{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:35:01Z","timestamp":1792715701876,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["23NSFSC3685"],"award-info":[{"award-number":["23NSFSC3685"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273812"],"award-info":[{"award-number":["82273812"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.phymed.2025.156859","type":"journal-article","created":{"date-parts":[[2025,5,18]],"date-time":"2025-05-18T10:21:09Z","timestamp":1747563669000},"page":"156859","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Voacamine initiates the PI3K\/mTOR\/Beclin1 pathway to induce autophagy and potentiate apoptosis in acute myeloid leukemia"],"prefix":"10.1016","volume":"143","author":[{"given":"Yuening","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1805-0677","authenticated-orcid":false,"given":"Chen","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maolin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1625-8682","authenticated-orcid":false,"given":"Jun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.156859_bib0001","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1038\/s41418-018-0260-y","article-title":"Accurate elimination of superfluous attachment cells is critical for the construction of functional multicellular proprioceptors in Drosophila","volume":"26","author":"Avetisyan","year":"2019","journal-title":"Cell. Death Differ."},{"key":"10.1016\/j.phymed.2025.156859_bib0002","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.semcancer.2020.05.015","article-title":"Natural compounds modulate the crosstalk between apoptosis-and autophagy-regulated signaling pathways: controlling the uncontrolled expansion of tumor cells","author":"Braicu","year":"2022","journal-title":"Semin. Cancer Biol"},{"key":"10.1016\/j.phymed.2025.156859_bib0003","doi-asserted-by":"crossref","DOI":"10.1021\/acs.bioconjchem.5c00145","article-title":"GSH-responsive heterodimeric dual-targeted nanomedicine modulates EMT to conquer paclitaxel-induced invasive breast cancer metastasis","author":"Chen","year":"2025","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.phymed.2025.156859_bib0004","first-page":"43","article-title":"Aptamer-functionalized triptolide with release controllability as a promising targeted therapy against triple-negative breast cancer","author":"Chen","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.phymed.2025.156859_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106415","article-title":"Voacamine is a novel inhibitor of EGFR exerting oncogenic activity against colorectal cancer through the mitochondrial pathway","volume":"184","author":"Chen","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2025.156859_bib0006","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.3390\/jcm9092934","article-title":"Targeting PI3K\/Akt\/mTOR in AML: rationale and clinical evidence","volume":"9","author":"Darici","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.phymed.2025.156859_bib0007","doi-asserted-by":"crossref","DOI":"10.4028\/b-7TThNX","article-title":"The antipsychotic drug aripiprazole suppresses colorectal cancer by targeting LAMP2a to induce RNH1\/miR-99a\/mTOR-mediated autophagy and apoptosis","author":"Hu","year":"2024","journal-title":"Adv. Sci. (Weinh)"},{"key":"10.1016\/j.phymed.2025.156859_bib0008","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1038\/s41418-021-00768-1","article-title":"Reducing FASN expression sensitizes acute myeloid leukemia cells to differentiation therapy","volume":"28","author":"Humbert","year":"2021","journal-title":"Cell. Death Differ."},{"key":"10.1016\/j.phymed.2025.156859_bib0009","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jare.2020.06.015","article-title":"Exercise training restores IGFIR survival signaling in d-galactose induced-aging rats to suppress cardiac apoptosis","volume":"28","author":"Lay","year":"2021","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.phymed.2025.156859_bib0010","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/s12935-022-02684-x","article-title":"ITGAL infers adverse prognosis and correlates with immunity in acute myeloid leukemia","volume":"22","author":"Li","year":"2022","journal-title":"Cancer Cell. Int."},{"key":"10.1016\/j.phymed.2025.156859_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2023.107069","article-title":"Novel sulfonyl-substituted tetrandrine derivatives for colon cancer treatment by inducing mitochondrial apoptosis and inhibiting PI3K\/AKT\/mTOR pathway","volume":"143","author":"Ling","year":"2024","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.phymed.2025.156859_bib0012","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.jare.2024.03.002","article-title":"Hybridization-based discovery of novel quinazoline-2-indolinone derivatives as potent and selective PI3K\u03b1 inhibitors","volume":"68","author":"Liu","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.phymed.2025.156859_bib0013","doi-asserted-by":"crossref","first-page":"408","DOI":"10.3389\/fphar.2020.00408","article-title":"Combination of an autophagy inducer and an autophagy inhibitor: a smarter strategy emerging in cancer therapy","volume":"11","author":"Liu","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156859_bib0014","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2113465119","article-title":"ATG7 is a haploinsufficient repressor of tumor progression and promoter of metastasis","volume":"119","author":"Long","year":"2022","journal-title":"Proc. Natl Acad. Sci."