{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T03:05:28Z","timestamp":1773716728969,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008233","name":"Shanghai Jiao Tong University School of Medicine","doi-asserted-by":"publisher","award":["SA1700208"],"award-info":[{"award-number":["SA1700208"]}],"id":[{"id":"10.13039\/501100008233","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004921","name":"Shanghai Jiao Tong University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973191"],"award-info":[{"award-number":["81973191"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.phymed.2025.157004","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T19:13:06Z","timestamp":1750965186000},"page":"157004","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["A novel triterpenoid saponin from Pimpinella candolleana alleviates postmenopausal osteoporosis via P38\/JNK MAPK-mediated osteogenesis"],"prefix":"10.1016","volume":"145","author":[{"given":"Jiajia","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuyin","family":"Ou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed Shams ul","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shikai","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huizi","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.157004_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155628","article-title":"Morinda Officinalis-derived extracellular vesicle-like particles: anti-osteoporosis effect by regulating MAPK signaling pathway","volume":"129","author":"Cao","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.157004_bib0002","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1007\/BF01623003","article-title":"Short-term effect of alendronate on bone mass and bone remodeling in postmenopausal women","volume":"3","author":"Chesnut","year":"1993","journal-title":"Osteoporos. Int."},{"issue":"9","key":"10.1016\/j.phymed.2025.157004_bib0003","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.00391-18","article-title":"The molecular chaperone heat shock protein 70 controls liver cancer initiation and progression by regulating adaptive DNA damage and mitogen-activated protein kinase\/extracellular signal-regulated kinase signaling pathways","volume":"39","author":"Cho","year":"2019","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2025.157004_bib0004","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2016.69","article-title":"Postmenopausal osteoporosis","volume":"2","author":"Eastell","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.phymed.2025.157004_bib0005","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.bone.2006.02.062","article-title":"Hydrogen peroxide-induced oxidative stress in MC3T3-E1 cells: the effects of glutamate and protection by purines","volume":"39","author":"Fatokun","year":"2006","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.phymed.2025.157004_bib0006","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/cdd.2017.144","article-title":"SIRT3\/SOD2 maintains osteoblast differentiation and bone formation by regulating mitochondrial stress","volume":"25","author":"Gao","year":"2017","journal-title":"Cell Death. Differ."},{"key":"10.1016\/j.phymed.2025.157004_bib0007","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1146\/annurev-cellbio-101512-122347","article-title":"Mitogen-activated protein kinase pathways in osteoblasts","volume":"29","author":"Greenblatt","year":"2013","journal-title":"Annu Rev. Cell Dev. Biol."},{"issue":"9","key":"10.1016\/j.phymed.2025.157004_bib0008","doi-asserted-by":"crossref","first-page":"4596","DOI":"10.1021\/acs.jafc.3c06557","article-title":"Discovery of new botanical insecticides: identification and insecticidal activity of saponins from Clematis obscura Maxim and insights into the stress response of Acyrthosiphon pisum Harris","volume":"72","author":"Hao","year":"2024","journal-title":"J. Agric. Food Chem."},{"issue":"1","key":"10.1016\/j.phymed.2025.157004_bib0009","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12906-023-04332-x","article-title":"Biochanin A abrogates osteoclastogenesis in type 2 diabetic osteoporosis via regulating ROS\/MAPK signaling pathway based on integrating molecular docking and experimental validation","volume":"24","author":"He","year":"2024","journal-title":"BMC. Complement. Med. Ther."