{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T00:59:39Z","timestamp":1793581179991,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274189"],"award-info":[{"award-number":["82274189"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chinese medicine Guangdong Laboratory","award":["HQCML-B-202402"],"award-info":[{"award-number":["HQCML-B-202402"]}]},{"name":"Chinese medicine Guangdong Laboratory","award":["HQL2025SU001"],"award-info":[{"award-number":["HQL2025SU001"]}]},{"DOI":"10.13039\/501100010618","name":"Guangzhou University of Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010618","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012829","name":"The Second Affiliated Hospital of Guangzhou University of Chinese Medicine","doi-asserted-by":"publisher","award":["SZ2022KF08"],"award-info":[{"award-number":["SZ2022KF08"]}],"id":[{"id":"10.13039\/100012829","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.phymed.2025.156937","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T08:02:06Z","timestamp":1750320126000},"page":"156937","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Suppressing ferroptosis via modulating FTH1 by silybin for treatment of renal fibrosis"],"prefix":"10.1016","volume":"145","author":[{"given":"Jia-Qin","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cang-Qiong","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Cao","family":"Pi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Ni","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4625-3957","authenticated-orcid":false,"given":"Li-Li","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3223-1797","authenticated-orcid":false,"given":"Ying","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.156937_bib0001","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/s41419-023-06072-9","article-title":"LZTR1 deficiency exerts high metastatic potential by enhancing sensitivity to EMT induction and controlling KLHL12-mediated collagen secretion","volume":"14","author":"Abe","year":"2023","journal-title":"Cell Death. Dis."},{"key":"10.1016\/j.phymed.2025.156937_bib0002","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.kisu.2020.12.003","article-title":"Iron metabolism and management: focus on chronic kidney disease","volume":"11","author":"Agarwal","year":"2021","journal-title":"Kidney Int. Suppl."},{"key":"10.1016\/j.phymed.2025.156937_bib0003","doi-asserted-by":"crossref","first-page":"8936","DOI":"10.1021\/acs.analchem.8b01103","article-title":"Biosensor-based active ingredients recognition system for screening STAT3 ligands from medical herbs","volume":"90","author":"Chen","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.phymed.2025.156937_bib0004","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/S0140-6736(19)32977-0","article-title":"The global burden of chronic kidney disease","volume":"395","author":"Cockwell","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2025.156937_bib0005","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.3390\/cells9122554","article-title":"FTH1 pseudogenes in cancer and cell metabolism","volume":"9","author":"Di Sanzo","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.phymed.2025.156937_bib0006","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2025.156937_bib0007","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1111\/liv.14945","article-title":"Inhibiting xCT\/SLC7A11 induces ferroptosis of myofibroblastic hepatic stellate cells but exacerbates chronic liver injury","volume":"41","author":"Du","year":"2021","journal-title":"Liver Int."},{"key":"10.1016\/j.phymed.2025.156937_bib0008","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41569-022-00735-4","article-title":"The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease","volume":"20","author":"Fang","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.phymed.2025.156937_bib0009","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41580-023-00648-1","article-title":"Mechanisms controlling cellular and systemic iron homeostasis","volume":"25","author":"Galy","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2025.156937_bib0010","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1042\/CS20201213","article-title":"Negative regulators of TGF-\u03b21 signaling in renal fibrosis; pathological mechanisms and novel therapeutic opportunities","volume":"135","author":"Gifford","year":"2021","journal-title":"Clin Sci (L.)"},{"key":"10.1016\/j.phymed.2025.156937_bib0011","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41419-023-05969-9","article-title":"The road from AKI to CKD: molecular mechanisms and therapeutic targets of ferroptosis","volume":"14","author":"Guo","year":"2023","journal-title":"Cell death dis."},{"key":"10.1016\/j.phymed.2025.156937_bib0012","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev-physiol-022516-034227","article-title":"Mechanisms of renal fibrosis","volume":"80","author":"Humphreys","year":"2018","journal-title":"Annu. rev. physiol."