","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.phymed.2025.156846_bib0046","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","article-title":"Autophagy: renovation of cells and tissues","volume":"147","author":"Mizushima","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2025.156846_bib0047","doi-asserted-by":"crossref","first-page":"720","DOI":"10.3390\/metabo5040720","article-title":"Obesity-related chronic kidney disease-the role of lipid metabolism","volume":"5","author":"Mount","year":"2015","journal-title":"Metabolites."},{"key":"10.1016\/j.phymed.2025.156846_bib0048","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1126\/science.1193497","article-title":"Autophagy and metabolism","volume":"330","author":"Rabinowitz","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.phymed.2025.156846_bib0049","first-page":"9968","article-title":"Oxidative stress, apoptosis, inflammation, and proliferation modulator function of visnagin provide gonadoprotective activity in testicular ischemia-reperfusion injury","volume":"27","author":"Sagir","year":"2023","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.phymed.2025.156846_bib0050","doi-asserted-by":"crossref","DOI":"10.1172\/JCI164486","article-title":"SGLT2 inhibitors mitigate kidney tubular metabolic and mTORC1 perturbations in youth-onset type 2 diabetes","volume":"133","author":"Schaub","year":"2023","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2025.156846_bib0051","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1080\/01480545.2024.2347541","article-title":"The nephroprotective effect of Quercetin in Cyclophosphamide-induced renal toxicity might be associated with MAPK\/ERK and NF-kappaB signal modulation activity","volume":"47","author":"Seker","year":"2024","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.phymed.2025.156846_bib0052","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/ncb2718","article-title":"TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop","volume":"15","author":"Settembre","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.phymed.2025.156846_bib0053","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1126\/science.1204592","article-title":"TFEB links autophagy to lysosomal biogenesis","volume":"332","author":"Settembre","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.phymed.2025.156846_bib0054","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/nature07976","article-title":"Autophagy regulates lipid metabolism","volume":"458","author":"Singh","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2025.156846_bib0055","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/sj.ki.5002039","article-title":"Accelerated expression of senescence associated cell cycle inhibitor p16INK4A in kidneys with glomerular disease","volume":"71","author":"Sis","year":"2007","journal-title":"Kidney Int."},{"key":"10.1016\/j.phymed.2025.156846_bib0056","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1053\/j.ajkd.2012.11.051","article-title":"Chronic kidney disease: a clinical model of premature aging","volume":"62","author":"Stenvinkel","year":"2013","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.phymed.2025.156846_bib0057","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1089\/rej.2008.0806","article-title":"Stimulation of autophagy by antilipolytic drugs may rescue rodents from age-associated hypercholesterolemia","volume":"12","author":"Straniero","year":"2009","journal-title":"Rejuvenation. Res."},{"key":"10.1016\/j.phymed.2025.156846_bib0058","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.105714","article-title":"Novel 18beta-glycyrrhetinic acid derivatives as a Two-in-One agent with potent antimicrobial and anti-inflammatory activity","volume":"122","author":"Tu","year":"2022","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.phymed.2025.156846_bib0059","doi-asserted-by":"crossref","first-page":"F1563","DOI":"10.1152\/ajprenal.90302.2008","article-title":"Accelerated senescence in the kidneys of patients with type 2 diabetic nephropathy","volume":"295","author":"Verzola","year":"2008","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.phymed.2025.156846_bib0060","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/s41586-023-06621-4","article-title":"Apoptotic stress causes mtDNA release during senescence and drives the SASP","volume":"622","author":"Victorelli","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2025.156846_bib0061","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2021.111403","article-title":"Cellular senescence and the senescence-associated secretory phenotype: potential therapeutic targets for renal fibrosis","volume":"151","author":"Wang","year":"2021","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.phymed.2025.156846_bib0062","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2019.110591","article-title":"Role of TFEB in autophagic modulation of ischemia reperfusion injury in mice kidney and protection by urolithin A","volume":"131","author":"Wang","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.phymed.2025.156846_bib0063","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/S0140-6736(16)32064-5","article-title":"Chronic Kidney Disease","volume":"389","author":"Webster","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2025.156846_bib0064","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155524","article-title":"Anti-psoriasis