{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:33:29Z","timestamp":1790512409472,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515012134"],"award-info":[{"award-number":["2024A1515012134"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82,374,206"],"award-info":[{"award-number":["82,374,206"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82,474,418"],"award-info":[{"award-number":["82,474,418"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82,304,928"],"award-info":[{"award-number":["82,304,928"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005891","name":"State Administration of Traditional Chinese Medicine of The Peoples Republic of China","doi-asserted-by":"publisher","award":["2025QN003"],"award-info":[{"award-number":["2025QN003"]}],"id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.phymed.2025.156897","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T15:12:36Z","timestamp":1748531556000},"page":"156897","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Resveratrol reduces the activation of NLRP3 inflammasomes in rheumatoid arthritis through SIRT1 and ITGB \u03b15\u03b21, especially in patients with high expression of ACPA"],"prefix":"10.1016","volume":"144","author":[{"given":"Li","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5852-2102","authenticated-orcid":false,"given":"Jian","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyun","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinxiu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2977-2966","authenticated-orcid":false,"given":"Juan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.phymed.2025.156897_bib0002","doi-asserted-by":"crossref","first-page":"787","DOI":"10.4049\/jimmunol.0901363","article-title":"Cutting edge: nF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression","volume":"183","author":"Bauernfeind","year":"2009","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.phymed.2025.156897_bib0003","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a004994","article-title":"Integrin structure, activation, and interactions","volume":"3","author":"Campbell","year":"2011","journal-title":"Cold. Spring. Harb. Perspect. Biol."},{"issue":"1","key":"10.1016\/j.phymed.2025.156897_bib0004","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/s12964-023-01177-2","article-title":"Involvement of the SIRT1-NLRP3 pathway in the inflammatory response","volume":"21","author":"Chen","year":"2023","journal-title":"Cell Commun. Signal."},{"issue":"1","key":"10.1016\/j.phymed.2025.156897_bib0005","doi-asserted-by":"crossref","first-page":"626","DOI":"10.3390\/ijms25010626","article-title":"The NLRP3 inflammasome as a pathogenic player showing therapeutic potential in rheumatoid arthritis and its comorbidities: a narrative review","volume":"25","author":"Chen","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.phymed.2025.156897_bib0006","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.3892\/etm.2021.10544","article-title":"NLRP3 gene polymorphisms and expression in rheumatoid arthritis","volume":"22","author":"Cheng","year":"2021","journal-title":"Exp. Ther. Med."},{"issue":"23","key":"10.1016\/j.phymed.2025.156897_bib0007","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232315105","article-title":"Resveratrol-like compounds as SIRT1 activators","volume":"23","author":"Ciccone","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.phymed.2025.156897_bib0008","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nm.3806","article-title":"A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases","volume":"21","author":"Coll","year":"2015","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.phymed.2025.156897_bib0009","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/mnfr.200500022","article-title":"Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications","volume":"49","author":"de la Lastra","year":"2005","journal-title":"Mol. Nutr. Food Res."},{"issue":"3","key":"10.1016\/j.phymed.2025.156897_bib0010","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41423-019-0201-9","article-title":"ACPAs promote IL-1\u03b2 production in rheumatoid arthritis by activating the NLRP3 inflammasome","volume":"17","author":"Dong","year":"2020","journal-title":"Cell Mol. Immunol."},{"issue":"1","key":"10.1016\/j.phymed.2025.156897_bib0011","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s12026-013-8479-7","article-title":"Induction of bone loss in DBA\/1J mice immunized with citrullinated autologous mouse type II collagen in the absence of adjuvant","volume":"58","author":"Dusad","year":"2014","journal-title":"Immunol. Res."},{"issue":"1","key":"10.1016\/j.phymed.2025.156897_bib0012","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1038\/s41598-017-01836-8","article-title":"Pro-inflammatory Ca++-activated K+ channels are inhibited by hydroxychloroquine","volume":"7","author":"Eugenia Schroeder","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2025.156897_bib0013","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.2147\/JIR.S320912","article-title":"Resveratrol relieves gouty arthritis by promoting mitophagy to inhibit activation of NLRP3 inflammasomes","volume":"14","author":"Fan","year":"2021","journal-title":"J. Inflamm. Res."},{"issue":"30","key":"10.1016\/j.phymed.2025.156897_bib0014","doi-asserted-by":"crossref","first-page":"E2772","DOI":"10.1073\/pnas.1303628110","article-title":"Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism","volume":"110","author":"Gertz","year":"2013","journal-title":"Proc. Natl. Acad. Sci. u S. a"},{"issue":"2","key":"10.1016\/j.phymed.2025.156897_bib0015","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/cei.13167","article-title":"NLRP3 inflammasome activation contributes to the pathogenesis of rheumatoid arthritis","volume":"194","author":"Guo","year":"2018","journal-title":"Clin. Exp. Immunol."},{"issue":"1","key":"10.1016\/j.phymed.2025.156897_bib0016","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1136\/annrheumdis-2014-205508","article-title":"Myeloid-derived suppressor cells have a proinflammatory role in the pathogenesis of autoimmune arthritis","volume":"75","author":"Guo","year":"2016","journal-title":"Ann. Rheum. Dis."