},{"key":"10.1016\/j.phymed.2025.156859_bib0015","doi-asserted-by":"crossref","first-page":"6283","DOI":"10.1038\/s41467-022-33933-2","article-title":"The cholesterol transport protein GRAMD1C regulates autophagy initiation and mitochondrial bioenergetics","volume":"13","author":"Ng","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2025.156859_bib0016","doi-asserted-by":"crossref","first-page":"619","DOI":"10.3233\/CBM-160603","article-title":"Beclin-1 and hypoxia-inducible factor-1\u03b1 genes expression: potential biomarkers in acute leukemia patients","volume":"16","author":"Radwan","year":"2016","journal-title":"Cancer Biomarkers"},{"key":"10.1016\/j.phymed.2025.156859_bib0017","doi-asserted-by":"crossref","first-page":"5805","DOI":"10.1007\/s12035-023-03433-5","article-title":"A review on caspases: key regulators of biological activities and apoptosis","volume":"60","author":"Sahoo","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phymed.2025.156859_bib0018","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3390\/cancers14020329","article-title":"A novel plant-derived choline transporter-like protein 1 inhibitor, Amb544925, induces apoptotic cell death via the ceramide\/survivin pathway in tongue squamous cell carcinoma","volume":"14","author":"Shibata","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.phymed.2025.156859_bib0019","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/s41419-020-02965-1","article-title":"miR-378-3p maintains the size of mouse primordial follicle pool by regulating cell autophagy and apoptosis","volume":"11","author":"Sun","year":"2020","journal-title":"Cell. Death. Dis."},{"key":"10.1016\/j.phymed.2025.156859_bib0020","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.7150\/thno.64233","article-title":"Targeting the anti-apoptotic Bcl-2 family proteins: machine learning virtual screening and biological evaluation of new small molecules","volume":"12","author":"Valentini","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.phymed.2025.156859_bib0021","article-title":"Hydroxyl-based acid-hypersensitive acetal ester bond: design, synthesis and the application potential in nanodrugs","author":"Wang","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.phymed.2025.156859_bib0022","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/s41467-022-28500-8","article-title":"PEBP balances apoptosis and autophagy in whitefly upon arbovirus infection","volume":"13","author":"Wang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2025.156859_bib0023","first-page":"20","article-title":"Wet adhesive hydrogel cardiac patch loaded with anti-oxidative, autophagy-regulating molecule capsules and MSCs for restoring infarcted myocardium","volume":"21","author":"Wu","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.phymed.2025.156859_bib0024","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/s41420-024-02167-0","article-title":"Enhancing antitumor efficacy of CLDN18.2-directed antibody-drug conjugates through autophagy inhibition in gastric cancer","volume":"10","author":"Xue","year":"2024","journal-title":"Cell. Death Discov."},{"key":"10.1016\/j.phymed.2025.156859_bib0025","article-title":"Dual targeting of FR+CD44 overexpressing tumors by self-assembled nanoparticles quantitatively conjugating folic acid-hyaluronic acid to the GSH-sensitively modified podophyllotoxin","volume":"505","author":"Zhang","year":"2025","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.phymed.2025.156859_bib0026","doi-asserted-by":"crossref","DOI":"10.15212\/AMM-2023-0038","article-title":"Advances in nanoscale carrier-based approaches to reduce toxicity and enhance efficacy of podophyllotoxin","volume":"2","author":"Zhang","year":"2023","journal-title":"Acta. Materia. Medica."},{"key":"10.1016\/j.phymed.2025.156859_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116183","article-title":"Carrier-free self-assembled nanomedicine based on celastrol and galactose for targeting therapy of hepatocellular carcinoma via inducing ferroptosis","volume":"267","author":"Zhang","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.phymed.2025.156859_bib0028","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1111\/cas.15469","article-title":"M6A demethylase fat mass and obesity-associated protein regulates cisplatin resistance of gastric cancer by modulating autophagy activation through ULK1","volume":"113","author":"Zhang","year":"2022","journal-title":"Cancer Sci."},{"key":"10.1016\/j.phymed.2025.156859_bib0029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12964-019-0412-9","article-title":"Estrogen inhibits autophagy and promotes growth of endometrial cancer by promoting glutamine metabolism","volume":"17","author":"Zhou","year":"2019","journal-title":"Cell. Commun. Signaling"},{"key":"10.1016\/j.phymed.2025.156859_bib0030","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.1023040","article-title":"A novel 10-gene ferroptosis-related prognostic signature in acute myeloid leukemia","volume":"12","author":"Zhu","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.phymed.2025.156859_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154015","article-title":"Activation of mitochondrial-associated apoptosis signaling pathway and inhibition of PI3K\/akt\/mTOR signaling pathway by voacamine suppress breast cancer progression","volume":"99","author":"Zuo","year":"2022","journal-title":"Phytomedicine"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325004970?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325004970?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T08:50:52Z","timestamp":1762332652000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325004970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":31,"alternative-id":["S0944711325004970"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156859","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Voacamine initiates the PI3K\/mTOR\/Beclin1 pathway to induce autophagy and potentiate apoptosis in acute myeloid leukemia","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156859","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156859"}}