},{"issue":"5","key":"10.1016\/j.phymed.2025.157004_bib0010","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.ejphar.2014.06.013","article-title":"Mangiferin ameliorates colitis by inhibiting IRAK1 phosphorylation in NF-\u03baB and MAPK pathways","volume":"740","author":"Jeong","year":"2014","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.phymed.2025.157004_bib0011","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.diff.2018.03.001","article-title":"Vitamin C-linker-conjugated tripeptide AHK stimulates BMP-2-induced osteogenic differentiation of mouse myoblast C2C12 cells","volume":"101","author":"Jung","year":"2018","journal-title":"Differentiation"},{"key":"10.1016\/j.phymed.2025.157004_bib0012","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1038\/s41467-021-22565-7","article-title":"Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts","volume":"12","author":"Kim","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2025.157004_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102649","article-title":"Genistein mitigates senescence of bone marrow mesenchymal stem cells via ERR\u03b1-mediated mitochondrial biogenesis and mitophagy in ovariectomized rats","volume":"61","author":"Li","year":"2023","journal-title":"Redox. Biol."},{"issue":"30","key":"10.1016\/j.phymed.2025.157004_bib0014","doi-asserted-by":"crossref","first-page":"16739","DOI":"10.1021\/acs.jafc.4c02798","article-title":"Dendrobine ameliorates glucocorticoid-induced osteoporosis by promoting osteogenesis through JNK\/p38 MAPK pathway activation and GR nuclear translocation Inhibition","volume":"72","author":"Li","year":"2024","journal-title":"J. Agr. Food Chem."},{"key":"10.1016\/j.phymed.2025.157004_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122331","article-title":"Binding-induced fibrillogenesis peptide inhibits RANKL-mediated osteoclast activation against osteoporosis","volume":"302","author":"Liang","year":"2023","journal-title":"Biomaterials"},{"issue":"36","key":"10.1016\/j.phymed.2025.157004_bib0016","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.cmet.2024.03.006","article-title":"An integrated multi-omics analysis reveals osteokines involved in global regulation","volume":"5","author":"Liang","year":"2024","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.phymed.2025.157004_bib0017","doi-asserted-by":"crossref","first-page":"7324","DOI":"10.1038\/s41467-024-51624-y","article-title":"Multi-omics profiling of retinal pigment epithelium reveals enhancer-driven activation of RANK-NFATc1 signaling in traumatic proliferative vitreoretinopathy","volume":"15","author":"Liao","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2025.157004_bib0018","article-title":"Anti-inflammatory and protective effects of Pimpinella candolleana on ulcerative colitis in rats: a comprehensive study of quality, chemical composition, and molecular mechanisms","volume":"15","author":"Liu","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"11","key":"10.1016\/j.phymed.2025.157004_bib0019","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1016\/j.cmet.2023.10.013","article-title":"Skeletal muscle-derived extracellular vesicles transport glycolytic enzymes to mediate muscle-to-bone crosstalk","volume":"35","author":"Ma","year":"2023","journal-title":"Cell Metab."},{"key":"10.1016\/j.phymed.2025.157004_bib0020","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/nrneph.2010.113","article-title":"Molecular diagnostics in transplantation","volume":"6","author":"Naesens","year":"2010","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.phymed.2025.157004_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154509","article-title":"Equol exerts a protective effect on postmenopausal osteoporosis by upregulating OPG\/RANKL pathway","volume":"108","author":"Ni","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.157004_bib0022","doi-asserted-by":"crossref","first-page":"5418","DOI":"10.1038\/ncomms6418","article-title":"Inhibition of osteoclastogenesis and inflammatory bone resorption by targeting BET proteins and epigenetic regulation","volume":"5","author":"Park-Min","year":"2014","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.phymed.2025.157004_bib0023","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1007\/s11999-011-1909-8","article-title":"The effect of antiresorptives on bone quality","volume":"469","author":"Recker","year":"2011","journal-title":"Clin. Orthop. Relat. Res."},{"issue":"1","key":"10.1016\/j.phymed.2025.157004_bib0024","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1478-811X-3-3","article-title":"Differential effects of ERK and p38 signaling in BMP-2 stimulated hypertrophy of cultured chick sternal chondrocytes","volume":"3","author":"Reilly","year":"2005","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.phymed.2025.157004_bib0025","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrrheum.2016.92","article-title":"Autophagy: controlling cell fate in rheumatic diseases","volume":"12","author":"Rockel","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.phymed.2025.157004_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.jare.2024.11.036","article-title":"Asperosaponin VI inhibition of DNMT alleviates GPX4 suppression-mediated osteoblast ferroptosis and diabetic osteoporosis","author":"Wei","year":"2024","journal-title":"J. Adv. Res."