{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T23:10:59Z","timestamp":1772320259915,"version":"3.50.1"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.phymed.2025.156956","type":"journal-article","created":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T18:04:41Z","timestamp":1749405881000},"page":"156956","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Multi-omics characterization of prognostic signature and novel molecular subtypes associated with anoikis and in vitro validation of CDKN2A in thyroid carcinoma"],"prefix":"10.1016","volume":"145","author":[{"given":"Kaigang","family":"Xie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8193-1772","authenticated-orcid":false,"given":"Xiaoming","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoting","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenjun","family":"Tong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.phymed.2025.156956_bib0001","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.phymed.2006.03.009","article-title":"Antiproliferative activity and induction of apoptosis in human colon cancer cells treated in vitro with constituents of a product derived from Pistacia lentiscus L. var. Chia","volume":"14","author":"Balan","year":"2007","journal-title":"Phytomedicine"},{"issue":"6","key":"10.1016\/j.phymed.2025.156956_bib0002","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1089\/thy.2018.0128","article-title":"Time-varying pattern of mortality and recurrence from papillary thyroid cancer: lessons from a long-term follow-up","volume":"29","author":"Dong","year":"2019","journal-title":"Thyroid"},{"issue":"12","key":"10.1016\/j.phymed.2025.156956_bib0003","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1038\/sj.bjc.6603479","article-title":"The status of CDKN2A alpha (p16INK4A) and beta (p14ARF) transcripts in thyroid tumour progression","volume":"95","author":"Ferru","year":"2006","journal-title":"Br. J. Cancer"},{"issue":"5","key":"10.1016\/j.phymed.2025.156956_bib0004","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0955-0674(97)80124-X","article-title":"Integrins and anoikis","volume":"9","author":"Frisch","year":"1997","journal-title":"Curr. Opin. Cell Biol."},{"issue":"5","key":"10.1016\/j.phymed.2025.156956_bib0005","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0955-0674(00)00251-9","article-title":"Anoikis mechanisms","volume":"13","author":"Frisch","year":"2001","journal-title":"Curr. Opin. Cell Biol."},{"issue":"6","key":"10.1016\/j.phymed.2025.156956_bib0006","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.phymed.2009.07.007","article-title":"The administration of demethyl fruticulin A from Salvia corrugata to mammalian cells lines induces \"anoikis\", a special form of apoptosis","volume":"17","author":"Giannoni","year":"2010","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.156956_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154409","article-title":"Modified Bu-Fei decoction inhibits lung metastasis via suppressing angiopoietin-like 4","volume":"106","author":"Hao","year":"2022","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.phymed.2025.156956_bib0008","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0086238","article-title":"Novel pharmacologic targeting of tight junctions and focal adhesions in prostate cancer cells","volume":"9","author":"Hensley","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.phymed.2025.156956_bib0009","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat. Protoc."},{"issue":"5","key":"10.1016\/j.phymed.2025.156956_bib0010","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1530\/ERC-10-0289","article-title":"Inhibition of gap junction transfer sensitizes thyroid cancer cells to anoikis","volume":"18","author":"Jensen","year":"2011","journal-title":"Endocr. Relat. Cancer"},{"issue":"13","key":"10.1016\/j.phymed.2025.156956_bib0011","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1001\/jama.2017.2719","article-title":"Trends in thyroid cancer incidence and mortality in the United States, 1974-2013","volume":"317","author":"Lim","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.phymed.2025.156956_bib0012","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.753678","article-title":"A preoperative nomogram for the prediction of high-volume Central lymph node metastasis in papillary thyroid carcinoma","volume":"12","author":"Lin","year":"2021","journal-title":"Front. Endocrinol."},{"issue":"6","key":"10.1016\/j.phymed.2025.156956_bib0013","doi-asserted-by":"crossref","first-page":"bbab260","DOI":"10.1093\/bib\/bbab260","article-title":"oncoPredict: an R package for predicting in vivo or cancer patient drug response and biomarkers from cell line screening data","volume":"22","author":"Maeser","year":"2021","journal-title":"Br. Bioinform."