{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T18:54:54Z","timestamp":1793904894325,"version":"4.8.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2023NSFSC1470"],"award-info":[{"award-number":["2023NSFSC1470"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008402","name":"Chengdu University of Traditional Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008402","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Special Funding for Postdoctoral Research Projects in Sichuan Province","award":["TB2024084"],"award-info":[{"award-number":["TB2024084"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900276"],"award-info":[{"award-number":["81900276"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fund of Hospital of Chengdu University of Traditional Chinese Medicine","award":["2025NSFCPY003"],"award-info":[{"award-number":["2025NSFCPY003"]}]},{"name":"Fund of Hospital of Chengdu University of Traditional Chinese Medicine","award":["2025NSFCPY051"],"award-info":[{"award-number":["2025NSFCPY051"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.phymed.2025.156939","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T11:09:11Z","timestamp":1748862551000},"page":"156939","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["The antitumor effects of lupenone on colon cancer and its mechanistic insights"],"prefix":"10.1016","volume":"145","author":[{"given":"Ruli","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuchu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Jian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzhi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boxun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisha","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rensong","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.156939_bib0001","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1017\/S1462399408000744","article-title":"P21 and p27: roles in carcinogenesis and drug resistance","volume":"10","author":"Abukhdeir","year":"2008","journal-title":"Expert Rev. Mol. Med."},{"key":"10.1016\/j.phymed.2025.156939_bib0002","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1111\/j.1600-0463.2007.00858.x","article-title":"Expression of beclin-1, an autophagy-related protein, in gastric and colorectal cancers","volume":"115","author":"Ahn","year":"2007","journal-title":"APMIS Acta Pathol. Microbiol. Immunol. Scand."},{"key":"10.1016\/j.phymed.2025.156939_bib0003","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.6004\/jnccn.2022.0051","article-title":"Rectal cancer, version 2.2022, NCCN clinical practice guidelines in oncology","volume":"20","author":"Benson","year":"2022","journal-title":"J. Natl. Compr. Cancer Netw. JNCCN"},{"key":"10.1016\/j.phymed.2025.156939_bib0004","doi-asserted-by":"crossref","first-page":"359","DOI":"10.6004\/jnccn.2018.0021","article-title":"NCCN guidelines insights: colon cancer, version 2.2018","volume":"16","author":"Benson","year":"2018","journal-title":"J. Natl. Compr. Cancer Netw. JNCCN"},{"key":"10.1016\/j.phymed.2025.156939_bib0005","doi-asserted-by":"crossref","first-page":"5503","DOI":"10.3390\/ijms20215503","article-title":"Immune and inflammatory cells of the tumor microenvironment represent novel therapeutic targets in classical Hodgkin lymphoma","volume":"20","author":"Calabretta","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2025.156939_bib0006","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/s41571-020-0341-y","article-title":"Targeting apoptosis in cancer therapy","volume":"17","author":"Carneiro","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.phymed.2025.156939_bib0007","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1186\/s12885-019-5673-6","article-title":"High expression of MMP19 is associated with poor prognosis in patients with colorectal cancer","volume":"19","author":"Chen","year":"2019","journal-title":"BMC Cancer"},{"key":"10.1016\/j.phymed.2025.156939_bib0008","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s41580-023-00585-z","article-title":"Autophagy and autophagy-related pathways in cancer","volume":"24","author":"Debnath","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2025.156939_bib0009","doi-asserted-by":"crossref","DOI":"10.3390\/cells8111349","article-title":"Functions and implications of autophagy in colon cancer","volume":"8","author":"Devenport","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.phymed.2025.156939_bib0010","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/35077213","article-title":"Proliferation, cell cycle and apoptosis in cancer","volume":"411","author":"Evan","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2025.156939_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2024.109623","article-title":"Cafestol inhibits colon cancer cell proliferation and tumor growth in xenograft mice by activating LKB1\/AMPK\/ULK1-dependent autophagy","volume":"129","author":"Feng","year":"2024","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.phymed.2025.156939_bib0012","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/ncb2082","article-title":"Autophagy negatively regulates Wnt signalling by promoting dishevelled degradation","volume":"12","author":"Gao","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.phymed.2025.156939_bib0013","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13045-019-0754-1","article-title":"Targeting mTOR for cancer therapy","volume":"12","author":"Hua","year":"2019","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.phymed.2025.156939_bib0014","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.cmet.2017.06.016","article-title":"Metabolic regulation of T cell longevity and function in tumor immunotherapy","volume":"26","author":"Kishton","year":"2017","journal-title":"Cell Metab"},{"key":"10.1016\/j.phymed.2025.156939_bib0015","article-title":"Lupenone protects neuroblastoma SH-SY5y cells against methamphetamine-induced apoptotic cell death via PI3K\/Akt\/mTOR signaling pathway","volume":"21","author":"Lee","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2025.156939_bib0016","doi-asserted-by":"crossref","first-page":"5015","DOI":"10.1158\/1078-0432.CCR-15-1204","article-title":"Cell death and cancer therapy: don\u2019t forget to kill the cancer cell!","volume":"21","author":"Letai","year":"2015","journal-title":"Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res."