{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:02:13Z","timestamp":1793041333873,"version":"4.5.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100011247","name":"State Key Laboratory of Pharmaceutical Biotechnology","doi-asserted-by":"publisher","award":["KF-202204"],"award-info":[{"award-number":["KF-202204"]}],"id":[{"id":"10.13039\/501100011247","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Jiangsu Province Natural Science Foundation","doi-asserted-by":"publisher","award":["BK20201196"],"award-info":[{"award-number":["BK20201196"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2019B1515120090"],"award-info":[{"award-number":["2019B1515120090"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016350","name":"Sichuan Provincial Administration of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["2022C010"],"award-info":[{"award-number":["2022C010"]}],"id":[{"id":"10.13039\/501100016350","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074003"],"award-info":[{"award-number":["82074003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51903246"],"award-info":[{"award-number":["51903246"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174083"],"award-info":[{"award-number":["82174083"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.phymed.2025.156905","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T15:58:54Z","timestamp":1748620734000},"page":"156905","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Hydroxysafflor yellow A promotes the proliferation and differentiation of endogenous neural stem cells with neural regenerative effects in ischemic stroke"],"prefix":"10.1016","volume":"144","author":[{"given":"Zhaojun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongqing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanchi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leisha","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guosheng","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.156905_bib0001","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3390\/ijms17030288","article-title":"Modulating astrocyte transition after stroke to promote brain rescue and functional recovery: emerging targets include rho kinase","volume":"17","author":"Abeysinghe","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2025.156905_bib0002","doi-asserted-by":"crossref","first-page":"4471","DOI":"10.3390\/ijms21124471","article-title":"MAPK\/ERK signaling in developing cognitive and emotional function and its effect on pathological and neurodegenerative processes","volume":"21","author":"Albert-Gasco","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2025.156905_bib0003","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.stem.2015.09.003","article-title":"Adult mammalian neural stem cells and neurogenesis: five decades later","volume":"17","author":"Bond","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.phymed.2025.156905_bib0004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2015.11.017","article-title":"Immunoregulation at the gliovascular unit in the healthy brain: a focus on Connexin 43","volume":"56","author":"Boulay","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.phymed.2025.156905_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110855","article-title":"Traditional Chinese medicine formulas, extracts, and compounds promote angiogenesis","volume":"132","author":"Bu","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2025.156905_bib0006","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1161\/STROKEAHA.120.032995","article-title":"Increased risk of stroke in patients with obsessive-compulsive disorder: a nationwide longitudinal study","volume":"52","author":"Chen","year":"2021","journal-title":"Stroke"},{"key":"10.1016\/j.phymed.2025.156905_bib0007","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1007\/s12035-018-1294-3","article-title":"Astragaloside VI promotes neural stem cell proliferation and enhances neurological function recovery in transient cerebral ischemic injury via activating EGFR\/MAPK signaling cascades","volume":"56","author":"Chen","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phymed.2025.156905_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114301","article-title":"Angelica sinensis extract promotes neuronal survival by enhancing p38 MAPK-mediated hippocampal neurogenesis and dendritic growth in the chronic phase of transient global cerebral ischemia in rats","volume":"278","author":"Cheng","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.156905_bib0009","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.stem.2015.08.002","article-title":"Adult neural stem cells from the subventricular zone give rise to reactive astrocytes in the cortex after stroke","volume":"17","author":"Faiz","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.phymed.2025.156905_bib0010","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.739864","article-title":"Hydroxysafflor yellow A and anhydrosafflor yellow B protect against cerebral ischemia\/reperfusion injury by attenuating oxidative stress and apoptosis via the silent information regulator 1 signaling pathway","volume":"12","author":"Fangma","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156905_bib0011","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1021\/acsnano.0c07973","article-title":"Neutrophil-like cell-membrane-coated nanozyme therapy for ischemic brain damage and long-term neurological functional recovery","volume":"15","author":"Feng","year":"2021","journal-title":"ACS Nano"},{"key":"10.1016\/j.phymed.2025.156905_bib0012","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s00401-002-0661-2","article-title":"Early modifications in the expression of mitogen-activated protein kinase (MAPK\/ERK), stress-activated kinases SAPK\/JNK and p38, and their phosphorylated substrates following focal cerebral ischemia","volume":"105","author":"Ferrer","year":"2003","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.phymed.2025.156905_bib0013","doi-asserted-by":"crossref","first-page":"e763","DOI":"10.1038\/cddis.2013.298","article-title":"Brimonidine promotes axon growth after optic nerve injury through Erk phosphorylation","volume":"4","author":"Fujita","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phymed.2025.156905_bib0014","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1177\/1073858420914509","article-title":"Wnt\/beta-catenin signaling in neural stem cell homeostasis and neurological