effect of 18beta-glycyrrhetinic acid by breaking CCL20\/CCR6 axis through its vital active group targeting GUSB\/ATF2 signaling","volume":"128","author":"Wei","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.156846_bib0065","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nature14156","article-title":"Mitochondrial DNA stress primes the antiviral innate immune response","volume":"520","author":"West","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2025.156846_bib0066","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1021\/jf505471a","article-title":"Protective Effects of glycyrrhizic acid and 18beta-glycyrrhetinic acid against cisplatin-induced nephrotoxicity in BALB\/c mice","volume":"63","author":"Wu","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2025.156846_bib0067","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpb.2023.110894","article-title":"SIRT1-NRF2-TFEB axis-mediated hepatic lipophagy alleviates the lipid deposition induced by high glucose in yellow catfish Pelteobagrus fulvidraco","volume":"269","author":"Wu","year":"2024","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"key":"10.1016\/j.phymed.2025.156846_bib0068","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1681\/ASN.2016070731","article-title":"High-fat diet-induced lysosomal dysfunction and impaired autophagic flux contribute to lipotoxicity in the kidney","volume":"28","author":"Yamamoto","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.phymed.2025.156846_bib0069","doi-asserted-by":"crossref","first-page":"10874","DOI":"10.7150\/thno.47037","article-title":"Dysfunction of estrogen-related receptor alpha-dependent hepatic VLDL secretion contributes to sex disparity in NAFLD\/NASH development","volume":"10","author":"Yang","year":"2020","journal-title":"Theranostics."},{"key":"10.1016\/j.phymed.2025.156846_bib0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104840","article-title":"18beta-Glycyrrhetinic acid acts through hepatocyte nuclear factor 4 alpha to modulate lipid and carbohydrate metabolism","volume":"157","author":"Yang","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2025.156846_bib0071","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.clnu.2017.04.007","article-title":"Changes of renal sinus fat and renal parenchymal fat during an 18-month randomized weight loss trial","volume":"37","author":"Zelicha","year":"2018","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.phymed.2025.156846_bib0072","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/s41419-022-04593-3","article-title":"The regulation, function, and role of lipophagy, a form of selective autophagy, in metabolic disorders","volume":"13","author":"Zhang","year":"2022","journal-title":"Cell Death. Dis."},{"key":"10.1016\/j.phymed.2025.156846_bib0073","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/s41420-020-0265-4","article-title":"Regulation of TFEB activity and its potential as a therapeutic target against kidney diseases","volume":"6","author":"Zhang","year":"2020","journal-title":"Cell Death. Discov."},{"key":"10.1016\/j.phymed.2025.156846_bib0074","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.theriogenology.2024.10.010","article-title":"Effects of PPARG on the proliferation, apoptosis, and estrogen secretion in goat granulosa cells","volume":"231","author":"Zhao","year":"2025","journal-title":"Theriogenology"},{"key":"10.1016\/j.phymed.2025.156846_bib0075","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.7150\/thno.50905","article-title":"Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance","volume":"11","author":"Zhao","year":"2021","journal-title":"Theranostics."},{"key":"10.1016\/j.phymed.2025.156846_bib0076","doi-asserted-by":"crossref","first-page":"7096","DOI":"10.18632\/aging.202566","article-title":"Berberine-induced TFEB deacetylation by SIRT1 promotes autophagy in peritoneal macrophages","volume":"13","author":"Zheng","year":"2021","journal-title":"Aging (Albany. NY)"},{"key":"10.1016\/j.phymed.2025.156846_bib0077","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1038\/ki.2013.276","article-title":"Therapeutic use of traditional Chinese herbal medications for chronic kidney diseases","volume":"84","author":"Zhong","year":"2013","journal-title":"Kidney Int."},{"key":"10.1016\/j.phymed.2025.156846_bib0078","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.freeradbiomed.2015.02.009","article-title":"NADPH oxidase NOX1 is involved in activation of protein kinase C and premature senescence in early stage diabetic kidney","volume":"83","author":"Zhu","year":"2015","journal-title":"Free Radic. Biol. Med."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325004842?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325004842?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T08:48:21Z","timestamp":1762332501000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325004842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":78,"alternative-id":["S0944711325004842"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156846","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"18\u03b2-glycyrrhetinic acid mitigates lipotoxicity-induced premature senescence of tubular epithelial cells by activating SIRT1-TFEB signaling","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156846","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156846"}}