{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:44:07Z","timestamp":1791974647691,"version":"4.4.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"Research on Delaying Renal Dysfunction in Elderly Patients Based on Prescription Simplification Model","award":["21BJZ36"],"award-info":[{"award-number":["21BJZ36"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.phymed.2025.156935","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T01:03:48Z","timestamp":1749171828000},"page":"156935","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Exploring the therapeutic mechanism of Miao nationality medicine Qijiao Shengbai capsule on leukopenia based on multi-omics, network pharmacology and experimental verification"],"prefix":"10.1016","volume":"144","author":[{"given":"Wei","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenguang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuntong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9753-3775","authenticated-orcid":false,"given":"Lihua","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4726-8472","authenticated-orcid":false,"given":"Mengli","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.phymed.2025.156935_bib0001","doi-asserted-by":"crossref","first-page":"999","DOI":"10.6002\/ect.2020.0100","article-title":"Drug-induced myelosuppression in kidney transplant patients","volume":"19","author":"Abbas","year":"2021","journal-title":"Exp. Clin. TransPlant"},{"issue":"9","key":"10.1016\/j.phymed.2025.156935_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e19949","article-title":"Exploring the effects of Qijiao Shengbai capsule on leukopenic mice from the perspective of intestinbased on metabolomics and 16S rRNA sequencing","volume":"9","author":"Cao","year":"2023","journal-title":"Heliyon."},{"issue":"1","key":"10.1016\/j.phymed.2025.156935_bib0005","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1080\/13880209.2022.2123933","article-title":"Genistein-induced mitochondrial dysfunction and FOXO3a\/PUMA expression in non-small lung cancer cells","volume":"60","author":"Chan","year":"2022","journal-title":"Pharm. Biol."},{"issue":"4","key":"10.1016\/j.phymed.2025.156935_bib0006","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/s11427-014-4640-3","article-title":"The yin and Yang of wnt\/ryk axon guidance in development and regeneration","volume":"57","author":"Clark","year":"2014","journal-title":"Sci. China Life Sci."},{"issue":"2","key":"10.1016\/j.phymed.2025.156935_bib0007","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.intimp.2012.12.029","article-title":"Enhanced hematopoietic protection from radiation by the combination of genistein and captopril","volume":"15","author":"Day","year":"2013","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2025.156935_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2020.122283","article-title":"A highly sensitive UPLC-MS\/MS method for hydroxyurea to assess pharmacokinetic intervention by phytotherapeutics in rats","volume":"1154","author":"Gour","year":"2020","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"issue":"5","key":"10.1016\/j.phymed.2025.156935_bib0009","first-page":"468","article-title":"The experimental evaluation of antiradiation effectiveness of genistein by survival rates and bone marrow hemopoiesis of mice irradiated by X-rays]","volume":"53","author":"Grebeniuk","year":"2013","journal-title":"Radiats. Biol. Radioecol."},{"issue":"12","key":"10.1016\/j.phymed.2025.156935_bib0010","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1111\/jcpt.13793","article-title":"Optimal exposure to docetaxel in adjuvant chemotherapy for early-stage breast cancer","volume":"47","author":"Guo","year":"2022","journal-title":"J. Clin. Pharm. Ther."},{"issue":"1\u20132","key":"10.1016\/j.phymed.2025.156935_bib0011","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s11010-015-2483-2","article-title":"Genistein ameliorates cardiac inflammation and oxidative stress in streptozotocin-induced diabetic cardiomyopathy in rats","volume":"408","author":"Gupta","year":"2015","journal-title":"Mol. Cell. Biochem."},{"issue":"5","key":"10.1016\/j.phymed.2025.156935_bib0012","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1097\/INF.0000000000003872","article-title":"Distinct clinical and laboratory features of COVID-19 in children during the pre-delta, delta and omicron wave","volume":"42","author":"Han","year":"2023","journal-title":"Pediatr. Infect. Dis. J."