},{"issue":"3","key":"10.1016\/j.phymed.2025.156897_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2020.01.009","article-title":"An acetylation switch of the NLRP3 inflammasome regulates aging-associated chronic inflammation and insulin resistance","volume":"31","author":"He","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.phymed.2025.156897_bib0018","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.intimp.2017.06.029","article-title":"Resveratrol alleviates cerebral ischemia\/reperfusion injury in rats by inhibiting NLRP3 inflammasome activation through Sirt1-dependent autophagy induction","volume":"50","author":"He","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2025.156897_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107879","article-title":"Celastrol inhibits rheumatoid arthritis through the ROS-NF-\u03bab-NLRP3 inflammasome axis","volume":"98","author":"Jing","year":"2021","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.phymed.2025.156897_bib0020","first-page":"151","article-title":"The effects of resveratrol on oxidant\/antioxidant systems and their cofactors in rats","volume":"22","author":"Kavas","year":"2013","journal-title":"Adv. Clin. Exp. Med."},{"issue":"8","key":"10.1016\/j.phymed.2025.156897_bib0021","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1007\/s10067-018-4080-8","article-title":"Resveratrol as an effective adjuvant therapy in the management of rheumatoid arthritis: a clinical study","volume":"37","author":"Khojah","year":"2018","journal-title":"Clin. Rheumatol."},{"issue":"2","key":"10.1016\/j.phymed.2025.156897_bib0022","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.cyto.2012.05.025","article-title":"SIRT1 regulates TNF-\u03b1-induced expression of CD40 in 3T3-L1 adipocytes via NF-\u03bab pathway","volume":"60","author":"Lin","year":"2012","journal-title":"Cytokine"},{"issue":"3","key":"10.1016\/j.phymed.2025.156897_bib0023","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1007\/s10875-012-9841-6","article-title":"Anti-citrullinated protein antibodies activated ERK1\/2 and JNK mitogen-activated protein kinases via binding to surface-expressed citrullinated GRP78 on mononuclear cells","volume":"33","author":"Lu","year":"2013","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.phymed.2025.156897_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174504","article-title":"The pharmacological assessment of resveratrol on preclinical models of rheumatoid arthritis through a systematic review and meta-analysis","volume":"910","author":"Mittal","year":"2021","journal-title":"Eur. J. Pharmacol."},{"issue":"12","key":"10.1016\/j.phymed.2025.156897_bib0025","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.3390\/nu9121306","article-title":"Resveratrol role in autoimmune disease-A mini-review","volume":"9","author":"Oliveira","year":"2017","journal-title":"Nutrients."},{"issue":"4","key":"10.1016\/j.phymed.2025.156897_bib0026","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.cell.2016.03.046","article-title":"Inflammasome complexes: emerging mechanisms and effector functions","volume":"165","author":"Rathinam","year":"2016","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.phymed.2025.156897_bib0027","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The inflammasomes","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"issue":"9746","key":"10.1016\/j.phymed.2025.156897_bib0028","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/S0140-6736(10)60826-4","article-title":"Rheumatoid arthritis","volume":"376","author":"Scott","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2025.156897_bib0029","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.phymed.2025.156897_bib0030","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/imr.12839","article-title":"Inflammasomes contributing to inflammation in arthritis","volume":"294","author":"Spel","year":"2020","journal-title":"Immunol. Rev."},{"issue":"8","key":"10.1016\/j.phymed.2025.156897_bib0031","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 inflammasome: molecular activation and regulation to therapeutics","volume":"19","author":"Swanson","year":"2019","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.phymed.2025.156897_bib0032","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.intimp.2012.05.007","article-title":"Citrullinated mouse collagen administered to DBA\/1J mice in the absence of adjuvant initiates arthritis","volume":"13","author":"Thiele","year":"2012","journal-title":"Int. Immunopharmacol."},{"issue":"9","key":"10.1016\/j.phymed.2025.156897_bib0033","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.3109\/13880209.2015.1125931","article-title":"Protective effects of fenofibrate and resveratrol in an aggressive model of rheumatoid arthritis in rats","volume":"54","author":"Wahba","year":"2016","journal-title":"Pharm. Biol."},{"issue":"15","key":"10.1016\/j.phymed.2025.156897_bib0034","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1167\/iovs.64.15.28","article-title":"Resveratrol alleviates retinal ischemia-reperfusion injury by inhibiting the NLRP3\/gasdermin D\/caspase-1\/interleukin-1\u03b2 pyroptosis pathway","volume":"64","author":"Xie","year":"2023","journal-title":"Invest. Ophthalmol. Vis. Sci."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325005355?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325005355?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T21:57:59Z","timestamp":1750283879000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325005355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":33,"alternative-id":["S0944711325005355"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156897","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Resveratrol reduces the activation of NLRP3 inflammasomes in rheumatoid arthritis through SIRT1 and ITGB \u03b15\u03b21, especially in patients with high expression of ACPA","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156897","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156897"}}