},{"key":"10.1016\/j.phymed.2025.156937_bib0013","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25073750","article-title":"Effects of anti-fibrotic drugs on transcriptome of peripheral blood mononuclear cells in idiopathic pulmonary fibrosis","volume":"25","author":"Ishii","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2025.156937_bib0014","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell death dis."},{"key":"10.1016\/j.phymed.2025.156937_bib0015","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1016\/j.molcel.2022.03.022","article-title":"Ferroptosis at the intersection of lipid metabolism and cellular signaling","volume":"82","author":"Liang","year":"2022","journal-title":"Mol. cell"},{"key":"10.1016\/j.phymed.2025.156937_bib0016","doi-asserted-by":"crossref","first-page":"E1395","DOI":"10.1152\/ajpendo.00188.2009","article-title":"Functional analysis of FSP27 protein regions for lipid droplet localization, caspase-dependent apoptosis, and dimerization with CIDEA","volume":"297","author":"Liu","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.phymed.2025.156937_bib0017","doi-asserted-by":"crossref","first-page":"21984","DOI":"10.1073\/pnas.0910040106","article-title":"Target identification using drug affinity responsive target stability (DARTS)","volume":"106","author":"Lomenick","year":"2009","journal-title":"Proc. Natl. Acad. Sci. u S. a"},{"key":"10.1016\/j.phymed.2025.156937_bib0018","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/s41419-022-05394-4","article-title":"IL-18 deficiency ameliorates the progression from AKI to CKD","volume":"13","author":"Luan","year":"2022","journal-title":"Cell Death. Dis."},{"key":"10.1016\/j.phymed.2025.156937_bib0019","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.freeradbiomed.2007.01.038","article-title":"Mass spectrometric analysis demonstrates that BODIPY 581\/591 C11 overestimates and inhibits oxidative lipid damage","volume":"42","author":"MacDonald","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2025.156937_bib0020","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.kint.2021.04.034","article-title":"The kidney hepcidin\/ferroportin axis controls iron reabsorption and determines the magnitude of kidney and systemic iron overload","volume":"100","author":"Mohammad","year":"2021","journal-title":"Kidney int."},{"key":"10.1016\/j.phymed.2025.156937_bib0021","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1093\/ndt\/gfv268","article-title":"Novel iron-containing phosphate binders and anemia treatment in CKD: oral iron intake revisited","volume":"31","author":"Nakanishi","year":"2016","journal-title":"Nephrol Dial Transpl."},{"key":"10.1016\/j.phymed.2025.156937_bib0022","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.freeradbiomed.2020.01.024","article-title":"The pathogenesis of CKD complications; attack of dysregulated iron and phosphate metabolism","volume":"157","author":"Nakanishi","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2025.156937_bib0023","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222212442","article-title":"Iron homeostasis disorder and Alzheimer\u2019s disease","volume":"22","author":"Peng","year":"2021","journal-title":"Int. j. mol. sci."},{"key":"10.1016\/j.phymed.2025.156937_bib0024","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.tcb.2023.05.003","article-title":"Regulation of ferroptosis by lipid metabolism","volume":"33","author":"Pope","year":"2023","journal-title":"Trends cell biol."},{"key":"10.1016\/j.phymed.2025.156937_bib0025","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1038\/s41401-021-00801-6","article-title":"Novel treatment for refractory rheumatoid arthritis with total glucosides of paeony and nobiletin codelivered in a self-nanoemulsifying drug delivery system","volume":"43","author":"Qu","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2025.156937_bib0026","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1681\/ASN.0000000000000027","article-title":"Hypoxia-inducible factor 2\u03b1 attenuates renal ischemia-reperfusion injury by suppressing CD36-mediated lipid accumulation in dendritic cells in a mouse model","volume":"34","author":"Qu","year":"2023","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.phymed.2025.156937_bib0027","doi-asserted-by":"crossref","first-page":"449","DOI":"10.3390\/ijms24010449","article-title":"Lipid peroxidation and iron metabolism: two corner stones in the homeostasis control of ferroptosis","volume":"24","author":"Rochette","year":"2022","journal-title":"Int. j. mol. sci."},{"key":"10.1016\/j.phymed.2025.156937_bib0028","doi-asserted-by":"crossref","first-page":"612","DOI":"10.4093\/dmj.2023.0067","article-title":"Dyslipidemia in patients with Chronic Kidney disease: an updated overview","volume":"47","author":"Suh","year":"2023","journal-title":"Diabetes. Metab. J."