},{"issue":"5","key":"10.1016\/j.phymed.2025.156956_bib0014","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1089\/thy.2021.0662","article-title":"Thyroid cancer incidence and mortality trends in the United States: 2000-2018","volume":"32","author":"Megwalu","year":"2022","journal-title":"Thyroid"},{"issue":"7","key":"10.1016\/j.phymed.2025.156956_bib0015","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1089\/thy.2013.0045","article-title":"The increasing incidence of thyroid cancer: the influence of access to care","volume":"23","author":"Morris","year":"2013","journal-title":"Thyroid"},{"issue":"11","key":"10.1016\/j.phymed.2025.156956_bib0016","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1089\/thy.2008.0110","article-title":"Tissue transglutaminase antibodies in individuals with celiac disease bind to thyroid follicles and extracellular matrix and may contribute to thyroid dysfunction","volume":"18","author":"Naiyer","year":"2008","journal-title":"Thyroid"},{"issue":"9","key":"10.1016\/j.phymed.2025.156956_bib0017","first-page":"7818","article-title":"Unraveling the unfolded protein response signature: implications for tumor immune microenvironment heterogeneity and clinical prognosis in stomach cancer","volume":"16","author":"Ouyang","year":"2024","journal-title":"Aging (Albany. NY)"},{"issue":"4","key":"10.1016\/j.phymed.2025.156956_bib0018","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/path.2440","article-title":"The Human Protein Atlas\u2013a tool for pathology","volume":"216","author":"Ponten","year":"2008","journal-title":"J. Pathol."},{"issue":"12","key":"10.1016\/j.phymed.2025.156956_bib0019","article-title":"A robust host-response-based signature distinguishes bacterial and viral infections across diverse global populations","volume":"3","author":"Rao","year":"2022","journal-title":"Cell Rep. Med."},{"issue":"24","key":"10.1016\/j.phymed.2025.156956_bib0020","doi-asserted-by":"crossref","first-page":"11230","DOI":"10.1158\/0008-5472.CAN-05-2763","article-title":"Anoikis and survival connections in the tumor microenvironment: is there a role in prostate cancer metastasis?","volume":"65","author":"Rennebeck","year":"2005","journal-title":"Cancer Res."},{"issue":"5","key":"10.1016\/j.phymed.2025.156956_bib0021","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1158\/0008-5472.CAN-09-2833","article-title":"Talin1 promotes tumor invasion and metastasis via focal adhesion signaling and anoikis resistance","volume":"70","author":"Sakamoto","year":"2010","journal-title":"Cancer Res."},{"issue":"D1","key":"10.1016\/j.phymed.2025.156956_bib0022","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"10.1016\/j.phymed.2025.156956_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2018.03.023","article-title":"The Immune Landscape of cancer","volume":"48","author":"Thorsson","year":"2018","journal-title":"Immunity"},{"issue":"suppl_2","key":"10.1016\/j.phymed.2025.156956_bib0024","doi-asserted-by":"crossref","first-page":"W214","DOI":"10.1093\/nar\/gkq537","article-title":"The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function","volume":"38","author":"Warde-Farley","year":"2010","journal-title":"Nucleic Acids Res."},{"issue":"10","key":"10.1016\/j.phymed.2025.156956_bib0025","doi-asserted-by":"crossref","first-page":"e7315","DOI":"10.1002\/cam4.7315","article-title":"Identification of the molecular subtypes and signatures to predict the prognosis, biological functions, and therapeutic response based on the anoikis-related genes in colorectal cancer","volume":"13","author":"Zhai","year":"2024","journal-title":"Cancer Med."},{"issue":"19","key":"10.1016\/j.phymed.2025.156956_bib0026","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000038144","article-title":"Identification and validation of a prognostic anoikis-related gene signature in papillary thyroid carcinoma by integrated analysis of single-cell and bulk RNA-sequencing","volume":"103","author":"Zheng","year":"2024","journal-title":"Med. (Baltimore)"},{"issue":"1","key":"10.1016\/j.phymed.2025.156956_bib0027","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2025.156956_bib0028","article-title":"CDKN2A Deletion in melanoma excludes T cell infiltration by repressing chemokine expression in a cell cycle-dependent manner","volume":"11","author":"Zhu","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.phymed.2025.156956_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155714","article-title":"Muscone restores anoikis sensitivity in TMZ-resistant glioblastoma cells by suppressing TOP2A via the EGFR\/Integrin \u03b21\/FAK signaling pathway","volume":"129","author":"Zou","year":"2024","journal-title":"Phytomedicine"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132500594X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132500594X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,10]],"date-time":"2025-08-10T06:27:01Z","timestamp":1754807221000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S094471132500594X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":29,"alternative-id":["S094471132500594X"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156956","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multi-omics characterization of prognostic signature and novel molecular subtypes associated with anoikis and in vitro validation of CDKN2A in thyroid carcinoma","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.156956","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156956"}}