},{"issue":"10","key":"10.1016\/j.phymed.2025.156935_bib0013","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1089\/107999001753238105","article-title":"Regulation of hematopoietic growth factor production by genetically modified human bone marrow stromal cells expressing interleukin-1beta antisense RNA","volume":"21","author":"Hartwig","year":"2001","journal-title":"J. Interferon Cytokine Res."},{"issue":"7","key":"10.1016\/j.phymed.2025.156935_bib0014","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18071385","article-title":"Pharmacological modulation of radiation damage. Does it exist a chance for other substances than hematopoietic growth factors and cytokines?","volume":"18","author":"Hofer","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"18","key":"10.1016\/j.phymed.2025.156935_bib0015","doi-asserted-by":"crossref","first-page":"4193","DOI":"10.1111\/bph.15162","article-title":"The coffee ingredients caffeic acid and caffeic acid phenylethyl ester protect against irinotecan-induced leukopenia and oxidative stress response","volume":"177","author":"Kalthoff","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156935_bib0016","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.901277","article-title":"GM-CSF: a double-edged sword in cancer immunotherapy","volume":"13","author":"Kumar","year":"2022","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.phymed.2025.156935_bib0017","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1007\/s10815-019-01555-1","article-title":"FoxO transcription factors 1 regulate mouse preimplantation embryo development","volume":"36","author":"Kuscu","year":"2019","journal-title":"J. Assist. Reprod. Genet."},{"issue":"3","key":"10.1016\/j.phymed.2025.156935_bib0018","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1093\/jrr\/rrz014","article-title":"Mechanism and therapeutic window of a genistein nanosuspension to protect against hematopoietic-acute radiation syndrome","volume":"60","author":"Landauer","year":"2019","journal-title":"J. Radiat. Res."},{"key":"10.1016\/j.phymed.2025.156935_bib0019","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13578-015-0057-3","article-title":"Granulocyte colony-stimulating factor exacerbates hematopoietic stem cell injury after irradiation","volume":"5","author":"Li","year":"2015","journal-title":"Cell Biosci."},{"issue":"43","key":"10.1016\/j.phymed.2025.156935_bib0020","doi-asserted-by":"crossref","first-page":"27781","DOI":"10.1039\/D2RA04720A","article-title":"Combining multiple acquisition modes and computational data annotation for structural characterization in traditional Chinese medicine: miao Nationality medicine Qijiao Shengbai Capsule as a case study","volume":"12","author":"Ma","year":"2022","journal-title":"RSC Adv."},{"issue":"3","key":"10.1016\/j.phymed.2025.156935_bib0021","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.stem.2012.05.026","article-title":"Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression","volume":"11","author":"Magee","year":"2012","journal-title":"Cell Stem Cell"},{"issue":"4","key":"10.1016\/j.phymed.2025.156935_bib0022","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.4049\/jimmunol.1500861","article-title":"G-CSF and GM-CSF in Neutropenia","volume":"195","author":"Mehta","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.phymed.2025.156935_bib0023","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3389\/fphar.2018.00245","article-title":"Editorial: adverse effects of cancer chemotherapy: anything new to improve tolerance and reduce sequelae?","volume":"9","author":"Nurgali","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156935_bib0024","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.585987","article-title":"A novel therapeutic approach for colorectal cancer stem cells: blocking the PI3K\/akt signaling axis with caffeic acid","volume":"8","author":"Park","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"79","key":"10.1016\/j.phymed.2025.156935_bib0026","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/newbio238017a0","article-title":"Proportional increase in the theta carrying lymphocytes in peripheral lymphoid tissue following treatment with cyclophosphamide","volume":"238","author":"Poulter","year":"1972","journal-title":"Nat. New. Biol."},{"issue":"4","key":"10.1016\/j.phymed.2025.156935_bib0027","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0033733","article-title":"Panax ginseng modulates cytokines in bone marrow toxicity and myelopoiesis: ginsenoside Rg1 partially supports myelopoiesis","volume":"7","author":"Raghavendran","year":"2012","journal-title":"PLoS One,"},{"issue":"5","key":"10.1016\/j.phymed.2025.156935_bib0028","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.semarthrit.2008.01.006","article-title":"Role of interleukin-6 in the anemia of chronic disease","volume":"38","author":"Raj","year":"2009","journal-title":"Semin. Arthritis Rheum."