},{"key":"10.1016\/j.phymed.2025.156937_bib0029","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3390\/cells11010143","article-title":"Differential discontinuation profiles between Pirfenidone and Nintedanib in patients with idiopathic pulmonary fibrosis","volume":"11","author":"Takehara","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.phymed.2025.156937_bib0030","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.phymed.2025.156937_bib0031","doi-asserted-by":"crossref","first-page":"9353","DOI":"10.1038\/s41598-018-27107-8","article-title":"Tubular iron deposition and iron handling proteins in human healthy kidney and chronic kidney disease","volume":"8","author":"van Raaij","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2025.156937_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114938","article-title":"Silybin B exerts protective effect on cisplatin-induced neurotoxicity by alleviating DNA damage and apoptosis","volume":"288","author":"Wang","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.156937_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173574","article-title":"Ferroptosis involves in renal tubular cell death in diabetic nephropathy","volume":"888","author":"Wang","year":"2020","journal-title":"Eur. j. pharmacol."},{"key":"10.1016\/j.phymed.2025.156937_bib0034","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.1111\/cas.15470","article-title":"Silybin suppresses ovarian cancer cell proliferation by inhibiting isocitrate dehydrogenase 1 activity","volume":"113","author":"Wei","year":"2022","journal-title":"Cancer Sci."},{"key":"10.1016\/j.phymed.2025.156937_bib0035","doi-asserted-by":"crossref","first-page":"5713","DOI":"10.1002\/ptr.8347","article-title":"Silybin: A review of its targeted and novel agents for treating liver diseases based on pathogenesis","volume":"38","author":"Wu","year":"2024","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2025.156937_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153339","article-title":"Suppression of up-regulated LXR\u03b1 by silybin ameliorates experimental rheumatoid arthritis and abnormal lipid metabolism","volume":"80","author":"Xie","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.156937_bib0037","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1093\/ndt\/gfab271","article-title":"Serum catalytic iron and progression of chronic kidney disease: findings from the ICKD study","volume":"37","author":"Yadav","year":"2022","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.phymed.2025.156937_bib0038","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1172\/JCI75417","article-title":"KIM-1-mediated phagocytosis reduces acute injury to the kidney","volume":"125","author":"Yang","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2025.156937_bib0039","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tcb.2015.10.014","article-title":"Ferroptosis: death by lipid peroxidation","volume":"26","author":"Yang","year":"2016","journal-title":"Trends cell biol."},{"key":"10.1016\/j.phymed.2025.156937_bib0040","article-title":"A novel quantification method of lung fibrosis based on Micro-CT images developed with the optimized pulmonary fibrosis mice model induced by bleomycin","volume":"9","author":"Yang","year":"2023","journal-title":"Heliyon."},{"key":"10.1016\/j.phymed.2025.156937_bib0041","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/s41419-021-04137-1","article-title":"Liproxstatin-1 attenuates unilateral ureteral obstruction-induced renal fibrosis by inhibiting renal tubular epithelial cells ferroptosis","volume":"12","author":"Zhang","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phymed.2025.156937_bib0042","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0140-6736(12)60033-6","article-title":"Prevalence of chronic kidney disease in China: a cross-sectional survey","volume":"379","author":"Zhang","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2025.156937_bib0043","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41419-021-04490-1","article-title":"Double-edge sword roles of iron in driving energy production versus instigating ferroptosis","volume":"13","author":"Zhang","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phymed.2025.156937_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2024.155978","article-title":"Cannabinoid receptor 2 plays a key role in renal fibrosis through inhibiting lipid metabolism in renal tubular cells","author":"Zhou","year":"2024","journal-title":"Metabolism."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325005756?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325005756?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T08:56:39Z","timestamp":1762332999000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325005756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":44,"alternative-id":["S0944711325005756"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156937","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Suppressing ferroptosis via modulating FTH1 by silybin for treatment of renal fibrosis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156937","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156937"}}