},{"key":"10.1016\/j.phymed.2025.156939_bib0017","article-title":"Damnacanthal isolated from morinda species inhibited ovarian cancer cell proliferation and migration through activating autophagy","volume":"100","author":"Li","year":"2022","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"10.1016\/j.phymed.2025.156939_bib0018","doi-asserted-by":"crossref","first-page":"17578","DOI":"10.1002\/jcp.28382","article-title":"Irisin ameliorates angiotensin II-induced cardiomyocyte apoptosis through autophagy","volume":"234","author":"Li","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.phymed.2025.156939_bib0019","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.yjmcc.2018.07.250","article-title":"Irisin alleviates pressure overload-induced cardiac hypertrophy by inducing protective autophagy via mTOR-independent activation of the AMPK-ULK1 pathway","volume":"121","author":"Li","year":"2018","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.phymed.2025.156939_bib0020","doi-asserted-by":"crossref","first-page":"680","DOI":"10.7150\/ijbs.84153","article-title":"Irisin attenuates vascular remodeling in hypertensive mice induced by Ang II by suppressing Ca2+-dependent endoplasmic reticulum stress in VSMCs","volume":"20","author":"Li","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.phymed.2025.156939_bib0021","article-title":"Cancer and ER stress: mutual crosstalk between autophagy, oxidative stress and inflammatory response","volume":"118","author":"Lin","year":"2019","journal-title":"Biomed. Pharmacother. Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2025.156939_bib0022","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12894","article-title":"Cellular senescence and cancer: focusing on traditional Chinese medicine and natural products","volume":"53","author":"Liu","year":"2020","journal-title":"Cell Prolif."},{"key":"10.1016\/j.phymed.2025.156939_bib0023","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nrc2602","article-title":"Cell cycle, CDKs and cancer: a changing paradigm","volume":"9","author":"Malumbres","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.phymed.2025.156939_bib0024","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nrclinonc.2016.217","article-title":"Tumour-associated macrophages as treatment targets in oncology","volume":"14","author":"Mantovani","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.phymed.2025.156939_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2018.06.110","article-title":"Ki67 is a graded rather than a binary marker of proliferation versus quiescence","volume":"24","author":"Miller","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.phymed.2025.156939_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112260","article-title":"Matrix metalloproteinase-9 (MMP-9) and its inhibitors in cancer: a mini review","volume":"194","author":"Mondal","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.phymed.2025.156939_bib0027","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031328","article-title":"The apoptosis paradox in cancer","volume":"23","author":"Morana","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2025.156939_bib0028","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s10495-014-0967-2","article-title":"Autophagy and apoptosis: where do they meet?","volume":"19","author":"Mukhopadhyay","year":"2014","journal-title":"Apoptosis Int. J. Program. Cell Death"},{"key":"10.1016\/j.phymed.2025.156939_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.173974","article-title":"Role of natural products for the treatment of Alzheimer\u2019s disease","volume":"898","author":"Noori","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2025.156939_bib0030","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1741-7015-4-38","article-title":"Collagen reorganization at the tumor-stromal interface facilitates local invasion","volume":"4","author":"Provenzano","year":"2006","journal-title":"BMC Med."},{"key":"10.1016\/j.phymed.2025.156939_bib0031","article-title":"Salidroside induces apoptosis and protective autophagy in human gastric cancer AGS cells through the PI3K\/Akt\/mTOR pathway","volume":"122","author":"Rong","year":"2020","journal-title":"Biomed. Pharmacother. Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2025.156939_bib0032","first-page":"260","article-title":"Matrix metalloproteinases 15 and 19 are stromal regulators of colorectal cancer development from the early stages","volume":"41","author":"Sena","year":"2012","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.phymed.2025.156939_bib0033","doi-asserted-by":"crossref","DOI":"10.3322\/caac.21708","article-title":"Cancer statistics, 2022. CA","volume":"72","author":"Siegel","year":"2022","journal-title":"Cancer J. Clin."