diseases","volume":"27","author":"Gao","year":"2021","journal-title":"Neuroscientist"},{"key":"10.1016\/j.phymed.2025.156905_bib0015","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.neuron.2015.05.041","article-title":"Novel stroke therapeutics: unraveling stroke pathophysiology and its impact on clinical treatments","volume":"87","author":"George","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.phymed.2025.156905_bib0016","first-page":"6","article-title":"Heart disease and stroke statistics-2013 update a report from the american heart association","volume":"127","author":"Go","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.phymed.2025.156905_bib0017","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202100027","article-title":"Strategy for designing a cell scaffold to enable wireless electrical stimulation for enhanced neuronal differentiation of stem cells","volume":"10","author":"Han","year":"2021","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.phymed.2025.156905_bib0018","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1177\/0271678X17748787","article-title":"Real-time quantitative monitoring of cerebral blood flow by laser speckle contrast imaging after cardiac arrest with targeted temperature management","volume":"39","author":"He","year":"2019","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.phymed.2025.156905_bib0019","doi-asserted-by":"crossref","first-page":"12456","DOI":"10.1021\/acs.jafc.1c04011","article-title":"Gallic acid induces neural stem cell differentiation into neurons and proliferation through the MAPK\/ERK pathway","volume":"69","author":"Jiang","year":"2021","journal-title":"J. Agr. Food Chem."},{"key":"10.1016\/j.phymed.2025.156905_bib0020","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1001\/jama.2017.9644","article-title":"Effect of endovascular contact aspiration vs stent retriever on revascularization in patients with acute ischemic stroke and large vessel occlusion: the ASTER randomized clinical trial","volume":"318","author":"Lapergue","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.phymed.2025.156905_bib0021","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.5966\/sctm.2015-0200","article-title":"PTEN promotes dopaminergic neuronal differentiation through regulation of ERK-dependent inhibition of S6K signaling in human neural stem cells","volume":"5","author":"Lee","year":"2016","journal-title":"Stem Cell Transl. Med."},{"key":"10.1016\/j.phymed.2025.156905_bib0022","article-title":"Baicalin attenuates oxygen-glucose deprivation\/reoxygenation-induced injury by modulating the BDNF-TrkB\/PI3K\/Akt and MAPK\/Erk1\/2 signaling axes in neuron-astrocyte cocultures","volume":"12","author":"Li","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156905_bib0023","doi-asserted-by":"crossref","DOI":"10.1038\/nplants.2017.109","article-title":"Demystifying traditional herbal medicine with modern approaches","volume":"3","author":"Li","year":"2017","journal-title":"Nat. Plants"},{"key":"10.1016\/j.phymed.2025.156905_bib0024","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1002\/jcb.25942","article-title":"Resveratrol enhances self-renewal of mouse embryonic stem cells","volume":"118","author":"Li","year":"2017","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.phymed.2025.156905_bib0025","doi-asserted-by":"crossref","first-page":"728","DOI":"10.3390\/antiox11040728","article-title":"Hydroxysafflor yellow A blocks HIF-1 alpha induction of NOX2 and protects ZO-1 protein in cerebral microvascular endothelium","volume":"11","author":"Li","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.phymed.2025.156905_bib0026","doi-asserted-by":"crossref","first-page":"5791","DOI":"10.1073\/pnas.1920251117","article-title":"bioPROTACs as versatile modulators of intracellular therapeutic targets including proliferating cell nuclear antigen (PCNA)","volume":"117","author":"Lim","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.phymed.2025.156905_bib0027","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.jgr.2019.03.001","article-title":"20(S)-protopanaxadiol promotes the migration, proliferation, and differentiation of neural stem cells by targeting GSK-3beta in the Wnt\/GSK-3beta\/beta-catenin pathway","volume":"44","author":"Lin","year":"2020","journal-title":"J. Ginseng Res."},{"key":"10.1016\/j.phymed.2025.156905_bib0028","doi-asserted-by":"crossref","first-page":"4187","DOI":"10.7150\/thno.49054","article-title":"SARM1 promotes neuroinflammation and inhibits neural regeneration after spinal cord injury through NF-kappaB signaling","volume":"11","author":"Liu","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.phymed.2025.156905_bib0029","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.pneurobio.2015.09.008","article-title":"Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke","volume":"144","author":"Liu","year":"2016","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.phymed.2025.156905_bib0030","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","article-title":"Reversible middle cerebral-artery occlusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke"},{"key":"10.1016\/j.phymed.2025.156905_bib0031","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12868-016-0327-y","article-title":"Hemodynamic effects of intraoperative anesthetics administration in photothrombotic stroke model: a study using laser speckle imaging","volume":"18","author":"Lu","year":"2017","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.phymed.2025.156905_bib0032","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1038\/ncb2299","article-title":"Phagocytic activity of neuronal progenitors regulates adult neurogenesis","volume":"13","author":"Lu","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.phymed.2025.156905_bib0033","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.redox.2018.07.021","article-title":"The Parkinson's disease gene product DJ-1 modulates miR-221 to promote neuronal survival against oxidative stress","volume":"19","author":"Oh","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.phymed.2025.156905_bib0034","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1007\/s00018-022-04457-1","article-title":"Adult neurogenesis of the median eminence contributes to structural reconstruction and recovery of body fluid metabolism in hypothalamic self-repair after pituitary stalk lesion","volume":"79","author":"Ou","year":"2022","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.phymed.2025.156905_bib0035","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s12974-017-0870-1","article-title":"HSYA