},{"issue":"2","key":"10.1016\/j.phymed.2025.156935_bib0029","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24021243","article-title":"The role of myeloperoxidase in clozapine-induced inflammation: a mechanistic update for idiosyncratic drug-induced agranulocytosis","volume":"24","author":"Sernoskie","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.phymed.2025.156935_bib40","first-page":"1","article-title":"Expert consensus on the prevention on and treatment with Chinese medcine of leukopenia after chemotherapy","volume":"25","author":"Tian","year":"2018","journal-title":"Mod. Chin. Clin. Med."},{"key":"10.1016\/j.phymed.2025.156935_bib0030","doi-asserted-by":"crossref","first-page":"408","DOI":"10.3389\/fphar.2019.00408","article-title":"Systems biology analysis of the effect and mechanism of Qi-Jing-Sheng-Bai granule on leucopenia in mice","volume":"10","author":"Tian","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"10","key":"10.1016\/j.phymed.2025.156935_bib41","first-page":"789","article-title":"Research progress and development trend of serum medicinal chemistry of traditional Chinese medicine","volume":"31","author":"Wang","year":"2006","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"10.1016\/j.phymed.2025.156935_bib0031","article-title":"Pharmacokinetics interaction between imatinib and genistein in rats","author":"Wang","year":"2015","journal-title":"Biomed. Res. Int."},{"issue":"01","key":"10.1016\/j.phymed.2025.156935_bib42","first-page":"6","article-title":"Effect of Icariin on TLR4\/MyD88\/NF-\u03baB p65 signaling pathway in hippocampus in rat models of alzheimers disease","volume":"55","author":"Xie","year":"2023","journal-title":"J. New Chin. Med."},{"key":"10.1016\/j.phymed.2025.156935_bib0033","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.freeradbiomed.2015.05.045","article-title":"Metformin ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice","volume":"87","author":"Xu","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2025.156935_bib0034","doi-asserted-by":"crossref","DOI":"10.1177\/15347354211021654","article-title":"Effectiveness of herbal medicine for leukopenia\/neutropenia induced by chemotherapy in adults with colorectal cancer: a systematic review and meta-analysis","volume":"20","author":"Yan","year":"2021","journal-title":"Integr. Cancer Ther."},{"issue":"2","key":"10.1016\/j.phymed.2025.156935_bib0036","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/bcpt.13696","article-title":"Effects of quercetin on ovarian function and regulation of the ovarian PI3K\/Akt\/FoxO3a signalling pathway and oxidative stress in a rat model of cyclophosphamide-induced premature ovarian failure","volume":"130","author":"Zheng","year":"2022","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"13","key":"10.1016\/j.phymed.2025.156935_bib0037","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.7150\/jca.24557","article-title":"The efficacy and toxicity of lobaplatin-contained chemotherapy in extensive-stage small-cell lung cancer","volume":"9","author":"Zhou","year":"2018","journal-title":"J. Cancer"},{"issue":"12","key":"10.1016\/j.phymed.2025.156935_bib39","first-page":"1719","article-title":"Analysis of 2808 cases of spontaneous report associated with drug-induced leukopenia","volume":"36","author":"Zhu","year":"2020","journal-title":"Chin. J. Clin. Pharmacol."},{"issue":"8","key":"10.1016\/j.phymed.2025.156935_bib0038","first-page":"714","article-title":"[Quercetin induces apoptosis of human breast cancer cells by activiting PTEN and inhibiting PI3K\/AKT and JNK signaling pathways]","volume":"38","author":"Zhu","year":"2022","journal-title":"Xi. Bao Yu Fen. Zi. Mian. Yi. Xue Za Zhi."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325005732?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325005732?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T21:59:59Z","timestamp":1750283999000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325005732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":37,"alternative-id":["S0944711325005732"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156935","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the therapeutic mechanism of Miao nationality medicine Qijiao Shengbai capsule on leukopenia based on multi-omics, network pharmacology and experimental verification","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156935","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156935"}}