},{"key":"10.1016\/j.phymed.2025.156939_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122107","article-title":"Lupenone attenuates thapsigargin-induced endoplasmic reticulum stress and apoptosis in pancreatic beta cells possibly through inhibition of protein tyrosine kinase 2 activity","volume":"332","author":"Song","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2025.156939_bib0035","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41572-023-00432-7","article-title":"Young-onset colorectal cancer","volume":"9","author":"Spaander","year":"2023","journal-title":"Nat. Rev. Dis. Primer"},{"key":"10.1016\/j.phymed.2025.156939_bib0036","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25116120","article-title":"Inhibition of SARS-CoV-2 Nsp9 ssDNA-binding activity and cytotoxic effects on H838, H1975, and A549 human non-small cell lung cancer cells: exploring the potential of Nepenthes miranda leaf extract for pulmonary disease treatment","volume":"25","author":"Su","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2025.156939_bib0037","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.ccell.2021.03.010","article-title":"Targeting cell-cycle machinery in cancer","volume":"39","author":"Suski","year":"2021","journal-title":"Cancer Cell"},{"key":"10.1016\/j.phymed.2025.156939_bib0038","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.3390\/nu7031672","article-title":"Structures of phytosterols and triterpenoids with potential anti-cancer activity in bran of black non-glutinous rice","volume":"7","author":"Suttiarporn","year":"2015","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2025.156939_bib0039","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S1470-2045(03)01321-4","article-title":"Cell-cycle targeted therapies","volume":"5","author":"Swanton","year":"2004","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.phymed.2025.156939_bib0040","doi-asserted-by":"crossref","DOI":"10.1172\/JCI179570","article-title":"Targeting apoptotic pathways for cancer therapy","volume":"134","author":"Tian","year":"2024","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2025.156939_bib0041","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.cell.2011.09.024","article-title":"Tumor metastasis: molecular insights and evolving paradigms","volume":"147","author":"Valastyan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2025.156939_bib0042","first-page":"960","article-title":"Functional outcomes of surgery for colon cancer: a systematic review and meta-analysis","volume":"47","author":"Verkuijl","year":"2021","journal-title":"Eur. J. Surg. Oncol. J. Eur. Soc. Surg. Oncol. Br. Assoc. Surg. Oncol."},{"key":"10.1016\/j.phymed.2025.156939_bib0043","article-title":"Magnoflorine improves sensitivity to doxorubicin (DOX) of breast cancer cells via inducing apoptosis and autophagy through AKT\/mTOR and p38 signaling pathways","volume":"121","author":"Wei","year":"2020","journal-title":"Biomed. Pharmacother. Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2025.156939_bib0044","first-page":"401","article-title":"ACLY facilitates colon cancer cell metastasis by CTNNB1","volume":"38","author":"Wen","year":"2019","journal-title":"J. Exp. Clin. Cancer Res. CR"},{"key":"10.1016\/j.phymed.2025.156939_bib0045","article-title":"Lupenone improves type 2 diabetic nephropathy by regulating NF-\u03baB pathway-mediated inflammation and TGF-\u03b21\/Smad\/CTGF-associated fibrosis","volume":"118","author":"Wu","year":"2023","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"10.1016\/j.phymed.2025.156939_bib0046","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.biopha.2018.04.019","article-title":"Beneficial health effects of lupenone triterpene: a review","volume":"103","author":"Xu","year":"2018","journal-title":"Biomed. Pharmacother. Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2025.156939_bib0047","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11030-019-09928-5","article-title":"Lupenone is a good anti-inflammatory compound based on the network pharmacology","volume":"24","author":"Xu","year":"2020","journal-title":"Mol. Divers."},{"key":"10.1016\/j.phymed.2025.156939_bib0048","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.602174","article-title":"A prognostic model for colon cancer patients based on eight signature autophagy genes","volume":"8","author":"Xu","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.phymed.2025.156939_bib0049","first-page":"197","article-title":"Lysosomal dysfunction and autophagy blockade contribute to autophagy-related cancer suppressing peptide-induced cytotoxic death of cervical cancer cells through the AMPK\/mTOR pathway","volume":"39","author":"Yang","year":"2020","journal-title":"J. Exp. Clin. Cancer Res. CR"},{"key":"10.1016\/j.phymed.2025.156939_bib0050","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.biopha.2017.12.057","article-title":"Brevilin A induces apoptosis and autophagy of colon adenocarcinoma cell CT26 via mitochondrial pathway and PI3K\/AKT\/mTOR inactivation","volume":"98","author":"You","year":"2018","journal-title":"Biomed. Pharmacother. Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2025.156939_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2018.11.005","article-title":"Redox signaling and unfolded protein response coordinate cell fate decisions under ER stress","volume":"25","author":"Zhang","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.phymed.2025.156939_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2018.11.005","article-title":"Redox signaling and unfolded protein response coordinate cell fate decisions under ER stress","volume":"25","author":"Zhang","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.phymed.2025.156939_bib0053","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.7150\/thno.38875","article-title":"NOTCH4 maintains quiescent mesenchymal-like breast cancer stem cells via transcriptionally activating SLUG and GAS1 in triple-negative breast cancer","volume":"10","author":"Zhou","year":"2020","journal-title":"Theranostics"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132500577X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132500577X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,10]],"date-time":"2025-08-10T06:38:18Z","timestamp":1754807898000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S094471132500577X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":53,"alternative-id":["S094471132500577X"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156939","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The antitumor effects of lupenone on colon cancer and its mechanistic insights","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156939","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156939"}}