alleviates secondary neuronal death through attenuating oxidative stress, inflammatory response, and neural apoptosis in SD rat spinal cord compression injury","volume":"14","author":"Pei","year":"2017","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.phymed.2025.156905_bib0036","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s12975-014-0346-x","article-title":"AKT-related autophagy contributes to the neuroprotective efficacy of hydroxysafflor yellow A against ischemic stroke in rats","volume":"5","author":"Qi","year":"2014","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.phymed.2025.156905_bib0037","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12975-020-00841-w","article-title":"Neurogenesis after stroke: a therapeutic perspective","volume":"12","author":"Rahman","year":"2021","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.phymed.2025.156905_bib0038","doi-asserted-by":"crossref","first-page":"10961","DOI":"10.1021\/acsnano.9b01515","article-title":"Targeting ligands deliver model drug cargo into the central nervous system along autonomic neurons","volume":"13","author":"Sellers","year":"2019","journal-title":"Acs Nano"},{"key":"10.1016\/j.phymed.2025.156905_bib0039","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1182\/blood.2020009064","article-title":"Transcriptomic landscape of circulating mononuclear phagocytes in Langerhans cell histiocytosis at the single-cell level","volume":"138","author":"Shi","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.phymed.2025.156905_bib0040","first-page":"351","article-title":"Single-cell transcriptomics reveals gene signatures and alterations associated with aging in distinct neural stem\/progenitor cell subpopulations","volume":"9","author":"Shi","year":"2018","journal-title":"Protein Cell"},{"key":"10.1016\/j.phymed.2025.156905_bib0041","doi-asserted-by":"crossref","first-page":"6507","DOI":"10.7150\/thno.56367","article-title":"Targeted delivery of neural progenitor cell-derived extracellular vesicles for anti-inflammation after cerebral ischemia","volume":"11","author":"Tian","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.phymed.2025.156905_bib0042","doi-asserted-by":"crossref","first-page":"7355","DOI":"10.1021\/acsnano.9b03830","article-title":"Correction to curcumin-loaded nanoparticles potently induce adult neurogenesis and reverse cognitive deficits in Alzheimer's disease model via canonical Wnt\/beta-catenin pathway","volume":"13","author":"Tiwari","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.phymed.2025.156905_bib0043","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.ymthe.2017.09.019","article-title":"MANF promotes differentiation and migration of neural progenitor cells with potential neural regenerative effects in stroke","volume":"26","author":"Tseng","year":"2018","journal-title":"Mol. Ther."},{"key":"10.1016\/j.phymed.2025.156905_bib0044","article-title":"Traditional Chinese medicine monomers: novel strategy for endogenous neural stem cells activation after stroke","volume":"15","author":"Wang","year":"2021","journal-title":"Front Cell Neurosci."},{"key":"10.1016\/j.phymed.2025.156905_bib0045","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/S1474-4422(18)30500-3","article-title":"China stroke study collaboration stroke in China: advances and challenges in epidemiology, prevention, and management. Stroke in China: advances and challenges in epidemiology, prevention, and management","volume":"18","author":"Wu","year":"2019","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.phymed.2025.156905_bib0046","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153694","article-title":"Hydroxysafflor yellow A, a natural compound from Carthamus tinctorius L with good effect of alleviating atherosclerosis","volume":"91","author":"Xue","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.156905_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119715","article-title":"Resveratrol-mediated neurorestoration after cerebral ischemic injury-Sonic Hedgehog signaling pathway","volume":"280","author":"Yu","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2025.156905_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112170","article-title":"MAPK\/ERK signaling pathway: a potential target for the treatment of intervertebral disc degeneration","volume":"143","author":"Zhang","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2025.156905_bib0049","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1172\/JCI81133","article-title":"Exosomes in stroke pathogenesis and therapy","volume":"126","author":"Zhang","year":"2016","journal-title":"J. Clin Invest."},{"key":"10.1016\/j.phymed.2025.156905_bib0050","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/cns.12334","article-title":"Botanical drug puerarin coordinates with nerve growth factor in the regulation of neuronal survival and neuritogenesis via activating ERK1\/2 and PI3K\/Akt signaling pathways in the neurite extension process","volume":"21","author":"Zhao","year":"2015","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.phymed.2025.156905_bib0051","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12974-019-1556-7","article-title":"Lipocalin-2 may produce damaging effect after cerebral ischemia by inducing astrocytes classical activation","volume":"16","author":"Zhao","year":"2019","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.phymed.2025.156905_bib0052","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.714943","article-title":"Janus Kinase Inhibition ameliorates ischemic stroke injury and neuroinflammation through reducing NLRP3 inflammasome activation via JAK2\/STAT3 pathway inhibition","volume":"12","author":"Zhu","year":"2021","journal-title":"Front Immunol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325005434?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325005434?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T08:48:17Z","timestamp":1762332497000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325005434"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":52,"alternative-id":["S0944711325005434"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156905","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hydroxysafflor yellow A promotes the proliferation and differentiation of endogenous neural stem cells with neural regenerative effects in ischemic stroke","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156905","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156905"}}