},{"issue":"44","key":"10.1016\/j.phymed.2025.157004_bib0027","doi-asserted-by":"crossref","first-page":"eadq6700","DOI":"10.1126\/sciadv.adq6700","article-title":"Stem cell\u2013homing biomimetic hydrogel promotes the repair of osteoporotic bone defects through osteogenic and angiogenic coupling","volume":"10","author":"Wei","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.phymed.2025.157004_bib0028","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.3390\/molecules28041571","article-title":"Emerging biopharmaceuticals from Pimpinella genus","volume":"28","author":"Wu","year":"2017","journal-title":"Molecules."},{"key":"10.1016\/j.phymed.2025.157004_bib0029","article-title":"G\u03b113 negatively controls osteoclastogenesis through inhibition of the Akt-GSK3\u03b2-NFATc1 signaling pathway","volume":"8","author":"Wu","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2025.157004_bib0030","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.739326","article-title":"Kaempferol ameliorates the inhibitory activity of dexamethasone in the osteogenesis of MC3T3-E1 cells by JNK and p38-MAPK Pathways","volume":"12","author":"Xie","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"356","key":"10.1016\/j.phymed.2025.157004_bib0031","article-title":"Structural characterizations and antiaging activities of hydrolyzed low-molecular-weight polysaccharides from Polygoni Multiflori Radix Praeparata","volume":"15","author":"Xu","year":"2025","journal-title":"Carbohyd. Polym."},{"key":"10.1016\/j.phymed.2025.157004_bib0032","article-title":"NAT10 promotes osteoclastogenesis in inflammatory bone loss by catalyzing Fos mRNA ac4C modification and upregulating MAPK signaling pathway","author":"Yang","year":"2024","journal-title":"J. Adv. Res."},{"issue":"112","key":"10.1016\/j.phymed.2025.157004_bib0033","first-page":"1651","article-title":"TGF-\u03b2 regulates \u03b2-Catenin signaling and osteoblast differentiation in human mesenchymal stem cells","volume":"6","author":"Zhou","year":"2021","journal-title":"J. Cell Biochem."},{"issue":"30","key":"10.1016\/j.phymed.2025.157004_bib0034","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1080\/14786419.2015.1095745","article-title":"A new triterpenoid saponin from Clinopodium chinense (Benth.) O. Kuntze","volume":"9","author":"Zeng","year":"2016","journal-title":"Nat. Prod. Res."},{"issue":"1","key":"10.1016\/j.phymed.2025.157004_bib0035","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12709","article-title":"CRYAB promotes osteogenic differentiation of human bone marrow stem cells via stabilizing \u03b2-catenin and promoting the Wnt signalling","volume":"53","author":"Zhu","year":"2020","journal-title":"Cell Proliferat"},{"key":"10.1016\/j.phymed.2025.157004_bib0036","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1126\/sciadv.abl6432","article-title":"Cytokine-scavenging nanodecoys reconstruct osteoclast\/osteoblast balance toward the treatment of postmenopausal osteoporosis","volume":"7","author":"Zhou","year":"2021","journal-title":"Sci. Adv."},{"issue":"5","key":"10.1016\/j.phymed.2025.157004_bib0037","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1016\/j.apsb.2024.02.005","article-title":"Rhizoma Drynariae-derived nanovesicles reverse osteoporosis by potentiating osteogenic differentiation of human bone marrow mesenchymal stem cells via targeting Era signaling","volume":"14","author":"Zhao","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phymed.2025.157004_bib0038","article-title":"Celastrol-loaded ginsenoside Rg3 liposomes boost immunotherapy by remodeling obesity-related immunosuppressive tumor microenvironment in melanoma","author":"Zhang","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phymed.2025.157004_bib0039","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/s41467-025-55929-4","article-title":"Regulation of enzymatic lipid peroxidation in osteoblasts protects against postmenopausal osteoporosis","volume":"16","author":"Zhang","year":"2025","journal-title":"Nat. Commun."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325006439?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325006439?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,10]],"date-time":"2025-08-10T06:34:09Z","timestamp":1754807649000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325006439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":39,"alternative-id":["S0944711325006439"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157004","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel triterpenoid saponin from Pimpinella candolleana alleviates postmenopausal osteoporosis via P38\/JNK MAPK-mediated osteogenesis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157004"}}